Complement Component 8
Complement component 8 (C8) initiates the polymerization phase of the membrane attack complex (MAC). It is a three-chain complex composed of an alpha and a beta chain joined by a disulfide bridge plus a non-covalently associated gamma chain; the beta chain binds the C5b-7 complex while the alpha chain inserts into the membrane. C8 recruitment converts the water-soluble C5b-7 complex into a membrane-bound C5b-8 intermediate that accepts multiple C9 monomers and directs their ring-shaped polymerization into the pore-forming MAC. Like other terminal component deficiencies, C8 deficiency causes recurrent Neisserial infections, and rare C8 variants influence meningococcal disease susceptibility across different ethnic groups.
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Complement Component 8 Recombinant Proteins (2)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
