2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Hepcidin

Hepcidin

Hepcidin is a 25-amino-acid peptide hormone secreted by hepatocytes. Hepcidin determines plasma iron concentrations and total body iron content. The function of hepcidin is to control the activity of the cellular iron exporter ferroportin, which delivers iron to plasma from intestinal iron absorption and from iron stores.

Hepcidin Related Products (17):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-113066A
    Guanosine 5'-diphosphate disodium salt
    		Inhibitor 98.20%
    Guanosine 5'-diphosphate (GDP) disodium salt, a purine nucleoside diphosphate, is interconverted to guanosine by the action of exonucleotidase and phosphorylation of nucleoside to guanine. Guanosine 5'-diphosphate disodium salt activates adenosine 5'-triphosphate-sensitive K+ channel and is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR). Guanosine 5'-diphosphate disodium salt is a potential iron mobilizer, which prevents the Hepcidin (HY-P70400)-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Elevated levels of guanosine 5’-diphosphate are associated with the pathogenesis of neurological diseases. Guanosine 5'-diphosphate disodium salt is promising for the research of inflammation, such as anemia of inflammation (AI).
    Guanosine 5'-diphosphate disodium salt
  • HY-113066C
    Guanosine 5'-diphosphate sodium, 96% (HPLC)
    		Inhibitor 99.88%
    Guanosine 5'-diphosphate (GDP) sodium, 96% (HPLC) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate sodium, 96% (HPLC) is an iron mobilizer, which forms a complex with hepcidin to inhibit the hepcidin-ferroportin (FPN) interaction and modulates the IL-6/stat-3 pathway. Guanosine 5'-diphosphate sodium, 96% (HPLC) ameliorates the Turpentine-induced anemia of inflammation (AI) in mice when combined with FeSO4. Guanosine 5'-diphosphate sodium, 96% (HPLC) can be used in the research of AI.
    Guanosine 5'-diphosphate sodium, 96% (HPLC)
  • HY-P3494B
    Hepcidin-25 (human) TFA
    Hepcidin-25 (human) TFA is an iron metabolism modulator and Antimicrobial agent. Hepcidin-25 (human) TFA shows anti-inflammatory and anti-bacterial activity via modulation of iron-mediated oxidant injury.
    Hepcidin-25 (human) TFA
  • HY-P990617
    Anti-Hepcidin/HAMP Antibody (LY2787106)
    		98.23%
    Anti-Hepcidin/HAMP Antibody (LY2787106) is a CHO-expressed human antibody that targets Hepcidin/HAMP.Anti-Hepcidin/HAMP Antibody (LY2787106) has a huIgG4SP type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 144.2 kDa. The isotype control for Anti-Hepcidin/HAMP Antibody (LY2787106) can be referred to as Human IgG4 kappa, Isotype Control (HY-P99003).
    Anti-Hepcidin/HAMP Antibody (LY2787106)
  • HY-113066
    Guanosine 5'-diphosphate
    		Inhibitor
    Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate is an iron mobilizer, which forms a complex with hepcidin to inhibit the hepcidin-ferroportin (FPN) interaction and modulates the IL-6/stat-3 pathway. Guanosine 5'-diphosphate ameliorates the Turpentine-induced anemia of inflammation (AI) in mice when combined with FeSO4. Guanosine 5'-diphosphate can be used in the research of AI.
    Guanosine 5'-diphosphate
  • HY-P992451
    RLYB331
    		Activator
    RLYB331 (KY1066) is a is a monoclonal antibody targeting Matriptase-2 (TMPRSS6). RLYB331 binds to the serine protease active site of matriptase-2, blocking protease activity to increase hepcidin expression. RLYB331 reduces iron overload, inhibits α-aggregates, reduces ROS, inhibits apoptosis, and enhances erythroid differentiation. RLYB331 ameliorates ineffective erythropoiesis in β-thalassemic mouse models. RLYB331 can be used for the research of β-thalassemia.
    RLYB331
  • HY-P992183
    AN-LP1
    		Inhibitor
    AN-LP1 is an anti-Hepcidin/HAMP monoclonal antibody.
