1. Metabolic Enzyme/Protease
    Apoptosis
  2. Glutathione Peroxidase
    Ferroptosis
  3. ML162

ML162 

Cat. No.: HY-100002 Purity: ≥98.0%
Handling Instructions

ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines

For research use only. We do not sell to patients.

ML162 Chemical Structure

ML162 Chemical Structure

CAS No. : 1035072-16-2

Size Stock
5 mg Check price and availability

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines[1][2]

In Vitro

ML162 (compound 1a) shows nanomolar potencies against two HRASG12V expressing cell lines, with IC50 values of 25 nM and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively[1].
ML162 (8 μM; 24 hours) treatment increases the expression of p62 and Nrf2 in chemoresistant HN3R and HN3-rslR cells, inactivates Keap1, and increases expression of the phospho-PERK-ATF4-SESN2 pathway[2].
ML162 induces the head and neck cancer (HNC) cell death to varying degrees, with parental HN3 cells more sensitive and cisplatin-resistant (HN3R) and acquired RSL3-resistant (HN3-rslR) cells less sensitive[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: HN3R cells
Concentration: 8 μM
Incubation Time: 24 hours
Result: Increased the expression of p62 and Nrf2 in chemoresistant HN3R and HN3-rslR cells.
Molecular Weight

477.40

Formula

C₂₃H₂₂Cl₂N₂O₃S

CAS No.
SMILES

O=C(CCl)N(C(C1=CC=CS1)C(NCCC2=CC=CC=C2)=O)C3=CC=C(OC)C(Cl)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: ≥98.0%

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

ML162ML 162ML-162Glutathione PeroxidaseFerroptosisGPX4HRASanticancerNrf2p62ferroptosisInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
ML162
Cat. No.:
HY-100002
Quantity:
MCE Japan Authorized Agent: