TBCK
TBCK is a multidomain protein pairing an N-terminal TBC (Tre-2/Bub2/Cdc16) domain, a RabGAP-like module, and a C-terminal pseudokinase domain of uncertain catalytic status. It localizes to the actin cytoskeleton and adhesion sites, where it is required for cell attachment, spreading, and cytoskeletal organization, and it has been proposed to act within mTORC1-related growth control through its GAP-like region. Biallelic TBCK mutations cause an autosomal-recessive infantile-onset syndrome of hypotonia, global developmental delay, epilepsy, and characteristic facial features, sometimes with elevated creatine kinase. Recombinant TBCK facilitates research on this neurodevelopmental disorder and on TBC-domain pseudokinase biology.
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TBCK Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
