5'-Guanylic acid disodium salt
Based on 2 publication(s) in Google Scholar
5'-Guanylic acid disodium salt is the disodium salt form of 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid disodium salt is a purine nucleotide that participates in physiological processes such as energy metabolism, signal transduction, and gene expression regulation. 5'-Guanylic acid disodium salt regulates the expression of genes related to fatty acid metabolism. 5'-Guanylic acid disodium salt is the weak agonist for ionotropic glutamate receptors (iGluR), reduces the activity of the glutamatergic system and exhibits neuroprotective effect. 5'-Guanylic acid disodium salt also causes neuronal cell death at high concentrations.
For research use only. We do not sell to patients.
- Purity: 99.53%
- CAS No.: 5550-12-9
- Formula: C10H12N5Na2O8P
- Molecular Weight:407.18
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-W009162
Cytidine 5'-monophosphate
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HY-W013175
Uridine 5'-monophosphate disodium salt
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HY-A0181
Adenosine monophosphate
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HY-N5134
5'-Guanylic acid
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HY-113066A
Guanosine 5'-diphosphate disodium salt
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HY-128738
Thymidine-5'-monophosphate disodium salt
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HY-A0181R
Adenosine monophosphate (Standard)
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HY-W011012
Adenosine 5'-monophosphate disodium
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HY-W009162R
Cytidine 5'-monophosphate (Standard)
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HY-101981
Uridine 5'-monophosphate
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HY-N0091
Hypoxanthine
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HY-W008915
Cytidine 5'-diphosphate trisodium salt
Publications Citing Use of MedChemExpress (MCE) 5'-Guanylic acid disodium salt
MoreAll Endogenous Metabolite Isoforms
MoreAll iGluR Isoforms
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Biological Activity
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Human Endogenous Metabolite |
5'-Guanylic acid disodium salt (50-500 μM, 48 h) regulates the expression of genes involved in fatty acid metabolism, affects fatty acid composition in Oncorhynchus mykiss hepatocytes, and regulates fatty acid metabolism[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Oncorhynchus mykiss hepatocytes
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Concentration:50-500 μM
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Incubation Time:12-48 h
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Result:Upregulated the expressions of Δ5 fads2, elovl2, elovl5 and srebp-1.
Downregulated the expression of pparα.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats models[2].
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Dosage:10-150 mg/kg
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Administration:ip, single dose
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Result:Increased the time rats spent in the light zone in the light-dark box test.
Increased the time rats spent in the open arms in the elevated plus maze test.
Chemical Information
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CAS No. 5550-12-9
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Appearance Solid
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Molecular Weight 407.18
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Formula C10H12N5Na2O8P
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Color White to off-white
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SMILES
O=P(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2N=C(N)NC3=O)O1)(O[Na])O[Na]
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Synonyms
5'-GMP disodium salt; 5'-guanosine monophosphate disodium salt
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Talanta
A simple, rapid and sensitive HILIC LC-MS/MS method for simultaneous determination of 16 purine metabolites in plasma and urine. [Abstract]2024 Jan 15:267:125171. PMID: 37696233 -
Noncoding RNA Res
Tongue squamous cell carcinoma-derived exosomes miR-21-5p affect tumor progression via promoting M2 macrophage polarization. [Abstract]2025 May 15:13:184-196. PMID: 40519608
Solvent & Solubility
H2O : 50 mg/mL (122.80 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (122.80 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Tansutaphanit S, et al. Impact of purine nucleotide on fatty acid metabolism and expression of lipid metabolism-related gene in the liver cell of rainbow trout Oncorhynchus mykiss. Comp Biochem Physiol B Biochem Mol Biol. 2023 Jun-Jul;266:110845. [Content Brief]
[2]. Almeida RF, et al. Systemic administration of GMP induces anxiolytic-like behavior in rats. Pharmacol Biochem Behav. 2010 Sep;96(3):306-11. [Content Brief]
[3]. Molz S, et al., Guanosine-5'-monophosphate induces cell death in rat hippocampal slices via ionotropic glutamate receptors activation and glutamate uptake inhibition. Neurochem Int. 2009 Dec;55(7):703-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.4559 mL | 12.2796 mL | 24.5592 mL | 61.3979 mL |
| 5 mM | 0.4912 mL | 2.4559 mL | 4.9118 mL | 12.2796 mL | |
| 10 mM | 0.2456 mL | 1.2280 mL | 2.4559 mL | 6.1398 mL | |
| 15 mM | 0.1637 mL | 0.8186 mL | 1.6373 mL | 4.0932 mL | |
| 20 mM | 0.1228 mL | 0.6140 mL | 1.2280 mL | 3.0699 mL | |
| 25 mM | 0.0982 mL | 0.4912 mL | 0.9824 mL | 2.4559 mL | |
| 30 mM | 0.0819 mL | 0.4093 mL | 0.8186 mL | 2.0466 mL | |
| 40 mM | 0.0614 mL | 0.3070 mL | 0.6140 mL | 1.5349 mL | |
| 50 mM | 0.0491 mL | 0.2456 mL | 0.4912 mL | 1.2280 mL | |
| 60 mM | 0.0409 mL | 0.2047 mL | 0.4093 mL | 1.0233 mL | |
| 80 mM | 0.0307 mL | 0.1535 mL | 0.3070 mL | 0.7675 mL | |
| 100 mM | 0.0246 mL | 0.1228 mL | 0.2456 mL | 0.6140 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
5'-Guanylic acid disodium salt Related Classifications
HY-W010970 Related Classifications
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