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Estrogen Receptor/ERR

Estrogen receptors are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen (17β-estradiol). Two classes of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and GPER (GPR30), which is a member of the rhodopsin-like family of G protein-coupled receptors. The ER's helix 12 domain plays a crucial role in determining interactions with coactivators and corepressors and, therefore, the respective agonist or antagonist effect of the ligand. Different ligands may differ in their affinity for alpha and beta isoforms of the estrogen receptor: estradiol binds equally well to both receptors, estrone, and raloxifene bind preferentially to the alpha receptor, estriol, and genistein to the beta receptor. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

Estrogen Receptor/ERR Related Products (76):

Cat. No. Product Name Effect Purity
  • HY-13757A
    Tamoxifen Inhibitor 99.46%
    Tamoxifen is an antiestrogen by inhibiting the binding of estrogen to estrogen receptors.
  • HY-13636
    Fulvestrant Inhibitor 99.89%
    Fulvestrant is a potent and specific inhibitor of estrogen action with IC50 of 9.4 nM for Estrogen Receptor.
  • HY-B0141
    Estradiol Agonist 98.45%
    Estradiol is a human sex hormone and steroid, and the primary female sex hormone.
  • HY-16950
    4-Hydroxytamoxifen Antagonist 99.27%
    4-Hydroxytamoxifen, an active metabolite of tamoxifen, is a selective estrogen receptor antagonist, with an IC50 of 3.3 nM for the [3H]oestradiol binding to oestrogen receptor, widely used to treat breast cancer; also increases CRISPR/Cas9-mediated editing frequency.
  • HY-12870
    AZD9496 Antagonist 99.15%
    AZD9496 is a potent and selective estrogen receptor (ERα) antagonist with IC50 of 0.28 nM.
  • HY-103456
    PHTPP Antagonist 99.07%
    PHTPP is a selective ERβ antagonist.
  • HY-107216
    G-1 Agonist 99.20%
    G-1 is a nonsteroidal, high-affinity and selective agonist of GPR30 with a Ki of 11 nM.
  • HY-N0250
    Saikosaponin D Activator >98.0%
    Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; inhibits selectin, STAT3 and NF-kB and activates estrogen receptor-β.
  • HY-19822A
    Elacestrant dihydrochloride Inhibitor 98.93%
    Elacestrant dihydrochloride (RAD1901 dihydrochloride) is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively.
  • HY-13757
    Tamoxifen Citrate Inhibitor 99.87%
    Tamoxifen Citrate is an antiestrogen by inhibiting the binding of estrogen to estrogen receptors.
  • HY-14590
    Kaempferol Inhibitor 99.47%
    Kaempferol inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK.
  • HY-13738A
    Raloxifene hydrochloride Antagonist 99.64%
    RaloxifeneHcl(LY156758 Hcl) is a second generation selective estrogen receptor antagonist.
  • HY-10426
    XCT790 Agonist 98.01%
    XCT-790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα); induces cell death in chemotherapeutic resistant cancer cells.
  • HY-A0036
    Bazedoxifene acetate Modulator 99.93%
    Bazedoxifene acetate (TSE 424; WAY-TES 424), a novel selective estrogen receptor modulator (SERM), has been developed to have favorable effects on bone and the lipid profile while minimizing stimulation of uterine or breast tissues.
  • HY-12864
    GDC-0810 Inhibitor 99.87%
    GDC-0810 is an orally bioavailable selective estrogen receptor degrader (SERD) with IC50 of 0.7 nM.
  • HY-N0322
    Cholesterol Agonist 98.00%
    Cholesterol is the major sterol in mammals, and its importance in fundamental cellular processes is becoming more appreciated.
  • HY-B0005
    Toremifene Citrate Modulator 99.57%
    Toremifene Citrate(NK 622; FC 1157a) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis.
  • HY-A0038
    Lasofoxifene Tartrate Modulator 99.91%
    Lasofoxifene Tartrate is a non-steroidal selective estrogen receptor modulator (SERM).
  • HY-N0835
    (20S)-Protopanaxatriol Agonist >98.0%
    (20S)-Protopanaxatriol is a metabolite of ginsenoside, works through the glucocorticoid receptor (GR) and oestrogen receptor (ER), and is also a LXRα inhibitor and a PPARγ activator.
  • HY-18719A
    Endoxifen Z-isomer hydrochloride Inhibitor 99.31%
    Endoxifen Z-isomer hydrochloride is the most important Tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα). Endoxifen Z-isomer hydrochloride inhibits hERG tail currents at 50 mV in a concentration-dependent manner with IC50 values of 1.6 μM.
Isoform Specific Products

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