2. Natural Products
  3. Quinones

Quinones

Quinones represent a class of compounds that are widely distributed in nature. They are found in a wide variety of plants. They are also present in fungi, bacteria and in small amounts in animals. Quinones have a common basic structural pattern: an ortho or a para substituted dione conjugated either to an aromatic nucleus (benzoquinones) or to a condensed polycyclic aromatic system, such as Benzene quinones, Naphthalene quinones, Phenanthrenequinones and Anthraquinones. Quinones have potential biological activities for antioxidant, anti-inflammatory, antibiotic, anti-microbial, and anti-cancer activities. Anthraquinone derivatives, an important subclass of quinones show a wide array of pharmacological activities including laxative, anti-cancer, anti-inflammatory, anti-arthritic, anti-fungal, anti-bacterial, antiviral, anti-platelet aggregation and neuroprotective activity.

 

Quinones (192):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-15142
    Doxorubicin hydrochloride 25316-40-9 99.60%
    Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy.
    Doxorubicin hydrochloride
  • HY-N0822
    Shikonin 517-89-5 99.80%
    Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway. Shikonin decreases exosome secretion through the inhibition of glycolysis. Shikonin inhibits AIM2 inflammasome activation.
    Shikonin
  • HY-13062
    Daunorubicin hydrochloride 23541-50-6 99.62%
    Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor.
    Daunorubicin hydrochloride
  • HY-15230
    Geldanamycin 30562-34-6 99.78%
    Geldanamycin is a Hsp90 inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria. Geldanamycin has anti-influenza virus H5N1 activities.
    Geldanamycin
  • HY-B0332
    Menadione 58-27-5 99.53%
    Menadione, a naphthoquinone, can be converted to active vitamin K2 in vivo.
    Menadione
  • HY-N2306A
    Aclacinomycin A hydrochloride 75443-99-1
    Aclacinomycin A (Aclarubicin) hydrochloride is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A hydrochloride is an inhibitor of topoisomerase I and II. Aclacinomycin A hydrochloride inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A hydrochloride might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis.
    Aclacinomycin A hydrochloride
  • HY-N9961
    2-Hydroxyl emodin-1-methyl ether 346434-45-5
    2-Hydroxyl emodin-1-methyl ether (Compound 5) is an anthraquinone that can be isolated from the seeds of Cassia obtusifolia.
    2-Hydroxyl emodin-1-methyl ether
  • HY-N9610
    Coenzyme Q6 1065-31-2
    Coenzyme Q6 (Ubiquinone 30) is an isoprenylated benzoquinone lipid. Coenzyme Q6 exhibits functions in respiratory electron transport and as a lipid antioxidant. Coenzyme Q6 also has antioxidant effects, which can prevent the production of free radicals and oxidative damage.
    Coenzyme Q6
  • HY-14393
    Emodin 518-82-1 99.20%
    Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice.
    Emodin
  • HY-N0111
    Coenzyme Q10 303-98-0 ≥98.0%
    Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.
    Coenzyme Q10
  • HY-B2156
    Menaquinone-4 863-61-6 99.81%
    Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.
    Menaquinone-4
  • HY-N0174
    Cryptotanshinone 35825-57-1 98.69%
    Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC50 of 4.6 μM.
    Cryptotanshinone
  • HY-13555
    β-Lapachone 4707-32-8 99.99%
    β-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.
    β-Lapachone
  • HY-N0135
    Tanshinone IIA 568-72-9 99.74%
    Tanshinone IIA (Tan IIA) is one of the main compositions in the root of Salvia miltiorrhiza Bunge. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.
    Tanshinone IIA
  • HY-N0105
    Rhein 478-43-3 98.06%
    Rhein is a lipophilic anthraquinone extensively found in medicinal herbs, and has many pharmacological effects, including epatoprotective, nephroprotective, anti-inflammatory, antioxidant, anticancer, and antimicrobial activities.
    Rhein
  • HY-N0684
    Vitamin K1 84-80-0 ≥98.0%
    Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.
    Vitamin K1
  • HY-N0283
    Diacerein 13739-02-1 98.78%
    Diacerein (Diacerhein), a interleukin-1 beta inhibitor, is a slow-acting medicine of the class anthraquinone used to treat joint diseases.
    Diacerein
  • HY-17473
    Embelin 550-24-3 98.75%
    Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC50=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells.
    Embelin
  • HY-N1497
    Plumbagin 481-42-5 99.23%
    Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica, exhibits anticancer and antiproliferative activities.
    Plumbagin
  • HY-N0365
    Sennoside A 81-27-6 99.71%
    Sennoside A is an anthraquinone glycoside, found in Senna (Cassia angustifolia). Sennoside A is a HIV-1 inhibitor effective on HIV-1 replication.
    Sennoside A