Phosphorylase

Phosphorylase is an enzyme that catalyzes the addition of a phosphate group from an inorganic phosphate (phosphate+hydrogen) to an acceptor, including glycogen phosphorylase, starch phosphorylase, nucleoside diphosphate kinase, etc. Phosphorylase participates in cell signal transduction and activates signal pathways through phosphorylation. Phosphorylase plays a crucial role in metabolic processes and is extensively involved in the metabolic regulation of substances such as sugars, nucleotides, and lipids. Phosphorylase can also regulate cell differentiation, proliferation, apoptosis, and gene expression, affecting the fate and function of cells. Abnormal activity or expression of phosphorylase leads to metabolic diseases such as glycogen storage disease, and is also closely related to the occurrence and development of cancer, neurodegenerative diseases, etc^[1].

References:

[1]. Watson KA, et al. Phosphorylase recognition and phosphorolysis of its oligosaccharide substrate: answers to a long outstanding question. EMBO J. 1999 Sep 1;18(17):4619-32. [Content Brief]

Phosphorylase Related Products (23):

By Effects:	Inhibitors (18) Control (1) Substrates (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-108615

CP-316819	Inhibitor	99.0%
CP-316819 (GPi 819) is a blood-brain barrier permeable glycogen phosphorylase inhibitor. CP-316819 inhibits hepatic glycogenolysis, safely reduces blood glucose in type 2 diabetes, and rarely induces hypoglycemia. CP-316819 increases brain glycogen reserves, protects neurons, alleviates hypoglycemic brain injury, and inhibits excessive platelet activation, exerting both neuroprotective and vasculoprotective effects. CP-316819 can be used in research related to hypoglycemia, thrombosis, autoimmune inflammatory diseases, and type 2 diabetes.

HY-113291

5'-Deoxyadenosine	Substrate	99.45%
5'-Deoxyadenosine is a 5'-methylthioadenosine phosphorylase substrate and deoxyadenosine. 5'-Deoxyadenosine serves as a non-metabolizable substrate for nucleoside transport assays only in cells lacking 5'-methylthioadenosine phosphorylase.

HY-W008491

TK-112690	Inhibitor	99.91%
TK-112690 is a UPP1 inhibitor. TK-112690 inhibits murine small intestinal uridine phosphorylase (UPase) with an IC₅₀ of 12.5 μM and human small intestinal UPase with an IC₅₀ of 20.0 μM in vitro. TK-112690 increases plasma uridine concentration in mice. TK-112690 can be used for the study of cancer and pulmonary fibrosis.

HY-19396

Ingliforib	Inhibitor	99.07%
Ingliforib (CP 368296) is a glycogen phosphorylase inhibitor, with IC₅₀s of 52, 352 and 150 nM for liver, muscle and brain glycogen phosphorylase, and has cardioprotective activity.

HY-W017441A

hUP1-IN-1 potassium	Inhibitor	99.28%
hUP1-IN-1 potassium (compound 6a) is a hUP1 inhibitor with K_ii and K_is Urd of 375 and 635 nM. hUP1-IN-1 potassium showes inhibitory activities over hUP1 catalyzed reaction with 70% at 1 μM. hUP1-IN-1 potassium can be used for the research of cancer.

HY-126756

Amorphin	Control
Amorphin is a phosphorylase b with glycogen metabolism activity. Amorphin binds directly to alpha-actinin, with alpha-actinin mediating its binding to actin filaments. Amorphin can be used for the research of McArdle’s disease and breast cancer.

HY-N1932

Bayogenin	Inhibitor	99.90%
Bayogenin is a triterpenoid saponin and one of the main components of Medicago sativa saponins. Bayogenin is an inhibitor of glycogen phosphorylase.

HY-100320

AVE5688	Inhibitor	98.79%
AVE5688 is an inhibitor of glycogen phosphorylase (GP), with IC₅₀s of 430 nM and 915 nM and K_ds of 170 nM and 530 nM for rabbit muscle glycogen phosphorylase (rmGPb and rmGPa, respectively); AVE5688 can be used for the research of type 2 diabetes.

HY-P2735

Phosphorylase b
Phosphorylase b is one of the two forms of phosphorylase present in skeletal muscle. The other is Phosphorylase a, which can be transformed into one another. The conversion process requires the addition of divalent metal ions and ATP.

