From 11:00 pm to 12:00 pm EST ( 8:00 pm to 9:00 pm PST ) on January 6th, the website will be under maintenance. We are sorry for the inconvenience. Please arrange your schedule properly.
The TAM receptors family is comprised of three conserved receptor tyrosine kinases, Tyro3 (also known as Sky and Rse), Axl (UFO, ARK, Tyro7, or JTK11), and Mer (Eyk, Nyk, Tyro12). They share conserved extracellular domain distinct from other receptor tyrosine kinases, which comprised of two tandem immunoglobulin-like (Ig) domains and two tandem fibronectin type III (Fn-III) domains, followed by a single trans-membrane spanning region and an intracellular tyrosine kinase domain. Common ligands for the TAM family include growth arrest specific factor-6 (Gas6), protein S, Tubby, Tubby-like protein 1 (TULP-1) and Galectin-3. Among them, Gas6 and protein S are the best-characterized ligands that bind to the extracellular Ig domains of TAMs and induce dimerization, tyrosine phosphorylation, and post-receptor activation of downstream signaling pathways.
Tyro3, Axl, and Mertk have pleiotropic roles in innate immunity and homeostasis and when overexpressed in cancer cells can drive tumorigenesis.
TYRO3/DTK protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as TULP1 or GAS6. TYRO3 is activated by ligand binding and regulates cell survival, migration, and differentiation, leading to dimerization and intracellular autophosphorylation to create docking sites for downstream signaling molecules. TYRO3/DTK Protein, Mouse (388a.a, HEK293, His) is the recombinant mouse-derived TYRO3/DTK protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TYRO3/DTK Protein, Mouse (388a.a, HEK293, His) is 388 a.a., with molecular weight of 55-70 kDa.
AXL protein is a receptor tyrosine kinase that mediates signals by binding to GAS6 and regulates cell survival, proliferation, migration and differentiation. After ligand binding, AXL dimerizes and autophosphorylates, activating downstream molecules, such as PI3 kinase subunits, GRB2, PLCG1, etc. AXL Protein, Human (HEK293, Fc) is the recombinant human-derived AXL protein, expressed by HEK293 , with C-hFc labeled tag. The total length of AXL Protein, Human (HEK293, Fc) is 424 a.a., with molecular weight of 80-110 kDa.
TYRO3/DTK protein is a receptor tyrosine kinase that transduces signals through ligands such as TULP1 or GAS6 to regulate cell survival, migration and differentiation. Ligand binding induces TYRO3 dimerization and autophosphorylation, creating docking sites for downstream molecules. TYRO3/DTK Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived TYRO3/DTK protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TYRO3/DTK Protein, Mouse (HEK293, hFc) is 388 a.a., with molecular weight of 90-120 kDa.
AXL Protein, a receptor tyrosine kinase, mediates signals by binding GAS6, regulating cell survival, proliferation, migration, and differentiation. Upon ligand binding, AXL undergoes dimerization and autophosphorylation, activating downstream molecules like PI3-kinase subunits, GRB2, PLCG1, and more. This triggers AKT kinase activation, influencing processes such as endothelial cell survival, cytokine signaling in NK cell development, hepatic regeneration, gonadotropin-releasing hormone neuron function, platelet activation, thrombotic responses, and immune modulation. AXL also serves as a receptor for lassa virus and lymphocytic choriomeningitis virus during microbial infection. AXL Protein, Cynomolgus (417a.a, HEK293, His) is the recombinant cynomolgus-derived AXL protein, expressed by HEK293 , with C-His labeled tag. The total length of AXL Protein, Cynomolgus (417a.a, HEK293, His) is 417 a.a., with molecular weight of 68-70 kDa.
The TYRO3/DTK protein is a tyrosine kinase receptor. TYRO3 transduces signals from the extracellular matrix by activating the PI3K/AKT/ NF-kappa-B pathway. TYRO3 plays an important role in inhibiting Toll-like receptor (TLRs) mediated innate immune response by activating STAT1. TYRO3 has the function of promoting tumor cell survival and/or proliferation, metastasis and chemotherapy resistance. TYRO3/DTK Protein, Human (Q261H, HEK293, Fc) is the recombinant human-derived TYRO3/DTK protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TYRO3/DTK Protein, Human (Q261H, HEK293, Fc) is 388 a.a., with molecular weight of 85-120 kDa.
rHuAXL, His; Tyrosine-protein kinase receptor UFO; AXL oncogene; UFO
Human
HEK293
AXL Protein, Human (HEK293, His), a recombinant human AXL produced in HEK293 cells, has a His tag. AXL is a member of the TAM family with the high-affinity ligand growth arrest-specific protein 6 (GAS6). Anti-cancer activity.
MER tyrosine kinase (MERTK) is a transmembrane protein with transmembrane receptor protein tyrosine kinase activity. MERTK has oncogenic properties and is often overexpressed or activated in various malignancies, activating several downstream signaling pathways including MAPK/ERK, PI3K/AKT, and JAK/STAT. MERTK is involved in animal organ development, synapse elimination, neutrophil clearance and protein kinase B signaling. Mer Protein, Human (HEK293, His) is the recombinant human-derived Mer protein, expressed by HEK293, with C-6*His labeled tag. The total length of Mer Protein, Human (HEK293, His) is 323 a.a., with molecular weight of 60-120 kDa.
Tyrosine-protein kinase receptor UFO; AXL oncogene; UFO
Mouse
HEK293
The AXL protein has predicted roles in various cellular functions, binds to phosphatidylinositol 3-kinase and phosphatidylserine, and serves as a viral receptor. It negatively regulates apoptosis and positively regulates protein kinase B signaling. AXL Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived AXL protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of AXL Protein, Mouse (HEK293, His-Fc) is 424 a.a., with molecular weight of 95-120 kDa.
Tyrosine-protein kinase receptor UFO; AXL oncogene; UFO
Human
HEK293
AXL protein is a receptor tyrosine kinase that mediates signals by binding to GAS6 and regulates cell survival, proliferation, migration and differentiation. After ligand binding, AXL dimerizes and autophosphorylates, activating downstream molecules, such as PI3 kinase subunits, GRB2, PLCG1, etc. AXL Protein, Human (449a.a, HEK293, His) is the recombinant human-derived AXL protein, expressed by HEK293 , with C-His labeled tag. The total length of AXL Protein, Human (449a.a, HEK293, His) is 417 a.a., with molecular weight of 55-90 kDa.
rMuAXL, His; Tyrosine-protein kinase receptor UFO; AXL oncogene; UFO
Mouse
HEK293
AXL Protein, Mouse (HEK293, His), a recombinant mouse AXL produced in HEK293 cells, has a His tag. AXL is a member of the TAM family with the high-affinity ligand growth arrest-specific protein 6 (GAS6). Anti-cancer activity.
Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1, or GAS6, regulating cell survival, migration, differentiation, and apoptotic cell phagocytosis (endocytosis). Ligand binding induces autophosphorylation of MERTK, creating a docking site for downstream molecules. Mer Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived Mer protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Mer Protein, Cynomolgus (HEK293, Fc) is 485 a.a., with molecular weight of approximately 150 kDa.
Mer; MerTK; STK kinase; Tyrosine-protein kinase Mer
Mouse
Sf9 insect cells
Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1 or GAS6. Mer is critical in processes such as cell survival, migration, differentiation, and phagocytosis of apoptotic cells, and autophosphorylation occurs upon ligand binding. Mer Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived Mer protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of Mer Protein, Mouse (sf9, His-GST) is 295 a.a., with molecular weight of ~58 kDa.
