1. Neuronal Signaling Apoptosis
  2. Cholinesterase (ChE) Apoptosis
  3. Galanthamine-d6

Galanthamine-d6 (Galantamine-d6) is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM[1][2].

For research use only. We do not sell to patients.

Galanthamine-d<sub>6</sub> Chemical Structure

Galanthamine-d6 Chemical Structure

CAS No. : 1128109-00-1

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1 mg USD 320 In-stock
5 mg USD 810 In-stock
10 mg USD 1300 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Galanthamine-d6 (Galantamine-d6) is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

293.39

Formula

C17H15D6NO3

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O(C([2H])([2H])[2H])C1=C2C=3[C@]4([C@@](O2)(C[C@@H](O)C=C4)[H])CCN(C([2H])([2H])[2H])CC3C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (340.84 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4084 mL 17.0422 mL 34.0843 mL
5 mM 0.6817 mL 3.4084 mL 6.8169 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4084 mL 17.0422 mL 34.0843 mL 85.2108 mL
5 mM 0.6817 mL 3.4084 mL 6.8169 mL 17.0422 mL
10 mM 0.3408 mL 1.7042 mL 3.4084 mL 8.5211 mL
15 mM 0.2272 mL 1.1361 mL 2.2723 mL 5.6807 mL
20 mM 0.1704 mL 0.8521 mL 1.7042 mL 4.2605 mL
25 mM 0.1363 mL 0.6817 mL 1.3634 mL 3.4084 mL
30 mM 0.1136 mL 0.5681 mL 1.1361 mL 2.8404 mL
40 mM 0.0852 mL 0.4261 mL 0.8521 mL 2.1303 mL
50 mM 0.0682 mL 0.3408 mL 0.6817 mL 1.7042 mL
60 mM 0.0568 mL 0.2840 mL 0.5681 mL 1.4202 mL
80 mM 0.0426 mL 0.2130 mL 0.4261 mL 1.0651 mL
100 mM 0.0341 mL 0.1704 mL 0.3408 mL 0.8521 mL
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Galanthamine-d6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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