2. Natural Products
  3. Quinones
  4. Naphthalene Quinones

Naphthalene Quinones

Naphthalene Quinones (140):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0822
    Shikonin 517-89-5 99.80%
    Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway. Shikonin decreases exosome secretion through the inhibition of glycolysis. Shikonin inhibits AIM2 inflammasome activation.
    Shikonin
  • HY-B0332
    Menadione 58-27-5 99.82%
    Menadione is a naphthoquinone that is converted into active vitamin K2 in the body. Menadione is a potential anticancer agent and radiosensitizer.
    Menadione
  • HY-N0135
    Tanshinone IIA 568-72-9 99.78%
    Tanshinone IIA (Tan IIA) is one of the main compositions in the root of Salvia miltiorrhiza Bunge. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.
    Tanshinone IIA
  • HY-B2156
    Menaquinone-4 863-61-6 99.96%
    Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.
    Menaquinone-4
  • HY-N0174
    Cryptotanshinone 35825-57-1 99.07%
    Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC50 of 4.6 μM.
    Cryptotanshinone
  • HY-134537
    Vitamin K2(5) 957-78-8
    Vitamin K2 (5) (Compound 1) is a prenylogue of the Vitamin K2 (HY-109569) series that can be found in the heartwood of Tabebuia avellanedae.
    Vitamin K2(5)
  • HY-N19811
    Eleuthoside B 194851-33-7
    Eleuthoside B is a naphthyl gentiobioside identified from the bulbs of Eleutherine americana. Eleuthoside B has an IC50 >1.00 mM against α-glucosidase, and it is not the main contributor to the antidiabetic (hypoglycemic) activity exhibited by the plant extract.
    Eleuthoside B
  • HY-N19645
    (-)-3-[2-(Acetyloxy)propyl]-2-hydroxy-8-methoxy-1,4-naphthoquinone 1092534-14-9
    (-)-3--2-hydroxy-8-methoxy-1,4-naphthoquinone (Compound 1) is a naphthoquinone compound. (-)-3--2-hydroxy-8-methoxy-1,4-naphthoquinone is isolated from the bulbs of Eleutherine americana. (-)-3--2-hydroxy-8-methoxy-1,4-naphthoquinone shows no activity against lipopolysaccharide-induced nitric oxide production.
    (-)-3-[2-(Acetyloxy)propyl]-2-hydroxy-8-methoxy-1,4-naphthoquinone
  • HY-N0684
    Vitamin K1 84-80-0 98.60%
    Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.
    Vitamin K1
  • HY-13555
    β-Lapachone 4707-32-8 99.96%
    β-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.
    β-Lapachone
  • HY-N6949
    Juglone 481-39-0 99.77%
    Juglone (5-hydroxy-1,4-naphthalenedione) is a yellow dye that can be extracted from Juglans regia. Juglone induces apoptosis through the mitochondrial pathway. Juglone has antibacterial and antitumor activity .
    Juglone
  • HY-N2493
    Lawsone 83-72-7 99.69%
    Lawsone is an orally active naphthoquinone dye that can be isolated from the leaves of Lawsonia inermis. Lawsone can induce apoptosis. Lawsone has antibacterial, antitumor and antioxidant activities. Lawsone can be used in anti-tumor drug research.
    Lawsone
  • HY-N1497
    Plumbagin 481-42-5 99.74%
    Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica, exhibits anticancer and antiproliferative activities.
    Plumbagin
  • HY-N2181
    Acetylshikonin 24502-78-1 99.89%
    Acetylshikonin is an oral active anti-cancer, anti-inflammatory, antioxidant, anti-fertility, antibacterial, and neuroprotective agent. Acetylshikonin is a inhibitor of acetylcholinase (AChE) (IC50=34.6 μM) and nonselective cytochrome P450. Acetylshikonin can induce Apoptosis and Autophagy in cancer cells. Acetylshikonin regulates blood glucose, liver fat metabolism, and renal fibrosis, and is used in the study of diabetes, diabetic nephropathy (DN), obesity, and nonalcoholic fatty liver disease (NAFLD).
    Acetylshikonin
  • HY-N2187
    Deoxyshikonin 43043-74-9 99.96%
    Deoxyshikonin increases the expression of VEGF-C and VEGF-A mRNA in HMVEC-dLy, promotes HIF-1α and HIF-1β subunit interaction and binds to specific DNA sequences targeted by HIF. Deoxyshikonin inhibited colorectal cancer (CRC) through the PI3K/Akt/mTOR pathway. Deoxyshikonin has proangiogenesis effect and antitumor activity. Deoxyshikonin is an antibacterial agent against methicillin-resistant S. aureus (MRSA) and S. pneumonia (MIC=17 μg/mL).
    Deoxyshikonin
  • HY-N4100
    Trilobatin 4192-90-9 98.90%
    Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd, Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope. Neuroprotective effects. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells.
    Trilobatin
  • HY-N7116
    Lawsone methyl ether 2348-82-5 99.64%
    Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone), isolated from Impatiens balsamina L. and Swertia calycina, exhibits potent antifungal and antibacterial activities.
    Lawsone methyl ether
  • HY-N7526
    Naphthazarin 475-38-7 99.59%
    Naphthazarin (DHNQ) is a microtubule depolymerizing agent. Naphthazarin can improve motor function and reduce neuroinflammation in mouse models of Parkinson's disease. Naphthazarin can induce tumor cell apoptosis, autophagy, and cell cycle arrest. Naphthazarin can also induce erythrocyte apoptosis. Naphthazarin can be used in the research of tumors and neurodegenerative diseases.
    Naphthazarin
  • HY-N5112B
    β,β-Dimethylacrylshikonin 24502-79-2 99.30%
    β,β-Dimethylacrylshikonin (Isoarnebin I) is a naphthoquinone derivative that can be isolated from Lithospermum erythrorhizon Sieb. et Zucc. β,β-Dimethylacrylshikonin promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. β,β-Dimethylacrylshikonin inhibits Notch-1 activation. β,β-Dimethylacrylshikonin inhibtis tumor cell proliferation, induces tumor cell apoptosis, and inhibits tumor growth.
    β,β-Dimethylacrylshikonin
  • HY-N6961
    Lapachol 84-79-7 99.49%
    Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity.
    Lapachol