2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Immunology/Inflammation JAK/STAT Signaling Stem Cell/Wnt
  3. Hepcidin Potassium Channel Endogenous Metabolite Interleukin Related STAT
  4. Guanosine 5'-diphosphate sodium, 96% (HPLC)

Guanosine 5'-diphosphate sodium, 96% (HPLC)  (Synonyms: GDP sodium, Type I, 96% (HPLC))

製品番号: HY-113066C 純度: 99.88%
COA 取扱説明書 Technical Support

Guanosine 5'-diphosphate (GDP) sodium, 96% (HPLC) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate sodium, 96% (HPLC) is an iron mobilizer, which forms a complex with hepcidin to inhibit the hepcidin-ferroportin (FPN) interaction and modulates the IL-6/stat-3 pathway. Guanosine 5'-diphosphate sodium, 96% (HPLC) ameliorates the Turpentine-induced anemia of inflammation (AI) in mice when combined with FeSO4. Guanosine 5'-diphosphate sodium, 96% (HPLC) can be used in the research of AI.

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CAS 番号 : 43139-22-6

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>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
5 mg $38 在庫あり
10 mg $60 在庫あり
25 mg $80 在庫あり
50 mg $100 在庫あり
100 mg $130 在庫あり
250 mg $260 在庫あり
500 mg $395 在庫あり
1 g $590 在庫あり
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カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Other Forms of Guanosine 5'-diphosphate sodium, 96% (HPLC):

Guanosine 5'-diphosphate sodium, 96% (HPLC) 関連抗体

Top Publications Citing Use of Products

    Guanosine 5'-diphosphate sodium, 96% (HPLC) purchased from MedChemExpress. Usage Cited in: Endocrinology. 2023 Aug 1;164(9):bqad114.  [Abstract]

    The mitochondrial respiration of BAT (left) and scWAT (right) was significantly increased at both basal and substrate-induced states in MiR-143 KO mice, and this increase was diminished by guanosine diphosphate (2 mM).

    Guanosine 5'-diphosphate sodium, 96% (HPLC) purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Oct 27;23(21):13058.  [Abstract]

    Guanosine diphosphate (2 mM) inhibited the oxygen consumption of mitochondria isolated from BAT of WT and miR-143 KO mice fed HFD for 1 week.

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

    Interleukin Related アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

    STAT アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    STAT3 STAT5 STAT6 STAT1

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

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    製品説明

    Guanosine 5'-diphosphate (GDP) sodium, 96% (HPLC) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate sodium, 96% (HPLC) is an iron mobilizer, which forms a complex with hepcidin to inhibit the hepcidin-ferroportin (FPN) interaction and modulates the IL-6/stat-3 pathway. Guanosine 5'-diphosphate sodium, 96% (HPLC) ameliorates the Turpentine-induced anemia of inflammation (AI) in mice when combined with FeSO4. Guanosine 5'-diphosphate sodium, 96% (HPLC) can be used in the research of AI[1][2].

    IC50 & Target[2]

    Human Endogenous Metabolite

     

    IL-6

     

    Stat-3

     

    体外実験

    Guanosine 5'-diphosphate (100 μM-1 mM) sodium, 96% (HPLC) can activate the ATP-sensitive K+ channel in the rabbit portal vein, in the presence of Pinacidil (HY-14290)[1].
    Guanosine 5'-diphosphate (10 μM, 24 h) sodium, 96% (HPLC) inhibits hepcidin-induced FPN internalization in FPN-GFP cell lines (HEK293T) and antagonizes hepcidin to increase the FPN-mediated cellular iron efflux in HepG2 and Caco-2 cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Guanosine 5'-diphosphate sodium, 96% (HPLC) 関連抗体
    体内実験

    Guanosine 5'-diphosphate (30 mg/kg, i.p., sigle dose) sodium, 96% (HPLC) increases iron absorption in normal BALB/c mice when combined with iron supplement FeSO4 (2 mg/kg)[2].
    Guanosine 5'-diphosphate (30 mg/kg, i.p., every 24 hours for 2 weeks) sodium, 96% (HPLC) ameliorates the Turpentine-induced AI in mice when combined with FeSO4 (2 mg/kg)[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male BALB/c mice (25 ± 3 g) injected once a week with Turpentine for 2 week[2]
    Dosage: 30 mg/kg
    Administration: i.p., every 24 hours for 2 weeks
    Result: Significantly increased haemoglobin level when combined with FeSO4.
    Significant increased serum iron level when combined with FeSO4.
    Reversed hepcidin-mediated FPN internalization with increased iron accumulation with decreased liver and spleen iron level, when combined with FeSO4.
    Increased FPN level (liver, Spleen, and enterocyte) and reduced iron storage ferritin level (spleen and enterocyte) for effective iron-mediated erythropoiesis thus improving hypoferremia.
    Significantly decreased Hamp mRNA expression and hepcidin expression at transcriptional level, when combined with FeSO4.
    Reduced Stat-3 phosphorylation in mice hepatocyte.
    分子量

    465.18

    分子式

    C10H14N5NaO11P2
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=P(OP(O)(O[Na])=O)(O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(N)NC3=O)=C3N=C2)O1
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
    溶剤 & 溶解度
    体外: 

    H2O : ≥ 100 mg/mL (214.97 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1497 mL 10.7485 mL 21.4971 mL
    5 mM 0.4299 mL 2.1497 mL 4.2994 mL
    10 mM 0.2150 mL 1.0749 mL 2.1497 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

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    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.88%

    COA (250 KB) HNMR (131 KB) CNMR (130 KB) RP-HPLC (224 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 2.1497 mL 10.7485 mL 21.4971 mL 53.7426 mL
    5 mM 0.4299 mL 2.1497 mL 4.2994 mL 10.7485 mL
    10 mM 0.2150 mL 1.0749 mL 2.1497 mL 5.3743 mL
    15 mM 0.1433 mL 0.7166 mL 1.4331 mL 3.5828 mL
    20 mM 0.1075 mL 0.5374 mL 1.0749 mL 2.6871 mL
    25 mM 0.0860 mL 0.4299 mL 0.8599 mL 2.1497 mL
    30 mM 0.0717 mL 0.3583 mL 0.7166 mL 1.7914 mL
    40 mM 0.0537 mL 0.2687 mL 0.5374 mL 1.3436 mL
    50 mM 0.0430 mL 0.2150 mL 0.4299 mL 1.0749 mL
    60 mM 0.0358 mL 0.1791 mL 0.3583 mL 0.8957 mL
    80 mM 0.0269 mL 0.1344 mL 0.2687 mL 0.6718 mL
    100 mM 0.0215 mL 0.1075 mL 0.2150 mL 0.5374 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Guanosine 5'-diphosphate sodium, 96% (HPLC) Related Classifications

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
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    C1   V1   C2   V2
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Guanosine 5'-diphosphate sodium, 96% (HPLC)43139-22-6GDP sodium, Type I, 96% (HPLC)HepcidinPotassium ChannelEndogenous MetaboliteInterleukin RelatedSTATKcsAILK+ channelIL-6/stat-3 pathwayhepcidininflammationanemiaAICaco-2HepG2Inhibitorinhibitorinhibit

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