Guanosine 5'-diphosphate sodium, 96% (HPLC)
Based on 2 publication(s) in Google Scholar
Guanosine 5'-diphosphate (GDP) sodium, 96% (HPLC) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate sodium, 96% (HPLC) is an iron mobilizer, which forms a complex with hepcidin to inhibit the hepcidin-ferroportin (FPN) interaction and modulates the IL-6/stat-3 pathway. Guanosine 5'-diphosphate sodium, 96% (HPLC) ameliorates the Turpentine-induced anemia of inflammation (AI) in mice when combined with FeSO4. Guanosine 5'-diphosphate sodium, 96% (HPLC) can be used in the research of AI.
For research use only. We do not sell to patients.
- Purity: 99.88%
- CAS No.: 43139-22-6
- Formula: C10H14N5NaO11P2
- Molecular Weight:465.18
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Guanosine 5'-diphosphate sodium, 96% (HPLC)
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Customer Validation & Images
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
IL-6 |
Stat-3 |
Guanosine 5'-diphosphate (100 μM-1 mM) sodium, 96% (HPLC) can activate the ATP-sensitive K+ channel in the rabbit portal vein, in the presence of Pinacidil (HY-14290)[1].
Guanosine 5'-diphosphate (10 μM, 24 h) sodium, 96% (HPLC) inhibits hepcidin-induced FPN internalization in FPN-GFP cell lines (HEK293T) and antagonizes hepcidin to increase the FPN-mediated cellular iron efflux in HepG2 and Caco-2 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Guanosine 5'-diphosphate (30 mg/kg, i.p., every 24 hours for 2 weeks) sodium, 96% (HPLC) ameliorates the Turpentine-induced AI in mice when combined with FeSO4 (2 mg/kg)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male BALB/c mice (25 ± 3 g) injected once a week with Turpentine for 2 week[2]
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Dosage:30 mg/kg
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Administration:i.p., every 24 hours for 2 weeks
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Result:Significantly increased haemoglobin level when combined with FeSO4.
Significant increased serum iron level when combined with FeSO4.
Reversed hepcidin-mediated FPN internalization with increased iron accumulation with decreased liver and spleen iron level, when combined with FeSO4.
Increased FPN level (liver, Spleen, and enterocyte) and reduced iron storage ferritin level (spleen and enterocyte) for effective iron-mediated erythropoiesis thus improving hypoferremia.
Significantly decreased Hamp mRNA expression and hepcidin expression at transcriptional level, when combined with FeSO4.
Reduced Stat-3 phosphorylation in mice hepatocyte.
Chemical Information
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CAS No. 43139-22-6
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Appearance Solid
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Molecular Weight 465.18
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Formula C10H14N5NaO11P2
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Color White to off-white
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SMILES
O=P(OP(O)(O[Na])=O)(O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(N)NC3=O)=C3N=C2)O1
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Synonyms
GDP sodium, Type I, 96% (HPLC)
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Int J Mol Sci
miR-143-null Is against Diet-Induced Obesity by Promoting BAT Thermogenesis and Inhibiting WAT Adipogenesis. [Abstract]2022 Oct 27;23(21):13058. PMID: 36361843
Guanosine 5'-diphosphate sodium, 96% (HPLC) purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Oct 27;23(21):13058. [Abstract]
Guanosine diphosphate (2 mM) inhibited the oxygen consumption of mitochondria isolated from BAT of WT and miR-143 KO mice fed HFD for 1 week.
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Endocrinology
MiR-143 targets SYK to regulate NEFA uptake and contribute to thermogenesis in male mice. [Abstract]2023 Aug 1;164(9):bqad114. PMID: 37486737
Guanosine 5'-diphosphate sodium, 96% (HPLC) purchased from MedChemExpress. Usage Cited in: Endocrinology. 2023 Aug 1;164(9):bqad114. [Abstract]
The mitochondrial respiration of BAT (left) and scWAT (right) was significantly increased at both basal and substrate-induced states in MiR-143 KO mice, and this increase was diminished by guanosine diphosphate (2 mM).
Solvent & Solubility
H2O : ≥ 100 mg/mL (214.97 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. S Kajioka, et al. Guanosine diphosphate activates an adenosine 5'-triphosphate-sensitive K+ channel in the rabbit portal vein. J Physiol. 1991 Dec;444:397-418. [Content Brief]
[2]. Angmo S, et al. Identification of Guanosine 5'-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. Sci Rep. 2017 Jan 5;7:40097. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.1497 mL | 10.7485 mL | 21.4971 mL | 53.7426 mL |
| 5 mM | 0.4299 mL | 2.1497 mL | 4.2994 mL | 10.7485 mL | |
| 10 mM | 0.2150 mL | 1.0749 mL | 2.1497 mL | 5.3743 mL | |
| 15 mM | 0.1433 mL | 0.7166 mL | 1.4331 mL | 3.5828 mL | |
| 20 mM | 0.1075 mL | 0.5374 mL | 1.0749 mL | 2.6871 mL | |
| 25 mM | 0.0860 mL | 0.4299 mL | 0.8599 mL | 2.1497 mL | |
| 30 mM | 0.0717 mL | 0.3583 mL | 0.7166 mL | 1.7914 mL | |
| 40 mM | 0.0537 mL | 0.2687 mL | 0.5374 mL | 1.3436 mL | |
| 50 mM | 0.0430 mL | 0.2150 mL | 0.4299 mL | 1.0749 mL | |
| 60 mM | 0.0358 mL | 0.1791 mL | 0.3583 mL | 0.8957 mL | |
| 80 mM | 0.0269 mL | 0.1344 mL | 0.2687 mL | 0.6718 mL | |
| 100 mM | 0.0215 mL | 0.1075 mL | 0.2150 mL | 0.5374 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Guanosine 5'-diphosphate sodium, 96% (HPLC) Related Classifications
HY-113066C Related Classifications
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