HY-128029

Glycogen phosphorylase-IN-1	Inhibitor	98.15%
Glycogen phosphorylase-IN-1 (Compound 42) is an inhibitor for human liver glycogen phosphorylase (hlGPa) and hepatocyte glycogen-derived glucose production with IC₅₀s of 53 and 380 nM, respectively. Glycogen phosphorylase-IN-1 reveals efficacy towards type 2 diabetes.

HY-172805

Glycogen phosphorylase-IN-2	Inhibitor
Glycogen phosphorylase-IN-2 (compound 9C) is an inhibitor of glycogen phosphorylase with a K_i value of 1.9 nM and an IC₅₀ value of 4 nM.

HY-W750643

m-APTA	Substrate	99.54%
m-APTA (5'-S-(3-aminophenyl)-5'-thioadenosine) is a selective chemoprotective agent targeting methylthioadenosine phosphorylase (MTAP). m-APTA can be converted into adenine, which is a crucial step in protecting normal cells from the toxicity of nucleobase analogues (NBA). m-APTA is promising for research of MTAP-deficient cancers.

HY-117172

CP320626	Inhibitor
CP320626 is a potent inhibitor of human liver glycogen phosphorylase (IC₅₀=205 nM). CP320626 reduces blood glucose in diabetic mice without changing plasma insulin levels. CP320626 can be used in the study of type 2 diabetes.

HY-P2916

Thymidine phosphorylase
Thymidine phosphorylase is a nucleoside metabolism enzyme that plays an important role in the pyrimidine salvage pathway. Thymidine phosphorylase catalyzes the conversion of thymidine to thymine and 2-deoxy-α-D-ribose-1-phosphate (dRib-1-P). Thymidine phosphorylase plays an important role in platelet activation in vitro and thrombosis in vivo by participating in multiple signaling pathways. Thymidine phosphorylase can be used for the study of myocardial infarction, stroke, pulmonary embolism and cancer.

HY-N1932R

Bayogenin (Standard)	Inhibitor
Bayogenin (Standard) is the analytical standard of Bayogenin (HY-N1932). This product is intended for research and analytical applications. Bayogenin is a triterpenoid saponin and one of the main components of Medicago sativa saponins. Bayogenin is an inhibitor of glycogen phosphorylase.

HY-139140

BAY R3401	Inhibitor
BAY R3401 is an orally active glycogen phosphorylase inhibitor that can achieve irreversible and non-selective inhibition of hepatic glycogenolysis. BAY R3401 inhibits glycogenolysis in liver cells, with IC₅₀ values of 27.06 and 52.83 μM in HL-7702 and HepG2 cells, respectively. BAY R3401 can be used for the research of type 2 diabetes.

HY-108614

GPi688	Inhibitor
GPi688 is a potent and orally active glycogen phosphorylase (GPa) inhibitor with IC₅₀s of 19 nM, 61 nM and 12 nM for human liver GPa, rat liver GPa and human skeletal muscle GPa, respectively. GPi688 can inhibit glucagons-mediated glucose output in rat primary hepatocytes. GPi688 can be used for researching glucagon-mediated hyperglycaemia.

HY-W017441

hUP1-IN-1	Inhibitor
hUP1-IN-1 is a hUP1 inhibitor with K_ii and K_is Urd of 375 and 635 nM. hUP1-IN-1 showes inhibitory activities over hUP1 catalyzed reaction with 70% at 1 μM. hUP1-IN-1 can be used for the research of cancer.

HY-108615R

CP-316819 (Standard)	Inhibitor
CP-316819 (GPi 819) Standard is the analytical standard of CP-316819 (HY-108615). This product is intended for research and analytical applications. CP-316819 (GPi 819) is a blood-brain barrier permeable glycogen phosphorylase inhibitor. CP-316819 inhibits hepatic glycogenolysis, safely reduces blood glucose in type 2 diabetes, and rarely induces hypoglycemia. CP-316819 increases brain glycogen reserves, protects neurons, alleviates hypoglycemic brain injury, and inhibits excessive platelet activation, exerting both neuroprotective and vasculoprotective effects. CP-316819 can be used in research related to hypoglycemia, thrombosis, autoimmune inflammatory diseases, and type 2 diabetes.

HY-W552525

Deoxyadenosine diphosphate sodium	Inhibitor
Deoxyadenosine diphosphate sodium is a nucleoside diphosphate, in which the nucleoside is deoxyadenosine. Deoxyadenosine diphosphate sodium participates in DNA synthesis and repair. Deoxyadenosine diphosphate sodium acts as the inhibitor of polynucleotide phosphorylase, interfers with the polymerization of ADP and CDP.

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