Cat. No.: HY-16569

Colchicine

62 Cited Publications

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Based on 62 publication(s) in Google Scholar

Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research.

For research use only. We do not sell to patients.

Purity: 99.86%
CAS No.: 64-86-8
Formula: C₂₂H₂₅NO₆
Molecular Weight:399.44

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Colchicine Chemical Structure

CAS No.: 64-86-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Induced Disease Models
- Clinical Trial
Chemical Information
Publications (62)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
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Bioz

Biological Activity

Description

IC₅₀ & Target

Microtubule/Tubulin^[1]

All NOD-like Receptor (NLR) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
1A9	IC₅₀	>2500 nM Compound: colchicine	Inhibitory activity against Taxol resistant 1A9 cell lines Inhibitory activity against Taxol resistant 1A9 cell lines	[PMID: 10571149]
1A9	IC₅₀	11.9 nM Compound: Colchicine	Cytotoxicity against ovarian cancer cell line (1A-9) of humans was determined Cytotoxicity against ovarian cancer cell line (1A-9) of humans was determined	[PMID: 12270161]
1A9/ptx-10	IC₅₀	>2500 nM Compound: colchicine	Inhibitory activity against Taxol resistant PTX10 cell lines Inhibitory activity against Taxol resistant PTX10 cell lines	[PMID: 10571149]
1A9/ptx-22	IC₅₀	>2500 nM Compound: colchicine	Inhibitory activity against Taxol resistant PTX22 cell lines Inhibitory activity against Taxol resistant PTX22 cell lines	[PMID: 10571149]
5637	EC₅₀	0.053 μM Compound: Colchicine	Antiproliferative activity against human 5637 cells after 96 hrs by MTT assay Antiproliferative activity against human 5637 cells after 96 hrs by MTT assay	[PMID: 29055869]
786-0	IC₅₀	0.022 μM Compound: Colchicine	Cytotoxicity against human 786-O cells after 72 hrs by MTT assay Cytotoxicity against human 786-O cells after 72 hrs by MTT assay	[PMID: 30106297]
786-0	IC₅₀	26.8 nM Compound: Colchicine	Antiproliferative activity against human 786-O cells incubated for 72 hrs by MTT assay Antiproliferative activity against human 786-O cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
A10	EC₅₀	0.03 μM Compound: 1	Inhibition of microtubule depolymerization in rat A10 cells after 18 hrs by immunofluorescence assay Inhibition of microtubule depolymerization in rat A10 cells after 18 hrs by immunofluorescence assay	[PMID: 23457660]
A10	EC₅₀	0.03 μM Compound: 1	Induction of interphase microtubule depolymerization in rat A10 cells after 18 to 24 hrs by DAPI staining-based indirect immunofluorescence assay Induction of interphase microtubule depolymerization in rat A10 cells after 18 to 24 hrs by DAPI staining-based indirect immunofluorescence assay	[PMID: 23961916]
A2780	IC₅₀	6.7 μM Compound: Colchicine	Cytotoxicity against human A2780 cells assessed as growth inhibition Cytotoxicity against human A2780 cells assessed as growth inhibition	[PMID: 23103097]
A2780	IC₅₀	>20 μM Compound: Colchicine	Cytotoxicity against taxol-resistant human A2780 cells by MTT assay Cytotoxicity against taxol-resistant human A2780 cells by MTT assay	[PMID: 23425970]
A2780	IC₅₀	0.02 μM Compound: Colchicine	Cytotoxicity against human A2780S cells by MTT assay Cytotoxicity against human A2780S cells by MTT assay	[PMID: 23425970]
A2780	IC₅₀	0.057 μM Compound: COL	Antiproliferative activity against human A2780 cells after 48 hrs by SRB method Antiproliferative activity against human A2780 cells after 48 hrs by SRB method	[PMID: 25061803]
A2780	IC₅₀	0.59 μM Compound: COL	Antiproliferative activity against taxol-resistant human A2780 cells after 48 hrs by SRB method Antiproliferative activity against taxol-resistant human A2780 cells after 48 hrs by SRB method	[PMID: 25061803]
A2780	IC₅₀	4 nM Compound: colchicine	Antiproliferative activity against human A2780S cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Antiproliferative activity against human A2780S cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 25208345]
A2780	IC₅₀	0.015 μM Compound: colchicine	Cytotoxicity against human A2780 cells after 24 hrs by MTT assay Cytotoxicity against human A2780 cells after 24 hrs by MTT assay	[PMID: 25426924]
A2780	IC₅₀	13.1 nM Compound: 4; COL	Cytotoxicity against human A2780 cells after 48 hrs by MTT assay Cytotoxicity against human A2780 cells after 48 hrs by MTT assay	[PMID: 30448418]
A2780	EC₅₀	8.7 nM Compound: Colchicine	Antiproliferative activity against D4-9-31 resistance human A2780 cells incubated for 72 hrs by ATPlite reagent based assay Antiproliferative activity against D4-9-31 resistance human A2780 cells incubated for 72 hrs by ATPlite reagent based assay	[PMID: 31047749]
A2780	EC₅₀	9.2 nM Compound: Colchicine	Antiproliferative activity against human A2780 cells incubated for 72 hrs by ATPlite reagent based assay Antiproliferative activity against human A2780 cells incubated for 72 hrs by ATPlite reagent based assay	[PMID: 31047749]
A2780	IC₅₀	0.008 μM Compound: Colchicine	Antiproliferative activity against human A2780 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31185410]
A2780	IC₅₀	14 nM Compound: Colchicine	Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33618157]
A2780	IC₅₀	0.02 μM Compound: Colchicine	Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36621138]
A2780	IC₅₀	0.023 μM Compound: Colchicine	Cytotoxicity against human A2780 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human A2780 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay	[PMID: 37567059]
A2780	IC₅₀	0.043 μM Compound: 2	Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth incubated for 1.5 hrs by CCK-8 assay Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth incubated for 1.5 hrs by CCK-8 assay	[PMID: 38107178]
A2780	IC₅₀	15 nM Compound: Colchicine	Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth	[PMID: 38294341]
A2780	IC₅₀	12.42 nM Compound: Colchicine	Antiproliferative activity against human A2780 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human A2780 cells incubated for 48 hrs by CCK8 assay	[PMID: 38972078]
A2780	IC₅₀	0.013 μM Compound: Colchicine	Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
A2780 ADR	IC₅₀	16.8 μM Compound: Colchicine	Cytotoxicity against multidrug-resistant human A2780AD cells overexpressing p-gp assessed as growth inhibition Cytotoxicity against multidrug-resistant human A2780AD cells overexpressing p-gp assessed as growth inhibition	[PMID: 23103097]
A2780 ADR	IC₅₀	16.8 nM Compound: colchicine	Cytotoxicity against human A2780AD cells expressing p-gp after 96 hrs by MTT assay Cytotoxicity against human A2780AD cells expressing p-gp after 96 hrs by MTT assay	[PMID: 23176628]
A2780 ADR	IC₅₀	0.306 μM Compound: colchicine	Cytotoxicity against human A2780AD cells after 24 hrs by MTT assay Cytotoxicity against human A2780AD cells after 24 hrs by MTT assay	[PMID: 25426924]
A2780/Taxol	IC₅₀	8671 nM Compound: 1	Cytotoxicity against beta-tubulin 3 overexpressing human A2780T cells assessed as reduction in cell growth after 24 hrs by MTT assay Cytotoxicity against beta-tubulin 3 overexpressing human A2780T cells assessed as reduction in cell growth after 24 hrs by MTT assay	[PMID: 27213819]
A2780/Taxol	IC₅₀	783.8 nM Compound: Colchicine	Antiproliferative activity against human A2780T cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human A2780T cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 33788562]
A2780/Taxol	IC₅₀	0.253 μM Compound: Colchicine	Antiproliferative activity against paclitaxel resistant human A2780/Taxol cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against paclitaxel resistant human A2780/Taxol cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36621138]
A2780/Taxol	IC₅₀	670.1 nM Compound: Colchicine	Antiproliferative activity against paclitaxel resistant human A2780/Taxol cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against paclitaxel resistant human A2780/Taxol cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 37145846]
A2780S	IC₅₀	30.8 nM Compound: 1	Antiproliferative activity against human A2780S cells after 24 hrs by MTT assay Antiproliferative activity against human A2780S cells after 24 hrs by MTT assay	[PMID: 27213819]
A2780S	IC₅₀	12.3 nM Compound: Colchicine	Antiproliferative activity against human A2780S cells after 48 hrs by MTT assay Antiproliferative activity against human A2780S cells after 48 hrs by MTT assay	[PMID: 28763646]
A2780S	IC₅₀	21.86 nM Compound: Colchicine	Antiproliferative activity against human A2780S cells after 48 to 72 hrs by MTT assay Antiproliferative activity against human A2780S cells after 48 to 72 hrs by MTT assay	[PMID: 29754076]
A2780S	IC₅₀	16.7 nM Compound: Colchicine	Antiproliferative activity against human A2780S cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human A2780S cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 33788562]
A2780S	IC₅₀	34.1 nM Compound: Colchicine	Antiproliferative activity against human A2780S cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A2780S cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
A2780S	IC₅₀	31 nM Compound: Colchicine	Antiproliferative activity against human A2780S cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Antiproliferative activity against human A2780S cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35084853]
A2780S	IC₅₀	23.2 nM Compound: Colchicine	Antiproliferative activity against parental human A2780S cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against parental human A2780S cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 37145846]
A-375	IC₅₀	0.02 μM Compound: colchicine	Cytotoxicity against human A375 cells after 48 hrs by SRB assay Cytotoxicity against human A375 cells after 48 hrs by SRB assay	[PMID: 19243174]
A-375	IC₅₀	20 nM Compound: Colchicine	Cytotoxicity against human A375 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human A375 cells after 48 hrs by sulforhodamine B assay	[PMID: 20919720]
A-375	IC₅₀	0.02 μM Compound: Colchicine	Antiproliferative activity against human A375 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human A375 cells after 48 hrs by sulforhodamine B assay	[PMID: 21775150]
A-375	IC₅₀	0.02 μM Compound: Colchicine	Antiproliferative activity against human A375 cells after 48 hrs by SRB assay Antiproliferative activity against human A375 cells after 48 hrs by SRB assay	[PMID: 22608389]
A-375	IC₅₀	20.6 nM Compound: Colchicine	Antiproliferative activity against human A375 cells after 48 hrs by SRB assay Antiproliferative activity against human A375 cells after 48 hrs by SRB assay	[PMID: 22783954]
A-375	IC₅₀	12 nM Compound: colchicine	Antiproliferative activity against human A375 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Antiproliferative activity against human A375 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 25208345]
A-375	IC₅₀	0.01 μM Compound: Colchicine	Antiproliferative activity against human A375 cells assessed as cell growth inhibition after 96 hrs by MTT assay Antiproliferative activity against human A375 cells assessed as cell growth inhibition after 96 hrs by MTT assay	[PMID: 27094151]
A-375	IC₅₀	6.4 nM Compound: Colchicine	Cytotoxicity against human A375 cells after 72 hrs by MTS assay Cytotoxicity against human A375 cells after 72 hrs by MTS assay	[PMID: 29406710]
A-375	IC₅₀	9.7 nM Compound: Colchicine	Antiproliferative activity against human A375 cells after 72 hrs by MTS assay Antiproliferative activity against human A375 cells after 72 hrs by MTS assay	[PMID: 30099258]
A-375	IC₅₀	14.1 nM Compound: Colchicine	Antiproliferative activity against human A375 cells after 72 hrs by MTT assay Antiproliferative activity against human A375 cells after 72 hrs by MTT assay	[PMID: 31251599]
A-375	IC₅₀	16.8 nM Compound: Colchicine	Cytotoxicity against human A-375 cells measured after 72 hrs by western blot Cytotoxicity against human A-375 cells measured after 72 hrs by western blot	[PMID: 34378386]
A-375	IC₅₀	10.9 nM Compound: Colchicine	Antiproliferative activity against human A-375 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay Antiproliferative activity against human A-375 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay	[PMID: 34406768]
A375/TxR	IC₅₀	29.6 nM Compound: Colchicine	Cytotoxicity against paclitaxel resistant human A-375/TxR cells measured after 72 hrs by western blot Cytotoxicity against paclitaxel resistant human A-375/TxR cells measured after 72 hrs by western blot	[PMID: 34378386]
A375/TxR	IC₅₀	23.6 nM Compound: Colchicine	Antiproliferative activity against human A375/TxR cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay Antiproliferative activity against human A375/TxR cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay	[PMID: 34406768]
A-427	EC₅₀	0.045 μM Compound: Colchicine	Antiproliferative activity against human A427 cells after 96 hrs by MTT assay Antiproliferative activity against human A427 cells after 96 hrs by MTT assay	[PMID: 29055869]
A-431	EC₅₀	0.0028 μM Compound: Colchicine	Cell cycle arrest in A431 cells by accumulation at G2/M phase cell Cell cycle arrest in A431 cells by accumulation at G2/M phase cell	[PMID: 16198562]
A-431	IC₅₀	53.2 nM Compound: Colchicine	Antiproliferative activity against human A431 cells after 72 hrs by sulforhodamine B assay Antiproliferative activity against human A431 cells after 72 hrs by sulforhodamine B assay	[PMID: 21480626]
A-431	IC₅₀	0.019 μM Compound: Colchicine	Cytotoxicity against human A431 cells after 72 hrs by MTT assay Cytotoxicity against human A431 cells after 72 hrs by MTT assay	[PMID: 23602523]
A-431	IC₅₀	0.008 μM Compound: Colchicine	Cytotoxicity against human A431 cells assessed as growth inhibition after 72 hrs by CCK-8 assay Cytotoxicity against human A431 cells assessed as growth inhibition after 72 hrs by CCK-8 assay	[PMID: 25091926]
A-431	IC₅₀	14 nM Compound: colchicine	Inhibition of A431 cell proliferation Inhibition of A431 cell proliferation	[PMID: 7990108]
A-431	ED₅₀	0.002 μg/mL Compound: colchicine	Cytotoxicity against human A431 cells Cytotoxicity against human A431 cells	[PMID: 8133298]
A549	IC₅₀	0.045 μM Compound: 1, colchicine	Antiproliferative activity against human A549 cells after 72 hrs Antiproliferative activity against human A549 cells after 72 hrs	[PMID: 18503262]
A549	IC₅₀	10.78 ng/mL Compound: colchicine	Cytotoxicity against human A549 cells after 24 hrs by propidium iodide assay Cytotoxicity against human A549 cells after 24 hrs by propidium iodide assay	[PMID: 19138858]
A549	IC₅₀	10.78 ng/mL Compound: colchicine	Cytotoxicity against human A549 cells after 24 hrs by YO-PRO-1 assay Cytotoxicity against human A549 cells after 24 hrs by YO-PRO-1 assay	[PMID: 19138858]
A549	ED₅₀	0.0199 μg/mL Compound: 1	Cytotoxicity against human A549 cells after 2 days Cytotoxicity against human A549 cells after 2 days	[PMID: 20542428]
A549	IC₅₀	<1 μM Compound: Colchicine	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 20833451]
A549	IC₅₀	0.12 μg/mL Compound: Colchicine	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 21440448]
A549	IC₅₀	37 nM Compound: Colchicine	Antiproliferative activity against human A549 cells after 72 hrs by sulforhodamine B assay Antiproliferative activity against human A549 cells after 72 hrs by sulforhodamine B assay	[PMID: 21480626]
A549	EC₅₀	27 nM Compound: Colchicine	Cytotoxicity against human A549 cells after 24 hrs by MTT assay Cytotoxicity against human A549 cells after 24 hrs by MTT assay	[PMID: 21873068]
A549	IC₅₀	0.75 μg/mL Compound: Colchicine	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 22261027]
A549	IC₅₀	0.74 μg/mL Compound: Colchicine	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 22503741]
A549	IC₅₀	0.75 μM Compound: Colchicine	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 22512906]
A549	IC₅₀	0.2 μg/mL Compound: Colchicine	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 22578453]
A549	IC₅₀	50.6 nM Compound: 1	Cytotoxicity against human A549 cells after 48 hrs by WST-8 assay Cytotoxicity against human A549 cells after 48 hrs by WST-8 assay	[PMID: 22727370]
A549	IC₅₀	20 nM Compound: 1	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 23214452]
A549	IC₅₀	20 nM Compound: 3	Cytotoxicity against human A549 cells after 72 hrs by CCK-8 assay Cytotoxicity against human A549 cells after 72 hrs by CCK-8 assay	[PMID: 23360369]
A549	IC₅₀	0.07 μM Compound: Colchicine	Cytotoxicity against human A549 cells assessed as growth inhibition Cytotoxicity against human A549 cells assessed as growth inhibition	[PMID: 23419737]
A549	IC₅₀	0.023 μM Compound: Colchicine	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 23602523]
A549	IC₅₀	0.054 μM Compound: 1	Cytotoxicity against human A549 cells after 96 hrs using tetracolor one Cytotoxicity against human A549 cells after 96 hrs using tetracolor one	[PMID: 24900316]
A549	IC₅₀	0.58 μg/mL Compound: 1	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 24916028]
A549	IC₅₀	0.05 μM Compound: COL	Antiproliferative activity against human A549 cells after 48 hrs by SRB method Antiproliferative activity against human A549 cells after 48 hrs by SRB method	[PMID: 25061803]
A549	IC₅₀	0.081 μM Compound: COL	Antiproliferative activity against cis-platinum-resistant human A549 cells after 48 hrs by SRB method Antiproliferative activity against cis-platinum-resistant human A549 cells after 48 hrs by SRB method	[PMID: 25061803]
A549	IC₅₀	0.12 μM Compound: Colchicine	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 25499929]
A549	IC₅₀	0.58 μM Compound: Colchicine	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 25703297]
A549	IC₅₀	0.105 μM Compound: Colchicine	Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 25805446]
A549	GI₅₀	0.03 μM Compound: Colchicine	Antiproliferative activity against human A549 cells after 48 hrs by SRB assay Antiproliferative activity against human A549 cells after 48 hrs by SRB assay	[PMID: 25827522]
A549	GI₅₀	4.4 μM Compound: Colchicine	Growth inhibition of human A549 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay Growth inhibition of human A549 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay	[PMID: 26070164]
A549	IC₅₀	23.9 nM Compound: 1	Cytotoxicity against human A549 cells after 48 hrs by Celltiter-Glo luminescent cell viability assay Cytotoxicity against human A549 cells after 48 hrs by Celltiter-Glo luminescent cell viability assay	[PMID: 26985296]
A549	IC₅₀	59.06 μM Compound: 1	Growth inhibition of human A549 cells incubated for 48 hrs by MTT assay Growth inhibition of human A549 cells incubated for 48 hrs by MTT assay	[PMID: 27172319]
A549	IC₅₀	400 nM Compound: 1	Cytotoxicity against 2D culture of human A549 cells measured after 72 hrs by MTT assay Cytotoxicity against 2D culture of human A549 cells measured after 72 hrs by MTT assay	[PMID: 27912174]
A549	IC₅₀	14 nM Compound: Colchicine	Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 27915168]
A549	IC₅₀	32.7 nM Compound: Colchicine	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 28763646]
A549	IC₅₀	0.02 μM Compound: Colchicine	Antiproliferative activity against human A549 cells by SRB assay Antiproliferative activity against human A549 cells by SRB assay	[PMID: 28988750]
A549	IC₅₀	4.64 μM Compound: Colchicine	Antiproliferative activity against human A549 cells after 24 hrs by MTT assay Antiproliferative activity against human A549 cells after 24 hrs by MTT assay	[PMID: 29268130]
A549	IC₅₀	12.2 nM Compound: Colchicine	Antiproliferative activity against human A549 cells after 2 days by MTT assay Antiproliferative activity against human A549 cells after 2 days by MTT assay	[PMID: 29550732]
A549	IC₅₀	32.76 nM Compound: Colchicine	Antiproliferative activity against human A549 cells after 48 to 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 to 72 hrs by MTT assay	[PMID: 29754076]
A549	IC₅₀	0.023 μM Compound: Colchicine	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 30093295]
A549	IC₅₀	62.7 nM Compound: Colchicine	Antiproliferative activity against human A549 cells after 72 hrs by MTS assay Antiproliferative activity against human A549 cells after 72 hrs by MTS assay	[PMID: 30099258]
