BChE

Butyrylcholinesterase (BuChE; acylcholine acylhydrolase), also known as nonspecific cholinesterase or pseudocholinesterase, is a serine hydrolase present in almost all mammalian tissues with the highest levels detected in plasma and liver. BChE hydrolyzes acetylcholine and all chemicals containing ester bonds, including anesthetics such as succinylcholine and procaine and drugs such as cocaine and heroin. BChE is found in glia and white matter in the brain and is also associated with neurons, particularly in the hippocampus, amygdala, and thalamus. BChE was also found in amyloid plaques and neurofibrillary tangles (NFTs), which suggests that the protein may be involved in the pathogenesis of Alzheimer’s disease.

BChE Inhibitors (37)

BChE Related Products (37):

By Type:	Pan (13) Selective (10)

Cat. No.	Product Name	Effect	Purity

HY-107569

Garcinol	Inhibitor	98.85%
Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC₅₀s of 0.66 µM and 7.39 µM, respectively.

HY-N0285

Imperatorin	Inhibitor	98.00%
Imperatorin is an effective of NO synthesis inhibitor (IC₅₀=9.2 μmol), which also is a BChE inhibitor (IC₅₀=31.4 μmol).

HY-N0226A

Epiberberine chloride	Inhibitor	99.03%
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC₅₀s of 1.07, 6.03 and 8.55 μM, respectively.

HY-N0226

Epiberberine	Inhibitor	98.46%
Epiberberine is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC₅₀s of 1.07, 6.03 and 8.55 μM, respectively.

HY-N2284

Sophoflavescenol	Inhibitor	98.15%
Sophoflavescenol is a prenylated flavonol, which shows great inhibitory activity with IC₅₀ of 0.013 μM against Phosphodiesterase 5 (PDE5), and also inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE with IC₅₀s of 0.30 µM, 0.17 µM, 17.89 µg/mL, 10.98 µM, 8.37 µM and 8.21 µM, respectively.

HY-151436

ZLMT-12	Inhibitor
ZLMT-12 (compound 35), tacrine derivatives, is a potent, orally active CDK2/9 inhibitor with IC₅₀ values of 0.002 and 0.011 μM for CDK9 and CDK2, respectively.

HY-152113

AChE/BChE/MAO-B-IN-3	Inhibitor
AChE/BChE/MAO-B-IN-3, an indan-1-one derivative, is a potent MAO-B inhibitor with an IC₅₀ of 0.0359 μM for human MAO-B.

HY-151405

Z164597606	Inhibitor
Z164597606 is a selective BChE inhibitor (IC₅₀: 1.3 and 1.7 μM for eqBChE and hBChE).

HY-146669

BChE-IN-6	Inhibitor
BChE-IN-6 (compound 12) is a potent BChE inhibitor, with a K_i of 0.182 μM.

HY-W130236

Methylene Violet 3RAX	Inhibitor
Methylene Violet 3RAX is a phenazine dye to stain the mitochondria of cells.

HY-16183

Echothiopate iodide	Inhibitor
Echothiopate iodide is a potent hBChE (human butyrylcholinesterase) inhibitor.

HY-107275

Ebeiedinone	Inhibitor
Ebeiedinone, a steroidal alkaloid from Fritillaria species, inhibits the bioactivity of human whole blood cholinesterase (ChE) at the concentration of 0.1 mM, with the inhibitory effects of 69.0%.

HY-N7263

Galanthamine N-Oxide	Inhibitor	99.90%
Galanthamine N-Oxide is an alkaloid obtained from the bulbs of Zephyranthes concolor.

HY-N10917

Xanthohumol I	Inhibitor
Xanthohumol I, a chalkone, is a derivative of Xanthohumol (HY-N1067).

HY-N10490

Blestrin D	Inhibitor
Blestrin D is a potent butyrylcholinesterase (BChE) mixed-type inhibitor with an IC₅₀ value of 8.1 μM.

HY-152632

BuChE-IN-7	Inhibitor
BuChE-IN-7 is a highly selective inhibitor of hBuChe and eqBuChE with IC₅₀ values of 40 nM, 80 nM respectively.

HY-144446

BuChE-IN-1	Inhibitor
BuChE-IN-1 (Compound 23) is a potent inhibitor of butyrylcholinesterase (BuChE).

HY-152112

AChE/BChE/MAO-B-IN-2	Inhibitor
AChE/BChE/MAO-B-IN-2 is a potent AChE, BChE, and MAO-B enzymes inhibitor with IC₅₀ values of 48.2 nM, 83.9 nM, and 31.2 nM, respectively.

HY-107922

Ethopropazine hydrochloride	Inhibitor	99.66%
Ethopropazine (Isothazine) hydrochloride is a potent, selective BChE inhibitor and a poor AChE inhibitor.

HY-146251

BuChE-IN-6	Inhibitor
BuChE-IN-6 (compound 1b) is a potent and selective BuChE (butyrylcholinesterase) inhibitor, with IC₅₀ values of 0.46 and 0.51 μM for eqBuChE and hBuChE, respectively.

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