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  4. Tamoxifen

Tamoxifen  (Synonyms: ICI 47699; (Z)-Tamoxifen; trans-Tamoxifen)

Cat. No.: HY-13757A Purity: 99.45%
COA Handling Instructions

Tamoxifène (ICI 47699) est un modulateur sélectif des récepteurs des œstrogènes (SERM) qui bloque l'action des œstrogènes dans les cellules du sein et peut activer l'activité des œstrogènes dans d'autres cellules, comme les os, le foie, et les cellules utérines. Tamoxifène est un puissant activateur de Hsp90 et améliore l'activité d'ATPase du chaperon moléculaire Hsp90. Tamoxifène active l'autophagie et induit l'apoptosis.

Tamoxifen (ICI 47699) ist ein selektiver estrogen receptor-Modulator (SERM), der die Östrogenwirkung in Brustzellen blockiert und die Östrogenaktivität in anderen Zellen, wie Knochen-, Leber- und Gebärmutterzellen, aktivieren kann. Tamoxifen ist ein potenter Hsp90-Aktivator und steigert die Aktivität des molekularen Hsp90-Chaperons ATPase. Tamoxifen aktiviert die autophagy und induziert die apoptosis.

Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 µM and 1.8 µM, respectively. Tamoxifen activates autophagy and induces apoptosis. Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse.

For research use only. We do not sell to patients.

Tamoxifen Chemical Structure

Tamoxifen Chemical Structure

CAS No. : 10540-29-1

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10 mM * 1 mL in DMSO
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5 g USD 288 In-stock
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Customer Review

Based on 70 publication(s) in Google Scholar

Other Forms of Tamoxifen:

Tamoxifen Related Antibodies

Top Publications Citing Use of Products

67 Publications Citing Use of MCE Tamoxifen

WB

    Tamoxifen purchased from MedChemExpress. Usage Cited in: Redox Biol. 18 October 2022, 102509.

    Expression of TFRC in primary fibroblasts from TFRCflox/flox and TFRC−/− mice was assessed by western blot after 5 days of Tamoxifen intraperitoneal injection and 7 days of waiting.

    Tamoxifen purchased from MedChemExpress. Usage Cited in: Clin Transl Med. 2020 Jan;10(1):137-150.  [Abstract]

    Different transmission of MAPK8/FoxO signaling pathway in breast cancer cells (MCF-7, T47D, ZR-75, and MDA-MB-231) and liver cells (LO2) exposed to TAM (Tamoxifen).

    Tamoxifen purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2019 May 23;17(1):50.  [Abstract]

    Tamoxifen inhibits the growth and metastasis of prostate tumors in vivo. Western blot analysis of the indicated proteins in prostate primary tumors tissues.

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    • Biological Activity

    • Purity & Documentation

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    Description

    Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[1][2][3]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 µM and 1.8 µM, respectively[5]. Tamoxifen activates autophagy and induces apoptosis[4]. Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse[6].

    IC50 & Target[1][4]

    Estrogen receptor

     

    HSP90

     

    In Vitro

    Tamoxifen (ICI 47699) shows strong inhibition of MCF-7 cells (EC50=1.41 μM) and to a lesser extent the T47D cells (EC50=2.5 μM) but does not affect the MDA-MB-231 cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Tamoxifen Related Antibodies
    In Vivo

    Injection of pre-mutant mice with Tamoxifen (75 mg/kg; injected for 5 days at 6 weeks of age) results in the excision of the floxed exon and, thus, in a gene knockout[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Aldh1l1-cre/ERT2 x Ai95 mice[3]
    Dosage: 75 mg/kg
    Administration: Injected for 5 days at 6 weeks of age
    Result: Resulted in the excision of the floxed exon and a gene knockout.
    Clinical Trial
    Molecular Weight

    371.51

    Appearance

    Solid

    Formula

    C26H29NO
    CAS No.
    SMILES

    CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)\C3=CC=CC=C3
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (134.59 mM; Need ultrasonic)

    Ethanol : 50 mg/mL (134.59 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.6917 mL 13.4586 mL 26.9172 mL
    5 mM 0.5383 mL 2.6917 mL 5.3834 mL
    10 mM 0.2692 mL 1.3459 mL 2.6917 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  Corn Oil

      Solubility: 40 mg/mL (107.67 mM); Clear solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  30% PEG400  0.5% Tween80  5% Propanediol  64.5%H2O

      Solubility: 5 mg/mL (13.46 mM); Suspended solution; Need ultrasonic

    • 3.

      Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% Saline

      Solubility: 2.5 mg/mL (6.73 mM); Suspended solution; Need ultrasonic

    • 4.

      Add each solvent one by one:  10% EtOH    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (6.73 mM); Clear solution

    • 5.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (5.60 mM); Clear solution

    • 6.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: 2.08 mg/mL (5.60 mM); Suspended solution; Need ultrasonic

    • 7.

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.08 mg/mL (5.60 mM); Clear solution

    • 8.

      Add each solvent one by one:  5% DMSO    40% PEG300    5% Tween-80    50% Saline

      Solubility: ≥ 0.83 mg/mL (2.23 mM); Clear solution

    • 9.

      Add each solvent one by one:  5% DMSO    95% (20% SBE-β-CD in Saline)

      Solubility: 0.83 mg/mL (2.23 mM); Suspended solution; Need ultrasonic

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.92%

    COA (249 KB) LCMS (112 KB) Elemental Analysis Report (107 KB)

    Handling Instructions (2659 KB)
    References
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    Tamoxifen Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    × = ×
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    Keywords:

    Tamoxifen10540-29-1ICI 47699 (Z)-Tamoxifen trans-TamoxifenICI47699ICI-47699Estrogen Receptor/ERRHSPAutophagyApoptosisHeat shock proteinsestrogenmodulatorSERMbreastboneliveruterineHsp90chaperoneATPaseInhibitorinhibitorinhibit

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