1. Signaling Pathways
  2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)

NOD-like Receptor (NLR)

Nucleotide oligomerization domain (NOD)-like receptors (NLRs) are a specialized group of intracellular proteins that play a critical role in the regulation of the host innate immune response. NLRs act as scaffolding proteins that assemble signaling platforms that trigger nuclear factor-κB and mitogen-activated protein kinase signaling pathways and control the activation of inflammatory caspases. Importantly, mutations in several members of the NLR family have been linked to a variety of inflammatory diseases consistent with these molecules playing an important role in host-pathogen interactions and the inflammatory response. NLRs including Nod1 and Nod2 are thought to be kept in an inactive state by intra-molecular interactions.

The central role of the Nod-like receptor (NLR) protein family became increasingly appreciated in innate immune responses. NLRs are classified as part of the signal transduction ATPases with numerous domains (STAND) clade within the AAA+ ATPase family.

NOD-like Receptor (NLR) Related Products (11):

Cat. No. Product Name Effect Purity
  • HY-12815A
    MCC950 sodium Inhibitor 99.43%
    MCC950 sodium is a potent, selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively.
  • HY-12815
    MCC950 Inhibitor >98.0%
    MCC950 is a potent and selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively.
  • HY-103666
    CY-09 Inhibitor >98.0%
    CY-09 is an NLRP3 inhibitor.
  • HY-100691
    NOD-IN-1 Inhibitor 98.99%
    NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC50 of 5.74 μM and 6.45 μM, respectively.
  • HY-101868
    INF39 Inhibitor 99.61%
    INF39 is an irreversible and noncytotoxic NLRP3 inhibitor.
  • HY-17629
    Dapansutrile Inhibitor >98.0%
    Dapansutrile (OLT1177) is a potent, selective and orally active inhibitor of NLRP3 inflammasome. Anti-inflammatory, analgesic activity.
  • HY-111815
    N4-Acetylcytidine triphosphate Activator
    N4-Acetylcytidine triphosphate is a endogenous nucleoside metabolite from the degradation of tRNA, primes and activates NLRP3 inflammation by inducing HMGB1 expression.
  • HY-N0496
    Ruscogenin Inhibitor
    Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway and exerts significant anti-inflammatory and anti-thrombotic activities.
  • HY-N0139
    Troxerutin Inhibitor 98.05%
    Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation.
  • HY-18639
    Nodinitib-1 Inhibitor >98.0%
    Nodinitib-1 (ML130;CID-1088438) is a NOD1 inhibitor with an IC50 of 0.56 μM.
  • HY-16059
    Arglabin Inhibitor 99.17%
    Arglabin is a sesquiterpene gamma-lactone is isolated from Artemisia glabella; anticancer natural compound.
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