TAM Receptor
The TAM receptors family is comprised of three conserved receptor tyrosine kinases, Tyro3 (also known as Sky and Rse), Axl (UFO, ARK, Tyro7, or JTK11), and Mer (Eyk, Nyk, Tyro12). They share conserved extracellular domain distinct from other receptor tyrosine kinases, which comprised of two tandem immunoglobulin-like (Ig) domains and two tandem fibronectin type III (Fn-III) domains, followed by a single trans-membrane spanning region and an intracellular tyrosine kinase domain. Common ligands for the TAM family include growth arrest specific factor-6 (Gas6), protein S, Tubby, Tubby-like protein 1 (TULP-1) and Galectin-3. Among them, Gas6 and protein S are the best-characterized ligands that bind to the extracellular Ig domains of TAMs and induce dimerization, tyrosine phosphorylation, and post-receptor activation of downstream signaling pathways. Tyro3, Axl, and Mertk have pleiotropic roles in innate immunity and homeostasis and when overexpressed in cancer cells can drive tumorigenesis.
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TAM Receptor Recombinant Proteins (34)
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Inhibitors & Agonists (108)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
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- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
