Axl Proteins
Axl is the best-characterized member of the TAM family of receptor tyrosine kinases and the highest-affinity receptor for the vitamin K-dependent ligand Gas6. Gas6-Axl engagement activates PI3K-AKT, RAS-MAPK, and STAT signaling that promotes cell survival, migration, and immune modulation. Expression is low in most resting tissues but rises sharply during epithelial-to-mesenchymal transition, tissue injury, and malignant transformation. Axl upregulation is a recognized mechanism of resistance to EGFR, HER2, and BRAF inhibitors, and shed soluble Axl serves as a disease biomarker. Selective inhibitors such as bemcentinib and Axl-directed antibodies are in clinical development across solid tumors and leukemia.
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Axl Recombinant Proteins (13)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
