1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Glutathione Peroxidase

Glutathione Peroxidase

Glutathione Peroxidase (GPx) is the general name of an enzyme family with peroxidase activity whose main biological role is to protect the organism from oxidative damage. Glutathione peroxidase functions to reduce lipid hydroperoxides to their corresponding alcohols and to reduce free hydrogen peroxide to water.

Glutathione peroxidase plays a role in the development of celiac disease. Several isozymes glutathione peroxidase are encoded by different genes, which vary in cellular location and substrate specificity. Glutathione peroxidase 1 (GPx1) is the most abundant version, existing in the cytoplasm of nearly all mammalian tissues, whose preferred substrate is hydrogen peroxide. Glutathione peroxidase 4 (GPx4) has a high preference for lipid hydroperoxides; it is expressed in almost all the mammalian cells, though at much lower levels. Glutathione peroxidase 2 is an intestinal and extracellular enzyme, while glutathione peroxidase 3 is extracellular, especially abundant in plasma. So far, eight different isoforms of glutathione peroxidase (GPx1-8) have been identified in humans.

Glutathione Peroxidase Related Products (7):

Cat. No. Product Name Effect Purity
  • HY-100218A
    (1S,3R)-RSL3 Inhibitor 99.87%
    (1S,3R)-RSL3 is a glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 10 μM in cellular assay.
  • HY-111341
    AZD5904 Inhibitor >98.0%
    AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC50 of 140 nM and has similar potency in mouse and rat.
  • HY-105008
    Secoisolariciresinol diglucoside Inhibitor 99.95%
    Secoisolariciresinol diglucoside (SDG; LGM2605) is a non-toxic free radical scavenger and antioxidant, reduces reduces ROS generation. Secoisolariciresinol diglucoside enhances activatation Nrf2 signaling, inhibits myeloperoxidase (MPO).
  • HY-17646
    Verdiperstat Inhibitor 99.84%
    Verdiperstat (AZD3241) is a selective, irreversible and orally active myeloperoxidase inhibitor, with an IC50 of 630 nM, and can be used in the research of neurodegenerative brain disorders.
  • HY-19321
    PF-06282999 Inhibitor 99.05%
    PF-06282999 is a potent and selective myeloperoxidase inhibitor which is potential useful for the treatment of cardiovascular diseases.
  • HY-115486
    MPO-IN-28 Inhibitor
    MPO-IN-28 (Compound 28) is a myeloperoxidase (MPO) inhibitor with an IC50 of 44 nM.
  • HY-111354
    Tinoridine hydrochloride Activator 98.07%
    Tinoridine hydrochloride is a nonsteroidal anti-inflammatory drug and also has potent radical scavenger and antiperoxidative activity.
Isoform Specific Products

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