Siglec-5/CD170
Siglec-5, the CD170 antigen, is an inhibitory member of the sialic acid-binding immunoglobulin-like lectin family expressed predominantly on neutrophils, monocytes and macrophages. Its N-terminal V-set domain carries the canonical arginine that recognizes sialylated glycans, and the cytoplasmic tail contains ITIM motifs that recruit phosphatases to restrain myeloid activation. Pathogens have co-opted this biology: the beta protein of group B Streptococcus binds Siglec-5 directly, a strategy of bacterial immune evasion that helped establish the field of siglec-pathogen interactions. Siglec-5 is studied for its role in neutrophil regulation and serves as a myeloid marker in flow cytometry panels.
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Siglec-5/CD170 Recombinant Proteins (7)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
