VEGF-C
VEGF-C is the master regulator of lymphangiogenesis. Secreted as a precursor that binds only VEGFR3, it gains VEGFR2-binding capacity after stepwise proteolytic maturation, coupling lymphatic growth with blood-vascular responses. VEGF-C expression in adult tissues centers on lymphatic endothelium-associated sites, and tumor-derived VEGF-C drives lymphatic vessel formation and nodal metastasis. It is also required for lymphatic development, immune-cell trafficking, and, notably, blood-pressure regulation via lymphatic endothelial signaling. Recombinant VEGF-C protein, supplied as mature or pro-form, supports lymphatic endothelial cell culture, VEGFR3 phosphorylation assays, and screening of anti-lymphangiogenic therapeutics.
-
VEGF-C Recombinant Proteins (8)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
