L-Selectin/CD62L
L-Selectin (CD62L), encoded by SELL, is a C-type lectin adhesion receptor that initiates the rolling step of leukocyte recruitment. It recognizes sulfate-rich carbohydrate ligands such as peripheral lymph node addressins (PNAd) on high endothelial venules, guiding naive and central memory lymphocytes into lymph nodes and mediating neutrophil rolling on inflamed endothelium. Cell activation triggers rapid shedding of L-Selectin by the protease ADAM17, converting adhesion from rolling to firm arrest. Clinically, CD62L distinguishes naive from effector T cell subsets, and its ligand-binding biology underpins research on lymphocyte trafficking, vaccination and tumor metastasis.
-
L-Selectin/CD62L Recombinant Proteins (6)
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