A549	IC₅₀	0.043 μM Compound: Colchicine	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 30106297]
A549	IC₅₀	0.137 μM Compound: 1	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 30245397]
A549	IC₅₀	0.22 μM Compound: Colchicine	Antiproliferative activity against human A549 cells after 24 hrs by MTT assay Antiproliferative activity against human A549 cells after 24 hrs by MTT assay	[PMID: 30606674]
A549	IC₅₀	9.7 μM Compound: Colchicine	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30878833]
A549	IC₅₀	0.013 μM Compound: Colchicine	Antiproliferative activity against human A549 cells harboring control siRNA after 48 hrs by MTT assay Antiproliferative activity against human A549 cells harboring control siRNA after 48 hrs by MTT assay	[PMID: 31185410]
A549	IC₅₀	0.015 μM Compound: Colchicine	Antiproliferative activity against human A549 cells harboring katanin siRNA after 48 hrs by MTT assay Antiproliferative activity against human A549 cells harboring katanin siRNA after 48 hrs by MTT assay	[PMID: 31185410]
A549	IC₅₀	0.017 μM Compound: Colchicine	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31185410]
A549	IC₅₀	125.2 nM Compound: 1	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay	[PMID: 31653441]
A549	IC₅₀	21 nM Compound: 1; (-)-Colchicine	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay	[PMID: 31655432]
A549	IC₅₀	1.17 μM Compound: Colchicine	Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay	[PMID: 32035399]
A549	IC₅₀	0.042 μM Compound: 1	Cytotoxicity against human A549 cells incubated for 48 hrs by MTT assay Cytotoxicity against human A549 cells incubated for 48 hrs by MTT assay	[PMID: 32432867]
A549	IC₅₀	0.054 μM Compound: 1	Antiproliferative activity against human A549 cells incubated for 72 hrs by sulforhodamine B assay Antiproliferative activity against human A549 cells incubated for 72 hrs by sulforhodamine B assay	[PMID: 32432867]
A549	IC₅₀	0.107 μM Compound: Colchicine	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay	[PMID: 32650183]
A549	IC₅₀	37 nM Compound: Colchicine	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 33234343]
A549	IC₅₀	125 nM Compound: 1	Antiproliferative activity against human A549 cells incubated for 72 hrs by SRB assay Antiproliferative activity against human A549 cells incubated for 72 hrs by SRB assay	[PMID: 33465696]
A549	IC₅₀	45.2 nM Compound: 1	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay	[PMID: 33611191]
A549	IC₅₀	0.053 μM Compound: Colchicine	Cytotoxicity against human A549 cells assessed as reduction in cell growth by CCK8 assay Cytotoxicity against human A549 cells assessed as reduction in cell growth by CCK8 assay	[PMID: 33753264]
A549	IC₅₀	0.108 μM Compound: Colchicine	Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 33788562]
A549	IC₅₀	0.19 μM Compound: Colchicine	Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay	[PMID: 33965530]
A549	IC₅₀	0.19 μM Compound: Colchicine	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay	[PMID: 34022412]
A549	IC₅₀	76 nM Compound: 1	Antiproliferative activity against human A549 cells assessed as inhibition of proliferation after 72 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as inhibition of proliferation after 72 hrs by SRB assay	[PMID: 34116158]
A549	IC₅₀	0.111 μM Compound: Colchicine	Antiproliferative activity against human A549 assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human A549 assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34175541]
A549	IC₅₀	0.024 μM Compound: Col	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 34311158]
A549	IC₅₀	77.6 nM Compound: Colchicine	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay	[PMID: 34406768]
A549	IC₅₀	0.016 μM Compound: Colchicine	Cytotoxicity against human A549 cells assessed as reduction in cell viability Cytotoxicity against human A549 cells assessed as reduction in cell viability	[PMID: 34416378]
A549	IC₅₀	0.095 μM Compound: Colchicine	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 34571171]
A549	IC₅₀	19.3 nM Compound: COLCH	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay	[PMID: 34592435]
A549	IC₅₀	0.47 μM Compound: Colchicine	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay	[PMID: 35367708]
A549	IC₅₀	0.031 μM Compound: Colchicine	Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35447432]
A549	IC₅₀	5.13 μM Compound: COL	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 35694693]
A549	IC₅₀	0.184 μM Compound: Colchicine	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36455508]
A549	IC₅₀	0.03 μM Compound: Colchicine	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 36511661]
A549	IC₅₀	107.6 nM Compound: Colchicine	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 36621138]
A549	IC₅₀	43 nM Compound: Colchicine	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth by MTT assay	[PMID: 36893627]
A549	IC₅₀	0.89 μM Compound: Col	Cytotoxicity against human A549 cells assessed as inhibition of cell growth measured for 24 hrs by MTT assay Cytotoxicity against human A549 cells assessed as inhibition of cell growth measured for 24 hrs by MTT assay	[PMID: 36970147]
A549	IC₅₀	1.09 μM Compound: Colchicine	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37122544]
A549	IC₅₀	0.064 μM Compound: 1	Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
A549	IC₅₀	0.017 μM Compound: Colchicine	Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for72 hrs by MTT assay	[PMID: 37890199]
A549	IC₅₀	9.7 μM Compound: Colchicine	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38107170]
A549	IC₅₀	49 nM Compound: Colchicine	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth Antiproliferative activity against human A549 cells assessed as inhibition of cell growth	[PMID: 38294341]
A549	IC₅₀	0.04 μM Compound: Colchicine	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth after 72 hrs by MTT assay	[PMID: 38336655]
A549	IC₅₀	0.078 μM Compound: Colchicine	Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay	[PMID: 38471357]
A549	IC₅₀	0.04 μM Compound: Colchicine	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 38703557]
A549	IC₅₀	0.042 μg/mL Compound: Colchicine	Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 38716896]
A549	IC₅₀	45.9 nM Compound: Colchicine	Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay	[PMID: 38972078]
A549	IC₅₀	0.029 μM Compound: Colchicine	Antiproliferative activity against human A549 assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human A549 assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
A549	ED₅₀	18 nM Compound: 1	Cytotoxicity against human solid tumor lung carcinoma A549 cell line Cytotoxicity against human solid tumor lung carcinoma A549 cell line	[PMID: 8496935]
A549	ED₅₀	0.002 μg/mL Compound: colchicine	Cytotoxicity against human lung carcinoma cells (A-549) using SRB assay. Cytotoxicity against human lung carcinoma cells (A-549) using SRB assay.	[PMID: 9544215]
A549	EC₅₀	0.022 μg/mL Compound: 1	In vitro growth inhibition of A549, lung carcinoma. In vitro growth inhibition of A549, lung carcinoma.	[PMID: 9599244]
A549	IC₅₀	54.4 nM Compound: 1	Cytotoxicity against human A549 cells after 96 hrs by microplate reader analysis Cytotoxicity against human A549 cells after 96 hrs by microplate reader analysis	10.1039/C2MD20250F
A549	IC₅₀	54.4 nM Compound: 1	Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 96 hrs Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 96 hrs	10.1039/C3MD00287J
A549	IC₅₀	0.47 μM Compound: Colchicine	Antiproliferative activity against human A549 cells measured after 24 hrs by MTT assay Antiproliferative activity against human A549 cells measured after 24 hrs by MTT assay	10.1039/C6MD00255B
A549/TR	IC₅₀	167.34 nM Compound: Colchicine	Antiproliferative activity against human A549/TR cells after 48 to 72 hrs by MTT assay Antiproliferative activity against human A549/TR cells after 48 to 72 hrs by MTT assay	[PMID: 29754076]
A549/TR	IC₅₀	202.9 nM Compound: Colchicine	Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay	[PMID: 34406768]
ACHN	IC₅₀	39.8 nM Compound: colchicine	Antiproliferative activity against drug resistant ACHN cell line expressing MDR1 by Alamar Blue assay Antiproliferative activity against drug resistant ACHN cell line expressing MDR1 by Alamar Blue assay	[PMID: 17286393]
AGS	IC₅₀	0.05 μM Compound: Colchicine	Cytotoxicity against human AGS cells assessed as growth inhibition Cytotoxicity against human AGS cells assessed as growth inhibition	[PMID: 23419737]
AGS	IC₅₀	9 nM Compound: colchicine	Antiproliferative activity against human AGS cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Antiproliferative activity against human AGS cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 25208345]
AGS	GI₅₀	0.04 μM Compound: Colchicine	Antiproliferative activity against human AGS cells after 48 hrs by MTT assay Antiproliferative activity against human AGS cells after 48 hrs by MTT assay	[PMID: 28763647]
ARPE-19	IC₅₀	21.8 nM Compound: 1	Cytotoxicity against human ARPE-19 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against human ARPE-19 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
B16	IC₅₀	0.031 μM Compound: Colchicine	Cytotoxicity against mouse B16 cells assessed as cell viability after 48 hrs by MTT test Cytotoxicity against mouse B16 cells assessed as cell viability after 48 hrs by MTT test	[PMID: 18583138]
B16-F0	IC₅₀	0.087 μM Compound: Colchicine	Antiproliferative activity against mouse B16-F0 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay Antiproliferative activity against mouse B16-F0 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay	[PMID: 32650183]
B16-F1	IC₅₀	0.029 μM Compound: colchicine	Cytotoxicity against mouse B16-F1 cells after 48 hrs by SRB assay Cytotoxicity against mouse B16-F1 cells after 48 hrs by SRB assay	[PMID: 19243174]
B16-F1	IC₅₀	29 nM Compound: Colchicine	Cytotoxicity against mouse B16-F1 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against mouse B16-F1 cells after 48 hrs by sulforhodamine B assay	[PMID: 20919720]
B16-F10	IC₅₀	0.029 μM Compound: 1, colchicine	Antiproliferative activity against mouse B16F10 cells after 72 hrs Antiproliferative activity against mouse B16F10 cells after 72 hrs	[PMID: 18503262]
B16-F10	IC₅₀	0.5 μg/mL Compound: Colchicine	Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay	[PMID: 21440448]
B16-F10	IC₅₀	0.5 μg/mL Compound: 1	Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT based ELISA assay Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT based ELISA assay	[PMID: 21783370]
B16-F10	IC₅₀	0.8 μg/mL Compound: Colchicine	Cytotoxicity against mouse B16F10 cells after 48 hrs by MTT assay Cytotoxicity against mouse B16F10 cells after 48 hrs by MTT assay	[PMID: 22578453]
B16-F10	IC₅₀	0.48 μg/mL Compound: 1	Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay	[PMID: 24916028]
B16-F10	IC₅₀	0.48 μM Compound: Colchicine	Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay	[PMID: 25703297]
B16-F10	IC₅₀	32 nM Compound: Colchicine	Antiproliferative activity against mouse B16F10 cells after 72 hrs by MTS assay Antiproliferative activity against mouse B16F10 cells after 72 hrs by MTS assay	[PMID: 30099258]
B16-F10	IC₅₀	44.25 nM Compound: Colchicine	Antiproliferative activity against mouse B16F10 cells after 72 hrs by MTT assay Antiproliferative activity against mouse B16F10 cells after 72 hrs by MTT assay	[PMID: 30197030]
B16-F10	IC₅₀	0.083 μM Compound: Colchicine	Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 33788562]
B16-F10	IC₅₀	9.6 μM Compound: Colchicine	Induction of cell cycle arrest in mouse B16-F10 cells assessed as accumulation of cells at G2/M phase incubated for 48 hrs by RNase/PI staining based flow cytometry analysis Induction of cell cycle arrest in mouse B16-F10 cells assessed as accumulation of cells at G2/M phase incubated for 48 hrs by RNase/PI staining based flow cytometry analysis	[PMID: 35043615]
B16-F10	IC₅₀	0.003 μM Compound: Colchicine	Antiproliferative activity against mouse B16-F10 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against mouse B16-F10 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 36511661]
B16-F10	IC₅₀	0.088 μM Compound: Colchicine	Antiproliferative activity against mouse B16-F10 cells incubated for 48 hrs by MTT assay Antiproliferative activity against mouse B16-F10 cells incubated for 48 hrs by MTT assay	[PMID: 36516438]
B16-F10	IC₅₀	29.2 nM Compound: Colchicine	Antiproliferative activity against mouse B16-F10 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against mouse B16-F10 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 36621138]
B16-F10	IC₅₀	32.84 μM Compound: Col	Cytotoxicity against mouse B16-F10 cells assessed as inhibition of cell growth measured for 24 hrs by MTT assay Cytotoxicity against mouse B16-F10 cells assessed as inhibition of cell growth measured for 24 hrs by MTT assay	[PMID: 36970147]
B16-F10	IC₅₀	0.088 μM Compound: Colchicine	Antiproliferative activity against mouse B16-F10 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against mouse B16-F10 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 37145846]
B16-F10	IC₅₀	18.75 nM Compound: Colchicine	Antiproliferative activity against mouse B16-F10 cells incubated for 48 hrs by MTT assay Antiproliferative activity against mouse B16-F10 cells incubated for 48 hrs by MTT assay	[PMID: 39197251]
BALB/3T3	IC₅₀	139.4 nM Compound: 1	Antiproliferative activity against mouse BALB/3T3 cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay Antiproliferative activity against mouse BALB/3T3 cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay	[PMID: 31653441]
BALB/3T3	IC₅₀	0.054 μM Compound: 1	Cytotoxicity against mouse BALB/3T3 cells incubated for 72 hrs by sulforhodamine B assay Cytotoxicity against mouse BALB/3T3 cells incubated for 72 hrs by sulforhodamine B assay	[PMID: 32432867]
BALB/3T3	IC₅₀	106 nM Compound: 1	Antiproliferative activity against mouse BALB/3T3 cells incubated for 72 hrs by SRB assay Antiproliferative activity against mouse BALB/3T3 cells incubated for 72 hrs by SRB assay	[PMID: 33465696]
BALB/3T3	IC₅₀	33.1 nM Compound: 1	Cytotoxicity against mouse BALB/3T3 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay Cytotoxicity against mouse BALB/3T3 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay	[PMID: 33611191]
BALB/3T3	IC₅₀	100 nM Compound: 1	Antiproliferative activity against mouse BALB/3T3 cells assessed as inhibition of proliferation after 72 hrs by SRB assay Antiproliferative activity against mouse BALB/3T3 cells assessed as inhibition of proliferation after 72 hrs by SRB assay	[PMID: 34116158]
BALB/3T3	IC₅₀	82.3 nM Compound: COLCH	Cytotoxicity against mouse BALB/3T3 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Cytotoxicity against mouse BALB/3T3 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 34592435]
BEAS-2B	IC₅₀	0.016 μM Compound: Colchicine	Cytotoxicity against human BEAS-2B cells assessed as reduction in cell growth by CCK8 assay Cytotoxicity against human BEAS-2B cells assessed as reduction in cell growth by CCK8 assay	[PMID: 33753264]
Bel-7402	IC₅₀	0.4 μg/mL Compound: Colchicine	Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay	[PMID: 15165134]
Bel-7402	IC₅₀	0.3 μg/mL Compound: colchicine	Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay	[PMID: 15620246]
Bel-7402	IC₅₀	0.04 μM Compound: Colchicine	Antiproliferative activity against human Bel7402 cells after 72 hrs by sulforhodamine B assay Antiproliferative activity against human Bel7402 cells after 72 hrs by sulforhodamine B assay	[PMID: 21480626]
Bel-7402	IC₅₀	1.31 μM Compound: Colchicine	Cytotoxicity against human Bel7402 cells by MTT assay Cytotoxicity against human Bel7402 cells by MTT assay	[PMID: 23425970]
BGC-823	IC₅₀	0.6 μg/mL Compound: colchicine	Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay	[PMID: 15620246]
BGC-823	IC₅₀	0.016 μM Compound: Colchicine	Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 36511661]
BJAB	IC₅₀	0.02 μM Compound: 1	Antiproliferative activity against human BJAB cells after 24 hrs by CASY cell counting method Antiproliferative activity against human BJAB cells after 24 hrs by CASY cell counting method	10.1039/C5MD00320B
BT-474	IC₅₀	3.8 nM Compound: 1	Cytotoxicity against human BT474 cells assessed as cell viability after 4 days by MTS assay Cytotoxicity against human BT474 cells assessed as cell viability after 4 days by MTS assay	[PMID: 24210503]
BT-474	IC₅₀	12.46 μM Compound: Col	Cytotoxicity against human BT-474 cells assessed as inhibition of cell growth measured for 24 hrs by MTT assay Cytotoxicity against human BT-474 cells assessed as inhibition of cell growth measured for 24 hrs by MTT assay	[PMID: 36970147]
BT-483	IC₅₀	1.45 μM Compound: Colchicine	Cytotoxicity against human BT-483 cells assessed as growth inhibition Cytotoxicity against human BT-483 cells assessed as growth inhibition	[PMID: 23419737]
BT-549	IC₅₀	0.023 μM Compound: colchicine	Antiproliferative activity against human BT549 cells after 48 hrs by alamar blue assay Antiproliferative activity against human BT549 cells after 48 hrs by alamar blue assay	[PMID: 21563750]
Burkitts lymphoma cell	IC₅₀	0.05 μM Compound: 1	Growth inhibition on human burkitt lymphoma cells after 36 h Growth inhibition on human burkitt lymphoma cells after 36 h	[PMID: 8496935]
BXPC-3	IC₅₀	0.016 μM Compound: 1	Cell cycle arrest in human BxPC3 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis Cell cycle arrest in human BxPC3 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis	[PMID: 21126027]
BXPC-3	IC₅₀	80 nM Compound: 1	Cytotoxicity against 2D culture of human BxPC3 cells measured after 72 hrs by MTT assay Cytotoxicity against 2D culture of human BxPC3 cells measured after 72 hrs by MTT assay	[PMID: 27912174]
BXPC-3	IC₅₀	0.042 μM Compound: 1	Cytotoxicity against human BxPC-3 cells incubated for 48 hrs by MTT assay Cytotoxicity against human BxPC-3 cells incubated for 48 hrs by MTT assay	[PMID: 32432867]
BXPC-3	IC₅₀	16 nM Compound: 1	Cytotoxicity against human BxPC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human BxPC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 33479669]
BXPC-3	IC₅₀	0.041 μM Compound: 1	Antiproliferative activity against human BXPC-3 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human BXPC-3 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
C6	EC₅₀	1 x 10^-1 μM Compound: Colchicine	Inhibition of tubulin polymerization in rat C6 cells after 4 hrs Inhibition of tubulin polymerization in rat C6 cells after 4 hrs	[PMID: 8988604]
C6	EC₅₀	1 x 10^-7 M Compound: Colchicine	Inhibition of tubulin polymerization in rat C6 cells after 4 hrs Inhibition of tubulin polymerization in rat C6 cells after 4 hrs	[PMID: 8988604]
CA46	IC₅₀	15 μM Compound: 1a	Inhibits the growth of the human Burkitt lymphoma CA46 cell Inhibits the growth of the human Burkitt lymphoma CA46 cell	[PMID: 9083485]
Caco-2	GI₅₀	0.03 μM Compound: Colchicine	Antiproliferative activity against human Caco2 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay Antiproliferative activity against human Caco2 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay	[PMID: 30288225]
CAKI-1	ED₅₀	0.4 μg/mL Compound: colchicine	Cytotoxicity against human renal cancer cells (CAKI-1) using SRB assay. Cytotoxicity against human renal cancer cells (CAKI-1) using SRB assay.	[PMID: 9544215]
CAKI-1	EC₅₀	0.4 μg/mL Compound: 1	In vitro growth inhibition of CAKI-1, Kidney carcinoma In vitro growth inhibition of CAKI-1, Kidney carcinoma	[PMID: 9599244]
CAL-27	IC₅₀	37.5 nM Compound: Colchicine	Antiproliferative activity against human CAL-27 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human CAL-27 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay	[PMID: 35576703]
CCRF-CEM	IC₅₀	0.0172 μM Compound: Colchicine	Cytotoxicity against human CEM cells after 72 hrs by MTT assay Cytotoxicity against human CEM cells after 72 hrs by MTT assay	[PMID: 21536450]
CCRF-CEM	IC₅₀	7.9 nM Compound: Col	Antiproliferative activity against human CEM cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human CEM cells after 48 hrs by sulforhodamine B assay	[PMID: 21604746]
