1. Neuronal Signaling
  2. AChE

Galanthamine (Synonyms: Galantamine)

Cat. No.: HY-76299 Purity: 99.78%
Handling Instructions

Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with IC50 of 500 nM.

For research use only. We do not sell to patients.
Galanthamine Chemical Structure

Galanthamine Chemical Structure

CAS No. : 357-70-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
50 mg USD 60 In-stock
100 mg USD 96 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of Galanthamine:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with IC50 of 500 nM.

IC50 & Target

IC50: 0.5 μM (AChE)[1]

In Vitro

Galanthamine inhibits AChE and BChE with IC50 of 0.5 and 8.5 μM[1]. Galanthamine acts as a positive allosteric modulator (PAM) of human α4β2 AChRs expressed in permanently transfected HEK 293 cells. Galanthamine increases the response of (α4β2)2α5 AChRs to 1 μM ACh by up to 220% with very low concerntration(EC50=0.25 nM). Only small potentiation (20%) of either α4β2 or (α4β2)2β3 AChRs is detected using FLEXstation assays. Galanthamine at concentrations of 1 μM and above inhibits all three AChR subtypes[2].

In Vivo

Acute administration of Galantamine (0.3-3 mg/kg, i.p.) increases IGF2 mRNA levels in the hippocampus, but not in the prefrontal cortex, in time- and dose-dependent manner. Galantamine (3 mg/kg, i.p.) causes a transient increase in fibroblast growth factor 2 mRNA levels and a decrease in brain-derived neurotrophic factor mRNA levels in the hippocampus, while it does not affect the mRNA levels of other neurotrophic/growth factors. The Galantamine-induced increase in the hippocampal IGF2 mRNA levels is blocked by Mecamylamine, a nonselective nicotinic acetylcholine (ACh) receptor (nAChR) antagonist, and Methyllycaconitine, a selective α7 nAChR antagonist, but not by Telenzepine, a preferential M1muscarinic ACh receptor antagonist. Moreover, the selective α7 nAChR agonist PHA-543613 increasea the IGF2 mRNA levels, while Donepezil, an acetylcholinesterase inhibitor, does not. Galantamine also increases hippocampal IGF2 protein, which is blocked by Methyllycaconitine[2].

Clinical Trial
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.4801 mL 17.4004 mL 34.8008 mL
5 mM 0.6960 mL 3.4801 mL 6.9602 mL
10 mM 0.3480 mL 1.7400 mL 3.4801 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration

Galanthamine is dissolved in saline (0.9 % solution of NaCl) (Mice)[2].

Eight-week-old male ddY mice are housed in cages (24 cm×17 cm×12 cm) in each group of five to six animals under controlled environmental conditions (22±1°C; 12:12-h light-dark cycle, lights on at 0800 hours, food and water ad libitum) for 1 week before use in the experiments. 453 mice are used in total and in single use for each purpose. The following drugs are used: mecamylamine, methyllycaconitine, oxotremorine, and telenzepine, and Galantamine, Donepezil, and PHA-543613. All drugs are dissolved in saline (0.9 % solution of NaCl). Drugs are administered in a volume of 10 mL/kg intraperitoneally (i.p.) (Galantamine, Donepezil, Mecamylamine, Methyllycaconitine, Oxotremorine) or subcutaneously (s.c.) (PHA-543613, Telenzepine). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight







O[[email protected]@H]1C[[email protected]@H]2OC3=C4C(CN(C)CC[[email protected]]42C=C1)=CC=C3OC

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 59 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.78%

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