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Estrogen Receptor/ERR

Estrogen receptors are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen (17β-estradiol). Two classes of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and GPER (GPR30), which is a member of the rhodopsin-like family of G protein-coupled receptors. The ER's helix 12 domain plays a crucial role in determining interactions with coactivators and corepressors and, therefore, the respective agonist or antagonist effect of the ligand. Different ligands may differ in their affinity for alpha and beta isoforms of the estrogen receptor: estradiol binds equally well to both receptors, estrone, and raloxifene bind preferentially to the alpha receptor, estriol, and genistein to the beta receptor. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

Estrogen Receptor/ERR Related Products (55):

Cat. No. Product Name Effect Purity
  • HY-13636
    Fulvestrant Inhibitor 99.89%
    Fulvestrant is a potent and specific inhibitor of estrogen action with IC50 of 9.4 nM for Estrogen Receptor.
  • HY-13757A
    Tamoxifen Inhibitor 99.23%
    Tamoxifen is an antiestrogen by inhibiting the binding of estrogen to estrogen receptors.
  • HY-13757
    Tamoxifen Citrate Inhibitor 99.87%
    Tamoxifen Citrate is an antiestrogen by inhibiting the binding of estrogen to estrogen receptors.
  • HY-B0141
    Estradiol Agonist 98.45%
    Estradiol (E2) is a potent mammalian estrogenic hormone that is produced in the ovaries (by the granulosa cells), placenta, testis and possibly the adrenal cortex.
  • HY-12870
    AZD9496 Antagonist 99.55%
    AZD9496 is a potent and selective estrogen receptor (ERα)antagonist with IC50 of 0.28 nM.
  • HY-19822A
    Elacestrant dihydrochloride Inhibitor 98.93%
    Elacestrant dihydrochloride (RAD1901 dihydrochloride) is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively.
  • HY-N2335
    Coumestrol Inhibitor 98.28%
    Coumestrol, a phytoestrogen present in soybean products, exhibits activities against cancers, neurological disorders, and autoimmune diseases.
  • HY-14590
    Kaempferol Inhibitor 99.47%
    Kaempferol inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK.
  • HY-12864
    GDC-0810 Inhibitor 99.87%
    GDC-0810 is an orally bioavailable selective estrogen receptor degrader (SERD) with IC50 of 0.7 nM.
  • HY-10426
    XCT790 Agonist 98.01%
    XCT-790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα); induces cell death in chemotherapeutic resistant cancer cells.
  • HY-13738A
    Raloxifene hydrochloride Antagonist 99.64%
    RaloxifeneHcl(LY156758 Hcl) is a second generation selective estrogen receptor antagonist.
  • HY-A0038
    Lasofoxifene Tartrate Modulator 99.91%
    Lasofoxifene Tartrate is a non-steroidal selective estrogen receptor modulator (SERM).
  • HY-A0036
    Bazedoxifene acetate Modulator 99.40%
    Bazedoxifene acetate (TSE 424; WAY-TES 424), a novel selective estrogen receptor modulator (SERM), has been developed to have favorable effects on bone and the lipid profile while minimizing stimulation of uterine or breast tissues.
  • HY-18719A
    Endoxifen Z-isomer hydrochloride Inhibitor
    Endoxifen Z-isomer hydrochloride is the most important Tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα). Endoxifen Z-isomer hydrochloride inhibits hERG tail currents at 50 mV in a concentration-dependent manner with IC50 values of 1.6 μM.
  • HY-B0005
    Toremifene Citrate Modulator 99.59%
    Toremifene Citrate(NK 622; FC 1157a) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis.
  • HY-N0835
    (20S)-Protopanaxatriol Modulator 99.97%
    (20S)-Protopanaxatriol(g-PPT) is a metabolites of ginsenoside, protopanaxatriol (g-PPT), could modulate endothelial cell functions through the glucocorticoid receptor (GR) and oestrogen receptor (ER).
  • HY-15449
    Kaempferide Inhibitor 99.26%
    Kaempferide is an O-methylated flavonol, a type of chemical compound.
  • HY-B0652
    Etonogestrel Agonist 99.91%
    Etonogestrel is a steroidal progestin used in hormonal contraceptives.
  • HY-B1100
    Estradiol cypionate Inhibitor >98.0%
    Estradiol cypionate is a 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor.
  • HY-B0412
    Estriol Antagonist >98.0%
    Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.