1. Natural Products
  2. Quinones
  3. Naphthalene Quinones

Naphthalene Quinones

Naphthalene Quinones (43):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0822
    Shikonin 517-89-5 98.62%
    Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway. Shikonin decreases exosome secretion through the inhibition of glycolysis. Shikonin inhibits AIM2 inflammasome activation.
  • HY-B0332
    Menadione 58-27-5 98.07%
    Menadione, a synthetic naphthoquinone, can be converted to active vitamin K2 in vivo.
  • HY-N0174
    Cryptotanshinone 35825-57-1 98.69%
    Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC50 of 4.6 μM.
  • HY-13555
    β-Lapachone 4707-32-8 99.85%
    β-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.
  • HY-N0135
    Tanshinone IIA 568-72-9 99.74%
    Tanshinone IIA (Tan IIA) is one of the main compositions in the root of red-rooted salvia. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.
    Tanshinone IIA
  • HY-111321
    Fuscin 83-85-2
    Fuscin, a fungal metabolite, CCR5 receptor antagonist with anti-HIV effects. Fuscin is a respiration and oxidative phosphorylation inhibitor, and also a mitochondrial SH-dependent transport-linked functions inhibitor.
  • HY-N8139
    2-Amino-3-carboxy-1,4-naphthoquinone 173043-38-4
    2-Amino-3-carboxy-1,4-naphthoquinone is the electron transfer mediator. 2-Amino-3-carboxy-1,4-naphthoquinone changes glucose metabolism of the homofermentative lactic acid bacteria.
  • HY-N10233
    6-Ethyl-2,7-dimethoxyjuglone 15254-86-1
    6-Ethyl-2,7-dimethoxyjuglone is a metabolite isolated from freshwater fungi.
  • HY-B2156
    Menaquinone-4 863-61-6 ≥98.0%
    Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.
  • HY-N0684
    Vitamin K1 84-80-0 ≥98.0%
    Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.
    Vitamin K1
  • HY-N1497
    Plumbagin 481-42-5 99.65%
    Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica L, exhibits anticancer and antiproliferative activities.
  • HY-N6949
    Juglone 481-39-0
    Juglone is a yellow pigment found in black walnut (Juglans regia). Juglone also shows antimicrobial activity.
  • HY-N6012
    (-)-Alkannin 517-88-4 99.58%
    (-)-Alkannin, found in Alkanna tinctoria, is used as a food coloring. (-)-Alkannin shows anticancer activity, arrests cell cycle, and induces apoptosis. (-)-Alkannin improves hepatic inflammation in a Rho-kinase pathway.
  • HY-N2181
    Acetylshikonin 24502-78-1 98.10%
    Acetylshikonin, derived from the root of Lithospermum erythrorhizon, has anti-cancer and antiinflammation activity. Acetylshikonin is a non-selective cytochrome P450 inhibitor against all P450s (IC50 values range from 1.4-4.0 μM). Acetylshikonin is an AChE inhibitor and exhibits potent antiapoptosis activity.
  • HY-N5112B
    β,β-Dimethylacrylshikonin 24502-79-2 99.64%
    β,β-Dimethylacrylshikonin (Isoarnebin I) is a naphthoquinone derivative isolated from Arnebia nobilis, promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway.β,β-Dimethylacrylshikonin has anti-tumor activity.
  • HY-N2187
    Deoxyshikonin 43043-74-9 99.96%
    Deoxyshikonin is isolated from Lithospermum erythrorhizon Sieb with antitumor activity. Deoxyshikonin increases the expression of VEGF-C and VEGF-A mRNA in HMVEC-dLy, promotes HIF-1α and HIF-1β subunit interaction and binds to specific DNA sequences targeted by HIF, indicates a prolymphangiogenesis as well as a proangiogenesis effect in vitro. Deoxyshikonin shows significant synergic antimicrobial activity against S. pneumonia (MIC=17 μg/mL), also shows significantly inhibitory activities against MRSA.
  • HY-N6961
    Lapachol 84-79-7
    Lapachol is a naphthoquinone that was first isolated from Tabebuia avellanedae (Bignoniaceae). Lapachol shows anti-abscess, anti-ulcer, antileishmanial, anticarcinomic, antiedemic, anti-inflammatory, antimalarial, antiseptic, antitumor, antiviral, antibacterial, antifungal and pesticidal activities.
  • HY-125365
    Rifamycin S 13553-79-2 99.22%
    Rifamycin S, a quinone, is an antibiotic against Gram-positive bacteria (including MRSA). Rifamycin S is the oxidized forms of a reversible oxidation-reduction system involving two electrons. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation. Rifamycin S can be used for tuberculosis and leprosy.
    Rifamycin S
  • HY-N5112A
    β,β-Dimethylacrylalkannin 34539-65-6 98.03%
    β,β-Dimethylacrylalkannin (Arnebin 1) is a napthoquinone isolated from Arnebia nobilis Reichb.f, increases collagen and involucrin content in skin cells.
  • HY-N4201
    β-Hydroxyisovalerylshikonin 7415-78-3 99.83%
    Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermium radix, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC50s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells.