1. Recombinant Proteins
  2. Receptor Proteins Enzymes & Regulators
  3. Receptor Tyrosine Kinases Protein Tyrosine Kinases
  4. TAM Receptor

The TAM receptors family is comprised of three conserved receptor tyrosine kinases, Tyro3 (also known as Sky and Rse), Axl (UFO, ARK, Tyro7, or JTK11), and Mer (Eyk, Nyk, Tyro12). They share conserved extracellular domain distinct from other receptor tyrosine kinases, which comprised of two tandem immunoglobulin-like (Ig) domains and two tandem fibronectin type III (Fn-III) domains, followed by a single trans-membrane spanning region and an intracellular tyrosine kinase domain. Common ligands for the TAM family include growth arrest specific factor-6 (Gas6), protein S, Tubby, Tubby-like protein 1 (TULP-1) and Galectin-3. Among them, Gas6 and protein S are the best-characterized ligands that bind to the extracellular Ig domains of TAMs and induce dimerization, tyrosine phosphorylation, and post-receptor activation of downstream signaling pathways. Tyro3, Axl, and Mertk have pleiotropic roles in innate immunity and homeostasis and when overexpressed in cancer cells can drive tumorigenesis.

Cat. No. Product Name / Synonyms Species Source
  • HY-P70057
    TYRO3/DTK Protein, Mouse (HEK293, Fc)

    rHuTyrosine-protein kinase receptor TYRO3/TYRO3, His; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase BYK; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase TIF; TYRO3; BYK; DTK; RSE; SKY; TIF

    Mouse HEK293
  • HY-P70043
    TYRO3/DTK Protein, Mouse (HEK293, hFc)

    rMuTyrosine-protein kinase receptor TYRO3/DTK, Fc; Tyrosine-protein kinase receptor TYRO3; Etk2; tyro3; TK19-2; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kinase TIF

    Mouse HEK293
  • HY-P78489
    Mer Protein, Human (HEK293, mFc)

    MERTK; MER; c-Eyk; MGC133349; c-mer; RP38; Tyro12

    Human HEK293
  • HY-P7622
    AXL Protein, Human (415a.a, HEK293, His)

    rHuAXL, His; Tyrosine-protein kinase receptor UFO; AXL oncogene; UFO

    Human HEK293
    AXL Protein, Human (HEK293, His), a recombinant human AXL produced in HEK293 cells, has a His tag. AXL is a member of the TAM family with the high-affinity ligand growth arrest-specific protein 6 (GAS6). Anti-cancer activity.
  • HY-P70958
    Mer Protein, Human (HEK293, His)

    Tyrosine-protein kinase Mer/Proto-oncogene c-Mer/Receptor tyrosine kinase MerTK/MERTK/MER

    Mouse HEK293
  • HY-P7623
    AXL Protein, Mouse (HEK293, His)

    rMuAXL, His; Tyrosine-protein kinase receptor UFO; AXL oncogene; UFO

    Mouse HEK293
    AXL Protein, Mouse (HEK293, His), a recombinant mouse AXL produced in HEK293 cells, has a His tag. AXL is a member of the TAM family with the high-affinity ligand growth arrest-specific protein 6 (GAS6). Anti-cancer activity.
  • HY-P77863
    TYRO3/DTK Protein, Mouse (HEK293, His)

    BYK; DTK; RSE; SKY; TIF; TYRO3; Brt; Rse

    Mouse HEK293
Cat. No. Product Name Effect Purity