2. Recombinant Proteins
  3. Receptor Proteins Enzymes & Regulators
  4. Receptor Tyrosine Kinases Protein Tyrosine Kinases
  5. TAM Receptor

TAM Receptor

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The TAM receptors family is comprised of three conserved receptor tyrosine kinases, Tyro3 (also known as Sky and Rse), Axl (UFO, ARK, Tyro7, or JTK11), and Mer (Eyk, Nyk, Tyro12). They share conserved extracellular domain distinct from other receptor tyrosine kinases, which comprised of two tandem immunoglobulin-like (Ig) domains and two tandem fibronectin type III (Fn-III) domains, followed by a single trans-membrane spanning region and an intracellular tyrosine kinase domain. Common ligands for the TAM family include growth arrest specific factor-6 (Gas6), protein S, Tubby, Tubby-like protein 1 (TULP-1) and Galectin-3. Among them, Gas6 and protein S are the best-characterized ligands that bind to the extracellular Ig domains of TAMs and induce dimerization, tyrosine phosphorylation, and post-receptor activation of downstream signaling pathways. Tyro3, Axl, and Mertk have pleiotropic roles in innate immunity and homeostasis and when overexpressed in cancer cells can drive tumorigenesis.

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