1. Signaling Pathways
  2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. BChE Isoform


Butyrylcholinesterase (BuChE; acylcholine acylhydrolase), also known as nonspecific cholinesterase or pseudocholinesterase, is a serine hydrolase present in almost all mammalian tissues with the highest levels detected in plasma and liver. BChE hydrolyzes acetylcholine and all chemicals containing ester bonds, including anesthetics such as succinylcholine and procaine and drugs such as cocaine and heroin. BChE is found in glia and white matter in the brain and is also associated with neurons, particularly in the hippocampus, amygdala, and thalamus. BChE was also found in amyloid plaques and neurofibrillary tangles (NFTs), which suggests that the protein may be involved in the pathogenesis of Alzheimer’s disease.

BChE Related Products (37):

Cat. No. Product Name Effect Purity
  • HY-107569
    Inhibitor 98.85%
    Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 µM and 7.39 µM, respectively.
  • HY-N0285
    Inhibitor 98.00%
    Imperatorin is an effective of NO synthesis inhibitor (IC50=9.2 μmol), which also is a BChE inhibitor (IC50=31.4 μmol).
  • HY-N0226A
    Epiberberine chloride
    Inhibitor 99.03%
    Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively.
  • HY-N0226
    Inhibitor 98.46%
    Epiberberine is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively.
  • HY-N2284
    Inhibitor 98.15%
    Sophoflavescenol is a prenylated flavonol, which shows great inhibitory activity with IC50 of 0.013 μM against Phosphodiesterase 5 (PDE5), and also inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE with IC50s of 0.30 µM, 0.17 µM, 17.89 µg/mL, 10.98 µM, 8.37 µM and 8.21 µM, respectively.
  • HY-151436
    ZLMT-12 (compound 35), tacrine derivatives, is a potent, orally active CDK2/9 inhibitor with IC50 values of 0.002 and 0.011 μM for CDK9 and CDK2, respectively.
  • HY-152113
    AChE/BChE/MAO-B-IN-3, an indan-1-one derivative, is a potent MAO-B inhibitor with an IC50 of 0.0359 μM for human MAO-B.
  • HY-151405
    Z164597606 is a selective BChE inhibitor (IC50: 1.3 and 1.7 μM for eqBChE and hBChE).
  • HY-146669
    BChE-IN-6 (compound 12) is a potent BChE inhibitor, with a Ki of 0.182 μM.
  • HY-W130236
    Methylene Violet 3RAX
    Methylene Violet 3RAX is a phenazine dye to stain the mitochondria of cells.
  • HY-16183
    Echothiopate iodide
    Echothiopate iodide is a potent hBChE (human butyrylcholinesterase) inhibitor.
  • HY-107275
    Ebeiedinone, a steroidal alkaloid from Fritillaria species, inhibits the bioactivity of human whole blood cholinesterase (ChE) at the concentration of 0.1 mM, with the inhibitory effects of 69.0%.
  • HY-N7263
    Galanthamine N-Oxide
    Inhibitor 99.90%
    Galanthamine N-Oxide is an alkaloid obtained from the bulbs of Zephyranthes concolor.
  • HY-N10917
    Xanthohumol I
    Xanthohumol I, a chalkone, is a derivative of Xanthohumol (HY-N1067).
  • HY-N10490
    Blestrin D
    Blestrin D is a potent butyrylcholinesterase (BChE) mixed-type inhibitor with an IC50 value of 8.1 μM.
  • HY-152632
    BuChE-IN-7 is a highly selective inhibitor of hBuChe and eqBuChE with IC50 values of 40 nM, 80 nM respectively.
  • HY-144446
    BuChE-IN-1 (Compound 23) is a potent inhibitor of butyrylcholinesterase (BuChE).
  • HY-152112
    AChE/BChE/MAO-B-IN-2 is a potent AChE, BChE, and MAO-B enzymes inhibitor with IC50 values of 48.2 nM, 83.9 nM, and 31.2 nM, respectively.
  • HY-107922
    Ethopropazine hydrochloride
    Inhibitor 99.66%
    Ethopropazine (Isothazine) hydrochloride is a potent, selective BChE inhibitor and a poor AChE inhibitor.
  • HY-146251
    BuChE-IN-6 (compound 1b) is a potent and selective BuChE (butyrylcholinesterase) inhibitor, with IC50 values of 0.46 and 0.51 μM for eqBuChE and hBuChE, respectively.