1. Signaling Pathways
  2. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  3. HSP
  4. HSP90 Inhibitors

HSP90 Inhibitors

HSP40

HSP70

HSP90

HSP105

HSF1

HSP

HSPA5

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Sorry. There is currently no product that acts on isoform HSP90 together.

Please try each isoform separately.

HSP90 Specific Inhibitors, Antagonists & Activators
Product Name HSP90 HSP70 HSP90 Selectivity Purity
Tanespimycin
HSP90, IC50: 5 nM
  Selective Inhibitor 99.07%
Geldanamycin
HSP90, Kd: 1.2 μM
  Selective Inhibitor 99.78%
Ganetespib
HSP90
  Selective Inhibitor 99.84%
Luminespib
HSP90α, IC50: 7.8 nM
HSP90β, IC50: 21 nM
GRP94, IC50: 535 nM
  Selective Inhibitor 99.89%
Gamitrinib TPP hexafluorophosphate
HSP90
  Selective Inhibitor 98.16%
Alvespimycin hydrochloride
HSP90, EC50: 62 nM
GRP94, EC50: 65 nM
  Selective Inhibitor 98.68%
Pimitespib
HSP90α, Ki: 34.7 nM
HSP90β, Ki: 21.3 nM
  Selective Inhibitor 99.31%
Grp94 Inhibitor-1
GRP94, IC50: 2 nM
  Selective Inhibitor 98.63%
Onalespib
HSP90, Kd: 0.71 nM
  Selective Inhibitor 99.71%
BIIB021
HSP90, Ki: 1.7 nM
HSP90, EC50: 38 nM
  Selective Inhibitor 99.93%
NVP-HSP990
HSP90α, IC50: 0.6 nM
HSP90β, IC50: 0.8 nM
GRP94, IC50: 8.5 nM
  Selective Inhibitor 99.77%
XL888
HSP90, IC50: 24 nM
  Selective Inhibitor 99.62%
Debio 0932
HSP90α, IC50: 100 nM
HSP90β, IC50: 103 nM
  Selective Inhibitor 99.97%
Radicicol
HSP90, IC50: 1 μM
  Selective Inhibitor ≥99.0%
VER-82576
HSP90β, IC50: 58 nM
GRP94, IC50: 4.1 μM
  Selective Inhibitor 99.76%
KW-2478
HSP90α, IC50: 3.8 nM
  Selective Inhibitor 99.90%
Retaspimycin Hydrochloride
HSP90, EC50: 119 nM
GRP94, EC50: 119 nM
  Selective Inhibitor 98.35%
AMP-PCP disodium
HSP90, Kd: 3.8 μM
  Selective Activator ≥99.0%
Ethoxyquin
HSP90
  Selective Inhibitor 98.29%
3-Phenyltoxoflavin
HSP90, Kd: 585 nM
  Selective Inhibitor 99.86%
VER-50589
HSP90, IC50: 21 nM
  Selective Inhibitor 99.97%
VER-49009
HSP90, IC50: 25 nM
  Selective Inhibitor 99.39%
Geldanamycin-FITC
HSP90
  Selective Inhibitor 98.02%
Cucurbitacin D
HSP90
  Selective Inhibitor 99.91%
HS-27
HSP90
  Selective Inhibitor 98.48%
NMS-E973
HSP90α, DC50: 10 nM
  Selective Inhibitor ≥98.0%
Gedunin
HSP90
  Selective Inhibitor ≥98.0%
Alvespimycin
HSP90, EC50: 62 nM
GRP94, EC50: 65 nM
  Selective Inhibitor
Gamitrinib TPP
HSP90
  Selective Inhibitor
NCT-58
HSP90
  Selective Inhibitor 99.82%
YZ129
HSP90
  Selective Inhibitor
Cemdomespib
HSP90
  Selective Inhibitor
Shepherdin (79-87)
HSP90
  Selective Antagonist
Macbecin
HSP90, IC50: 2 μM
HSP90, Kd: 0.24 μM
  Selective Inhibitor
Aminohexylgeldanamycin hydrochloride
HSP90
  Selective Inhibitor
HDAC/HSP90-IN-3
HSP90, IC50: 0.83 μM (fungal Hsp90)
HSP90, IC50: 19.52 μM (human Hsp90)
  Selective Inhibitor
17-AEP-GA
HSP90
  Selective Inhibitor
HDAC6/HSP90-IN-1
HSP90, IC50: 46.8 nM
  Selective Inhibitor
HSP90-IN-14
HSP90β, Kd: 0.26 ± 0.0 μM
  Selective Inhibitor
AMP-PCP
HSP90, Kd: 3.8 μM
  Selective Activator
MPC-0767
HSP90
  Selective Inhibitor
CH5138303
HSP90α, Kd: 0.52 nM
  Selective Inhibitor
Retaspimycin
HSP90, EC50: 119 nM
GRP94, EC50: 119 nM
  Selective Inhibitor
Tamoxifen
HSP90
  Pan Activator 99.92%
Tamoxifen Citrate
HSP90
  Pan Activator 99.93%
Dihydroberberine
HSP90
  Pan Inhibitor 98.44%
HSP90-IN-13
HSP90, IC50: 25.07 nM
  Pan Inhibitor
CCT018159
human Hsp90β, IC50: 3.2 μM
yeast Hsp90, IC50: 6.6 μM
  Pan Inhibitor
17-GMB-APA-GA
HSP90
  Pan Inhibitor
Tamoxifen-​d5
HSP90
  Pan Activator
PROTAC HSP90 degrader BP3
HSP90
  Inhibitor
Novobiocin sodium
HSP90
  Antagonist
Aminohexylgeldanamycin
HSP90
  Inhibitor
Chetomin
HSP90
  Inhibitor ≥99.0%
YK5
HSP90
HSP70
Inhibitor
Hsp90-IN-15
HSP90
  Inhibitor
HSP90-IN-9
HSP90
  Inhibitor