Guanosine 5'-diphosphate
Based on 2 publication(s) in Google Scholar
Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate is an iron mobilizer, which forms a complex with hepcidin to inhibit the hepcidin-ferroportin (FPN) interaction and modulates the IL-6/stat-3 pathway. Guanosine 5'-diphosphate ameliorates the Turpentine-induced anemia of inflammation (AI) in mice when combined with FeSO4. Guanosine 5'-diphosphate can be used in the research of AI.
For research use only. We do not sell to patients.
- CAS No.: 146-91-8
- Formula: C10H15N5O11P2
- Molecular Weight:443.20
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Guanosine 5'-diphosphate
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
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Biological Activity
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Human Endogenous Metabolite |
IL-6 |
Stat-3 |
Guanosine 5'-diphosphate (100 μM-1 mM) can activate the ATP-sensitive K+ channel in the rabbit portal vein, in the presence of Pinacidil (HY-14290)[1].
Guanosine 5'-diphosphate (10 μM, 24 h) inhibits hepcidin-induced FPN internalization in FPN-GFP cell lines (HEK293T) and antagonizes hepcidin to increase the FPN-mediated cellular iron efflux in HepG2 and Caco-2 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Guanosine 5'-diphosphate (30 mg/kg, i.p., every 24 hours for 2 weeks) ameliorates the Turpentine-induced AI in mice when combined with FeSO4 (2 mg/kg)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male BALB/c mice (25 ± 3 g) injected once a week with Turpentine for 2 week[2]
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Dosage:30 mg/kg
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Administration:i.p., every 24 hours for 2 weeks
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Result:Significantly increased haemoglobin level when combined with FeSO4.
Significant increased serum iron level when combined with FeSO4.
Reversed hepcidin-mediated FPN internalization with increased iron accumulation with decreased liver and spleen iron level, when combined with FeSO4.
Increased FPN level (liver, Spleen, and enterocyte) and reduced iron storage ferritin level (spleen and enterocyte) for effective iron-mediated erythropoiesis thus improving hypoferremia.
Significantly decreased Hamp mRNA expression and hepcidin expression at transcriptional level, when combined with FeSO4.
Reduced Stat-3 phosphorylation in mice hepatocyte.
Chemical Information
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CAS No. 146-91-8
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Molecular Weight 443.20
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Formula C10H15N5O11P2
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SMILES
O=P(O)(OP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2N=C(N)NC3=O)O1)(O)=O)O
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Synonyms
GDP
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Int J Mol Sci
miR-143-null Is against Diet-Induced Obesity by Promoting BAT Thermogenesis and Inhibiting WAT Adipogenesis. [Abstract]2022 Oct 27;23(21):13058. PMID: 36361843
Guanosine 5'-diphosphate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Oct 27;23(21):13058. [Abstract]
Guanosine diphosphate (2 mM) inhibited the oxygen consumption of mitochondria isolated from BAT of WT and miR-143 KO mice fed HFD for 1 week.
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Endocrinology
MiR-143 targets SYK to regulate NEFA uptake and contribute to thermogenesis in male mice. [Abstract]2023 Aug 1;164(9):bqad114. PMID: 37486737
Guanosine 5'-diphosphate purchased from MedChemExpress. Usage Cited in: Endocrinology. 2023 Aug 1;164(9):bqad114. [Abstract]
The mitochondrial respiration of BAT (left) and scWAT (right) was significantly increased at both basal and substrate-induced states in MiR-143 KO mice, and this increase was diminished by guanosine diphosphate (2 mM).
Purity & Documentation
References
[1]. S Kajioka, et al. Guanosine diphosphate activates an adenosine 5'-triphosphate-sensitive K+ channel in the rabbit portal vein. J Physiol. 1991 Dec;444:397-418. [Content Brief]
[2]. Angmo S, et al. Identification of Guanosine 5'-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. Sci Rep. 2017 Jan 5;7:40097. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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