1035072-16-2
1035072-16-2
Chemical Structure
ML162
- CAS No.: 1035072-16-2
- Formula:C23H22Cl2N2O3S
- Molecular Weight:477.40
IUPAC Name: 2-chloro-N-(3-chloro-4-methoxyphenyl)-N-(2-oxo-2-(phenethylamino)-1-(thiophen-2-yl)ethyl)acetamide
InChIKey: UNVKYJSNMVDZJE-UHFFFAOYSA-N
SMILES: O=C(CCl)N(C(C1=CC=CS1)C(NCCC2=CC=CC=C2)=O)C3=CC=C(OC)C(Cl)=C3
Biological Activity: ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines[1][2]
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ML162 | 99.52% | ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines | ||||||||||||||||||||
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ML162 (Standard) | ≥98% | ML162 (Standard) is the analytical standard of ML162 (HY-100002). This product is intended for research and analytical applications. ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines | ||||||||||||||||||||
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References
- [1]. Michel Weïwer, et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6. [Content Brief]
- [2]. Daiha Shin, et al. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Free Radic Biol Med. 2018 Dec;129:454-462. [Content Brief]
Keywords
