2. Tacrine hydrochloride

Tacrine hydrochloride is a potent inhibitor of both AChE and BChE, with IC50s of 31 nM and 25.6 nM, respectively. Tacrine hydrochloride is also a NMDAR inhibitor, with an IC50 of 26 μM. Tacrine hydrochloride can be used for the research of Alzheimer’s disease.

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Tacrine hydrochloride Chemical Structure

Tacrine hydrochloride Chemical Structure

CAS No. : 1684-40-8

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Solid + Solvent
10 mM * 1 mL in Water
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Based on 5 publication(s) in Google Scholar

Other Forms of Tacrine hydrochloride:

Tacrine hydrochloride Related Antibodies

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Description

Tacrine hydrochloride is a potent inhibitor of both AChE and BChE, with IC50s of 31 nM and 25.6 nM, respectively. Tacrine hydrochloride is also a NMDAR inhibitor, with an IC50 of 26 μM. Tacrine hydrochloride can be used for the research of Alzheimer’s disease[1][2].

IC50 & Target

IC50: 31 nM (AChE), 25.6 nM (BChE), 26 μM (NMDAR)[1][2]
In Vitro

Tacrine (12.5-37.5 nM) inhibits venom acetylcholinesterase as well as human serum butyrylcholinesterase in a concentration-dependent manner[1].
Tacrine reduces the neurotoxicity induced by the activation of the NMDARs in murine cortical neuronal cultures with an IC50of ~500 μM[2].
Tacrine inhibits the NMDAR responses in a concentration-dependent manner with an IC50 of ~190 μM at -60 mV[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tacrine hydrochloride Related Antibodies
In Vivo

Tacrine (20-40 μmol/kg; s.c.) disrupts retention of learning in 17- and 30-day old mice in passive avoidance, and while the low dose of tacrine treatment (5 μmol/kg; s.c.) improves retention in 17-day old mice[2].
Tacrine (0.1-0.4 mg/mL; i.p. for 7 d) inhibits the expression of AChE, but does not significantly improve the protection of the retina function and morphology in mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

234.72

Formula

C13H15ClN2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

NC1=C(CCCC2)C2=NC3=CC=CC=C31.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 33.33 mg/mL (142.00 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2604 mL 21.3020 mL 42.6040 mL
5 mM 0.8521 mL 4.2604 mL 8.5208 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Concentration (final)

C2

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In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 16.67 mg/mL (71.02 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.95%

COA (253 KB) HNMR (262 KB) LCMS (265 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.2604 mL 21.3020 mL 42.6040 mL 106.5099 mL
5 mM 0.8521 mL 4.2604 mL 8.5208 mL 21.3020 mL
10 mM 0.4260 mL 2.1302 mL 4.2604 mL 10.6510 mL
15 mM 0.2840 mL 1.4201 mL 2.8403 mL 7.1007 mL
20 mM 0.2130 mL 1.0651 mL 2.1302 mL 5.3255 mL
25 mM 0.1704 mL 0.8521 mL 1.7042 mL 4.2604 mL
30 mM 0.1420 mL 0.7101 mL 1.4201 mL 3.5503 mL
40 mM 0.1065 mL 0.5325 mL 1.0651 mL 2.6627 mL
50 mM 0.0852 mL 0.4260 mL 0.8521 mL 2.1302 mL
60 mM 0.0710 mL 0.3550 mL 0.7101 mL 1.7752 mL
80 mM 0.0533 mL 0.2663 mL 0.5325 mL 1.3314 mL
100 mM 0.0426 mL 0.2130 mL 0.4260 mL 1.0651 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tacrine1684-40-8Inhibitorinhibitorinhibit

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