2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Immunology/Inflammation JAK/STAT Signaling Stem Cell/Wnt
  3. Hepcidin Potassium Channel Endogenous Metabolite Interleukin Related STAT
  4. Guanosine 5'-diphosphate

Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate is an iron mobilizer, which forms a complex with hepcidin to inhibit the hepcidin-ferroportin (FPN) interaction and modulates the IL-6/stat-3 pathway. Guanosine 5'-diphosphate ameliorates the Turpentine-induced anemia of inflammation (AI) in mice when combined with FeSO4. Guanosine 5'-diphosphate can be used in the research of AI.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Guanosine 5'-diphosphate disodium salt) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

CAS No. : 146-91-8

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Guanosine 5'-diphosphate Related Antibodies

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Bio/Physico-chemical Assay

    Guanosine 5'-diphosphate purchased from MedChemExpress. Usage Cited in: Endocrinology. 2023 Aug 1;164(9):bqad114.  [Abstract]

    The mitochondrial respiration of BAT (left) and scWAT (right) was significantly increased at both basal and substrate-induced states in MiR-143 KO mice, and this increase was diminished by guanosine diphosphate (2 mM).

    Guanosine 5'-diphosphate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Oct 27;23(21):13058.  [Abstract]

    Guanosine diphosphate (2 mM) inhibited the oxygen consumption of mitochondria isolated from BAT of WT and miR-143 KO mice fed HFD for 1 week.

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    Description

    Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate is an iron mobilizer, which forms a complex with hepcidin to inhibit the hepcidin-ferroportin (FPN) interaction and modulates the IL-6/stat-3 pathway. Guanosine 5'-diphosphate ameliorates the Turpentine-induced anemia of inflammation (AI) in mice when combined with FeSO4. Guanosine 5'-diphosphate can be used in the research of AI[1][2].

    IC50 & Target[2]

    Human Endogenous Metabolite

     

    IL-6

     

    Stat-3

     

    In Vitro

    Guanosine 5'-diphosphate (100 μM-1 mM) can activate the ATP-sensitive K+ channel in the rabbit portal vein, in the presence of Pinacidil (HY-14290)[1].
    Guanosine 5'-diphosphate (10 μM, 24 h) inhibits hepcidin-induced FPN internalization in FPN-GFP cell lines (HEK293T) and antagonizes hepcidin to increase the FPN-mediated cellular iron efflux in HepG2 and Caco-2 cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Guanosine 5'-diphosphate Related Antibodies
    In Vivo

    Guanosine 5'-diphosphate (30 mg/kg, i.p., sigle dose) increases iron absorption in normal BALB/c mice when combined with iron supplement FeSO4 (2 mg/kg)[2].
    Guanosine 5'-diphosphate (30 mg/kg, i.p., every 24 hours for 2 weeks) ameliorates the Turpentine-induced AI in mice when combined with FeSO4 (2 mg/kg)[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male BALB/c mice (25 ± 3 g) injected once a week with Turpentine for 2 week[2]
    Dosage: 30 mg/kg
    Administration: i.p., every 24 hours for 2 weeks
    Result: Significantly increased haemoglobin level when combined with FeSO4.
    Significant increased serum iron level when combined with FeSO4.
    Reversed hepcidin-mediated FPN internalization with increased iron accumulation with decreased liver and spleen iron level, when combined with FeSO4.
    Increased FPN level (liver, Spleen, and enterocyte) and reduced iron storage ferritin level (spleen and enterocyte) for effective iron-mediated erythropoiesis thus improving hypoferremia.
    Significantly decreased Hamp mRNA expression and hepcidin expression at transcriptional level, when combined with FeSO4.
    Reduced Stat-3 phosphorylation in mice hepatocyte.
    Molecular Weight

    443.20

    Formula

    C10H15N5O11P2
    CAS No.
    SMILES

    O=P(O)(OP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2N=C(N)NC3=O)O1)(O)=O)O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
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    Guanosine 5'-diphosphate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Guanosine 5'-diphosphate146-91-8GDPHepcidinPotassium ChannelEndogenous MetaboliteInterleukin RelatedSTATKcsAILK+ channelIL-6/stat-3 pathwayhepcidininflammationanemiaAICaco-2HepG2Inhibitorinhibitorinhibit

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