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Animal-free means that no animal-derived material is involved in the production process. Animal-free recombinant proteins have the same biological activity as proteins produced using standard laboratory techniques, while researchers do not have to worry at all about traces of animal components or mammalian pathogens affecting their experiments.
BAFF/TNFSF13B protein is a cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA, forming a key ligand-receptor pathway together with TNFSF13/APRIL. These interactions play a crucial role in stimulating B-cell and T-cell function and regulating humoral immunity. Animal-Free BAFF/TNFSF13B Protein, Human (His) is the recombinant human-derived animal-FreeBAFF/TNFSF13B protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free BAFF/TNFSF13B Protein, Human (His) is 152 a.a., with molecular weight of ~17.98 kDa.
Nerve Growth Factor-β (Beta-NGF; NGF) is a neurotrophic factor that regulates neuronal survival and differentiation. NGF is also a seminal plasma protein involved in ovulation and luteinizing. NGF has potential functions in the female reproductive system to help overcome the current problem of early embryo loss. Animal-Free Beta-NGF Protein, Human (His) is produced by E.coli (S122-A241), with C-terminal His-tag.
BMP-9/GDF-2 Protein, a robust angiogenesis inhibitor, selectively signals through ACVRL1 in endothelial cells. Its signaling pathway requires the TGF-beta coreceptor endoglin/ENG for efficient activation of SMAD1. Existing as a homodimer with disulfide-linked structures, the protein forms complexes with ACVRL1, BMPR2, and ACVR2B, crucial for signal transduction. Additionally, it engages in high-affinity interactions with ENG, forming a heterotetramer or a heteromeric complex with ENG and ACVRL1. Notably, it interacts with the type I receptor ACVR1, contributing to the intricate regulatory network in the TGF-beta signaling pathway. Animal-Free BMP-9/GDF-2 Protein, Human (His) is the recombinant human-derived animal-FreeBMP-9/GDF-2 protein, expressed by E. coli, with N-His labeled tag. The total length of Animal-Free BMP-9/GDF-2 Protein, Human (His) is 110 a.a., with molecular weight of ~12.89 kDa.
CD30 ligand/TNFSF8 protein is a cytokine that specifically binds to TNFRSF8/CD30 and acts as a potent inducer of T cell proliferation. As a homotrimer, this ligand plays a crucial role in regulating T cell activation and growth, contributing to the dynamic coordination of immune responses. Animal-Free CD30 Ligand/TNFSF8 Protein, Human (His) is the recombinant human-derived animal-FreeCD30 Ligand/TNFSF8 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free CD30 Ligand/TNFSF8 Protein, Human (His) is 172 a.a., with molecular weight of ~20.57 kDa.
The SDF-1 alpha/CXCL12 protein is a chemoattractant for immune cells. Animal-Free SDF-1 Beta/CXCL12 Protein, Human (His) is the recombinant human-derived animal-FreeSDF-1 Beta/CXCL12 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free SDF-1 Beta/CXCL12 Protein, Human (His) is 65 a.a., with molecular weight of ~8.55 kDa.
EGF protein does not possess the conserved residue(s) necessary for propagating feature annotation. Animal-Free EGF Protein, Human (His) is the recombinant human-derived animal-FreeEGF protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free EGF Protein, Human (His) is 53 a.a., with molecular weight of ~7.16 kDa.
G-CSF, a pivotal cytokine, regulates hematopoiesis by controlling the production, differentiation, and function of granulocytes and monocytes-macrophages. This monomeric protein specifically promotes granulocyte development, playing a crucial role in immune system regulation and blood cell formation. Animal-Free G-CSF Protein, Human (His) is the recombinant human-derived animal-FreeG-CSF protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free G-CSF Protein, Human (His) is 174 a.a., with molecular weight of ~19.48 kDa.
Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. Animal-Free GDNF Protein, Human (His), a recombinant animal-free protein, is produced in E.coil with a C-Terminal His-tag. It consists of 134 amino acids (S78-I211).
The GM-CSF protein functions as a key cytokine that promotes the growth and differentiation of hematopoietic precursor cells of different lineages, such as granulocytes, macrophages, eosinophils, and erythrocytes. In its monomeric form, GM-CSF acts as a signaling molecule, orchestrating complex receptor assemblies. Animal-Free GM-CSF Protein, Human (His) is the recombinant human-derived animal-FreeGM-CSF protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free GM-CSF Protein, Human (His) is 127 a.a., with molecular weight of ~15.4 kDa.
Leukocyte Interferon; IFNA1; B cell Interferon; Type I Interferon; Interferon alpha-1/13; IFN-alpha-1/13; LeIF D; IFNA1a; IFNA13
Human
E. coli
IFN-alpha 1a/IFNA1 Protein, produced by macrophages, demonstrates robust antiviral activities. It stimulates essential enzymes—a protein kinase and an oligoadenylate synthetase—contributing to the intricate molecular response that fortifies the host's immune defenses against viral threats. Animal-Free IFN-alpha 1a/IFNA1 Protein, Human (His) is the recombinant human-derived animal-FreeIFN-alpha 1a/IFNA1 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free IFN-alpha 1a/IFNA1 Protein, Human (His) is 166 a.a., with molecular weight of ~20.19 kDa.
