IL-1RA
Interleukin-1 receptor antagonist (IL-1RA, also known as IL-1RN) is a naturally occurring inhibitor of the IL-1 signaling pathway, secreted by monocytes, macrophages, neutrophils and hepatocytes in response to inflammatory stimuli. IL-1RA binds to IL-1 receptor type 1 (IL-1RI) with comparable affinity to IL-1α and IL-1β, yet fails to recruit the IL-1 receptor accessory protein (IL-1RAcP), thereby acting as a competitive antagonist that blocks IL-1-driven inflammation. Recombinant IL-1RA (anakinra) is clinically used to treat autoinflammatory diseases such as rheumatoid arthritis, cryopyrin-associated periodic syndromes and Still's disease, highlighting its essential role in limiting IL-1-mediated tissue damage.
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IL-1RA Recombinant Proteins (10)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