CCRF-CEM	IC₅₀	7.9 nM Compound: Col	Antiproliferative activity against human CEM after 48 hrs by SRB assay Antiproliferative activity against human CEM after 48 hrs by SRB assay	[PMID: 21920638]
CCRF-CEM	IC₅₀	0.013 μM Compound: 1, colch	Antiproliferative activity against human CEM cells after 48 to 96 hrs by coulter counter analysis Antiproliferative activity against human CEM cells after 48 to 96 hrs by coulter counter analysis	[PMID: 24773591]
CCRF-CEM	IC₅₀	0.031 μM Compound: Colchicine	Antiproliferative activity against human CEM cells assessed as inhibition of cell proliferation after 96 hrs by Coulter counter based cell counting method Antiproliferative activity against human CEM cells assessed as inhibition of cell proliferation after 96 hrs by Coulter counter based cell counting method	[PMID: 25282265]
CCRF-CEM	EC₅₀	0.021 μM Compound: Colchicine	Antiproliferative activity against human CCRF-CEM cells after 96 hrs by MTT assay Antiproliferative activity against human CCRF-CEM cells after 96 hrs by MTT assay	[PMID: 29055869]
CCRF-CEM	IC₅₀	0.013 μM Compound: Colchicine	Antiproliferative activity against human CEM cells after 96 hrs by coulter counting method Antiproliferative activity against human CEM cells after 96 hrs by coulter counting method	[PMID: 29471122]
CCRF-CEM	IC₅₀	0.013 μM Compound: 5	Antiproliferative activity against human CEM cells measured after 96 hrs by Coulter counter method Antiproliferative activity against human CEM cells measured after 96 hrs by Coulter counter method	[PMID: 30921759]
CEM-VLB	IC₅₀	360 nM Compound: Col	Antiproliferative activity against multidrug-resistant human CEM/VLB cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against multidrug-resistant human CEM/VLB cells after 48 hrs by sulforhodamine B assay	[PMID: 21604746]
CEM-VLB	IC₅₀	360 nM Compound: Col	Antiproliferative activity against human multidrug-resistant CEM/VLB cells after 48 hrs by SRB assay Antiproliferative activity against human multidrug-resistant CEM/VLB cells after 48 hrs by SRB assay	[PMID: 21920638]
CHL-1	IC₅₀	3.6 nM Compound: Colchicine	Antiproliferative activity against human CHL-1 cells after 72 hrs by MTS assay Antiproliferative activity against human CHL-1 cells after 72 hrs by MTS assay	[PMID: 30099258]
CHO	IC₅₀	220 nM Compound: Col	Antiproliferative activity against CHO cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against CHO cells after 48 hrs by sulforhodamine B assay	[PMID: 21604746]
CHO	IC₅₀	220 nM Compound: Col	Antiproliferative activity against human CHO after 48 hrs by SRB assay Antiproliferative activity against human CHO after 48 hrs by SRB assay	[PMID: 21920638]
CHO	IC₅₀	0.697 μM Compound: 1	Antiproliferative activity against Chinese hamster CHO cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against Chinese hamster CHO cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
CHO-K1	IC₅₀	9.201 μM Compound: 1	Antiproliferative activity against Chinese hamster CHO-K1 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against Chinese hamster CHO-K1 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
CHO-TAX 5-6	IC₅₀	140 nM Compound: Col	Antiproliferative activity against paclitaxel-resistant CHO-TAX 5-6 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against paclitaxel-resistant CHO-TAX 5-6 cells after 48 hrs by sulforhodamine B assay	[PMID: 21604746]
CHO-TAX 5-6	IC₅₀	140 nM Compound: Col	Antiproliferative activity against paclitaxel-resistant CHO-TAX 5-6 cells after 48 hrs by SRB assay Antiproliferative activity against paclitaxel-resistant CHO-TAX 5-6 cells after 48 hrs by SRB assay	[PMID: 21920638]
CHO-VV 3-2	IC₅₀	620 nM Compound: Col	Antiproliferative activity against paclitaxel-resistant CHO-VV 3-2 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against paclitaxel-resistant CHO-VV 3-2 cells after 48 hrs by sulforhodamine B assay	[PMID: 21604746]
CHO-VV 3-2	IC₅₀	620 nM Compound: Col	Antiproliferative activity against colchicine and vinblastine-resistant CHO-VV 3-2 cells after 48 hrs by SRB assay Antiproliferative activity against colchicine and vinblastine-resistant CHO-VV 3-2 cells after 48 hrs by SRB assay	[PMID: 21920638]
CHP-134	GI₅₀	0.008 μM Compound: Colchicine	Growth inhibition of MYCN-amplified human CHP-134 cells assessed as reduction in cell viability measured after 3 days by Celltiter-glo assay Growth inhibition of MYCN-amplified human CHP-134 cells assessed as reduction in cell viability measured after 3 days by Celltiter-glo assay	[PMID: 37736192]
CNE-2	IC₅₀	0.034 μM Compound: COL	Antiproliferative activity against human CNE2 cells after 48 hrs by SRB method Antiproliferative activity against human CNE2 cells after 48 hrs by SRB method	[PMID: 25061803]
Col2	ED₅₀	0.001 μg/mL Compound: colchicine	Cytotoxicity against human Col2 cells Cytotoxicity against human Col2 cells	[PMID: 8133298]
COLO 205	IC₅₀	0.021 μM Compound: colchicine	Antiproliferative activity against human COLO205 cells after 48 hrs by alamar blue assay Antiproliferative activity against human COLO205 cells after 48 hrs by alamar blue assay	[PMID: 21563750]
COLO 205	IC₅₀	0.003 μM Compound: Colchicine	Cytotoxicity against human COLO205 cells assessed as growth inhibition by MTT assay Cytotoxicity against human COLO205 cells assessed as growth inhibition by MTT assay	[PMID: 25091926]
COLO 205	IC₅₀	0.032 μM Compound: 1; (-)-Colchicine	Antiproliferative activity against human COLO205 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human COLO205 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 31655432]
COLO 205	IC₅₀	12.8 nM Compound: 1	Cytotoxicity against human COLO 205 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against human COLO 205 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
COLO357	IC₅₀	160 nM Compound: 1	Cytotoxicity against 2D culture of human Colo-357 cells measured after 72 hrs by MTT assay Cytotoxicity against 2D culture of human Colo-357 cells measured after 72 hrs by MTT assay	[PMID: 27912174]
COLO357	IC₅₀	1.3 nM Compound: 1	Cytotoxic activity in human Colo-357 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxic activity in human Colo-357 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 29028531]
COLO357	IC₅₀	1.3 nM Compound: 1	Antiproliferative activity against human COLO357 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human COLO357 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 32827941]
COLO357	IC₅₀	16 nM Compound: 1	Cytotoxicity against human COLO-357 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human COLO-357 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 33479669]
CWR22R	IC₅₀	18 nM Compound: 1	Cytotoxicity against human 22Rv1 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against human 22Rv1 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
DAN-G	EC₅₀	0.059 μM Compound: Colchicine	Antiproliferative activity against human DAN-G cells after 96 hrs by MTT assay Antiproliferative activity against human DAN-G cells after 96 hrs by MTT assay	[PMID: 29055869]
DLD-1	EC₅₀	0.19 μM Compound: 12	Tested for caspase activation activity in colorectal DLD-1 cell line Tested for caspase activation activity in colorectal DLD-1 cell line	[PMID: 12773051]
DLD-1	EC₅₀	0.19 μM Compound: colchicine	Induction of apoptosis in human DLD1 cells assessed as caspase activation after 24 hrs Induction of apoptosis in human DLD1 cells assessed as caspase activation after 24 hrs	[PMID: 15566300]
DLD-1	EC₅₀	0.18 μM Compound: Colchicine	Induction of apoptosis in human DLD1 cells assessed as caspase activation after 48 hrs Induction of apoptosis in human DLD1 cells assessed as caspase activation after 48 hrs	[PMID: 19500976]
DLD-1	IC₅₀	0.089 μM Compound: colchicine	Antiproliferative activity against human DLD1 cells after 48 hrs by alamar blue assay Antiproliferative activity against human DLD1 cells after 48 hrs by alamar blue assay	[PMID: 21563750]
DLD-1	IC₅₀	45.5 nM Compound: Colchicine	Cytotoxicity against human DLD1 cells assessed as growth inhibition Cytotoxicity against human DLD1 cells assessed as growth inhibition	[PMID: 23103097]
DLD-1	IC₅₀	15.6 nM Compound: colchicine	Cytotoxicity against human DLD1 cells after 96 hrs by MTT assay Cytotoxicity against human DLD1 cells after 96 hrs by MTT assay	[PMID: 23176628]
DLD-1	IC₅₀	11 nM Compound: colchicine	Antiproliferative activity against human DLD1 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Antiproliferative activity against human DLD1 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 25208345]
DLD-1	IC₅₀	43 nM Compound: 1	Cytotoxicity against human DLD1 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Cytotoxicity against human DLD1 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay	[PMID: 30429975]
DLD-1	IC₅₀	43 nM Compound: 1; (-)-Colchicine	Antiproliferative activity against human DLD1 cells assessed as reduction in cell viability Antiproliferative activity against human DLD1 cells assessed as reduction in cell viability	[PMID: 31655432]
DU-145	IC₅₀	0.01 μM Compound: colchicine	Cytotoxicity against human DU145 cells after 48 hrs by SRB assay Cytotoxicity against human DU145 cells after 48 hrs by SRB assay	[PMID: 19243174]
DU-145	ED₅₀	0.0027 μg/mL Compound: 1	Cytotoxicity against human DU145 cells after 2 days Cytotoxicity against human DU145 cells after 2 days	[PMID: 20542428]
DU-145	IC₅₀	10 nM Compound: Colchicine	Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay	[PMID: 20919720]
DU-145	IC₅₀	10 nM Compound: Col	Antiproliferative activity against human DU145 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human DU145 cells after 48 hrs by sulforhodamine B assay	[PMID: 21604746]
DU-145	IC₅₀	0.01 μM Compound: Colchicine	Antiproliferative activity against human DU145 cells after 96 hrs by sulforhodamine B assay Antiproliferative activity against human DU145 cells after 96 hrs by sulforhodamine B assay	[PMID: 21775150]
DU-145	IC₅₀	10 nM Compound: Col	Antiproliferative activity against human DU145 after 48 hrs by SRB assay Antiproliferative activity against human DU145 after 48 hrs by SRB assay	[PMID: 21920638]
DU-145	IC₅₀	11.2 nM Compound: Colchicine	Antiproliferative activity against human DU145 cells after 48 hrs by SRB assay Antiproliferative activity against human DU145 cells after 48 hrs by SRB assay	[PMID: 22783954]
DU-145	IC₅₀	0.3 μM Compound: Colchicine	Cytotoxicity against human DU145 cells by MTT assay Cytotoxicity against human DU145 cells by MTT assay	[PMID: 23425970]
DU-145	IC₅₀	0.69 μM Compound: Colchicine	Cytotoxicity against human DU145 cells after 48 hrs by MTT assay Cytotoxicity against human DU145 cells after 48 hrs by MTT assay	[PMID: 25499929]
DU-145	EC₅₀	0.018 μM Compound: Colchicine	Antiproliferative activity against human DU145 cells after 96 hrs by MTT assay Antiproliferative activity against human DU145 cells after 96 hrs by MTT assay	[PMID: 29055869]
DU-145	IC₅₀	25.7 nM Compound: Colchicine	Cytotoxicity against human DU145 cells after 72 hrs by MTS assay Cytotoxicity against human DU145 cells after 72 hrs by MTS assay	[PMID: 29406710]
DU-145	IC₅₀	3.45 nM Compound: Colchicine	Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay	[PMID: 30197030]
DU-145	IC₅₀	35.5 nM Compound: Colchicine	Antiproliferative activity against human DU145 cells Antiproliferative activity against human DU145 cells	[PMID: 31251599]
DU-145	IC₅₀	17.3 nM Compound: Colchicine	Antiproliferative activity against human DU145 cells measured after 72 hrs by MTS assay Antiproliferative activity against human DU145 cells measured after 72 hrs by MTS assay	[PMID: 31860298]
DU-145	IC₅₀	0.003 μM Compound: Colchicine	Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 36511661]
DU-145	IC₅₀	0.07 μM Compound: Colchicine	Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth after 72 hrs by MTT assay Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth after 72 hrs by MTT assay	[PMID: 38336655]
DU-145	IC₅₀	0.02 μM Compound: Colchicine	Antiproliferative activity against human DU-145 assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human DU-145 assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
EA.hy 926	IC₅₀	>800 nM Compound: 1	Cytotoxicity against 2D culture of human EAhy926 cells measured after 72 hrs by MTT assay Cytotoxicity against 2D culture of human EAhy926 cells measured after 72 hrs by MTT assay	[PMID: 27912174]
ECa-109 cell line	IC₅₀	1.24 μM Compound: Colchicine	Antiproliferative activity against human EC109 cells after 48 hrs by MTT assay Antiproliferative activity against human EC109 cells after 48 hrs by MTT assay	[PMID: 30075402]
Epithelial cell	IC₅₀	9.26 μM Compound: Colchicine	Antiproliferative activity against human mammary epithelial cells after 48 hrs by MTT assay Antiproliferative activity against human mammary epithelial cells after 48 hrs by MTT assay	[PMID: 27608432]
FaDu	IC₅₀	22.8 nM Compound: Colchicine	Antiproliferative activity against human FaDu cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human FaDu cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay	[PMID: 35576703]
H9	EC₅₀	0.01 μM Compound: 1	Cytotoxicity against human H9 cells Cytotoxicity against human H9 cells	[PMID: 1919593]
H9	IC₅₀	0.018 μM Compound: 1	Antiviral activity against HIV1 HTLV-3B in human H9 cells after 3 days by p24 antigen capture assay Antiviral activity against HIV1 HTLV-3B in human H9 cells after 3 days by p24 antigen capture assay	[PMID: 1919593]
HaCaT	IC₅₀	12 nM Compound: Colchicine	Antiproliferative activity against human HaCaT cells assessed as cell viability by MTT assay Antiproliferative activity against human HaCaT cells assessed as cell viability by MTT assay	[PMID: 23063401]
HaCaT	IC₅₀	80 nM Compound: 1	Cytotoxicity against 2D culture of human HaCaT cells measured after 72 hrs by MTT assay Cytotoxicity against 2D culture of human HaCaT cells measured after 72 hrs by MTT assay	[PMID: 27912174]
HaCaT	IC₅₀	0.3 nM Compound: 1	Cytotoxicity against human HaCat cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human HaCat cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 32827941]
HaCaT	IC₅₀	3 nM Compound: 1	Cytotoxicity against human HaCaT cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human HaCaT cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 33479669]
HaCaT	IC₅₀	9.3 nM Compound: 1	Cytotoxicity against human HaCaT cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against human HaCaT cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
HCC827	IC₅₀	9.31 nM Compound: Colchicine	Antiproliferative activity against human HCC827 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human HCC827 cells incubated for 48 hrs by CCK8 assay	[PMID: 38972078]
HCT-116	EC₅₀	0.02 μM Compound: Colchicine	Antitumor activity against Homo sapiens (human) HCT116 cells Antitumor activity against Homo sapiens (human) HCT116 cells	[PMID: 11378362]
HCT-116	GI₅₀	8.4 ng/mL Compound: Colchicine	In vitro cytotoxic activity (growth inhibition) of compound against HCT 116 cancer cell line was determined In vitro cytotoxic activity (growth inhibition) of compound against HCT 116 cancer cell line was determined	[PMID: 12372531]
HCT-116	IC₅₀	2.75 nM Compound: Colchicine	Cytotoxicity against HCT116 cell line Cytotoxicity against HCT116 cell line	[PMID: 17249649]
HCT-116	EC₅₀	0.015 μM Compound: colchicine	Induction of apoptosis in human HCT116 cells assessed as caspase activation after 24 hrs by HTS assay Induction of apoptosis in human HCT116 cells assessed as caspase activation after 24 hrs by HTS assay	[PMID: 18197614]
HCT-116	IC₅₀	0.04 μM Compound: 1, colchicine	Antiproliferative activity against human HCT116 cells after 72 hrs Antiproliferative activity against human HCT116 cells after 72 hrs	[PMID: 18503262]
HCT-116	EC₅₀	0.015 μM Compound: colchicine	Induction of apoptosis in human HCT116 cells assessed as caspase 3 activation after 24 hrs Induction of apoptosis in human HCT116 cells assessed as caspase 3 activation after 24 hrs	[PMID: 18651728]
HCT-116	IC₅₀	32 nM Compound: colchicine	Cytotoxicity against human HCT116 cells after 72 hrs Cytotoxicity against human HCT116 cells after 72 hrs	[PMID: 19530698]
HCT-116	IC₅₀	20 nM Compound: 1	Cytotoxicity against human HCT116 assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay Cytotoxicity against human HCT116 assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay	[PMID: 23214452]
HCT-116	IC₅₀	0.037 μM Compound: Colchicine	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 23602523]
HCT-116	IC₅₀	0.011 μM Compound: 1	Cytotoxicity against human HCT116 cells after 96 hrs using tetracolor one Cytotoxicity against human HCT116 cells after 96 hrs using tetracolor one	[PMID: 24900316]
HCT-116	IC₅₀	15 nM Compound: colchicine	Antiproliferative activity against human HCT116 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 25208345]
HCT-116	IC₅₀	0.04 μM Compound: Colchicine	Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 25805446]
HCT-116	IC₅₀	27.8 nM Compound: 1	Antiproliferative activity against human HCT116 cells after 24 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 24 hrs by MTT assay	[PMID: 27213819]
HCT-116	IC₅₀	13.9 nM Compound: Colchicine	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 28763646]
HCT-116	IC₅₀	0.01 μM Compound: Colchicine	Antiproliferative activity against human HCT116 cells by SRB assay Antiproliferative activity against human HCT116 cells by SRB assay	[PMID: 28988750]
HCT-116	IC₅₀	0.039 μM Compound: Colchicine	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 30093295]
HCT-116	IC₅₀	13.9 nM Compound: Colchicine	Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay	[PMID: 30099258]
HCT-116	IC₅₀	26.18 nM Compound: Colchicine	Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 30197030]
HCT-116	GI₅₀	1.2 μM Compound: Colchicine	Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay	[PMID: 30288225]
HCT-116	IC₅₀	0.04 μM Compound: Colchicine	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by SRB assay Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 30883116]
HCT-116	IC₅₀	0.005 μM Compound: Colchicine	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31185410]
HCT-116	IC₅₀	0.05 μM Compound: 1; (-)-Colchicine	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 31655432]
HCT-116	IC₅₀	0.25 μM Compound: Colchicine	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability	[PMID: 31753698]
HCT-116	IC₅₀	2.13 μM Compound: Colchicine	Antiproliferative activity against human HCT116 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells incubated for 48 hrs by MTT assay	[PMID: 32035399]
HCT-116	IC₅₀	0.042 μM Compound: Colchicine	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay	[PMID: 32650183]
HCT-116	IC₅₀	0.129 μM Compound: Colchicine	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 32682200]
HCT-116	IC₅₀	5.13 μM Compound: Colchicine	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay	[PMID: 32768647]
HCT-116	IC₅₀	0.083 μM Compound: Colchicine	Antiproliferative activity against human HCT-116 assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human HCT-116 assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34175541]
HCT-116	IC₅₀	0.022 μM Compound: Colchicine	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability	[PMID: 34416378]
HCT-116	IC₅₀	27.5 nM Compound: Colchicine	Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
HCT-116	IC₅₀	0.046 μM Compound: Colchicine	Antiproliferative activity against human HCT-116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells after 48 hrs by MTT assay	[PMID: 34968813]
HCT-116	IC₅₀	0.13 μM Compound: Colchicine	Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition measured after 48 hrs by CCK8 assay Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition measured after 48 hrs by CCK8 assay	[PMID: 34971875]
HCT-116	IC₅₀	0.108 μM Compound: Colchicine	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 35605363]
HCT-116	IC₅₀	0.081 μM Compound: Colchicine	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35834904]