PDGF R beta protein is a receptor protein that binds to platelet-derived growth factor (PDGF). It is expressed in a variety of cells, including fibroblasts and smooth muscle cells. Animal-Free IFN-beta Protein, Human (His) is the recombinant human-derived animal-FreeIFN-beta protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IFN-beta Protein, Human (His) is 166 a.a., with molecular weight of ~20.84 kDa.
IFN-gamma Protein is a dimeric soluble cytokine. It exerts antibacterial, antiviral and antitumor effects through JAK-STAT, mTOR, MAPK and PI3K/AKT signaling pathways. Animal-Free IFN-gamma Protein, Human (His) is the recombinant human-derived animal-FreeIFN-gamma protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IFN-gamma Protein, Human (His) is 143 a.a., with molecular weight of ~17.7 kDa.
IFN-omega protein is a member of the alpha/beta interferon family. Animal-Free IFN-omega Protein, Human (His) is the recombinant human-derived animal-FreeIFN-omega protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free IFN-omega Protein, Human (His) is 172 a.a., with molecular weight of ~20.93 kDa.
The IGF2 protein is an important member of the insulin-like growth factor family and plays an important role in mammalian growth, fetoplacental development, and adult glucose metabolism. Regulated by placental prolactin, affecting tissue differentiation. Animal-Free IGF2 Protein, Human (His) is the recombinant human-derived animal-FreeIGF2 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free IGF2 Protein, Human (His) is 67 a.a., with molecular weight of ~8.28 kDa.
IL-1 alpha protein is located in cells and is a key cytokine connecting innate immunity and adaptive immunity. After binding to IL1R1 through IL1RAP, it forms a high-affinity receptor complex, initiates a signaling cascade with adapter molecules such as MYD88, IRAK1 or IRAK4, and activates the NF-kappa-B and MAPK pathways. Animal-Free IL-1 alpha Protein, Human (His) is the recombinant human-derived animal-FreeIL-1 alpha protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-1 alpha Protein, Human (His) is 159 a.a., with molecular weight of ~18.99 kDa.
IL-1 beta protein is a potent proinflammatory cytokine that plays multiple roles in immune responses. It induces inflammatory events including prostaglandin synthesis, neutrophil activation, and cytokine production. Animal-Free IL-1 beta Protein, Human (His) is the recombinant human-derived animal-FreeIL-1 beta protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-1 beta Protein, Human (His) is 153 a.a., with molecular weight of ~18.48 kDa.
IL-10 protein is a major immunoregulatory cytokine with profound anti-inflammatory functions that limits excessive tissue destruction caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptors IL10RA and IL10RB, leading to JAK1- and STAT2-mediated phosphorylation of STAT3, which translocates to the nucleus and drives the expression of anti-inflammatory mediators. Animal-Free IL-10 Protein, Human (His) is the recombinant human-derived animal-FreeIL-10 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-10 Protein, Human (His) is 160 a.a., with molecular weight of ~19.6 kDa.
IL-35 Protein plays a pivotal role in immune regulation, forming the IL-12 cytokine with IL12B or the IL-35 cytokine with EBI3/IL27B. IL-12 regulates T-cell and natural killer-cell responses, inducing interferon-gamma production. IL-35 contributes significantly to maintaining immune homeostasis in the liver, acting as an immune-suppressive cytokine. Mechanistically, IL-12 exerts effects through the IL12R1 and IL12R2 receptor subunits, phosphorylating cellular substrates and regulating cytokine-responsive genes via phosphorylated STAT4. In the IL-35 context, unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers mediate signaling, requiring transcription factors STAT1 and STAT4. IL-35 interacts with NBR1, promoting IL-12 secretion, and the IL-35 heterodimer with EBI3/IL27B is non-disulfide-linked, distinguishing it from IL-12. Animal-Free IL-12 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived animal-FreeIL-12 protein, expressed by HEK293, with C-His labeled tag. Animal-Free IL-12 Protein, Human (HEK293, His), has molecular weight of ~59.55 kDa.
The IL-17A protein is an important effector cytokine that is critical in both innate and adaptive immunity to defend against microorganisms and maintain tissue integrity. It acts through the IL17RA-IL17RC heterodimeric receptor complex, triggering signaling pathways, activating immune-related gene transcription and promoting strong immune inflammation. Animal-Free IL-17A Protein, Human (His) is the recombinant human-derived animal-FreeIL-17A protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-17A Protein, Human (His) is 136 a.a., with molecular weight of ~16.47 kDa.
IL-17F protein is a key effector cytokine in innate and adaptive immunity that maintains tissue integrity and protects against microorganisms. It acts through the IL17RA-IL17RC receptor complex, activates the NF-kappa-B and MAPkinase pathways, and induces the transcription of immune-related genes. Animal-Free IL-17F Protein, Human (His) is the recombinant human-derived animal-FreeIL-17F protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-17F Protein, Human (His) is 133 a.a., with molecular weight of ~15.84 kDa.