2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. Hepcidin Potassium Channel Endogenous Metabolite
  4. Guanosine 5'-diphosphate disodium salt

Guanosine 5'-diphosphate disodium salt  (Synonyms: GDP disodium salt)

Cat. No.: HY-113066A Purity: 96.42%
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Guanosine 5'-diphosphate (GDP) disodium salt, a purine nucleoside diphosphate, is interconverted to guanosine by the action of exonucleotidase and phosphorylation of nucleoside to guanine. Guanosine 5'-diphosphate disodium salt activates adenosine 5'-triphosphate-sensitive K+ channel and is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR). Guanosine 5'-diphosphate disodium salt is a potential iron mobilizer, which prevents the Hepcidin (HY-P70400)-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Elevated levels of guanosine 5’-diphosphate are associated with the pathogenesis of neurological diseases. Guanosine 5'-diphosphate disodium salt is promising for the research of inflammation, such as anemia of inflammation (AI).

For research use only. We do not sell to patients.

CAS No. : 7415-69-2

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Guanosine 5'-diphosphate disodium salt Related Antibodies

Top Publications Citing Use of Products

2 Publications Citing Use of MCE Guanosine 5'-diphosphate disodium salt

Bio/Physico-chemical Assay

    Guanosine 5'-diphosphate disodium salt purchased from MedChemExpress. Usage Cited in: Endocrinology. 2023 Aug 1;164(9):bqad114.  [Abstract]

    The mitochondrial respiration of BAT (left) and scWAT (right) was significantly increased at both basal and substrate-induced states in MiR-143 KO mice, and this increase was diminished by guanosine diphosphate (2 mM).

    Guanosine 5'-diphosphate disodium salt purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Oct 27;23(21):13058.  [Abstract]

    Guanosine diphosphate (2 mM) inhibited the oxygen consumption of mitochondria isolated from BAT of WT and miR-143 KO mice fed HFD for 1 week.

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    • References

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    Description

    Guanosine 5'-diphosphate (GDP) disodium salt, a purine nucleoside diphosphate, is interconverted to guanosine by the action of exonucleotidase and phosphorylation of nucleoside to guanine. Guanosine 5'-diphosphate disodium salt activates adenosine 5'-triphosphate-sensitive K+ channel and is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR). Guanosine 5'-diphosphate disodium salt is a potential iron mobilizer, which prevents the Hepcidin (HY-P70400)-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Elevated levels of guanosine 5’-diphosphate are associated with the pathogenesis of neurological diseases. Guanosine 5'-diphosphate disodium salt is promising for the research of inflammation, such as anemia of inflammation (AI)[1][2][3][4][5].
    IC50 & Target[2]

    Human Endogenous Metabolite

     

    In Vitro

    Guanosine 5'-diphosphate disodium salt (10 μM, 24 h) prevents Hepcidin (HY-P70400)-induced ferroportin (FPN) internalization with effective cellular iron efflux in HepG2 and Caco-2 cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Guanosine 5'-diphosphate disodium salt Related Antibodies

    RT-PCR[2]

    Cell Line: HepG2, Caco-2 cell
    Concentration: 10 μM
    Incubation Time: 24 h
    Result: Increased FPN protein level whereas, ferritin protein levels were significantly decreased compared to control.
    In Vivo

    Guanosine 5'-diphosphate disodium salt (30 mg/kg, i.p., a single dose for 24 h) combined with FeSO4 (2 mg/kg, i.p., a single dose for 24 h) suppresses the iron storage ferritin level, thus preventing Hepcidin (HY-P70400)-induced internalization of FPN with increased iron absorption in normal mice[2].
    Guanosine 5'-diphosphate disodium salt (30 mL/kg, i.p., three times a week for two weeks) can improve turpentine-induced inflammatory anemia in mice[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male BALB/c mice[2].
    Dosage: 30 mL/kg
    Administration: Intraperitoneal injection (i.p.)
    Result: Increased hemoglobin levels and serum iron levels in the long-term dosing model.
    Decreased Hamp mRNA expression, and spleen iron content was reduced by 46% in the short-term dosing model.
    Molecular Weight

    487.16

    Formula

    C10H13N5Na2O11P2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O[C@H]1[C@@H](O)[C@H](N2C(N=C(N)NC3=O)=C3N=C2)O[C@@H]1COP(OP(O)([O-])=O)([O-])=O.[2Na+]
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (205.27 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.0527 mL 10.2636 mL 20.5271 mL
    5 mM 0.4105 mL 2.0527 mL 4.1054 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    V1

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (205.27 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 98.20%

    SDS (393 KB)

    COA (253 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 2.0527 mL 10.2636 mL 20.5271 mL 51.3178 mL
    5 mM 0.4105 mL 2.0527 mL 4.1054 mL 10.2636 mL
    10 mM 0.2053 mL 1.0264 mL 2.0527 mL 5.1318 mL
    15 mM 0.1368 mL 0.6842 mL 1.3685 mL 3.4212 mL
    20 mM 0.1026 mL 0.5132 mL 1.0264 mL 2.5659 mL
    25 mM 0.0821 mL 0.4105 mL 0.8211 mL 2.0527 mL
    30 mM 0.0684 mL 0.3421 mL 0.6842 mL 1.7106 mL
    40 mM 0.0513 mL 0.2566 mL 0.5132 mL 1.2829 mL
    50 mM 0.0411 mL 0.2053 mL 0.4105 mL 1.0264 mL
    60 mM 0.0342 mL 0.1711 mL 0.3421 mL 0.8553 mL
    80 mM 0.0257 mL 0.1283 mL 0.2566 mL 0.6415 mL
    100 mM 0.0205 mL 0.1026 mL 0.2053 mL 0.5132 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Guanosine 5'-diphosphate disodium salt Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Guanosine 5'-diphosphate disodium7415-69-2GDP disodiumHepcidinPotassium ChannelEndogenous MetaboliteKcsAK+ channelIL-6/stat-3 pathwayhepcidininflammationanemiaAICaco-2HepG2neurological diseasesGTPasesInhibitorinhibitorinhibit

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