HCT-116	IC₅₀	0.08 μM Compound: Colchicine	Cytotoxicity in human HCT-116 cells assessed as growth inhibition level after 48 hrs by SRB assay Cytotoxicity in human HCT-116 cells assessed as growth inhibition level after 48 hrs by SRB assay	[PMID: 36162138]
HCT-116	IC₅₀	0.011 μM Compound: Colchicine	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36455508]
HCT-116	IC₅₀	0.003 μM Compound: Colchicine	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 36511661]
HCT-116	IC₅₀	0.022 μM Compound: Colchicine	Antiproliferative activity against human HCT-116 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells incubated for 48 hrs by MTT assay	[PMID: 36516438]
HCT-116	IC₅₀	0.078 μM Compound: Colchicine	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36940611]
HCT-116	IC₅₀	0.55 μM Compound: Col	Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth measured for 24 hrs by MTT assay Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth measured for 24 hrs by MTT assay	[PMID: 36970147]
HCT-116	IC₅₀	1.85 μM Compound: Colchicine	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37122544]
HCT-116	IC₅₀	0.035 μM Compound: 2	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 1.5 hrs by CCK-8 assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 1.5 hrs by CCK-8 assay	[PMID: 38107178]
HCT-116	IC₅₀	0.055 μM Compound: Colchicine	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38150962]
HCT-116	IC₅₀	0.039 μM Compound: Colchicine	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by CCK8 method Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by CCK8 method	[PMID: 38181651]
HCT-116	IC₅₀	0.02 μM Compound: Colchicine	Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by MTT assay	[PMID: 38703557]
HCT-116	IC₅₀	0.017 μM Compound: Colchicine	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
HCT-116	IC₅₀	9.37 nM Compound: Colchicine	Antiproliferative activity against human HCT-116 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells incubated for 48 hrs by MTT assay	[PMID: 39197251]
HCT-116	IC₅₀	10.6 nM Compound: 1	Cytotoxicity against human HCT116 cells after 96 hrs by microplate reader analysis Cytotoxicity against human HCT116 cells after 96 hrs by microplate reader analysis	10.1039/C2MD20250F
HCT-116	IC₅₀	10.6 nM Compound: 1	Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 96 hrs Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 96 hrs	10.1039/C3MD00287J
HCT-15	IC₅₀	140 nM Compound: Colchicine	Antiproliferative activity against the MDR positive human colon adenocarcinoma cell line HCT-15 Antiproliferative activity against the MDR positive human colon adenocarcinoma cell line HCT-15	[PMID: 11814821]
HCT-15	IC₅₀	100 nM Compound: colchicine	Antiproliferative activity against drug resistant HCT15 cell line expressing MDR1 by Alamar Blue assay Antiproliferative activity against drug resistant HCT15 cell line expressing MDR1 by Alamar Blue assay	[PMID: 17286393]
HCT-15	IC₅₀	86 nM Compound: 1	Cytotoxicity against human HCT15 cells assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay Cytotoxicity against human HCT15 cells assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay	[PMID: 23214452]
HCT-15	IC₅₀	0.08 μM Compound: Colchicine	Cytotoxicity against human HCT15 cells by MTT assay Cytotoxicity against human HCT15 cells by MTT assay	[PMID: 23425970]
HCT-15	IC₅₀	16 nM Compound: colchicine	Antiproliferative activity against human HCT15 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Antiproliferative activity against human HCT15 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 25208345]
HCT-15	IC₅₀	9 nM Compound: 1; (-)-Colchicine	Antiproliferative activity against human HCT15 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay Antiproliferative activity against human HCT15 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay	[PMID: 31655432]
HCT-8	ED₅₀	0.054 μg/mL Compound: 1	Cytotoxicity against human HCT8 cells after 2 days Cytotoxicity against human HCT8 cells after 2 days	[PMID: 20542428]
HCT-8	IC₅₀	11.8 μM Compound: Colchicine	Cytotoxicity against taxol-resistant human HCT8 cells by MTT assay Cytotoxicity against taxol-resistant human HCT8 cells by MTT assay	[PMID: 23425970]
HCT-8	IC₅₀	0.059 μM Compound: COL	Antiproliferative activity against human HCT8 cells after 48 hrs by SRB method Antiproliferative activity against human HCT8 cells after 48 hrs by SRB method	[PMID: 25061803]
HCT-8	IC₅₀	1.1 μM Compound: COL	Antiproliferative activity against vincristine-resistant human HCT8 cells after 48 hrs by SRB method Antiproliferative activity against vincristine-resistant human HCT8 cells after 48 hrs by SRB method	[PMID: 25061803]
HCT-8	IC₅₀	2433 nM Compound: 1	Cytotoxicity against vinblastine resistant/P-gp overexpressing human HCT8 cells assessed as reduction in cell growth after 24 hrs by MTT assay Cytotoxicity against vinblastine resistant/P-gp overexpressing human HCT8 cells assessed as reduction in cell growth after 24 hrs by MTT assay	[PMID: 27213819]
HCT-8	IC₅₀	29.7 nM Compound: 1	Antiproliferative activity against human HCT8 cells after 24 hrs by MTT assay Antiproliferative activity against human HCT8 cells after 24 hrs by MTT assay	[PMID: 27213819]
HCT-8	IC₅₀	13.4 nM Compound: Colchicine	Antiproliferative activity against human HCT8 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT8 cells after 48 hrs by MTT assay	[PMID: 28763646]
HCT-8	IC₅₀	0.022 μM Compound: Colchicine	Antiproliferative activity against human HCT-8 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT-8 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 36511661]
HCT-8	ED₅₀	175 nM Compound: 1	Cytotoxicity against human solid tumor Colon carcinoma HCT-8 cell line Cytotoxicity against human solid tumor Colon carcinoma HCT-8 cell line	[PMID: 8496935]
HCT-8	ED₅₀	0.016 μg/mL Compound: colchicine	Cytotoxicity against human ileocecal carcinoma cells (HCT-8) using SRB assay. Cytotoxicity against human ileocecal carcinoma cells (HCT-8) using SRB assay.	[PMID: 9544215]
HEK293	IC₅₀	0.009 μM Compound: Colchicine	Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay	[PMID: 23932339]
HEK293	EC₅₀	0.03 μM Compound: Colchicine	Cytotoxicity against HEK293 cells after 48 hrs by MTS assay Cytotoxicity against HEK293 cells after 48 hrs by MTS assay	[PMID: 24842619]
HEK293	IC₅₀	0.005 μM Compound: colchicine	Cytotoxicity against human HEK293 cells after 3 days by MTT assay Cytotoxicity against human HEK293 cells after 3 days by MTT assay	[PMID: 25426924]
HEK293	IC₅₀	5 nM Compound: Colchicine	Cytotoxicity against HEK293 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against HEK293 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 27915168]
HEK293	IC₅₀	10.2 nM Compound: Colchicine	Antiproliferative activity against HEK293 cells after 48 hrs by MTT assay Antiproliferative activity against HEK293 cells after 48 hrs by MTT assay	[PMID: 28763646]
HEK293	IC₅₀	32 nM Compound: 1	Cytotoxic activity in HEK293 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxic activity in HEK293 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 29028531]
HEK293	IC₅₀	5 nM Compound: Colchicine	Antiproliferative activity against HEK293 cells after 2 days by MTT assay Antiproliferative activity against HEK293 cells after 2 days by MTT assay	[PMID: 29550732]
HEK293	IC₅₀	13 nM Compound: Colchicine	Antiproliferative activity against human HEK293 cells after 2 days by MTT assay Antiproliferative activity against human HEK293 cells after 2 days by MTT assay	[PMID: 29604583]
HEK293	IC₅₀	0.02 μM Compound: 2	Cytotoxicity against HEK293 cells after 68 hrs by MTT assay Cytotoxicity against HEK293 cells after 68 hrs by MTT assay	[PMID: 32243160]
HEK293	IC₅₀	0.042 μM Compound: 1	Cytotoxicity against HEK293 cells incubated for 48 hrs by MTT assay Cytotoxicity against HEK293 cells incubated for 48 hrs by MTT assay	[PMID: 32432867]
HEK293	IC₅₀	16 nM Compound: 1	Cytotoxicity against human HEK293 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human HEK293 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 32827941]
HEK293	IC₅₀	16 nM Compound: 1	Cytotoxicity against human HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 33479669]
HEK293	IC₅₀	>25 μM Compound: COL	Cytotoxicity against human HEK293 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human HEK293 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 35694693]
HEK293	IC₅₀	0.17 μM Compound: 2	Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated 1.5 hrs by MTT assay Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated 1.5 hrs by MTT assay	[PMID: 38107178]
HEK-293T	IC₅₀	6.38 μM Compound: Colchicine	Antiproliferative activity against human 293T cells after 24 hrs by MTT assay Antiproliferative activity against human 293T cells after 24 hrs by MTT assay	[PMID: 29268130]
HEK-293T	CC₅₀	129.32 μM Compound: Colchicine	Cytotoxicity against HEK293T cells after 24 hrs by MTT assay Cytotoxicity against HEK293T cells after 24 hrs by MTT assay	[PMID: 30606674]
HEK-293T	CC₅₀	8.43 μM Compound: Colchicine	Antiproliferative activity against human HEK293T cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HEK293T cells incubated for 48 hrs by MTT assay	[PMID: 32035399]
HEK-293T	IC₅₀	801.2 μM Compound: Colchicine	Cytotoxicity against human HEK293T cells expressing ABCB1 (unknown origin) measured after 72 hrs by MTT assay Cytotoxicity against human HEK293T cells expressing ABCB1 (unknown origin) measured after 72 hrs by MTT assay	[PMID: 34546748]
HEK-293T	IC₅₀	1.03 μM Compound: Colchicine	Cytotoxicity against human HEK293T cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay Cytotoxicity against human HEK293T cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay	[PMID: 35367708]
HEK-293T	IC₅₀	>25 μM Compound: Colchicine	Cytotoxicity against human HEK293T cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against human HEK293T cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 36067627]
HEK-293T	IC₅₀	3.86 μM Compound: Col	Cytotoxicity against human HEK293T cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Cytotoxicity against human HEK293T cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 36760739]
HEK-293T	CC₅₀	152 μM Compound: Colchicine	Antiproliferative activity against human 293T cells measured after 24 hrs by MTT assay Antiproliferative activity against human 293T cells measured after 24 hrs by MTT assay	10.1039/C6MD00255B
HEL	IC₅₀	0.156 μM Compound: Colchicine	Cytotoxicity against human HEL cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human HEL cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37201429]
HeLa	IC₅₀	21 μg/mL Compound: Colchicine	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 11473441]
HeLa	IC₅₀	0.023 μM Compound: Colchicine	In vitro inhibitory activity against HeLa/KB cells using XTT proliferation assay. In vitro inhibitory activity against HeLa/KB cells using XTT proliferation assay.	[PMID: 11741473]
HeLa	IC₅₀	0.1 μg/mL Compound: Colchicine	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 15165134]
HeLa	IC₅₀	0.1 μg/mL Compound: colchicine	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 15620246]
HeLa	IC₅₀	1.84 nM Compound: Colchicine	Cytotoxicity against HeLa cell line Cytotoxicity against HeLa cell line	[PMID: 17249649]
HeLa	EC₅₀	0.039 μM Compound: Colchicine	Cytotoxicity against human HeLa cells after 48 hrs by luminescence cell viability assay Cytotoxicity against human HeLa cells after 48 hrs by luminescence cell viability assay	[PMID: 18684625]
HeLa	IC₅₀	<1 μM Compound: Colchicine	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 20833451]
HeLa	EC₅₀	0.03 μM Compound: Colchicine	Induction of mitotic arrest in human HeLa cells assessed as reduction in cell density by immunofluorescence staining Induction of mitotic arrest in human HeLa cells assessed as reduction in cell density by immunofluorescence staining	[PMID: 22564383]
HeLa	IC₅₀	20.2 nM Compound: 1	Cytotoxicity against human HeLa cells after 48 hrs by WST-8 assay Cytotoxicity against human HeLa cells after 48 hrs by WST-8 assay	[PMID: 22727370]
HeLa	IC₅₀	0.1 μM Compound: Colchicine	Cytotoxicity against human HeLa cells after 48 hrs Cytotoxicity against human HeLa cells after 48 hrs	[PMID: 23022053]
HeLa	IC₅₀	8.2 μM Compound: Colchicine	Cytotoxicity against human HeLa cells assessed as growth inhibition Cytotoxicity against human HeLa cells assessed as growth inhibition	[PMID: 23103097]
HeLa	IC₅₀	9.7 μM Compound: Colchicine	Cytotoxicity against human HeLa cells harboring class 3 beta tubulin mutant assessed as growth inhibition Cytotoxicity against human HeLa cells harboring class 3 beta tubulin mutant assessed as growth inhibition	[PMID: 23103097]
HeLa	IC₅₀	8.2 nM Compound: colchicine	Cytotoxicity against human HeLa cells after 96 hrs by MTT assay Cytotoxicity against human HeLa cells after 96 hrs by MTT assay	[PMID: 23176628]
HeLa	IC₅₀	9.7 nM Compound: colchicine	Cytotoxicity against human HeLa cells expressing class 3 tubulin after 96 hrs by MTT assay Cytotoxicity against human HeLa cells expressing class 3 tubulin after 96 hrs by MTT assay	[PMID: 23176628]
HeLa	IC₅₀	28 nM Compound: 1	Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 23214452]
HeLa	IC₅₀	37.38 nM Compound: 3	Cytotoxicity against human HeLa cells after 72 hrs by CCK-8 assay Cytotoxicity against human HeLa cells after 72 hrs by CCK-8 assay	[PMID: 23360369]
HeLa	IC₅₀	0.66 μM Compound: Colchicine	Cytotoxicity against human HeLa cells assessed as growth inhibition Cytotoxicity against human HeLa cells assessed as growth inhibition	[PMID: 23419737]
HeLa	EC₅₀	32.5 nM Compound: 1a	Antimitotic activity in human HeLa cells assessed as cell density loss after 24 hrs by Hoechst 33342 staining Antimitotic activity in human HeLa cells assessed as cell density loss after 24 hrs by Hoechst 33342 staining	[PMID: 23524161]
HeLa	IC₅₀	0.0087 μM Compound: 1, colch	Antiproliferative activity against human HeLa cells after 4 days by coulter counter analysis Antiproliferative activity against human HeLa cells after 4 days by coulter counter analysis	[PMID: 24773591]
HeLa	IC₅₀	0.704 μM Compound: Colchicine	Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by CCK-8 assay Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by CCK-8 assay	[PMID: 25091926]
HeLa	IC₅₀	0.028 μM Compound: Colchicine	Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation after 4 days by Coulter counter based cell counting method Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation after 4 days by Coulter counter based cell counting method	[PMID: 25282265]
HeLa	IC₅₀	0.54 μM Compound: Colchicine	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 25499929]
HeLa	GI₅₀	0.04 μM Compound: Colchicine	Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay	[PMID: 25827522]
HeLa	IC₅₀	0.037 μM Compound: COL	Cytotoxicity against human HeLa cells after 3 days by SRB assay Cytotoxicity against human HeLa cells after 3 days by SRB assay	[PMID: 26927488]
HeLa	IC₅₀	21.8 nM Compound: 1	Cytotoxicity against human HeLa cells after 48 hrs by Celltiter-Glo luminescent cell viability assay Cytotoxicity against human HeLa cells after 48 hrs by Celltiter-Glo luminescent cell viability assay	[PMID: 26985296]
HeLa	IC₅₀	0.0076 μM Compound: 1	Growth inhibition of human HeLa cells incubated for 72 hrs by MTT assay Growth inhibition of human HeLa cells incubated for 72 hrs by MTT assay	[PMID: 27172319]
HeLa	IC₅₀	0.02 μM Compound: Colchicine	Cytotoxicity against human HeLa cells assessed as reduction in cell growth measured after 48 hrs by WST-8 assay Cytotoxicity against human HeLa cells assessed as reduction in cell growth measured after 48 hrs by WST-8 assay	[PMID: 27665177]
HeLa	IC₅₀	0.5 μM Compound: Colchicine	Antiproliferative activity against human HeLa cells by SRB assay Antiproliferative activity against human HeLa cells by SRB assay	[PMID: 28988750]
HeLa	EC₅₀	0.027 μM Compound: Colchicine	Antiproliferative activity against human HeLa cells after 96 hrs by MTT assay Antiproliferative activity against human HeLa cells after 96 hrs by MTT assay	[PMID: 29055869]
HeLa	IC₅₀	0.003 μM Compound: 1	Cytotoxicity in human HeLa cells assessed as reduction in cell viability after 4 days under dark condition by MTT assay Cytotoxicity in human HeLa cells assessed as reduction in cell viability after 4 days under dark condition by MTT assay	[PMID: 29172077]
HeLa	IC₅₀	2.54 μM Compound: Colchicine	Antiproliferative activity against human HeLa cells after 24 hrs by MTT assay Antiproliferative activity against human HeLa cells after 24 hrs by MTT assay	[PMID: 29268130]
HeLa	IC₅₀	0.0087 μM Compound: Colchicine	Antiproliferative activity against human HeLa cells after 3 days by coulter counting method Antiproliferative activity against human HeLa cells after 3 days by coulter counting method	[PMID: 29471122]
HeLa	IC₅₀	14 nM Compound: Colchicine	Antiproliferative activity against human HeLa cells after 2 days by MTT assay Antiproliferative activity against human HeLa cells after 2 days by MTT assay	[PMID: 29604583]
HeLa	IC₅₀	0.051 μM Compound: Colchicine	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 30093295]
HeLa	IC₅₀	9.5 nM Compound: Colchicine	Antiproliferative activity against human HeLa cells after 72 hrs by MTS assay Antiproliferative activity against human HeLa cells after 72 hrs by MTS assay	[PMID: 30099258]
HeLa	IC₅₀	0.027 μM Compound: Colchicine	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 30106297]
HeLa	IC₅₀	8.89 nM Compound: Colchicine	Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay	[PMID: 30197030]
HeLa	IC₅₀	0.36 μM Compound: Colchicine	Antiproliferative activity against human HeLa cells after 24 hrs by MTT assay Antiproliferative activity against human HeLa cells after 24 hrs by MTT assay	[PMID: 30606674]
HeLa	IC₅₀	10.2 μM Compound: Colchicine	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30878833]
HeLa	IC₅₀	0.011 μM Compound: Colchicine	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by SRB assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 30883116]
HeLa	IC₅₀	0.0087 μM Compound: 5	Antiproliferative activity against human HeLa cells measured after 3 days by Coulter counter method Antiproliferative activity against human HeLa cells measured after 3 days by Coulter counter method	[PMID: 30921759]
HeLa	IC₅₀	0.013 μM Compound: Colchicine	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31185410]
HeLa	IC₅₀	0.03 μM Compound: Colchicine	Antiproliferative activity against human HeLa cells assessed as reduction in cell growth after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell growth after 48 hrs by MTT assay	[PMID: 31753698]
HeLa	IC₅₀	0.058 μM Compound: 1	Cytotoxicity against human HeLa cells after 24 to 72 hrs by Cell Titer Blue assay Cytotoxicity against human HeLa cells after 24 to 72 hrs by Cell Titer Blue assay	[PMID: 32432867]
HeLa	IC₅₀	0.081 μM Compound: Colchicine	Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay	[PMID: 32650183]
HeLa	IC₅₀	1.3 nM Compound: 1	Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 32827941]
HeLa	IC₅₀	55 nM Compound: Colchicine	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 33234343]
HeLa	IC₅₀	0.083 μM Compound: Colchicine	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 33788562]
HeLa	IC₅₀	0.103 μM Compound: Colchicine	Antiproliferative activity against human HeLa assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human HeLa assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34175541]
HeLa	IC₅₀	0.01 μM Compound: Colchicine	Cytotoxicity against human HeLa cells assessed as reduction in cell viability Cytotoxicity against human HeLa cells assessed as reduction in cell viability	[PMID: 34416378]
HeLa	IC₅₀	19.5 nM Compound: Colchicine	Antiproliferative activity against human HeLa cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HeLa cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
HeLa	IC₅₀	0.138 μM Compound: Colchicine	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 34968813]
HeLa	IC₅₀	16 nM Compound: Colchicine	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35084853]
