2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Hepcidin
  5. Hepcidin Inhibitor

Hepcidin Inhibitor

Hepcidin Inhibitors (12):

Cat. No. Product Name Effect Purity
  • HY-113066A
    Guanosine 5'-diphosphate disodium salt
    		Inhibitor 98.20%
    Guanosine 5'-diphosphate (GDP) disodium salt, a purine nucleoside diphosphate, is interconverted to guanosine by the action of exonucleotidase and phosphorylation of nucleoside to guanine. Guanosine 5'-diphosphate disodium salt activates adenosine 5'-triphosphate-sensitive K+ channel and is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR). Guanosine 5'-diphosphate disodium salt is a potential iron mobilizer, which prevents the Hepcidin (HY-P70400)-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Elevated levels of guanosine 5’-diphosphate are associated with the pathogenesis of neurological diseases. Guanosine 5'-diphosphate disodium salt is promising for the research of inflammation, such as anemia of inflammation (AI).
  • HY-113066C
    Guanosine 5'-diphosphate sodium, 96% (HPLC)
    		Inhibitor 99.88%
    Guanosine 5'-diphosphate (GDP) sodium, 96% (HPLC) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate sodium, 96% (HPLC) is an iron mobilizer, which forms a complex with hepcidin to inhibit the hepcidin-ferroportin (FPN) interaction and modulates the IL-6/stat-3 pathway. Guanosine 5'-diphosphate sodium, 96% (HPLC) ameliorates the Turpentine-induced anemia of inflammation (AI) in mice when combined with FeSO4. Guanosine 5'-diphosphate sodium, 96% (HPLC) can be used in the research of AI.
  • HY-113066
    Guanosine 5'-diphosphate
    		Inhibitor
    Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate is an iron mobilizer, which forms a complex with hepcidin to inhibit the hepcidin-ferroportin (FPN) interaction and modulates the IL-6/stat-3 pathway. Guanosine 5'-diphosphate ameliorates the Turpentine-induced anemia of inflammation (AI) in mice when combined with FeSO4. Guanosine 5'-diphosphate can be used in the research of AI.
  • HY-P992183
    AN-LP1
    		Inhibitor
    AN-LP1 is an anti-Hepcidin/HAMP monoclonal antibody.
  • HY-113066AR
    Guanosine 5'-diphosphate disodium salt (Standard)
    		Inhibitor
    Guanosine 5'-diphosphate (disodium salt) (Standard) is the analytical standard of Guanosine 5'-diphosphate (disodium salt). This product is intended for research and analytical applications. Guanosine 5'-diphosphate (GDP) disodium salt, a purine nucleoside diphosphate, is interconverted to guanosine by the action of exonucleotidase and phosphorylation of nucleoside to guanine. Guanosine 5'-diphosphate disodium salt activates adenosine 5'-triphosphate-sensitive K+ channel and is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR). Guanosine 5'-diphosphate disodium salt is a potential iron mobilizer, which prevents the Hepcidin (HY-P70400)-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Elevated levels of guanosine 5’-diphosphate are associated with the pathogenesis of neurological diseases. Guanosine 5'-diphosphate disodium salt is promising for the research of inflammation, such as anemia of inflammation (AI).
  • HY-177641A
    Lexaptepid Pegol sodium
    		Inhibitor
    Lexaptepid Pegol sodium is a pegylated structured L-oligoribonucleotide. It binds and inhibits hepcidin.
  • HY-113066B
    Guanosine 5'-diphosphate ditromethamine
    		Inhibitor
    Guanosine 5'-diphosphate ditromethamine is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate ditromethamine is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate ditromethamine can be used in the research of inflammation, such as anemia of inflammation (AI).
  • HY-177641
    Lexaptepid Pegol
    		Inhibitor
    Lexaptepid Pegol is a pegylated structured L-oligoribonucleotide. It binds and inhibits hepcidin.
  • HY-P991881
    KY1070
    		Inhibitor
    KY1070 is a fully human anti-BMP6 antibody with a Kd of 0.00014 μM against the human BMP6. It exhibits high specificity for BMP6, showing no cross-reactivity with other members of the BMP family, and effectively inhibits BMP6-induced BMP receptor heterodimerization and hepcidin expression. KY1070 modulates Ferroportin expression on erythroid progenitor cells and accelerates erythropoiesis. In rodent anemia models, KY1070 reduces the required dose of erythropoietin (EPO) when used in combination with EPO and enhances the responsiveness of mice with chronic kidney disease (CKD)-associated anemia to EPO treatment. KY1070 is applicable for research on anemia of chronic disease [1] [2].
  • HY-177641B
    Lexaptepid Pegol sodium scrambled negative control
    		Inhibitor
    Lexaptepid Pegol sodium scrambled negative control is the sequence scrambled negative control of Lexaptepid Pegol sodium.
  • HY-123878
    DS79182026
    		Inhibitor
    DS79182026 is an inhibitor of hepcidin production. DS79182026 exhibits hepcidin lowering ability in IL-6-induced acute inflammatory mouse model.
  • HY-107980R
    DS28120313 (Standard)
    		Inhibitor
    DS28120313 (Standard) is the analytical standard of DS28120313 (HY-107980). This product is intended for research and analytical applications. DS28120313 (compound 32) is an orally hepcidin production inhibitor with an IC50 of 0.093 μM.