Guanosine 5'-diphosphate (Synonyms: GDP)

Cat. No.: HY-113066: FAQs
Data Sheet Handling Instructions

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Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Guanosine 5'-diphosphate disodium salt) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Guanosine 5'-diphosphate Chemical Structure

CAS No. : 146-91-8

Size	Stock
5 mg	Get quote	Estimated Time of Arrival: December 31
10 mg	Get quote	Estimated Time of Arrival: December 31
25 mg	Get quote	Estimated Time of Arrival: December 31

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Other Forms of Guanosine 5'-diphosphate:

Guanosine 5'-diphosphate disodium salt In-stock
Guanosine 5'-diphosphate sodium Get quote
Guanosine 5'-diphosphate-¹⁵N₅ dilithium Get quote
Guanosine 5'-diphosphate-¹³C₁₀ dilithium Get quote
Guanosine 5'-diphosphate-d¹³ dilithium Get quote
Guanosine 5'-diphosphate-¹³C₁₀,¹⁵N₅ dilithium Get quote

2 Publications Citing Use of MCE Guanosine 5'-diphosphate

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[2]

Human Endogenous Metabolite

Clinical Trial

Molecular Weight

443.20

Formula

C₁₀H₁₅N₅O₁₁P₂

CAS No.

146-91-8

SMILES

O=P(O)(OP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2N=C(N)NC3=O)O1)(O)=O)O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. S Kajioka, et al. Guanosine diphosphate activates an adenosine 5'-triphosphate-sensitive K+ channel in the rabbit portal vein. J Physiol. 1991 Dec;444:397-418. [Content Brief]

[2]. Angmo S, et al. Identification of Guanosine 5'-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. Sci Rep. 2017 Jan 5;7:40097. [Content Brief]

Guanosine 5'-diphosphate Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Guanosine 5'-diphosphate146-91-8GDPEndogenous MetabolitePotassium ChannelKcsAK+ channelIL-6/stat-3 pathwayhepcidininflammationanemiaAICaco-2HepG2Inhibitorinhibitorinhibit

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