HeLa	IC₅₀	0.042 μM Compound: Col	Antiproliferation activity against human HeLa cells assessed as reduction in cell growth measured after 48 to 72 hrs by CCK-8 assay Antiproliferation activity against human HeLa cells assessed as reduction in cell growth measured after 48 to 72 hrs by CCK-8 assay	[PMID: 35339837]
HeLa	IC₅₀	0.15 μM Compound: Colchicine	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay	[PMID: 35367708]
HeLa	IC₅₀	17.79 μM Compound: Colchicine	Anticancer activity against human HeLa cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Anticancer activity against human HeLa cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 35367708]
HeLa	IC₅₀	0.008 μM Compound: Colchicine	Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35447432]
HeLa	IC₅₀	17.79 μM Compound: Colchicine	Antiproliferative activity against human HeLa cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 36067627]
HeLa	IC₅₀	0.006 μM Compound: Colchicine	Cytotoxicity in human HeLa cells assessed as growth inhibition level after 48 hrs by SRB assay Cytotoxicity in human HeLa cells assessed as growth inhibition level after 48 hrs by SRB assay	[PMID: 36162138]
HeLa	IC₅₀	0.126 μM Compound: Colchicine	Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTT assay	[PMID: 36516438]
HeLa	IC₅₀	33.5 nM Compound: Colchicine	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 36621138]
HeLa	IC₅₀	0.28 μM Compound: Col	Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation incubated for 24 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation incubated for 24 hrs by MTT assay	[PMID: 36760739]
HeLa	IC₅₀	0.126 μM Compound: Colchicine	Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 37145846]
HeLa	IC₅₀	0.015 μM Compound: Colchicine	Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37201429]
HeLa	IC₅₀	0.033 μM Compound: 1	Antiproliferative activity against human HeLa cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
HeLa	IC₅₀	10.2 μM Compound: Colchicine	Antiproliferative activity against human HeLa cells assessed as reduction in cell growth Antiproliferative activity against human HeLa cells assessed as reduction in cell growth	[PMID: 38107170]
HeLa	IC₅₀	0.026 μM Compound: 2	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 1.5 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 1.5 hrs by CCK-8 assay	[PMID: 38107178]
HeLa	IC₅₀	11 nM Compound: Colchicine	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth	[PMID: 38294341]
HeLa	IC₅₀	19 nM Compound: Colchicine	Antiproliferative activity against human HeLa cells expressing tubulin betaIII assessed as inhibition of cell growth Antiproliferative activity against human HeLa cells expressing tubulin betaIII assessed as inhibition of cell growth	[PMID: 38294341]
HeLa	IC₅₀	16.7 nM Compound: Colchicine	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs in absence of verapamil by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs in absence of verapamil by MTT assay	[PMID: 38959729]
HeLa	IC₅₀	9.3 nM Compound: Colchicine	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs in presence of verapamil by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs in presence of verapamil by MTT assay	[PMID: 38959729]
HeLa	IC₅₀	0.01 μM Compound: Colchicine	Antiproliferative activity against human HeLa assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HeLa assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
HeLa	IC₅₀	9.35 nM Compound: Colchicine	Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTT assay	[PMID: 39197251]
HeLa	IC₅₀	18 nM Compound: colchicine	Inhibition of HeLa cell proliferation Inhibition of HeLa cell proliferation	[PMID: 7990108]
HeLa	IC₅₀	0.45 μM Compound: Colchicine	Antiproliferative activity against human HeLa cells measured after 24 hrs by MTT assay Antiproliferative activity against human HeLa cells measured after 24 hrs by MTT assay	10.1039/C6MD00255B
Hep 3B2	IC₅₀	0.014 μM Compound: Colchicine	Cytotoxicity against human Hep3B cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human Hep3B cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 25805446]
Hep 3B2	IC₅₀	0.14 μM Compound: Colchicine	Antiproliferative activity against human Hep3B cells measured after 72 hrs by MTT assay Antiproliferative activity against human Hep3B cells measured after 72 hrs by MTT assay	[PMID: 35193066]
Hepatocyte	CC₅₀	152.78 μM Compound: Colchicine	Cytotoxicity against mouse primary hepatocytes after 24 hrs by MTT assay Cytotoxicity against mouse primary hepatocytes after 24 hrs by MTT assay	[PMID: 30606674]
HepG2	EC₅₀	0.031 μM Compound: Colchicine	Cytotoxicity against human HepG2 cells after 48 hrs by luminescence cell viability assay Cytotoxicity against human HepG2 cells after 48 hrs by luminescence cell viability assay	[PMID: 18684625]
HepG2	IC₅₀	0.23 μg/mL Compound: Colchicine	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 21440448]
HepG2	IC₅₀	1.9 μM Compound: Colchicin	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 21576023]
HepG2	IC₅₀	0.05 μM Compound: Colchicin	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 21724404]
HepG2	IC₅₀	0.23 μM Compound: Colchicine	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 22512906]
HepG2	IC₅₀	0.02 μM Compound: Colchicine	Cytotoxicity against human HepG2 cells after 48 hrs Cytotoxicity against human HepG2 cells after 48 hrs	[PMID: 23022053]
HepG2	IC₅₀	46.74 nM Compound: 3	Cytotoxicity against human HepG2 cells after 72 hrs by CCK-8 assay Cytotoxicity against human HepG2 cells after 72 hrs by CCK-8 assay	[PMID: 23360369]
HepG2	IC₅₀	1.8 μM Compound: Colchicin	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 23735826]
HepG2	IC₅₀	>10 μM Compound: Colchicine	Growth inhibition of human HepG2 cells after 72 hrs by MTT assay Growth inhibition of human HepG2 cells after 72 hrs by MTT assay	[PMID: 23747810]
HepG2	IC₅₀	0.035 μM Compound: COL	Antiproliferative activity against human HepG2 cells after 48 hrs by SRB method Antiproliferative activity against human HepG2 cells after 48 hrs by SRB method	[PMID: 25061803]
HepG2	IC₅₀	1.71 μM Compound: Colchicine	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by CCK-8 assay Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by CCK-8 assay	[PMID: 25091926]
HepG2	IC₅₀	42 nM Compound: colchicine	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 25208345]
HepG2	IC₅₀	1.8 μM Compound: Colchicine	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 25778766]
HepG2	IC₅₀	0.027 μM Compound: Colchicine	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 25805446]
HepG2	GI₅₀	10.5 μM Compound: Colchicine	Growth inhibition of human HepG2 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay Growth inhibition of human HepG2 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay	[PMID: 26070164]
HepG2	IC₅₀	0.019 μM Compound: 1	Growth inhibition of human HepG2 cells incubated for 72 hrs by MTT assay Growth inhibition of human HepG2 cells incubated for 72 hrs by MTT assay	[PMID: 27172319]
HepG2	IC₅₀	42.8 nM Compound: 1	Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay	[PMID: 27213819]
HepG2	IC₅₀	0.1239 μM Compound: Colchicine	Antiproliferative activity against human HepG2 cells after 48 hrs by SRB assay Antiproliferative activity against human HepG2 cells after 48 hrs by SRB assay	[PMID: 27744186]
HepG2	IC₅₀	0.042 μM Compound: Colchicine	Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 28863359]
HepG2	IC₅₀	4.65 μM Compound: Colchicine	Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay	[PMID: 29268130]
HepG2	IC₅₀	0.046 μM Compound: Colchicine	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 30093295]
HepG2	IC₅₀	0.078 μM Compound: Colchicine	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 30106297]
HepG2	IC₅₀	0.42 μM Compound: Colchicine	Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay	[PMID: 30606674]
HepG2	IC₅₀	4.6 μM Compound: Colchicine	Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay	[PMID: 30690300]
HepG2	IC₅₀	5.8 μM Compound: Colchicine	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30878833]
HepG2	IC₅₀	1.47 μM Compound: Colchicine	Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay	[PMID: 32035399]
HepG2	IC₅₀	45 nM Compound: Colchicine	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 33234343]
HepG2	IC₅₀	13.6 nM Compound: Colchicine	Antiproliferative activity against human HepG2 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
HepG2	IC₅₀	0.064 μM Compound: Colchicine	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 34968813]
HepG2	IC₅₀	4.65 μM Compound: Colchicine	Anticancer activity against human HepG2 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Anticancer activity against human HepG2 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 35367708]
HepG2	IC₅₀	0.054 μM Compound: Colchicine	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36455508]
HepG2	IC₅₀	0.002 μM Compound: Colchicine	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 36511661]
HepG2	IC₅₀	0.025 μM Compound: Colchicine	Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay	[PMID: 36516438]
HepG2	IC₅₀	83.7 nM Compound: Colchicine	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 36621138]
HepG2	IC₅₀	0.025 μM Compound: Colchicine	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 37145846]
HepG2	IC₅₀	75 nM Compound: 1	Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
HepG2	IC₅₀	5.8 μM Compound: Colchicine	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 38107170]
HepG2	IC₅₀	5 nM Compound: Colchicine	Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay	[PMID: 39197251]
HepG2	IC₅₀	0.64 μM Compound: Colchicine	Antiproliferative activity against human HepG2 cells measured after 24 hrs by MTT assay Antiproliferative activity against human HepG2 cells measured after 24 hrs by MTT assay	10.1039/C6MD00255B
HGC-27	IC₅₀	0.003 μM Compound: Colchicine	Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 36511661]
HL-60	IC₅₀	1.6 μg/mL Compound: Colchicine	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 15165134]
HL-60	IC₅₀	1.6 μg/mL Compound: colchicine	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 15620246]
HL-60	IC₅₀	>100 μM Compound: 1	Cytotoxicity against vincristine-resistant human HL60 cells after 72 hrs MTS assay Cytotoxicity against vincristine-resistant human HL60 cells after 72 hrs MTS assay	[PMID: 20411988]
HL-60	IC₅₀	0.053 μM Compound: 1	Cytotoxicity against human HL60 cells after 72 hrs MTS assay Cytotoxicity against human HL60 cells after 72 hrs MTS assay	[PMID: 20411988]
HL-60	EC₅₀	0.0086 μM Compound: Colchicine	Antiproliferative activity against human HL60 cells after 96 hrs by MTT assay Antiproliferative activity against human HL60 cells after 96 hrs by MTT assay	[PMID: 29055869]
HMEC	IC₅₀	8.1 μM Compound: Colchicine	Antiproliferative activity against human HMEC cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HMEC cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30878833]
HMEC-1	IC₅₀	0.0038 μM Compound: 1, colch	Antiproliferative activity against HMEC1 after 4 days by coulter counter analysis Antiproliferative activity against HMEC1 after 4 days by coulter counter analysis	[PMID: 24773591]
HMEC-1	IC₅₀	0.0038 μM Compound: Colchicine	Antiproliferative activity against human HMEC1 cells assessed as inhibition of cell proliferation after 4 days by Coulter counter based cell counting method Antiproliferative activity against human HMEC1 cells assessed as inhibition of cell proliferation after 4 days by Coulter counter based cell counting method	[PMID: 25282265]
HMEC-1	IC₅₀	0.0038 μM Compound: Colchicine	Antiproliferative activity against human HMEC1 cells after 4 days by coulter counting method Antiproliferative activity against human HMEC1 cells after 4 days by coulter counting method	[PMID: 29471122]
HMEC-1	IC₅₀	0.0038 μM Compound: 5	Antiproliferative activity against human HMEC1 cells measured after 4 days by Coulter counter method Antiproliferative activity against human HMEC1 cells measured after 4 days by Coulter counter method	[PMID: 30921759]
HN-6	IC₅₀	19.5 nM Compound: Colchicine	Antiproliferative activity against human HN-6 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human HN-6 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay	[PMID: 35576703]
HT	ED₅₀	0.004 μg/mL Compound: colchicine	Cytotoxicity against human HT cells Cytotoxicity against human HT cells	[PMID: 8133298]
HT-1080	IC₅₀	1.1 nM Compound: Col	Antiproliferative activity against human HT1080 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human HT1080 cells after 48 hrs by sulforhodamine B assay	[PMID: 21604746]
HT-1080	IC₅₀	1.1 nM Compound: Col	Antiproliferative activity against human HT1080 after 48 hrs by SRB assay Antiproliferative activity against human HT1080 after 48 hrs by SRB assay	[PMID: 21920638]
HT-1080	IC₅₀	15.38 nM Compound: 3	Cytotoxicity against human HT1080 cells after 72 hrs by CCK-8 assay Cytotoxicity against human HT1080 cells after 72 hrs by CCK-8 assay	[PMID: 23360369]
HT-1080	IC₅₀	0.042 μM Compound: 1	Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay	[PMID: 30245397]
HT-1080	IC₅₀	0.073 μM Compound: 1	Antiproliferative activity against human HT-1080 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human HT-1080 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37182330]
HT-29	GI₅₀	0.004 μM Compound: colchicine	Growth inhibition of human HT29 cells after 48 hrs Growth inhibition of human HT29 cells after 48 hrs	[PMID: 17498960]
HT-29	GI₅₀	0.004 μM Compound: colchicine	Antiproliferative activity against human HT29 cells Antiproliferative activity against human HT29 cells	[PMID: 18502639]
HT-29	GI₅₀	0.004 μM Compound: colchicine	Growth inhibition of human HT29 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HT29 cells after 48 hrs by sulforhodamine B assay	[PMID: 18579387]
HT-29	GI₅₀	0.004 μM Compound: COL	Antiproliferative activity against human HT29 cells after 48 hrs by sulforhodamine B method Antiproliferative activity against human HT29 cells after 48 hrs by sulforhodamine B method	[PMID: 18617414]
HT-29	IC₅₀	10 nM Compound: 1	Growth inhibition of human HT-29 cells after 72 hrs by methylene blue dye assay Growth inhibition of human HT-29 cells after 72 hrs by methylene blue dye assay	[PMID: 19053773]
HT-29	IC₅₀	10 nM Compound: Colchicine	Cytotoxicity against human HT-29 cells after 72 hrs by methylene blue dye assay Cytotoxicity against human HT-29 cells after 72 hrs by methylene blue dye assay	[PMID: 19586033]
HT-29	IC₅₀	13.2 nM Compound: 3	Antiproliferative activity against human HT-29 cells after 72 hrs by methylene blue dye assay Antiproliferative activity against human HT-29 cells after 72 hrs by methylene blue dye assay	[PMID: 20148562]
HT-29	IC₅₀	<1 μM Compound: Colchicine	Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 20833451]
HT-29	IC₅₀	16.6 nM Compound: Colchicine	Cytotoxicity against human HT-29 cells after 72 hrs by XTT/PMS method Cytotoxicity against human HT-29 cells after 72 hrs by XTT/PMS method	[PMID: 21106379]
HT-29	IC₅₀	21.9 nM Compound: Colchicine	Antiproliferative activity against human HT-29 cells after 72 hrs by sulforhodamine B assay Antiproliferative activity against human HT-29 cells after 72 hrs by sulforhodamine B assay	[PMID: 21480626]
HT-29	IC₅₀	15 nM Compound: 5	Antiproliferative activity against human HT-29 cells after 72 hrs by methylene blue assay Antiproliferative activity against human HT-29 cells after 72 hrs by methylene blue assay	[PMID: 21641700]
HT-29	IC₅₀	16.2 nM Compound: 1	Growth inhibition of human HT-29 cells after 72 hrs by methylene blue assay Growth inhibition of human HT-29 cells after 72 hrs by methylene blue assay	[PMID: 22060033]
HT-29	IC₅₀	16 nM Compound: colchicine	Cytotoxicity against human HT-29 cells after 48 hrs using resazurin by microplate fluorometer analysis Cytotoxicity against human HT-29 cells after 48 hrs using resazurin by microplate fluorometer analysis	[PMID: 22185476]
HT-29	IC₅₀	0.008 μM Compound: Colchicine	Cytotoxicity against human HT-29 cells Cytotoxicity against human HT-29 cells	[PMID: 22542017]
HT-29	IC₅₀	0.01 μM Compound: Colchicine	Cytotoxicity against human HT-29 cells after 96 hrs by MTT assay Cytotoxicity against human HT-29 cells after 96 hrs by MTT assay	[PMID: 22542017]
HT-29	IC₅₀	16 nM Compound: 1	Cytotoxicity against human HT-29 cells after 48 hrs by resazurin assay Cytotoxicity against human HT-29 cells after 48 hrs by resazurin assay	[PMID: 22727370]
HT-29	IC₅₀	9.3 nM Compound: 1	Cytotoxicity against human HT-29 cells after 48 hrs by XTT assay Cytotoxicity against human HT-29 cells after 48 hrs by XTT assay	[PMID: 22727370]
HT-29	IC₅₀	69.25 nM Compound: colchicine	Cytotoxicity against human HT-29 cells after 96 hrs by MTT assay Cytotoxicity against human HT-29 cells after 96 hrs by MTT assay	[PMID: 23176628]
HT-29	IC₅₀	18 nM Compound: 1	Cytotoxicity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 23214452]
HT-29	IC₅₀	0.02 μM Compound: Colchicine	Cytotoxicity against human HT-29 cells by MTT assay Cytotoxicity against human HT-29 cells by MTT assay	[PMID: 23425970]
HT-29	IC₅₀	0.07 μM Compound: Colchicine	Growth inhibition of human HT-29 cells after 72 hrs by MTT assay Growth inhibition of human HT-29 cells after 72 hrs by MTT assay	[PMID: 23747810]
HT-29	IC₅₀	15.2 nM Compound: 1	Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay	[PMID: 24106982]
HT-29	IC₅₀	12.8 nM Compound: colchicine	Cytotoxicity against human HT-29 cells after 72 hrs by methylene blue assay Cytotoxicity against human HT-29 cells after 72 hrs by methylene blue assay	[PMID: 24657567]
HT-29	IC₅₀	0.008 μM Compound: 1	Cytotoxicity against human HT-29 cells after 96 hrs using tetracolor one Cytotoxicity against human HT-29 cells after 96 hrs using tetracolor one	[PMID: 24900316]
HT-29	IC₅₀	0.05 μM Compound: colchicine	Cytotoxicity against human HT-29 cells after 3 days by MTT assay Cytotoxicity against human HT-29 cells after 3 days by MTT assay	[PMID: 25426924]
HT-29	IC₅₀	18 nM Compound: Colchicine	Antiproliferative activity against human HT-29 cells after 96 hrs by MTT assay Antiproliferative activity against human HT-29 cells after 96 hrs by MTT assay	[PMID: 2778449]
HT-29	IC₅₀	50 nM Compound: Colchicine	Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 27915168]
HT-29	IC₅₀	50 nM Compound: Colchicine	Antiproliferative activity against human HT-29 cells after 2 days by MTT assay Antiproliferative activity against human HT-29 cells after 2 days by MTT assay	[PMID: 29550732]
HT-29	IC₅₀	13 nM Compound: Colchicine	Antiproliferative activity against human HT-29 cells after 2 days by MTT assay Antiproliferative activity against human HT-29 cells after 2 days by MTT assay	[PMID: 29604583]
HT-29	IC₅₀	11.5 nM Compound: Colchicine	Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay	[PMID: 30099258]
HT-29	IC₅₀	1.81 μM Compound: Colchicine	Antiproliferative activity against human HT29 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HT29 cells incubated for 48 hrs by MTT assay	[PMID: 32035399]
HT-29	IC₅₀	0.042 μM Compound: 1	Cytotoxicity against human HT-29 cells incubated for 48 hrs by MTT assay Cytotoxicity against human HT-29 cells incubated for 48 hrs by MTT assay	[PMID: 32432867]
HT-29	IC₅₀	5.19 μM Compound: Colchicine	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay	[PMID: 32768647]
HT-29	IC₅₀	20.5 nM Compound: Colchicine	Antiproliferative activity against human HT-29 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
HT-29	IC₅₀	0.018 μM Compound: Colchicine	Antiproliferative activity against human HT-29 cells over expressing GLUT1 measured after 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells over expressing GLUT1 measured after 72 hrs by MTT assay	[PMID: 35193066]
HT-29	IC₅₀	0.25 μM Compound: Colchicine	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35447432]
HT-29	IC₅₀	5.19 μM Compound: Colchicine	Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 36067627]
HT-29	IC₅₀	0.22 μM Compound: Col	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation incubated for 24 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation incubated for 24 hrs by MTT assay	[PMID: 36760739]
HT-29	IC₅₀	5.19 μM Compound: Colchicine	Cytotoxicity against human HT-29 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay	[PMID: 37567059]
