5'-Deoxyadenosine
Based on 2 publication(s) in Google Scholar
5'-Deoxyadenosine is a 5'-methylthioadenosine phosphorylase substrate and deoxyadenosine. 5'-Deoxyadenosine serves as a non-metabolizable substrate for nucleoside transport assays only in cells lacking 5'-methylthioadenosine phosphorylase.
For research use only. We do not sell to patients.
- Purity: 99.45%
- CAS No.: 4754-39-6
- Formula: C10H13N5O3
- Molecular Weight:251.25
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) 5'-Deoxyadenosine
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Biological Activity
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Human Endogenous Metabolite |
5'-Deoxyadenosine serves as a potent substrate for 5'-methylthioadenosine phosphorylase in Sarcoma 180 cells and plant cells[1].
5'-Deoxyadenosine is not significantly phosphorylated, deaminated, or metabolized by any other means in L1210 mouse leukemia cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 4754-39-6
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Appearance Solid
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Molecular Weight 251.25
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Formula C10H13N5O3
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Color White to off-white
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SMILES
O[C@@H]1[C@H](O)[C@@H](C)O[C@H]1N2C=NC3=C2N=CN=C3N
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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PLoS Pathog
Anti-orthopoxvirus drugs inhibit lumpy skin disease virus replication by targeting viral DNA polymerase. [Abstract]2026 Jan 26;22(1):e1013903. PMID: 41587213 -
Front Cardiovasc Med
Chick early amniotic fluid component improves heart function and protects against inflammation after myocardial infarction in mice. [Abstract]2022 Nov 16:9:1042852. PMID: 36465449
Solvent & Solubility
DMSO : 125 mg/mL (497.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (8.28 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (8.28 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (278 KB)
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SDS (252 KB)
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- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9801 mL | 19.9005 mL | 39.8010 mL | 99.5025 mL |
| 5 mM | 0.7960 mL | 3.9801 mL | 7.9602 mL | 19.9005 mL | |
| 10 mM | 0.3980 mL | 1.9900 mL | 3.9801 mL | 9.9502 mL | |
| 15 mM | 0.2653 mL | 1.3267 mL | 2.6534 mL | 6.6335 mL | |
| 20 mM | 0.1990 mL | 0.9950 mL | 1.9900 mL | 4.9751 mL | |
| 25 mM | 0.1592 mL | 0.7960 mL | 1.5920 mL | 3.9801 mL | |
| 30 mM | 0.1327 mL | 0.6633 mL | 1.3267 mL | 3.3167 mL | |
| 40 mM | 0.0995 mL | 0.4975 mL | 0.9950 mL | 2.4876 mL | |
| 50 mM | 0.0796 mL | 0.3980 mL | 0.7960 mL | 1.9900 mL | |
| 60 mM | 0.0663 mL | 0.3317 mL | 0.6633 mL | 1.6584 mL | |
| 80 mM | 0.0498 mL | 0.2488 mL | 0.4975 mL | 1.2438 mL | |
| 100 mM | 0.0398 mL | 0.1990 mL | 0.3980 mL | 0.9950 mL |
5'-Deoxyadenosine Related Classifications
HY-113291 Related Classifications
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