GID4 Ligand 1
GID4 Ligand 1 (compound 88) is a cell-permeable and high-selective GID4 binder (IC50=5.4 μM; Kd=5.6 μM), binds to GID4 in cells (EC50=558 nM). GID4 Ligand 1 can be used for the synthesis of PROTACs.
For research use only. We do not sell to patients.
- CAS No.: 3031442-96-0
- Formula: C28H34N4O5S
- Molecular Weight:538.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 5.4 μM (GID4)[1].
GID4 Ligand 1 (50 μM; 1 h) shows the ability to engage endogenous GID4 protein in HEK293 cells with considerable selectivity[1].
GID4 Ligand 1 (50 μM; 10 min) binds GID4 in lysates of HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293 cells (expressing FLAG-GID4)
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Concentration:50 μM
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Incubation Time:1 h
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Result:Exhibited the ability to permeate the cell membrane and engage FLAG-GID4 in living cells.
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Cell Line:HEK293 cells (expressing FLAG-GID4)
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Concentration:50 μM
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Incubation Time:10 min
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Result:Produced a Tm shift of 5.4°C.
Chemical Information
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CAS No. 3031442-96-0
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Molecular Weight 538.66
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Formula C28H34N4O5S
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SMILES
O=C(NC)[C@@H](NC([C@H](NC(CNCC1=CC=C(OC)C=C1OC)=O)C2=CC=CS2)=O)CCC3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GID4 Ligand 1 Related Classifications
HY-151475 Related Classifications
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