HT-29	IC₅₀	0.031 μM Compound: 1	Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
HT-29	IC₅₀	0.059 μM Compound: Colchicine	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
HT-29	IC₅₀	15.2 nM Compound: 6	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth after 72 hrs by methylene blue dye assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth after 72 hrs by methylene blue dye assay	10.1039/C0MD00052C
HT-29	IC₅₀	8.2 nM Compound: 1	Cytotoxicity against human HT-29 cells after 96 hrs by microplate reader analysis Cytotoxicity against human HT-29 cells after 96 hrs by microplate reader analysis	10.1039/C2MD20250F
HT-29	IC₅₀	0.008 μM Compound: Colchicine	Antiproliferative activity against human HT-29 cells by MTS assay Antiproliferative activity against human HT-29 cells by MTS assay	10.1039/C3MD00077J
HT-29	IC₅₀	8.2 nM Compound: 1	Cytotoxicity against human HT-29 cells assessed as inhibition of cell proliferation after 96 hrs Cytotoxicity against human HT-29 cells assessed as inhibition of cell proliferation after 96 hrs	10.1039/C3MD00287J
Huh-7	IC₅₀	26.1 nM Compound: Colchicine	Antiproliferative activity against human Huh-7 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human Huh-7 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
Huh-7	IC₅₀	0.024 μM Compound: Colchicine	Antiproliferative activity against human Huh-7 cells assessed as cell growth inhibition incubated for72 hrs by MTT assay Antiproliferative activity against human Huh-7 cells assessed as cell growth inhibition incubated for72 hrs by MTT assay	[PMID: 37890199]
HUVEC	IC₅₀	7.6 nM Compound: 3	Antiproliferative activity against quesicent HUVECs after 48 hrs by CCK-8 assay Antiproliferative activity against quesicent HUVECs after 48 hrs by CCK-8 assay	[PMID: 23360369]
HUVEC	IC₅₀	8.91 nM Compound: 3	Antiproliferative activity against activated HUVECs after 48 hrs by CCK-8 assay Antiproliferative activity against activated HUVECs after 48 hrs by CCK-8 assay	[PMID: 23360369]
HUVEC	IC₅₀	0.023 μM Compound: 1a	Cytotoxicity against human HUVEC cells after 24 hrs by MTT assay Cytotoxicity against human HUVEC cells after 24 hrs by MTT assay	[PMID: 23524161]
HUVEC	IC₅₀	13.2 nM Compound: 1	Cytotoxicity against HUVEC assessed as cell viability after 4 days by MTS assay Cytotoxicity against HUVEC assessed as cell viability after 4 days by MTS assay	[PMID: 24210503]
HUVEC	GI₅₀	25 nM Compound: Colchicine	Growth inhibition of HUVEC after 72 hrs by crystal violet staining-based assay Growth inhibition of HUVEC after 72 hrs by crystal violet staining-based assay	[PMID: 27690431]
HUVEC	IC₅₀	>10000 nM Compound: Colchicine	Antiproliferative activity against HUVEC after 72 hrs by MTS assay Antiproliferative activity against HUVEC after 72 hrs by MTS assay	[PMID: 30099258]
HUVEC	IC₅₀	0.012 μM Compound: Colchicine	Cytotoxicity against HUVEC measured after 72 hrs by MTT assay Cytotoxicity against HUVEC measured after 72 hrs by MTT assay	[PMID: 35193066]
HUVEC	IC₅₀	0.025 μM Compound: Colchicine	Anti-angiogenesis activity against HUVEC cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Anti-angiogenesis activity against HUVEC cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 36511661]
HUVEC	IC₅₀	0.21 μM Compound: 1	Cytotoxicity against HUVEC cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Cytotoxicity against HUVEC cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37182330]
HUVEC	IC₅₀	9.62 μM Compound: 2	Cytotoxicity against human HUVEC cells assessed as inhibition of cell growth incubated 1.5 hrs by MTT assay Cytotoxicity against human HUVEC cells assessed as inhibition of cell growth incubated 1.5 hrs by MTT assay	[PMID: 38107178]
J774	IC₅₀	0.21 μM Compound: colchicine	Cytotoxicity against mouse J774 cells by alamar blue assay Cytotoxicity against mouse J774 cells by alamar blue assay	[PMID: 17637068]
J774	ED₅₀	17 μM Compound: 1a	Cytotoxic activity against mouse macrophage cell line J7.VBL-1 Cytotoxic activity against mouse macrophage cell line J7.VBL-1	[PMID: 1956052]
J774	ED₅₀	200 μM Compound: 1a	Cytotoxic activity against mouse macrophage cell line J7.COL-100. Cytotoxic activity against mouse macrophage cell line J7.COL-100.	[PMID: 1956052]
J774	IC₅₀	93.1 nM Compound: Colchicine	Inhibitory concentration required for cytotoxicity in J774.2 murine macrophage-like cells Inhibitory concentration required for cytotoxicity in J774.2 murine macrophage-like cells	10.1016/0960-894X(95)00300-I
J774.2	ED₅₀	0.06 μM Compound: 1a	Cytotoxic activity against mouse macrophage cell line J774.2 Cytotoxic activity against mouse macrophage cell line J774.2	[PMID: 1956052]
J774.2	IC₅₀	228.3 nM Compound: Colchicine	Inhibitory concentration required for cytotoxicity in DOX-resistant (DOX/R) cells Inhibitory concentration required for cytotoxicity in DOX-resistant (DOX/R) cells	10.1016/0960-894X(95)00300-I
J774.2	IC₅₀	51.5 nM Compound: Colchicine	Inhibitory concentration required for cytotoxicity in hydroxyrubicin-resistant (WP159/R) cells Inhibitory concentration required for cytotoxicity in hydroxyrubicin-resistant (WP159/R) cells	10.1016/0960-894X(95)00300-I
Jurkat	IC₅₀	0.017 μM Compound: 1	Cell cycle arrest in human Jurkat cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis Cell cycle arrest in human Jurkat cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis	[PMID: 21126027]
Jurkat	IC₅₀	0.0077 μM Compound: 1a	Cytotoxicity against human Jurkat cells after 48 hrs by MTT assay Cytotoxicity against human Jurkat cells after 48 hrs by MTT assay	[PMID: 23524161]
Jurkat	IC₅₀	13.5 nM Compound: 1	Cytotoxicity against human Jurkat cells after 48 hrs by Celltiter-Glo luminescent cell viability assay Cytotoxicity against human Jurkat cells after 48 hrs by Celltiter-Glo luminescent cell viability assay	[PMID: 26985296]
Jurkat	IC₅₀	19.8 nM Compound: Colchicine	Antiproliferative activity against human Jurkat cells after 72 hrs by MTS assay Antiproliferative activity against human Jurkat cells after 72 hrs by MTS assay	[PMID: 30099258]
K562	IC₅₀	0.02 μM Compound: 2 (Colchicine)	In vitro inhibitory concentration against human chronic myelogenous leukemia K562 cell growth In vitro inhibitory concentration against human chronic myelogenous leukemia K562 cell growth	[PMID: 12852768]
K562	IC₅₀	0.02 μM Compound: 2	Antiproliferative activity against human K562 cell line Antiproliferative activity against human K562 cell line	[PMID: 17181164]
K562	IC₅₀	0.02 μM Compound: colchicine	Antiproliferative activity against human K562 cells after 48 hrs Antiproliferative activity against human K562 cells after 48 hrs	[PMID: 17973361]
K562	IC₅₀	0.02 μM Compound: colchicine	Antiproliferative activity against human K562 cells after 48 hrs Antiproliferative activity against human K562 cells after 48 hrs	[PMID: 19220018]
K562	IC₅₀	29 nM Compound: colchicine	Cytotoxicity against human K562 cells after 72 hrs Cytotoxicity against human K562 cells after 72 hrs	[PMID: 19530698]
K562	IC₅₀	0.02 μM Compound: 2	Antiproliferative activity against human K562 cells after 48 hrs Antiproliferative activity against human K562 cells after 48 hrs	[PMID: 20537765]
K562	IC₅₀	0.02 μM Compound: 2	Cell growth inhibition of human K562 cells after 48 hrs Cell growth inhibition of human K562 cells after 48 hrs	[PMID: 20546980]
K562	IC₅₀	1.4 μM Compound: 2	Inhibition of tubulin polymerization in human K562 cells Inhibition of tubulin polymerization in human K562 cells	[PMID: 20546980]
K562	IC₅₀	0.02 μM Compound: 18	Growth inhibition of human K562 cells after 48 hrs by trypan blue assay Growth inhibition of human K562 cells after 48 hrs by trypan blue assay	[PMID: 21530013]
K562	IC₅₀	0.02 μM Compound: colchicine	Antiproliferative activity against human K562 cells after 48 hrs by hemocytometric analysis Antiproliferative activity against human K562 cells after 48 hrs by hemocytometric analysis	[PMID: 21563750]
K562	IC₅₀	6.8 nM Compound: Col	Antiproliferative activity against human K562 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human K562 cells after 48 hrs by sulforhodamine B assay	[PMID: 21604746]
K562	IC₅₀	0.02 μM Compound: 2	Antiproliferative activity against human K562 cells after 48 hrs by hemocytometer Antiproliferative activity against human K562 cells after 48 hrs by hemocytometer	[PMID: 21705223]
K562	IC₅₀	6.8 nM Compound: Col	Antiproliferative activity against human K562 after 48 hrs by SRB assay Antiproliferative activity against human K562 after 48 hrs by SRB assay	[PMID: 21920638]
K562	IC₅₀	0.55 μM Compound: Colchicine	Cytotoxicity against human K562 cells after 48 hrs Cytotoxicity against human K562 cells after 48 hrs	[PMID: 23022053]
K562	IC₅₀	0.02 μM Compound: Colchicine	Growth inhibition of human K562 cells after 24 hrs by trypan blue exclusion assay Growth inhibition of human K562 cells after 24 hrs by trypan blue exclusion assay	[PMID: 23747810]
K562	IC₅₀	0.001 μM Compound: Colchicine	Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by CCK-8 assay Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by CCK-8 assay	[PMID: 25091926]
K562	IC₅₀	16 nM Compound: colchicine	Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 25208345]
K562	IC₅₀	0.02 μM Compound: Colchicine	Growth inhibition of human K562 cells incubated for 24 hrs by trypan blue dye exclusion assay Growth inhibition of human K562 cells incubated for 24 hrs by trypan blue dye exclusion assay	[PMID: 26344588]
K562	IC₅₀	0.02 μM Compound: colchicine	Antiproliferative activity against human K562 cells after 48 hrs by Alamar blue dye based neubauer hemocytometer method Antiproliferative activity against human K562 cells after 48 hrs by Alamar blue dye based neubauer hemocytometer method	[PMID: 28045256]
K562	IC₅₀	19 μM Compound: 2	Cytotoxicity against human K562 cells assessed as growth inhibition after 5 days by MTT assay Cytotoxicity against human K562 cells assessed as growth inhibition after 5 days by MTT assay	[PMID: 28143677]
K562	GI₅₀	0.02 μM Compound: Colchicine	Antiproliferative activity against human K562 cells after 48 hrs by MTT assay Antiproliferative activity against human K562 cells after 48 hrs by MTT assay	[PMID: 28763647]
K562	IC₅₀	0.44 μM Compound: Colchicine	Antiproliferative activity against human K562 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human K562 cells incubated for 48 hrs by MTT assay	[PMID: 32035399]
K562	IC₅₀	6.59 μM Compound: Colchicine	Antiproliferative activity against drug resistant human K562 cells incubated for 48 hrs by MTT assay Antiproliferative activity against drug resistant human K562 cells incubated for 48 hrs by MTT assay	[PMID: 32035399]
K562	IC₅₀	0.013 μM Compound: Colchicine	Antiproliferative activity against human K562 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 33212157]
K562	IC₅₀	101.8 nM Compound: Colchicine	Antiproliferative activity against human K562 cells measured after 72 hrs by SRB assay Antiproliferative activity against human K562 cells measured after 72 hrs by SRB assay	[PMID: 34794817]
K562	IC₅₀	0.975 μM Compound: Colchicine	Cytotoxicity against human K562 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human K562 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37201429]
K562	IC₅₀	14.1 nM Compound: colchicine	Inhibition of K562 cell proliferation Inhibition of K562 cell proliferation	[PMID: 7990108]
K562/Adr	IC₅₀	6553 nM Compound: Colchicine	Antiproliferative activity against human K562/Adr cells measured after 72 hrs by SRB assay Antiproliferative activity against human K562/Adr cells measured after 72 hrs by SRB assay	[PMID: 34794817]
KB	IC₅₀	>100 nM Compound: Colchicine	The compound was tested for its cytotoxic concentration required to inhibit the replication of human tumor nasopharynx (KB-VIN) cell lines which is drug resistant The compound was tested for its cytotoxic concentration required to inhibit the replication of human tumor nasopharynx (KB-VIN) cell lines which is drug resistant	[PMID: 12270161]
KB	IC₅₀	11.9 nM Compound: Colchicine	The compound was tested for its cytotoxic concentration required to inhibit the replication of human tumor nasopharynx (KB) cell lines The compound was tested for its cytotoxic concentration required to inhibit the replication of human tumor nasopharynx (KB) cell lines	[PMID: 12270161]
KB	IC₅₀	0.03 μM Compound: 2 (Colchicine)	Cytotoxic activity against cellular metabolic activity of Cervix KB/HeLa tumor cell line using XTT proliferation assay after incubation with the compound for 48 h Cytotoxic activity against cellular metabolic activity of Cervix KB/HeLa tumor cell line using XTT proliferation assay after incubation with the compound for 48 h	[PMID: 12852768]
KB	IC₅₀	117 nM Compound: Colchicine	Cytotoxicity against KB-VIN 10 cell line by methylene blue dye assay Cytotoxicity against KB-VIN 10 cell line by methylene blue dye assay	[PMID: 17154496]
KB	IC₅₀	13.3 nM Compound: Colchicine	Cytotoxicity against human KB cell line by methylene blue dye assay Cytotoxicity against human KB cell line by methylene blue dye assay	[PMID: 17154496]
KB	EC₅₀	14 nM Compound: 2	Cell cycle arrest in KB/HeLa cells by accumulation at G2/M phase Cell cycle arrest in KB/HeLa cells by accumulation at G2/M phase	[PMID: 17181164]
KB	IC₅₀	0.03 μM Compound: 2	Antiproliferative activity against KB/HeLa cells by XTT assay after 48 hrs Antiproliferative activity against KB/HeLa cells by XTT assay after 48 hrs	[PMID: 17181164]
KB	IC₅₀	12 nM Compound: colchichine	Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay	[PMID: 17685504]
KB	EC₅₀	14 nM Compound: colchicine	Cell cycle arrest in KB/HeLa cells assessed as accumulation at G2/M phase after 24 hrs by flow cytometric analysis Cell cycle arrest in KB/HeLa cells assessed as accumulation at G2/M phase after 24 hrs by flow cytometric analysis	[PMID: 17973361]
KB	IC₅₀	0.03 μM Compound: colchicine	Cytotoxicity against human KB/HeLa cells after 48 hrs by XTT assay Cytotoxicity against human KB/HeLa cells after 48 hrs by XTT assay	[PMID: 17973361]
KB	IC₅₀	0.02 μM Compound: 1, colchicine	Cytotoxicity against human KB cells after 72 hrs Cytotoxicity against human KB cells after 72 hrs	[PMID: 18503262]
KB	IC₅₀	11.4 nM Compound: 4	Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay	[PMID: 18588280]
KB	IC₅₀	11 nM Compound: 1	Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay	[PMID: 19053773]
KB	IC₅₀	116 nM Compound: 1	Growth inhibition of human Pgp170 overexpressing multidrug resistant-KB-VIN10 cells after 72 hrs by methylene blue dye assay Growth inhibition of human Pgp170 overexpressing multidrug resistant-KB-VIN10 cells after 72 hrs by methylene blue dye assay	[PMID: 19053773]
KB	EC₅₀	14 nM Compound: colchicine	Cell cycle arrest in human KB/HeLa cells assessed as G2/M phase accumulation after 24 hrs by FACS analysis Cell cycle arrest in human KB/HeLa cells assessed as G2/M phase accumulation after 24 hrs by FACS analysis	[PMID: 19220018]
KB	IC₅₀	0.01 μM Compound: colchicine	Antiproliferative activity against human KB/HeLa cells by XTT assay Antiproliferative activity against human KB/HeLa cells by XTT assay	[PMID: 19220018]
KB	IC₅₀	11 nM Compound: Colchicine	Cytotoxicity against human KB cells after 72 hrs by methylene blue dye assay Cytotoxicity against human KB cells after 72 hrs by methylene blue dye assay	[PMID: 19586033]
KB	ED₅₀	<0.3 μg/mL Compound: 19 (-)-Colchicine	In vitro effective dose to inhibit KB cell growth from a human epidermoid carcinoma. In vitro effective dose to inhibit KB cell growth from a human epidermoid carcinoma.	[PMID: 1992152]
KB	IC₅₀	12 nM Compound: 3	Antiproliferative activity against human KB cells after 72 hrs by methylene blue dye assay Antiproliferative activity against human KB cells after 72 hrs by methylene blue dye assay	[PMID: 20148562]
KB	IC₅₀	0.013 μM Compound: Colchicine	Cytotoxicity against human KB cells after 48 hrs by MTT assay Cytotoxicity against human KB cells after 48 hrs by MTT assay	[PMID: 20363142]
KB	EC₅₀	14 nM Compound: 2	Cell cycle arrest in human KB/HeLa cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis Cell cycle arrest in human KB/HeLa cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis	[PMID: 20537765]
KB	IC₅₀	0.03 μM Compound: 2	Antiproliferative activity against human KB/HeLa cells after 48 hrs by XTT assay Antiproliferative activity against human KB/HeLa cells after 48 hrs by XTT assay	[PMID: 20537765]
KB	ED₅₀	0.0038 μg/mL Compound: 1	Cytotoxicity against human KB cells after 2 days Cytotoxicity against human KB cells after 2 days	[PMID: 20542428]
KB	EC₅₀	10 nM Compound: Colchicine	Cell cycle arrest in human KB cells assessed as accumulation of cells at G2/M phase after 24 hrs by propidium iodide-based FACScan Cell cycle arrest in human KB cells assessed as accumulation of cells at G2/M phase after 24 hrs by propidium iodide-based FACScan	[PMID: 21480626]
KB	IC₅₀	10 nM Compound: 5	Antiproliferative activity against human KB cells after 72 hrs by methylene blue assay Antiproliferative activity against human KB cells after 72 hrs by methylene blue assay	[PMID: 21641700]
KB	EC₅₀	14 nM Compound: 2	Cell cycle arrest in human KB/HeLa cells assessed as accumulation of cells at G2/M phase after 24 hrs by flow cytometry Cell cycle arrest in human KB/HeLa cells assessed as accumulation of cells at G2/M phase after 24 hrs by flow cytometry	[PMID: 21705223]
KB	IC₅₀	0.03 μM Compound: 2	Cytotoxicity against human KB/HeLa cells after 48 hrs by XTT assay Cytotoxicity against human KB/HeLa cells after 48 hrs by XTT assay	[PMID: 21705223]
KB	IC₅₀	10.3 nM Compound: 1	Growth inhibition of human KB cells after 72 hrs by methylene blue assay Growth inhibition of human KB cells after 72 hrs by methylene blue assay	[PMID: 22060033]
KB	IC₅₀	10.3 nM Compound: 1	Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay	[PMID: 24106982]
KB	IC₅₀	12.4 nM Compound: colchicine	Cytotoxicity against human KB cells after 72 hrs by methylene blue assay Cytotoxicity against human KB cells after 72 hrs by methylene blue assay	[PMID: 24657567]
KB	IC₅₀	12.4 nM Compound: Colchicine	Antiproliferative activity against human KB cells after 72 hrs by methylene blue assay Antiproliferative activity against human KB cells after 72 hrs by methylene blue assay	[PMID: 26160020]
KB	GI₅₀	4.2 nM Compound: Colchicine	Growth inhibition of human KB cells after 72 hrs by MTS assay Growth inhibition of human KB cells after 72 hrs by MTS assay	[PMID: 26778612]
KB	IC₅₀	18.2 nM Compound: Colchicine	Antiproliferative activity against human KB cells measured after 72 hrs by SRB assay Antiproliferative activity against human KB cells measured after 72 hrs by SRB assay	[PMID: 34794817]
KB	ED₅₀	0.23 μg/mL Compound: Colchicine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 7130986]
KB	ED₅₀	0.2 μg/mL Compound: Colchicine	Cytotoxicity against human KB cells after 3 days by SRB assay Cytotoxicity against human KB cells after 3 days by SRB assay	[PMID: 7528785]
KB	IC₅₀	5.6 nM Compound: colchicine	Inhibition of KB cell proliferation Inhibition of KB cell proliferation	[PMID: 7990108]
KB	ED₅₀	0.02 μg/mL Compound: colchicine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 8133298]
KB	ED₅₀	2 nM Compound: 1	Cytotoxicity against human solid tumor nasopharyngeal carcinoma KB cell line Cytotoxicity against human solid tumor nasopharyngeal carcinoma KB cell line	[PMID: 8496935]
KB	ED₅₀	0.002 μg/mL Compound: colchicine	Cytotoxicity against human epidermoid carcinoma of the nasopharyngeal cells (KB) using SRB assay. Cytotoxicity against human epidermoid carcinoma of the nasopharyngeal cells (KB) using SRB assay.	[PMID: 9544215]
KB	EC₅₀	0.002 μg/mL Compound: 1	In vitro growth inhibition of KB, epidermoid carcinoma of the nasopharynx. In vitro growth inhibition of KB, epidermoid carcinoma of the nasopharynx.	[PMID: 9599244]
KB	IC₅₀	10.3 nM Compound: 6	Antiproliferative activity against human KB cells assessed as inhibition of cell growth after 72 hrs by methylene blue dye assay Antiproliferative activity against human KB cells assessed as inhibition of cell growth after 72 hrs by methylene blue dye assay	10.1039/C0MD00052C
