2134571-29-0
2134571-29-0
Chemical Structure
KUNG94
- CAS No.: 2134571-29-0
- Formula:C22H18FNO3
- Molecular Weight:363.39
IUPAC Name: (5-(4-fluorobenzyl)-2,4-dihydroxyphenyl)(isoindolin-2-yl)methanone
InChIKey: SDHXQALTNKXTMI-UHFFFAOYSA-N
SMILES: O=C(C=1C=C(C(O)=CC1O)CC2=CC=C(F)C=C2)N3CC=4C=CC=CC4C3
Biological Activity: KUNG94 is a selective Grp94/HSP90B inhibitor (IC50=8 nM). By inhibiting the chaperone function of Grp94, KUNG94 reduces the maturation and cell surface trafficking of its specific client proteins. KUNG94 can be used for studies on Grp94-related biological mechanisms, as well as diseases including cancer and primary open-angle glaucoma[1].
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KUNG94 | KUNG94 is a selective Grp94/HSP90B inhibitor (IC50=8 nM). By inhibiting the chaperone function of Grp94, KUNG94 reduces the maturation and cell surface trafficking of its specific client proteins. KUNG94 can be used for studies on Grp94-related biological mechanisms, as well as diseases including cancer and primary open-angle glaucoma. | |||||||||||||||||||||
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