1. Signaling Pathways
  2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. AChE Isoform

AChE

Acetylcholinesterase (AChE or acetylhydrolase) is a serine hydrolase that terminates the action of the neurotransmitter acetylcholine by hydrolyzing it into acetic acid and choline. AChE is found at mainly neuromuscular junctions and cholinergic brain synapses, where its activity serves to terminate synaptic transmission. AChE plays an important role in the pathogenesis of neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative stress and aggregation of pathological proteins.

AChE Related Products (80):

Cat. No. Product Name Effect Purity
  • HY-108477
    TMPyP4 tosylate
    Inhibitor ≥98.0%
    TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand.
  • HY-N0342
    Scopoletin
    Inhibitor 99.70%
    Scopoletin is an inhibitor of acetylcholinesterase (AChE).
  • HY-76299
    Galanthamine
    Inhibitor 99.96%
    Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.
  • HY-17387
    (-)-Huperzine A
    Inhibitor ≥98.0%
    (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity.
  • HY-75247
    Coumaran
    Inhibitor 99.54%
    Coumaran (2,3-Dihydrobenzofuran) is an acetylcholinesterase (AChE) inhibitor isolated from leaves of L.
  • HY-151436
    ZLMT-12
    Inhibitor
    ZLMT-12 (compound 35), tacrine derivatives, is a potent, orally active CDK2/9 inhibitor with IC50 values of 0.002 and 0.011 μM for CDK9 and CDK2, respectively.
  • HY-W130236
    Methylene Violet 3RAX
    Inhibitor
    Methylene Violet 3RAX is a phenazine dye to stain the mitochondria of cells.
  • HY-151927
    AChE-IN-28
    Inhibitor
    AChE-IN-28 (Compound 2h) is a selective slow-binding inhibitor of acetylcholinesterase with an IC50 of 0.2 nM.
  • HY-N0285
    Imperatorin
    Inhibitor 98.00%
    Imperatorin is an effective of NO synthesis inhibitor (IC50=9.2 μmol), which also is a BChE inhibitor (IC50=31.4 μmol).
  • HY-N2181
    Acetylshikonin
    Inhibitor 98.10%
    Acetylshikonin, derived from the root of Lithospermum erythrorhizon, has anti-cancer and antiinflammation activity.
  • HY-N5077
    Sinapine
    Inhibitor 99.72%
    Sinapine is an alkaloid isolated from seeds of the cruciferous species.
  • HY-N0810
    Timosaponin AIII
    98.88%
    Timosaponin AIII could inhibit acetylcholinesterase (AChE) activity, with an IC50 of 35.4 μM.
  • HY-B0949
    Protriptyline hydrochloride
    Inhibitor 99.91%
    Protriptyline hydrochloride is a tricyclic antidepressant (TCA), specifically a secondary amine, for the treatment of depression and ADHD.
  • HY-16009
    Buntanetap
    Inhibitor 98.09%
    Buntanetap ((+)-Phenserine) is a novel selective cholinesterase noncompetitive inhibitor with an IC50 of 45.3 μM.
  • HY-N0528
    Linarin
    Inhibitor ≥98.0%
    Linarin (Buddleoside), isolated from the flower extract of Mentha arvensis, shows selective dose dependent inhibitory effect on acetylcholinesterase (AChE).
  • HY-N0450
    Sinapine thiocyanate
    Inhibitor 99.42%
    Sinapine thiocyanate is an alkaloid isolated from seeds of the cruciferous species.
  • HY-N0286
    Isoimperatorin
    Inhibitor 98.93%
    Isoimperatorin is a methanolic extract of the roots of Angelica dahurica shows significant inhibitory effects on acetylcholinesterase (AChE) with the IC50 of 74.6 μM.
  • HY-N4142
    Cyanidin-3-O-galactoside chloride
    Inhibitor 99.87%
    Cyanidin-3-O-galactoside chloride (Ideain chloride) is a component from extract peel of hawthorn fruit (EPHF) with the value of 179.4 mg/g.
  • HY-N0923
    Corydaline
    Inhibitor 98.44%
    Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC50 of 226 µM.
  • HY-N0226
    Epiberberine
    Inhibitor 98.46%
    Epiberberine is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively.