Cat. No.: HY-101981

Uridine 5'-monophosphate

(Synonyms: 5'-Uridylic acid)

3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.

For research use only. We do not sell to patients.

Purity: 99.98%
CAS No.: 58-97-9
Formula: C₉H₁₃N₂O₉P
Molecular Weight:324.18

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Uridine 5'-monophosphate Chemical Structure

CAS No.: 58-97-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Endogenous Metabolite Isoforms :

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

Uridine 5'-monophosphate (10 mM; 6 h) promotes late apoptosis in pig intestinal epithelial cells IPEC-J2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

IPEC-J2
Concentration:

10 mM
Incubation Time:

6 h
Result:

Increased the late apoptosis rate.

In Vivo

Uridine 5'-monophosphate (476 mg; oral; daily; 10 days) promotes apoptosis and renewal of intestinal villus tip epithelial cells in pigs, which benefits gut development and reduces the rate of diarrhea^[1].
Uridine 5'-monophosphate (0.02-1 mmol/kg; i.g.; single dose) can enhance the synthesis of CDP-choline in the brains of gerbils^[2].
Uridine 5'-monophosphate (30 mg/kg; i.v.; single dose) has protective properties for the heart in rats, preventing ischemic injury and some arrhythmias^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Piglets^[1]
Dosage:

476 mg, daily, 10 days
Administration:

Oral
Result:

Improved daily weight gain in piglets, reduced diarrhea rates, lowered the expression of jejunal mucosal CAD and RRM2, and increased the apoptosis rate of intestinal epithelial cells.

Animal Model:

Male gerbils (60-80g)^[2]
Dosage:

0.02, 0.05, 0.1, 1 mmol/kg, single dose
Administration:

i.g.
Result:

Increased choline levels after 15 minutes, and after thirty minutes, plasma uridine and brain tissue uridine increased, with plasma and brain cytidine also rising significantly.

Animal Model:

Male wistar rats (250-300 g)^[3]
Dosage:

30 mg/kg, single dose
Administration:

Intravenous injection (i.v.)
Result:

Reduced the index of myocardial ischemia changes and T-wave amplitude, decreased the frequency of ventricular premature beats, and shortened the duration of ventricular tachycardia and fibrillation.

Chemical Information

CAS No. 58-97-9
Appearance Solid
Molecular Weight 324.18
Formula C₉H₁₃N₂O₉P
Color White to off-white
SMILES

O[C@H]1[C@@H](O)[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COP(O)(O)=O
Synonyms

5'-Uridylic acid
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganisms
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (3)

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Journal Impact Factor

Int J Biol Macromol

Reticuline isomerase AKR1B1 with aldo-keto reductase activity and detoxification function from the insect Blaps rhynchopetera. [Abstract]

2026 Mar:352:151224. PMID: 41791543
Pestic Biochem Physiol

Plumbagin targets dihydroorotase in Magnaporthe oryzae to inhibit infection and shows antifungal activity against multiple phytopathogenic fungi. [Abstract]

2026 Jun:221:107096. PMID: 42264707
J Pharm Biomed Anal

A novel UHPLC-MS/MS approach for simultaneous quantification of pyrimidine metabolites in human biofluids. [Abstract]

2025 Nov 15:265:117026. PMID: 40544701

Solvent & Solubility

In Vitro:

H₂O : 150 mg/mL (462.71 mM; Need ultrasonic)

DMSO : 100 mg/mL (308.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.0847 mL

15.4235 mL

30.8471 mL

5 mM

0.6169 mL

3.0847 mL

6.1694 mL

10 mM

0.3085 mL

1.5424 mL

3.0847 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 5 mg/mL (15.42 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 5 mg/mL (15.42 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 5 mg/mL (15.42 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (308.47 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li G, et al. Uridine/UMP metabolism and their function on the gut in segregated early weaned piglets. Food Funct. 2019 Jul 17;10(7):4081-4089. [Content Brief]

[2]. Mehmet Cansev, et al. Oral uridine-5'-monophosphate (UMP) increases brain CDP-choline levels in gerbils. Brain Res. 2005 Oct 5;1058(1-2):101-8. [Content Brief]

[3]. Irina B Krylova, et al. The cardioprotective effect of uridine and uridine-5'-monophosphate: the role of the mitochondrial ATP-dependent potassium channel. Exp Gerontol. 2006 Jul;41(7):697-703. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	3.0847 mL	15.4235 mL	30.8471 mL	77.1177 mL
	5 mM	0.6169 mL	3.0847 mL	6.1694 mL	15.4235 mL
	10 mM	0.3085 mL	1.5424 mL	3.0847 mL	7.7118 mL
	15 mM	0.2056 mL	1.0282 mL	2.0565 mL	5.1412 mL
	20 mM	0.1542 mL	0.7712 mL	1.5424 mL	3.8559 mL
	25 mM	0.1234 mL	0.6169 mL	1.2339 mL	3.0847 mL
	30 mM	0.1028 mL	0.5141 mL	1.0282 mL	2.5706 mL
	40 mM	0.0771 mL	0.3856 mL	0.7712 mL	1.9279 mL
	50 mM	0.0617 mL	0.3085 mL	0.6169 mL	1.5424 mL
	60 mM	0.0514 mL	0.2571 mL	0.5141 mL	1.2853 mL
	80 mM	0.0386 mL	0.1928 mL	0.3856 mL	0.9640 mL
	100 mM	0.0308 mL	0.1542 mL	0.3085 mL	0.7712 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Uridine 5'-monophosphate

3 Cited Publications

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Uridine 5'-monophosphate

Bioactive Compound Library Max

Bioactive Compound Library

Apoptosis Compound Library

Membrane Transporter/Ion Channel Compound Library

Metabolism/Protease Compound Library

Neuronal Signaling Compound Library

Natural Product Library

Anti-Cardiovascular Disease Compound Library

Orally Active Compound Library

Traditional Chinese Medicine Active Compound Library

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Microbial Metabolite Library

Food-Sourced Compound Library

Potassium Channel Compound Library

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Membrane Receptor-targeted Compound Library

Cell Death Library

Ion Channel Compound Library

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Natural Product and Natural Product-Like Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

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Mass Spectrometry Human Metabolite Library

Mouse Metabolite Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Nucleotide Metabolite Compound Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Uridine 5'-monophosphate

All Endogenous Metabolite Isoforms

All Cholinesterase (ChE) Isoforms

Biological Activity

Chemical Information

Publications (3)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Uridine 5'-monophosphate Related Classifications

HY-101981 Related Classifications