KB 3-1	IC₅₀	3.99 nM Compound: Colchicine	Cytotoxicity against KB-3-1 cell line Cytotoxicity against KB-3-1 cell line	[PMID: 17249649]
KB 3-1	IC₅₀	0.018 μM Compound: Colchicine	Cytotoxicity against human KB-3-1 cells after 72 hrs by MTT assay Cytotoxicity against human KB-3-1 cells after 72 hrs by MTT assay	[PMID: 23932339]
KB 3-1	IC₅₀	0.02 μM Compound: 2	Cytotoxicity against human KB3-1 cells after 68 hrs by MTT assay Cytotoxicity against human KB3-1 cells after 68 hrs by MTT assay	[PMID: 32243160]
KB 3-1	IC₅₀	9 nM Compound: 1	Antiproliferative activity against human KB-31 cells incubated for 96 hrs by spectrophotometric method Antiproliferative activity against human KB-31 cells incubated for 96 hrs by spectrophotometric method	[PMID: 32432867]
KB 3-1	IC₅₀	1.9 μM Compound: Colchicine	Antiproliferative activity against human KB-3-1 cells assessed as cell growth inhibition Antiproliferative activity against human KB-3-1 cells assessed as cell growth inhibition	[PMID: 38733884]
KB-V1	IC₅₀	620 nM Compound: Colchicine	Cytotoxicity against P-glycoprotein-overexpressing KB-V1 cell line Cytotoxicity against P-glycoprotein-overexpressing KB-V1 cell line	[PMID: 17249649]
KB-V1	IC₅₀	1340 nM Compound: Colchicine	Antiproliferative activity against human KB-V1 cells measured after 72 hrs by SRB assay Antiproliferative activity against human KB-V1 cells measured after 72 hrs by SRB assay	[PMID: 34794817]
KB-V1	ED₅₀	3.5 μg/mL Compound: colchicine	Cytotoxicity against multidrug-resistant human KBV1 cells Cytotoxicity against multidrug-resistant human KBV1 cells	[PMID: 8133298]
Kelly	GI₅₀	0.009 μM Compound: Colchicine	Growth inhibition of MYCN-amplified human Kelly cells assessed as reduction in cell viability measured after 3 days by Celltiter-glo assay Growth inhibition of MYCN-amplified human Kelly cells assessed as reduction in cell viability measured after 3 days by Celltiter-glo assay	[PMID: 37736192]
KP-4	IC₅₀	0.033 μM Compound: 1	Antiproliferative activity against human KP-4 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human KP-4 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
KYSE-30	IC₅₀	0.28 μM Compound: Colchicine	Antiproliferative activity against human KYSE-30 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human KYSE-30 cells incubated for 48 hrs by CCK8 assay	[PMID: 33965530]
KYSE-30	IC₅₀	0.28 μM Compound: Colchicine	Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay	[PMID: 34022412]
KYSE-30	IC₅₀	0.068 μM Compound: Colchicine	Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38150962]
KYSE-30	IC₅₀	0.048 μM Compound: Colchicine	Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell growth measured after 48 hrs by CCK8 method Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell growth measured after 48 hrs by CCK8 method	[PMID: 38181651]
KYSE-450	IC₅₀	0.22 μM Compound: Colchicine	Antiproliferative activity against human KYSE-450 cells assessed as cell growth inhibition measured after 48 hrs by CCK8 assay Antiproliferative activity against human KYSE-450 cells assessed as cell growth inhibition measured after 48 hrs by CCK8 assay	[PMID: 34971875]
KYSE-450	IC₅₀	0.122 μM Compound: Colchicine	Antiproliferative activity against human KYSE-450 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human KYSE-450 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 35605363]
KYSE-450	IC₅₀	0.077 μM Compound: Colchicine	Antiproliferative activity against human KYSE-450 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human KYSE-450 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35834904]
KYSE-450	IC₅₀	0.07 μM Compound: Colchicine	Antiproliferative activity against human KYSE-450 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human KYSE-450 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36940611]
L02	IC₅₀	26.5 nM Compound: Colchicine	Antiproliferative activity against human LO2 cells after 48 hrs by MTT assay Antiproliferative activity against human LO2 cells after 48 hrs by MTT assay	[PMID: 28763646]
L02	IC₅₀	3.01 μM Compound: Colchicine	Antiproliferative activity against human LO2 cells after 24 hrs by MTT assay Antiproliferative activity against human LO2 cells after 24 hrs by MTT assay	[PMID: 29268130]
L02	IC₅₀	9.2 μM Compound: Colchicine	Antiproliferative activity against human HL7702 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HL7702 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30878833]
L02	CC₅₀	9.18 μM Compound: Colchicine	Antiproliferative activity against human LO2 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human LO2 cells incubated for 48 hrs by MTT assay	[PMID: 32035399]
L02	IC₅₀	2.3 μM Compound: Colchicine	Cytotoxicity against human L02 cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay Cytotoxicity against human L02 cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay	[PMID: 35367708]
L02	IC₅₀	5.74 μM Compound: Col	Cytotoxicity against human L02 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Cytotoxicity against human L02 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 36760739]
L02	IC₅₀	269.4 nM Compound: 1	Cytotoxicity against human L02 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against human L02 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
L1210	IC₅₀	0.0064 μM Compound: Colchicine	Concentration required to inhibit proliferation of cultured lymphoid leukemia L1210 cells to 50% growth over 48 hours Concentration required to inhibit proliferation of cultured lymphoid leukemia L1210 cells to 50% growth over 48 hours	[PMID: 1433180]
L1210	IC₅₀	6.4 nM Compound: colchicine	Concentration that inhibits proliferation of cultured lymphoid leukemia L1210 cells to 50% control growth during 48 h Concentration that inhibits proliferation of cultured lymphoid leukemia L1210 cells to 50% control growth during 48 h	[PMID: 1479582]
L1210	IC₅₀	6.9 nM Compound: Col	Antiproliferative activity against mouse L1210 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against mouse L1210 cells after 48 hrs by sulforhodamine B assay	[PMID: 21604746]
L1210	IC₅₀	6.9 nM Compound: Col	Antiproliferative activity against mouse L1210 after 48 hrs by SRB assay Antiproliferative activity against mouse L1210 after 48 hrs by SRB assay	[PMID: 21920638]
L1210	IC₅₀	40 nM Compound: 1 (Colchicine)	In vitro cytotoxicity against L1210 (murine leukemia) cells. In vitro cytotoxicity against L1210 (murine leukemia) cells.	[PMID: 2299625]
L1210	IC₅₀	0.01 μM Compound: 1, colch	Antiproliferative activity against mouse L1210 cells after 48 to 96 hrs by coulter counter analysis Antiproliferative activity against mouse L1210 cells after 48 to 96 hrs by coulter counter analysis	[PMID: 24773591]
L1210	IC₅₀	0.014 μM Compound: Colchicine	Antiproliferative activity against mouse L1210 assessed as inhibition of cell proliferation after 48 hrs by Coulter counter based cell counting method Antiproliferative activity against mouse L1210 assessed as inhibition of cell proliferation after 48 hrs by Coulter counter based cell counting method	[PMID: 25282265]
L1210	IC₅₀	6.4 nM Compound: Colchicine	The compound was tested in vitro for growth of inhibitory activity against lymphoid leukemia L1210 cells The compound was tested in vitro for growth of inhibitory activity against lymphoid leukemia L1210 cells	[PMID: 2795608]
L1210	IC₅₀	0.007 μM Compound: Colchicine	Antiproliferative activity against mouse L1210 cells after 96 hrs by coulter counting method Antiproliferative activity against mouse L1210 cells after 96 hrs by coulter counting method	[PMID: 29471122]
L1210	IC₅₀	0.01 μM Compound: 5	Antiproliferative activity against mouse L1210 cells measured after 96 hrs by Coulter counter method Antiproliferative activity against mouse L1210 cells measured after 96 hrs by Coulter counter method	[PMID: 30921759]
L1210	IC₅₀	14.7 nM Compound: colchicine	Inhibition of L1210 cell proliferation Inhibition of L1210 cell proliferation	[PMID: 7990108]
L929	IC₅₀	1.01 μM Compound: 1	Antiproliferative activity against mouse L929 cells after 72 hrs by MTT assay Antiproliferative activity against mouse L929 cells after 72 hrs by MTT assay	[PMID: 30245397]
LCLC-103H cell line	EC₅₀	0.07 μM Compound: Colchicine	Antiproliferative activity against human LCLC-103H cells after 96 hrs by MTT assay Antiproliferative activity against human LCLC-103H cells after 96 hrs by MTT assay	[PMID: 29055869]
LLC-PK1	IC₅₀	>50 μM Compound: Colchicine	Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay	[PMID: 12699389]
LLC-PK1	IC₅₀	>50 μM Compound: Colchicine	Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay	[PMID: 12699389]
LLC-PK1	IC₅₀	>50 μM Compound: Colchicine	Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay	[PMID: 12699389]
LLC-PK1	IC₅₀	>50 μM Compound: Colchicine	TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1a-expressing LLC-PK1 cells TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1a-expressing LLC-PK1 cells	[PMID: 12699389]
LLC-PK1	IC₅₀	>50 μM Compound: Colchicine	TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1b-expressing LLC-PK1 cells TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1b-expressing LLC-PK1 cells	[PMID: 12699389]
LLC-PK1	IC₅₀	>50 μM Compound: Colchicine	TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cells TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cells	[PMID: 12699389]
LNCaP	IC₅₀	0.016 μM Compound: colchicine	Cytotoxicity against human LNCAP cells after 48 hrs by SRB assay Cytotoxicity against human LNCAP cells after 48 hrs by SRB assay	[PMID: 19243174]
LNCaP	IC₅₀	16 nM Compound: Colchicine	Cytotoxicity against human LNCAP cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human LNCAP cells after 48 hrs by sulforhodamine B assay	[PMID: 20919720]
LNCaP	IC₅₀	0.02 μM Compound: Colchicine	Antiproliferative activity against human LNCAP cells after 96 hrs by sulforhodamine B assay Antiproliferative activity against human LNCAP cells after 96 hrs by sulforhodamine B assay	[PMID: 21775150]
LNCaP	IC₅₀	0.02 μM Compound: Colchicine	Antiproliferative activity against human LNCAP cells after 96 hrs by SRB assay Antiproliferative activity against human LNCAP cells after 96 hrs by SRB assay	[PMID: 22608389]
LNCaP	IC₅₀	16.3 nM Compound: Colchicine	Antiproliferative activity against human LNCAP cells after 48 hrs by SRB assay Antiproliferative activity against human LNCAP cells after 48 hrs by SRB assay	[PMID: 22783954]
LNCaP	IC₅₀	0.245 μM Compound: Colchicine	Cytotoxicity against human LNCaP cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human LNCaP cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37201429]
LNCaP	ED₅₀	0.06 μg/mL Compound: Colchicine	Cytotoxicity against human LNCAP cells after 3 days by SRB assay Cytotoxicity against human LNCAP cells after 3 days by SRB assay	[PMID: 7528785]
LNCaP	ED₅₀	0.06 μg/mL Compound: colchicine	Cytotoxicity against human LNCAP cells Cytotoxicity against human LNCAP cells	[PMID: 8133298]
LoVo	IC₅₀	0.101 μM Compound: Colchicine	Cytotoxicity against human LoVo cells after 72 hrs by MTT assay Cytotoxicity against human LoVo cells after 72 hrs by MTT assay	[PMID: 21536450]
LoVo	IC₅₀	119 nM Compound: 1	Cytotoxicity against human LoVo cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Cytotoxicity against human LoVo cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay	[PMID: 30429975]
LoVo	IC₅₀	108.4 nM Compound: 1	Antiproliferative activity against human LoVo cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay Antiproliferative activity against human LoVo cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay	[PMID: 31653441]
LoVo	IC₅₀	118.8 nM Compound: 1; (-)-Colchicine	Antiproliferative activity against human LoVo cells assessed as reduction in cell viability Antiproliferative activity against human LoVo cells assessed as reduction in cell viability	[PMID: 31655432]
LoVo	IC₅₀	0.054 μM Compound: 1	Antiproliferative activity against human LoVo cells incubated for 72 hrs by sulforhodamine B assay Antiproliferative activity against human LoVo cells incubated for 72 hrs by sulforhodamine B assay	[PMID: 32432867]
LoVo	IC₅₀	108 nM Compound: 1	Antiproliferative activity against human LoVo cells incubated for 72 hrs by SRB assay Antiproliferative activity against human LoVo cells incubated for 72 hrs by SRB assay	[PMID: 33465696]
LoVo	IC₅₀	9.9 nM Compound: 1	Antiproliferative activity against human LoVo cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay Antiproliferative activity against human LoVo cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay	[PMID: 33611191]
LoVo	IC₅₀	9.7 nM Compound: 1	Antiproliferative activity against human LoVo cells assessed as inhibition of proliferation after 72 hrs by SRB assay Antiproliferative activity against human LoVo cells assessed as inhibition of proliferation after 72 hrs by SRB assay	[PMID: 34116158]
LoVo	IC₅₀	12.7 nM Compound: COLCH	Antiproliferative activity against human LoVo cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay Antiproliferative activity against human LoVo cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay	[PMID: 34592435]
LoVo	IC₅₀	0.23 μM Compound: COL	Antiproliferative activity against human LoVo cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human LoVo cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 37099835]
LoVo	IC₅₀	6 nM Compound: colchicine	Inhibition of LOVO cell proliferation Inhibition of LOVO cell proliferation	[PMID: 7990108]
Lu1	ED₅₀	0.2 μg/mL Compound: Colchicine	Cytotoxicity against human Lu1 cells after 3 days by SRB assay Cytotoxicity against human Lu1 cells after 3 days by SRB assay	[PMID: 7528785]
Lu1	ED₅₀	0.02 μg/mL Compound: colchicine	Cytotoxicity against human Lu1 cells Cytotoxicity against human Lu1 cells	[PMID: 8133298]
M14	IC₅₀	6.5 nM Compound: Colchicine	Cytotoxicity against human M14 cells after 72 hrs by MTS assay Cytotoxicity against human M14 cells after 72 hrs by MTS assay	[PMID: 29406710]
M14	IC₅₀	16.6 nM Compound: Colchicine	Antiproliferative activity against human M14 cells after 72 hrs by MTT assay Antiproliferative activity against human M14 cells after 72 hrs by MTT assay	[PMID: 31251599]
M14	IC₅₀	9.3 nM Compound: Colchicine	Antiproliferative activity against human M14 cells measured after 72 hrs by MTS assay Antiproliferative activity against human M14 cells measured after 72 hrs by MTS assay	[PMID: 31860298]
M14	IC₅₀	>1 μM Compound: Colchicine	Cytotoxicity against paclitaxel resistant human M14 cells measured after 72 hrs by western blot Cytotoxicity against paclitaxel resistant human M14 cells measured after 72 hrs by western blot	[PMID: 34378386]
M14	IC₅₀	10.6 nM Compound: Colchicine	Cytotoxicity against human M14 cells measured after 72 hrs by western blot Cytotoxicity against human M14 cells measured after 72 hrs by western blot	[PMID: 34378386]
M14	IC₅₀	13.7 nM Compound: Colchicine	Antiproliferative activity against human M14 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay Antiproliferative activity against human M14 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay	[PMID: 34406768]
M21	GI₅₀	0.015 μM Compound: colchicine	Growth inhibition of human M21 cells after 48 hrs Growth inhibition of human M21 cells after 48 hrs	[PMID: 17498960]
M21	GI₅₀	0.015 μM Compound: colchicine	Antiproliferative activity against human M21 cells Antiproliferative activity against human M21 cells	[PMID: 18502639]
M21	GI₅₀	0.015 μM Compound: colchicine	Growth inhibition of human M21 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human M21 cells after 48 hrs by sulforhodamine B assay	[PMID: 18579387]
M21	GI₅₀	0.015 μM Compound: COL	Antiproliferative activity against human M21 cells after 48 hrs by sulforhodamine B method Antiproliferative activity against human M21 cells after 48 hrs by sulforhodamine B method	[PMID: 18617414]
MCF-10A	IC₅₀	0.006 μM Compound: Colchicine	Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34670362]
MCF-10A	IC₅₀	0.098 nM Compound: COL	Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay	[PMID: 37584263]
MCF7	GI₅₀	<0.05 μM Compound: Colchicine	In vivo growth inhibitory activity against human neoplastic MCF-7 cell line In vivo growth inhibitory activity against human neoplastic MCF-7 cell line	[PMID: 10091693]
MCF7	IC₅₀	12000 nM Compound: 1	Anti tumor activity on human breast cancer cell line MDR-positive MCF-7 ADRr after 72 hours of treatment Anti tumor activity on human breast cancer cell line MDR-positive MCF-7 ADRr after 72 hours of treatment	[PMID: 10602712]
MCF7	IC₅₀	13 nM Compound: colchicine	Growth inhibition of human MCF7 cells assessed as G2/M DNA content after 48 hrs Growth inhibition of human MCF7 cells assessed as G2/M DNA content after 48 hrs	[PMID: 15566282]
MCF7	EC₅₀	0.016 μM Compound: 1	Cytotoxicity against human MCF7 after 3 days by SRB assay Cytotoxicity against human MCF7 after 3 days by SRB assay	[PMID: 15730238]
MCF7	IC₅₀	13 nM Compound: 1	Growth inhibition of human MCF7 cells after 48 hrs Growth inhibition of human MCF7 cells after 48 hrs	[PMID: 17497841]
MCF7	GI₅₀	0.009 μM Compound: colchicine	Growth inhibition of human MCF7 cells after 48 hrs Growth inhibition of human MCF7 cells after 48 hrs	[PMID: 17498960]
MCF7	GI₅₀	0.009 μM Compound: colchicine	Antiproliferative activity against human MCF7 cells Antiproliferative activity against human MCF7 cells	[PMID: 18502639]
MCF7	GI₅₀	0.009 μM Compound: colchicine	Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay	[PMID: 18579387]
MCF7	GI₅₀	0.009 μM Compound: COL	Antiproliferative activity against human MCF7 cells after 48 hrs by sulforhodamine B method Antiproliferative activity against human MCF7 cells after 48 hrs by sulforhodamine B method	[PMID: 18617414]
MCF7	IC₅₀	0.0134 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells after 72 hrs by crystal violet biomass reduction assay Antiproliferative activity against human MCF7 cells after 72 hrs by crystal violet biomass reduction assay	[PMID: 20334421]
MCF7	IC₅₀	0.017 μM Compound: colchicine	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 20493717]
MCF7	IC₅₀	12 nM Compound: 1	Cytotoxicity against human MCF7 cells after 72 hrs by crystal violet staining Cytotoxicity against human MCF7 cells after 72 hrs by crystal violet staining	[PMID: 20529690]
MCF7	IC₅₀	0.017 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 21036623]
MCF7	IC₅₀	1.9 μM Compound: Colchicin	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 21576023]
MCF7	IC₅₀	5 nM Compound: 1	Growth inhibition of human MCF7 cells after 96 hrs Growth inhibition of human MCF7 cells after 96 hrs	[PMID: 22044164]
MCF7	IC₅₀	0.53 μg/mL Compound: Colchicine	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 22261027]
MCF7	IC₅₀	0.51 μg/mL Compound: Colchicine	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 22503741]
MCF7	IC₅₀	0.53 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 22512906]
MCF7	IC₅₀	5 nM Compound: 1	Cytotoxicity against human MCF7 cells assessed as growth inhibition by trypan blue exclusion assay Cytotoxicity against human MCF7 cells assessed as growth inhibition by trypan blue exclusion assay	[PMID: 23214452]
MCF7	IC₅₀	0.013 μM Compound: Colchicine	Cytotoxicity against human MCF7 cells by SRB assay Cytotoxicity against human MCF7 cells by SRB assay	[PMID: 23220647]
MCF7	IC₅₀	0.29 μM Compound: Colchicine	Cytotoxicity against human MCF7 cells by MTT assay Cytotoxicity against human MCF7 cells by MTT assay	[PMID: 23425970]
MCF7	IC₅₀	0.017 μM Compound: Colchicine	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 23602523]
MCF7	IC₅₀	0.019 μM Compound: Colchicine	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 23932339]
MCF7	IC₅₀	0.39 μg/mL Compound: 1	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 24916028]
MCF7	IC₅₀	5 nM Compound: 1	Cytotoxicity against human MCF7 cells after 96 hrs by Giemsa staining-based light microscopy Cytotoxicity against human MCF7 cells after 96 hrs by Giemsa staining-based light microscopy	[PMID: 25025991]
MCF7	IC₅₀	0.16 μM Compound: COL	Antiproliferative activity against human MCF7 cells after 48 hrs by SRB method Antiproliferative activity against human MCF7 cells after 48 hrs by SRB method	[PMID: 25061803]
