2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. KUNG94

KUNG94 is a selective Grp94/HSP90B inhibitor (IC50=8 nM). By inhibiting the chaperone function of Grp94, KUNG94 reduces the maturation and cell surface trafficking of its specific client proteins. KUNG94 can be used for studies on Grp94-related biological mechanisms, as well as diseases including cancer and primary open-angle glaucoma.

For research use only. We do not sell to patients.

KUNG94

KUNG94 Chemical Structure

CAS No. : 2134571-29-0

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KUNG94 Related Antibodies

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Description

KUNG94 is a selective Grp94/HSP90B inhibitor (IC50=8 nM). By inhibiting the chaperone function of Grp94, KUNG94 reduces the maturation and cell surface trafficking of its specific client proteins. KUNG94 can be used for studies on Grp94-related biological mechanisms, as well as diseases including cancer and primary open-angle glaucoma[1].

IC50 & Target[1]

HSP90β

 

In Vitro

KUNG94 inhibits recombinant canine Grp94NΔ41 with an IC50 of 8 nM at 4 h; it also inhibits human Hsp90αN with an IC50 of 77 nM at 4 h, and exhibits up to 10-fold selectivity for Grp94 in FP competition assays[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KUNG94 Related Antibodies
Molecular Weight

363.39

Formula

C22H18FNO3
CAS No.
SMILES

O=C(C=1C=C(C(O)=CC1O)CC2=CC=C(F)C=C2)N3CC=4C=CC=CC4C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KUNG94 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KUNG942134571-29-0KUNG 94KUNG-94HSPHeat shock proteinsGrp94Hsp90αTLR9AktHsp70integrin α2IL-6TLR2integrin αLTNF-αInhibitorinhibitorinhibit

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