Adrenomedullin
Adrenomedullin (ADM) is a 52-amino-acid vasodilatory peptide of the calcitonin gene-related peptide superfamily, originally isolated from human pheochromocytoma tissue. It signals through the calcitonin receptor-like receptor (CALCRL) paired with receptor activity-modifying proteins: the CLR/RAMP2 and CLR/RAMP3 complexes, raising cAMP in vascular smooth muscle and endothelium. Beyond hypotensive actions, adrenomedullin promotes angiogenesis, fluid balance and cytoprotection, and it is upregulated in sepsis, heart failure, hypertension and many tumors, where it supports survival and invasion; plasma ADM levels are being developed as a biomarker for sepsis and heart failure, and ADM pathway inhibitors have been explored in oncology.
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Adrenomedullin Recombinant Proteins (1)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
