1. Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. AChE
    iGluR
  3. Tacrine hydrochloride

Tacrine hydrochloride 

Cat. No.: HY-B1488 Purity: >98.0%
Handling Instructions

Tacrine hydrochloride is a potent inhibitor of both AChE and BChE, with IC50s of 31 nM and 25.6 nM, respectively. Tacrine hydrochloride is also a NMDAR inhibitor, with an IC50 of 26 μM. Tacrine hydrochloride can be used for the research of Alzheimer’s disease.

For research use only. We do not sell to patients.

Tacrine hydrochloride Chemical Structure

Tacrine hydrochloride Chemical Structure

CAS No. : 1684-40-8

Size Price Stock Quantity
10 mM * 1 mL in Water USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Tacrine hydrochloride:

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Description

Tacrine hydrochloride is a potent inhibitor of both AChE and BChE, with IC50s of 31 nM and 25.6 nM, respectively. Tacrine hydrochloride is also a NMDAR inhibitor, with an IC50 of 26 μM. Tacrine hydrochloride can be used for the research of Alzheimer’s disease[1][2].

IC50 & Target

IC50: 31 nM (AChE), 25.6 nM (BChE), 26 μM (NMDAR)[1][2]

In Vitro

Tacrine (12.5-37.5 nM) inhibits venom acetylcholinesterase as well as human serum butyrylcholinesterase in a concentration-dependent manner[1].
Tacrine reduces the neurotoxicity induced by the activation of the NMDARs in murine cortical neuronal cultures with an IC50of ~500 μM[2].
Tacrine inhibits the NMDAR responses in a concentration-dependent manner with an IC50 of ~190 μM at -60 mV[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tacrine (20-40 μmol/kg; s.c.) disrupts retention of learning in 17- and 30-day old mice in passive avoidance, and while the low dose of tacrine treatment (5 μmol/kg; s.c.) improves retention in 17-day old mice[2].
Tacrine (0.1-0.4 mg/mL; i.p. for 7 d) inhibits the expression of AChE, but does not significantly improve the protection of the retina function and morphology in mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

234.72

Formula

C₁₃H₁₅ClN₂

CAS No.

1684-40-8

SMILES

NC1=C(CCCC2)C2=NC3=CC=CC=C31.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 83.33 mg/mL (355.02 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2604 mL 21.3020 mL 42.6040 mL
5 mM 0.8521 mL 4.2604 mL 8.5208 mL
10 mM 0.4260 mL 2.1302 mL 4.2604 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

TacrineAChEiGluRAcetylcholinesteraseIonotropic glutamate receptorsBChENMDARAlzheimerInhibitorinhibitorinhibit

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Tacrine hydrochloride
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HY-B1488
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