1. Neuronal Signaling Membrane Transporter/Ion Channel
  2. Cholinesterase (ChE) iGluR
  3. Tacrine hydrochloride

Tacrine hydrochloride 

Cat. No.: HY-B1488 Purity: 99.95%
COA Handling Instructions

Tacrine hydrochloride is a potent inhibitor of both AChE and BChE, with IC50s of 31 nM and 25.6 nM, respectively. Tacrine hydrochloride is also a NMDAR inhibitor, with an IC50 of 26 μM. Tacrine hydrochloride can be used for the research of Alzheimer’s disease.

For research use only. We do not sell to patients.

Tacrine hydrochloride Chemical Structure

Tacrine hydrochloride Chemical Structure

CAS No. : 1684-40-8

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Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 39 In-stock
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10 mM * 1 mL in Water USD 39 In-stock
Solid
100 mg USD 35 In-stock
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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Tacrine hydrochloride:

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Description

Tacrine hydrochloride is a potent inhibitor of both AChE and BChE, with IC50s of 31 nM and 25.6 nM, respectively. Tacrine hydrochloride is also a NMDAR inhibitor, with an IC50 of 26 μM. Tacrine hydrochloride can be used for the research of Alzheimer’s disease[1][2].

IC50 & Target

IC50: 31 nM (AChE), 25.6 nM (BChE), 26 μM (NMDAR)[1][2]

In Vitro

Tacrine (12.5-37.5 nM) inhibits venom acetylcholinesterase as well as human serum butyrylcholinesterase in a concentration-dependent manner[1].
Tacrine reduces the neurotoxicity induced by the activation of the NMDARs in murine cortical neuronal cultures with an IC50of ~500 μM[2].
Tacrine inhibits the NMDAR responses in a concentration-dependent manner with an IC50 of ~190 μM at -60 mV[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tacrine (20-40 μmol/kg; s.c.) disrupts retention of learning in 17- and 30-day old mice in passive avoidance, and while the low dose of tacrine treatment (5 μmol/kg; s.c.) improves retention in 17-day old mice[2].
Tacrine (0.1-0.4 mg/mL; i.p. for 7 d) inhibits the expression of AChE, but does not significantly improve the protection of the retina function and morphology in mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

234.72

Formula

C13H15ClN2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=C(CCCC2)C2=NC3=CC=CC=C31.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 33.33 mg/mL (142.00 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2604 mL 21.3020 mL 42.6040 mL
5 mM 0.8521 mL 4.2604 mL 8.5208 mL
10 mM 0.4260 mL 2.1302 mL 4.2604 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 16.67 mg/mL (71.02 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.95%

References
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Tacrine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Tacrine hydrochloride
Cat. No.:
HY-B1488
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