AXL protein is a receptor tyrosine kinase that mediates signals by binding to GAS6 and regulates cell survival, proliferation, migration and differentiation. After ligand binding, AXL dimerizes and autophosphorylates, activating downstream molecules, such as PI3 kinase subunits, GRB2, PLCG1, etc. AXL Protein, Human (Biotinylated, HEK293, Fc) is the recombinant human-derived AXL protein, expressed by HEK293 , with C-hFc labeled tag. The total length of AXL Protein, Human (Biotinylated, HEK293, Fc) is 424 a.a., with molecular weight of 80-110 kDa.
AXL protein is a receptor tyrosine kinase that mediates signals by binding to GAS6 and regulates cell survival, proliferation, migration and differentiation. After ligand binding, AXL dimerizes and autophosphorylates, activating downstream molecules, such as PI3 kinase subunits, GRB2, PLCG1, etc. AXL Protein, Human (HEK293, His-Avi) is the recombinant human-derived AXL protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of AXL Protein, Human (HEK293, His-Avi) is 424 a.a., with molecular weight of 70-80 kDa.
AXL protein is a receptor tyrosine kinase that mediates signals by binding to GAS6 and regulates cell survival, proliferation, migration and differentiation. After ligand binding, AXL dimerizes and autophosphorylates, activating downstream molecules, such as PI3 kinase subunits, GRB2, PLCG1, etc. AXL Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived AXL protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of AXL Protein, Human (Biotinylated, HEK293, His-Avi) is 424 a.a., with molecular weight of 70-80 kDa.
Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1, or GAS6, regulating cell survival, migration, differentiation, and apoptotic cell phagocytosis (endocytosis). Ligand binding induces autophosphorylation of MERTK, creating a docking site for downstream molecules. MERTK Protein, Human (HEK293, His) is the recombinant human-derived MERTK protein, expressed by HEK293 , with C-10*His labeled tag. The total length of MERTK Protein, Human (HEK293, His) is 485 a.a., with molecular weight of 55.4 kDa.
Mer Protein, a receptor tyrosine kinase, transduces signals by binding to ligands like LGALS3, TUB, TULP1, or GAS6. Crucial in processes such as cell survival, migration, differentiation, and apoptotic cell phagocytosis, Mer undergoes autophosphorylation upon ligand binding. This creates binding sites for downstream molecules, leading to interactions with GRB2 or PLCG2 and subsequent phosphorylation of MAPK1, MAPK2, FAK/PTK2, or RAC1. Mer signaling influences macrophage clearance, platelet aggregation, cytoskeleton reorganization, and engulfment. Notably, in the retinal pigment epithelium, Mer regulates phagocytosis of rod outer segment fragments. Additionally, Mer inhibits the innate immune response triggered by Toll-like receptors (TLRs) by activating STAT1, inducing the production of suppressors of cytokine signaling SOCS1 and SOCS3. MERTK Protein, Mouse (HEK293, His) is the recombinant mouse-derived MERTK protein, expressed by HEK293, with C-10*His labeled tag. The total length of MERTK Protein, Mouse (HEK293, His) is 479 a.a., with molecular weight of 55.0 kDa.
Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1 or GAS6. Mer is critical in processes such as cell survival, migration, differentiation, and phagocytosis of apoptotic cells, and autophosphorylation occurs upon ligand binding. Mer Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Mer protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Mer Protein, Mouse (HEK293, Fc) is 498 a.a., with molecular weight of ~130 kDa.
Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1, or GAS6, regulating cell survival, migration, differentiation, and apoptotic cell phagocytosis (endocytosis). Ligand binding induces autophosphorylation of MERTK, creating a docking site for downstream molecules. Mer Protein, Human (sf9, His-GST) is the recombinant human-derived Mer protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of Mer Protein, Human (sf9, His-GST) is 295 a.a., with molecular weight of ~50 kDa.
Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1, or GAS6, regulating cell survival, migration, differentiation, and apoptotic cell phagocytosis (endocytosis). Ligand binding induces autophosphorylation of MERTK, creating a docking site for downstream molecules. Mer Protein, Human (HEK293, His-Fc) is the recombinant human-derived Mer protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of Mer Protein, Human (HEK293, His-Fc) is 479 a.a., with molecular weight of 140-150 kDa.
