Ig-β/CD79b
Ig-beta (CD79b, B29) is the partner chain of Ig-alpha in the B-cell receptor, anchoring membrane immunoglobulin molecules that cannot reach the surface on their own. Its single extracellular Ig-like domain and cytoplasmic ITAM complement those of CD79a, and phosphorylated CD79b helps recruit Syk and BTK after antigen engagement. Beyond signaling, CD79b controls the intracellular transport and degradation routing of the BCR. Biallelic CD79B loss produces a phenotype resembling severe B-cell deficiency, whereas in diffuse large B-cell lymphoma the chain is a validated drug target: polatuzumab vedotin delivers cytotoxins to CD79b-positive malignant cells.
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Ig-β/CD79b Recombinant Proteins (14)
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- 1
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
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- Fòrmula: Human
- Peso molecular: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
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