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Cat. No.: HY-119732

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KUNG94

KUNG94 is a selective Grp94/HSP90B inhibitor (IC₅₀=8 nM). By inhibiting the chaperone function of Grp94, KUNG94 reduces the maturation and cell surface trafficking of its specific client proteins. KUNG94 can be used for studies on Grp94-related biological mechanisms, as well as diseases including cancer and primary open-angle glaucoma.

For research use only. We do not sell to patients.

CAS No.: 2134571-29-0
Formula: C₂₂H₁₈FNO₃
Molecular Weight:363.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

KUNG94 Chemical Structure

CAS No.: 2134571-29-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

HSP90β

All HSP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
RPMI-8226	GI₅₀	1.4 μM Compound: 21	Growth inhibition of human RPMI8226 cells after 72 hrs by MTS/PMS assay Growth inhibition of human RPMI8226 cells after 72 hrs by MTS/PMS assay	[PMID: 29057043]

In Vitro

KUNG94 inhibits recombinant canine Grp94NΔ41 with an IC₅₀ of 8 nM at 4 h; it also inhibits human Hsp90αN with an IC₅₀ of 77 nM at 4 h, and exhibits up to 10-fold selectivity for Grp94 in FP competition assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 2134571-29-0
Molecular Weight 363.39
Formula C₂₂H₁₈FNO₃
SMILES

O=C(C=1C=C(C(O)=CC1O)CC2=CC=C(F)C=C2)N3CC=4C=CC=CC4C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jiang F, et al. Discovery of a Potent Grp94 Selective Inhibitor with Anti-Inflammatory Efficacy in a Mouse Model of Ulcerative Colitis. J Med Chem. 2018;61(21):9513-9533. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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