    AN-LP1
  • HY-113066AR
    Guanosine 5'-diphosphate disodium salt (Standard)
    		Inhibitor
    Guanosine 5'-diphosphate (disodium salt) (Standard) is the analytical standard of Guanosine 5'-diphosphate (disodium salt). This product is intended for research and analytical applications. Guanosine 5'-diphosphate (GDP) disodium salt, a purine nucleoside diphosphate, is interconverted to guanosine by the action of exonucleotidase and phosphorylation of nucleoside to guanine. Guanosine 5'-diphosphate disodium salt activates adenosine 5'-triphosphate-sensitive K+ channel and is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR). Guanosine 5'-diphosphate disodium salt is a potential iron mobilizer, which prevents the Hepcidin (HY-P70400)-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Elevated levels of guanosine 5’-diphosphate are associated with the pathogenesis of neurological diseases. Guanosine 5'-diphosphate disodium salt is promising for the research of inflammation, such as anemia of inflammation (AI).
    Guanosine 5'-diphosphate disodium salt (Standard)
  • HY-P3494
    Hepcidin-25 (human)
    Hepcidin-25 (human) is an iron metabolism regulator and Antimicrobial agent. Hepcidin-25 (human) exerts anti-inflammatory and antimicrobial activities by regulating iron-mediated oxidative damage.
    Hepcidin-25 (human)
  • HY-177641A
    Lexaptepid Pegol sodium
    		Inhibitor
    Lexaptepid Pegol sodium is a pegylated structured L-oligoribonucleotide. It binds and inhibits hepcidin.
    Lexaptepid Pegol sodium
  • HY-113066B
    Guanosine 5'-diphosphate ditromethamine
    		Inhibitor
    Guanosine 5'-diphosphate ditromethamine is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate ditromethamine is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate ditromethamine can be used in the research of inflammation, such as anemia of inflammation (AI).
    Guanosine 5'-diphosphate ditromethamine
  • HY-177641
    Lexaptepid Pegol
    		Inhibitor
    Lexaptepid Pegol is a pegylated structured L-oligoribonucleotide. It binds and inhibits hepcidin.
    Lexaptepid Pegol
  • HY-P991881
    KY1070
    		Inhibitor
    KY1070 is a fully human anti-BMP6 antibody with a Kd of 0.00014 μM against the human BMP6. It exhibits high specificity for BMP6, showing no cross-reactivity with other members of the BMP family, and effectively inhibits BMP6-induced BMP receptor heterodimerization and hepcidin expression. KY1070 modulates Ferroportin expression on erythroid progenitor cells and accelerates erythropoiesis. In rodent anemia models, KY1070 reduces the required dose of erythropoietin (EPO) when used in combination with EPO and enhances the responsiveness of mice with chronic kidney disease (CKD)-associated anemia to EPO treatment. KY1070 is applicable for research on anemia of chronic disease [1] [2].
    KY1070
  • HY-177641B
    Lexaptepid Pegol sodium scrambled negative control
    		Inhibitor
    Lexaptepid Pegol sodium scrambled negative control is the sequence scrambled negative control of Lexaptepid Pegol sodium.
    Lexaptepid Pegol sodium scrambled negative control
  • HY-145629
    Palsucibep pegol
    Palsucibep pegol is a engineered human lipocalin-2 binding protein. Palsucibep pegol binds to hepcidin.
    Palsucibep pegol
  • HY-123878
    DS79182026
    		Inhibitor
    DS79182026 is an inhibitor of hepcidin production. DS79182026 exhibits hepcidin lowering ability in IL-6-induced acute inflammatory mouse model.
    DS79182026
  • HY-107980R
    DS28120313 (Standard)
    		Inhibitor
    DS28120313 (Standard) is the analytical standard of DS28120313 (HY-107980). This product is intended for research and analytical applications. DS28120313 (compound 32) is an orally hepcidin production inhibitor with an IC50 of 0.093 μM.
    DS28120313 (Standard)