MCF7	IC₅₀	3.2 μM Compound: COL	Antiproliferative activity against doxorubicin-resistant human MCF7 cells after 48 hrs by SRB method Antiproliferative activity against doxorubicin-resistant human MCF7 cells after 48 hrs by SRB method	[PMID: 25061803]
MCF7	IC₅₀	58 nM Compound: colchicine	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 25208345]
MCF7	IC₅₀	0.012 μM Compound: colchicine	Cytotoxicity against human MCF7 cells after 3 days by MTT assay Cytotoxicity against human MCF7 cells after 3 days by MTT assay	[PMID: 25426924]
MCF7	IC₅₀	0.07 μM Compound: Colchicine	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 25499929]
MCF7	IC₅₀	0.39 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 25703297]
MCF7	GI₅₀	13.5 μM Compound: Colchicine	Growth inhibition of human MCF7 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay Growth inhibition of human MCF7 cells assessed as inhibition of cell proliferation after 24 hrs by MTT assay	[PMID: 26070164]
MCF7	IC₅₀	5 nM Compound: 1	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 26132075]
MCF7	IC₅₀	0.047 μM Compound: 1	Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 27172319]
MCF7	IC₅₀	64.1 nM Compound: 1	Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 27213819]
MCF7	IC₅₀	0.072 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 27608432]
MCF7	IC₅₀	0.1504 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 27744186]
MCF7	IC₅₀	12 nM Compound: Colchicine	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 27915168]
MCF7	IC₅₀	0.05 μM Compound: Colchicine	Cytotoxicity against vinblastine-sensitive human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against vinblastine-sensitive human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 28006904]
MCF7	IC₅₀	2.8 μM Compound: Colchicine	Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine containing medium assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine containing medium assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 28006904]
MCF7	IC₅₀	2.8 μM Compound: Colchicine	Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine free medium assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine free medium assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 28006904]
MCF7	IC₅₀	5 nM Compound: Colch	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 3 days by trypan blue exclusion assay Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 3 days by trypan blue exclusion assay	[PMID: 28523104]
MCF7	IC₅₀	13.4 nM Compound: Colchicine	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 28763646]
MCF7	IC₅₀	0.012 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 28863359]
MCF7	EC₅₀	0.061 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells after 96 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 96 hrs by MTT assay	[PMID: 29055869]
MCF7	IC₅₀	12 nM Compound: Colchicine	Antiproliferative activity against human MCF7 cells after 2 days by MTT assay Antiproliferative activity against human MCF7 cells after 2 days by MTT assay	[PMID: 29550732]
MCF7	IC₅₀	20 nM Compound: Colchicine	Antiproliferative activity against human MCF7 cells after 2 days by MTT assay Antiproliferative activity against human MCF7 cells after 2 days by MTT assay	[PMID: 29604583]
MCF7	IC₅₀	5 nM Compound: Colchicine	Growth inhibition of human MCF7 cells after 96 hrs by trypan blue exclusion assay Growth inhibition of human MCF7 cells after 96 hrs by trypan blue exclusion assay	[PMID: 29730191]
MCF7	GI₅₀	0.4 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay	[PMID: 30288225]
MCF7	IC₅₀	0.33 μg/mL Compound: Colchicine	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 30389289]
MCF7	IC₅₀	41 nM Compound: 1	Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay	[PMID: 30429975]
MCF7	IC₅₀	0.44 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 30606674]
MCF7	IC₅₀	14.3 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30878833]
MCF7	IC₅₀	54.3 nM Compound: 1	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay	[PMID: 31653441]
MCF7	IC₅₀	>300 nM Compound: 1; (-)-Colchicine	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay	[PMID: 31655432]
MCF7	IC₅₀	41.3 nM Compound: 1; (-)-Colchicine	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability	[PMID: 31655432]
MCF7	IC₅₀	5 nM Compound: Colchicine	Cytotoxicity against human MCF7 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay	[PMID: 31727471]
MCF7	IC₅₀	0.11 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay	[PMID: 32035399]
MCF7	IC₅₀	0.52 μM Compound: Colchicine	Antiproliferative activity against drug-resistant human MCF7 cells incubated for 48 hrs by MTT assay Antiproliferative activity against drug-resistant human MCF7 cells incubated for 48 hrs by MTT assay	[PMID: 32035399]
MCF7	IC₅₀	0.06 μM Compound: 2	Cytotoxicity against human MCF7 cells after 68 hrs by MTT assay Cytotoxicity against human MCF7 cells after 68 hrs by MTT assay	[PMID: 32243160]
MCF7	IC₅₀	0.054 μM Compound: 1	Antiproliferative activity against human MCF7 cells incubated for 72 hrs by sulforhodamine B assay Antiproliferative activity against human MCF7 cells incubated for 72 hrs by sulforhodamine B assay	[PMID: 32432867]
MCF7	IC₅₀	0.018 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay	[PMID: 32650183]
MCF7	IC₅₀	38 nM Compound: Colchicine	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 33234343]
MCF7	IC₅₀	20.7 nM Compound: 1	Antiproliferative activity against human MCF-7 cells incubated for 72 hrs by SRB assay Antiproliferative activity against human MCF-7 cells incubated for 72 hrs by SRB assay	[PMID: 33465696]
MCF7	IC₅₀	10.9 nM Compound: 1	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay	[PMID: 33611191]
MCF7	IC₅₀	0.021 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 33788562]
MCF7	IC₅₀	13 nM Compound: 1	Antiproliferative activity against human MCF-7 cells assessed as inhibition of proliferation after 72 hrs by SRB assay Antiproliferative activity against human MCF-7 cells assessed as inhibition of proliferation after 72 hrs by SRB assay	[PMID: 34116158]
MCF7	IC₅₀	0.048 μM Compound: Colchicine	Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34175541]
MCF7	IC₅₀	0.04 μM Compound: Col	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 34311158]
MCF7	IC₅₀	0.018 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 34571171]
MCF7	IC₅₀	10.1 nM Compound: COLCH	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay	[PMID: 34592435]
MCF7	IC₅₀	0.028 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 34968813]
MCF7	IC₅₀	64 nM Compound: Colchicine	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35084853]
MCF7	IC₅₀	0.043 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells over expressing GLUT1 measured after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells over expressing GLUT1 measured after 72 hrs by MTT assay	[PMID: 35193066]
MCF7	IC₅₀	24.98 μM Compound: Colchicine	Cytotoxicity against human MCF7 cells treated for 72 hrs by MTT assay Cytotoxicity against human MCF7 cells treated for 72 hrs by MTT assay	[PMID: 35344904]
MCF7	IC₅₀	0.22 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs in presence of foetal bovine serum by MTT assay	[PMID: 35367708]
MCF7	IC₅₀	0.16 μM Compound: Colchicine	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35447432]
MCF7	IC₅₀	5.19 μM Compound: COL	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 35694693]
MCF7	IC₅₀	10.47 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 36067627]
MCF7	IC₅₀	0.05 μM Compound: Colchicine	Cytotoxicity in human MCF7 cells assessed as growth inhibition level after 48 hrs by SRB assay Cytotoxicity in human MCF7 cells assessed as growth inhibition level after 48 hrs by SRB assay	[PMID: 36162138]
MCF7	IC₅₀	0.006 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 36511661]
MCF7	IC₅₀	0.41 μM Compound: Col	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 24 hrs by MTT assay	[PMID: 36760739]
MCF7	IC₅₀	43 nM Compound: Colchicine	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth by MTT assay	[PMID: 36893627]
MCF7	IC₅₀	0.022 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 37145846]
MCF7	IC₅₀	0.068 μM Compound: 1	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37182330]
MCF7	IC₅₀	10.41 μM Compound: Colchicine	Cytotoxicity against human MCF7 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay	[PMID: 37567059]
MCF7	IC₅₀	0.001 μM Compound: COL	Antiproliferative activity against ERalpha positive human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay Antiproliferative activity against ERalpha positive human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay	[PMID: 37584263]
MCF7	IC₅₀	0.046 μM Compound: 1	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
MCF7	IC₅₀	14.3 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay	[PMID: 38107170]
MCF7	IC₅₀	0.03 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay	[PMID: 38471357]
MCF7	IC₅₀	0.012 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 38703557]
MCF7	IC₅₀	0.025 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
MCF7	IC₅₀	10 nM Compound: Colchicine	Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay	[PMID: 39197251]
MCF7	IC₅₀	15.3 nM Compound: colchicine	Inhibition of MCF-7 cell proliferation Inhibition of MCF-7 cell proliferation	[PMID: 7990108]
MCF7	ED₅₀	>0.4 μg/mL Compound: colchicine	Cytotoxicity against human breast cancer cells (MCF-7) using SRB assay. Cytotoxicity against human breast cancer cells (MCF-7) using SRB assay.	[PMID: 9544215]
MCF7	EC₅₀	>0.4 μg/mL Compound: 1	In vitro growth inhibition of MCF-7, breast adenocarcinoma. In vitro growth inhibition of MCF-7, breast adenocarcinoma.	[PMID: 9599244]
MCF7	GI₅₀	<0.05 μM Compound: colchicine	Compound was evaluated for growth inhibition against MCF-7 cells using cellular assay Compound was evaluated for growth inhibition against MCF-7 cells using cellular assay	[PMID: 9871709]
MCF7	IC₅₀	0.54 μM Compound: Colchicine	Antiproliferative activity against human MCF7 cells measured after 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells measured after 24 hrs by MTT assay	10.1039/C6MD00255B
MCF7-VP	IC₅₀	1.57 μM Compound: Colchicine	Cytotoxicity in human MCF7/Vin cells assessed as growth inhibition level after 48 hrs by SRB assay Cytotoxicity in human MCF7/Vin cells assessed as growth inhibition level after 48 hrs by SRB assay	[PMID: 36162138]
MDA-MB-231	IC₅₀	1.8 nM Compound: 1	Anti tumor activity on human breast cancer cell line MDR-negative MDA-MB 231 after 72 hours of treatment Anti tumor activity on human breast cancer cell line MDR-negative MDA-MB 231 after 72 hours of treatment	[PMID: 10602712]
MDA-MB-231	IC₅₀	0.03 μM Compound: colchicine	Antiproliferative activity against human MDA-MB-231 cells after 4 days by microplate assay Antiproliferative activity against human MDA-MB-231 cells after 4 days by microplate assay	[PMID: 17889547]
MDA-MB-231	IC₅₀	0.07 μM Compound: 1, colchicine	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs Antiproliferative activity against human MDA-MB-231 cells after 72 hrs	[PMID: 18503262]
MDA-MB-231	IC₅₀	20 nM Compound: colchichine	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by alamar blue assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by alamar blue assay	[PMID: 19117761]
MDA-MB-231	IC₅₀	26 nM Compound: colchicine	Cytotoxicity against human MDA-MB-231 cells after 72 hrs Cytotoxicity against human MDA-MB-231 cells after 72 hrs	[PMID: 19530698]
MDA-MB-231	IC₅₀	2.9 nM Compound: Col	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay	[PMID: 21604746]
MDA-MB-231	IC₅₀	2.9 nM Compound: Col	Antiproliferative activity against human MDA-MB-231 after 48 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 after 48 hrs by SRB assay	[PMID: 21920638]
MDA-MB-231	IC₅₀	37 nM Compound: colchicine	Cytotoxicity against human MDA-MB-231 cells after 96 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 96 hrs by MTT assay	[PMID: 23176628]
MDA-MB-231	IC₅₀	475 nM Compound: 1a	Antimigratory activity against human MDA-MB-231 cells after 6 hrs by Boyden chamber migration assay Antimigratory activity against human MDA-MB-231 cells after 6 hrs by Boyden chamber migration assay	[PMID: 23524161]
MDA-MB-231	GI₅₀	<0.01 μM Compound: Colchicine	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by SRB assay	[PMID: 25827522]
MDA-MB-231	IC₅₀	3.55 μM Compound: Colchicine	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 27608432]
MDA-MB-231	IC₅₀	38.2 nM Compound: Colchicine	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 28763646]
MDA-MB-231	IC₅₀	3.89 μM Compound: Colchicine	Antiproliferative activity against human MDA231 cells after 24 hrs by MTT assay Antiproliferative activity against human MDA231 cells after 24 hrs by MTT assay	[PMID: 29268130]
MDA-MB-231	IC₅₀	2 μM Compound: Colchicine	Antiproliferative activity against human MDA-MB-231 cells by SRB assay Antiproliferative activity against human MDA-MB-231 cells by SRB assay	[PMID: 30119011]
MDA-MB-231	IC₅₀	77.62 nM Compound: Colchicine	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 30197030]
MDA-MB-231	GI₅₀	1.5 μM Compound: Colchicine	Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay	[PMID: 30288225]
MDA-MB-231	IC₅₀	25 nM Compound: 1	Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay	[PMID: 30429975]
MDA-MB-231	IC₅₀	25.3 nM Compound: 1; (-)-Colchicine	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability	[PMID: 31655432]
MDA-MB-231	IC₅₀	2.75 μM Compound: Colchi	Antimigratory activity in human MDA-MB-231 cells assessed as inhibition of cell motility after 24 hrs by microscopic analysis Antimigratory activity in human MDA-MB-231 cells assessed as inhibition of cell motility after 24 hrs by microscopic analysis	[PMID: 31838326]
MDA-MB-231	IC₅₀	2.94 μM Compound: Colchicine	Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay	[PMID: 32035399]
MDA-MB-231	IC₅₀	0.93 μM Compound: Colchicine	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay	[PMID: 32768647]
MDA-MB-231	IC₅₀	24.3 nM Compound: Colchicine	Cytotoxicity against human MDA-MB-231 cells measured after 72 hrs by western blot Cytotoxicity against human MDA-MB-231 cells measured after 72 hrs by western blot	[PMID: 34378386]
MDA-MB-231	IC₅₀	22.4 nM Compound: Colchicine	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay	[PMID: 34406768]
MDA-MB-231	IC₅₀	17.5 nM Compound: Colchicine	Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
MDA-MB-231	IC₅₀	0.097 μM Compound: Colchicine	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35447432]
MDA-MB-231	IC₅₀	0.176 μM Compound: Colchicine	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36455508]
MDA-MB-231	IC₅₀	0.023 μM Compound: Colchicine	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 36511661]
MDA-MB-231	IC₅₀	67.4 nM Compound: Colchicine	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 36621138]
MDA-MB-231	IC₅₀	1.98 μM Compound: Colchicine	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37122544]
MDA-MB-231	IC₅₀	0.12 μM Compound: Colchicine	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth after 72 hrs by MTT assay	[PMID: 38336655]
MDA-MB-231	IC₅₀	0.027 μg/mL Compound: Colchicine	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 38716896]
MDA-MB-231	IC₅₀	0.036 μM Compound: Colchicine	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
MDA-MB-231	IC₅₀	20.5 nM Compound: colchicine	Inhibition of MDA-MB-231 cell proliferation Inhibition of MDA-MB-231 cell proliferation	[PMID: 7990108]
MDA-MB-231	IC₅₀	0.03 μM Compound: Colchicine	Inhibition of the growth of MDA-MB 231 human breast cancer cells Inhibition of the growth of MDA-MB 231 human breast cancer cells	[PMID: 9357519]
MDA-MB-231	IC₅₀	7.07 μM Compound: Colchicine	Antimigratory activity against Homo sapiens (human) MDA-MB-231 cells after 24 to 48 hr by microscopic analysis Antimigratory activity against Homo sapiens (human) MDA-MB-231 cells after 24 to 48 hr by microscopic analysis	10.1007/s00044-012-0428-9
MDA-MB-231	IC₅₀	0.008 μM Compound: Colchicine	Antiproliferative activity against human MDA-MB-231 cells by MTS assay Antiproliferative activity against human MDA-MB-231 cells by MTS assay	10.1039/C3MD00077J
MDA-MB-435	IC₅₀	2 μM Compound: colchicine	Antiproliferative activity against human MDA-MB-435 cells after 48 hrs by SRB assay Antiproliferative activity against human MDA-MB-435 cells after 48 hrs by SRB assay	[PMID: 18083520]
MDA-MB-435	IC₅₀	0.04 μM Compound: 1, colchicine	Antiproliferative activity against human MDA-MB-435 cells after 72 hrs Antiproliferative activity against human MDA-MB-435 cells after 72 hrs	[PMID: 18503262]
MDA-MB-435	IC₅₀	65.8 nM Compound: Colchicine	Resistance index, ratio of IC50 for human multidrug-resistant MDA-MB-435/LCCMDR1 cells to IC50 for human MDA-MB-435 cells Resistance index, ratio of IC50 for human multidrug-resistant MDA-MB-435/LCCMDR1 cells to IC50 for human MDA-MB-435 cells	[PMID: 20919720]
MDA-MB-435	IC₅₀	658 nM Compound: Colchicine	Cytotoxicity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay	[PMID: 20919720]
MDA-MB-435	IC₅₀	0.0073 μM Compound: Colchicine	Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay	[PMID: 21536450]
MDA-MB-435	IC₅₀	0.016 μM Compound: colchicine	Antiproliferative activity against human MDA-MB-435 cells by sulforhodamine B assay Antiproliferative activity against human MDA-MB-435 cells by sulforhodamine B assay	[PMID: 22611477]
MDA-MB-435	IC₅₀	11 nM Compound: Colchicine	Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 23547728]
MDA-MB-435S	IC₅₀	0.007 μM Compound: Colchicine	Cytotoxicity against human MDA-MB-435S cells assessed as growth inhibition after 72 hrs by CCK-8 assay Cytotoxicity against human MDA-MB-435S cells assessed as growth inhibition after 72 hrs by CCK-8 assay	[PMID: 25091926]
MDA-MB-453	IC₅₀	5.8 nM Compound: Colchicine	Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay	[PMID: 34406768]
MDA-MB-468	IC₅₀	2.1 nM Compound: 1	Cytotoxicity against human MDA-MB-468 cells assessed as cell viability after 4 days by MTS assay Cytotoxicity against human MDA-MB-468 cells assessed as cell viability after 4 days by MTS assay	[PMID: 24210503]
MDA-MB-468	IC₅₀	0.06 μM Compound: Colchicine	Antiproliferative activity against human MDA-MB-468 cells by SRB assay Antiproliferative activity against human MDA-MB-468 cells by SRB assay	[PMID: 28988750]
MDA-MB-468	IC₅₀	9.9 nM Compound: Colchicine	Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay	[PMID: 34406768]
MDA-MB-468	IC₅₀	0.012 μM Compound: Colchicine	Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
MDA-MB-468	IC₅₀	6.9 nM Compound: colchicine	Inhibition of MDA-MB-468 cell proliferation Inhibition of MDA-MB-468 cell proliferation	[PMID: 7990108]
MES-SA	IC₅₀	6.3 nM Compound: colchicine	Antiproliferative activity against drug sensitive Messa cell line by Alamar Blue assay Antiproliferative activity against drug sensitive Messa cell line by Alamar Blue assay	[PMID: 17286393]
MES-SA	IC₅₀	11 nM Compound: 1	Cytotoxicity against human MESSA cells assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay Cytotoxicity against human MESSA cells assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay	[PMID: 23214452]
MES-SA	IC₅₀	11 nM Compound: 1	Cytotoxicity against human MESSA cells assessed as growth inhibition after 72 hrs by CellTitre-Glo assay Cytotoxicity against human MESSA cells assessed as growth inhibition after 72 hrs by CellTitre-Glo assay	[PMID: 25025991]
MES-SA	IC₅₀	11 nM Compound: 1	Cytotoxicity against human MESSA cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay Cytotoxicity against human MESSA cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay	[PMID: 26132075]
MES-SA	IC₅₀	15 nM Compound: Colchicine	Antiproliferative activity against human MES-SA cells after 72 hrs by resazurin assay Antiproliferative activity against human MES-SA cells after 72 hrs by resazurin assay	[PMID: 26602281]
MES-SA/Dx5	IC₅₀	63 nM Compound: colchicine	Antiproliferative activity against drug resistant Messa/DX5 cell line expressing MDR1 by Alamar Blue assay Antiproliferative activity against drug resistant Messa/DX5 cell line expressing MDR1 by Alamar Blue assay	[PMID: 17286393]
MES-SA/Dx5	IC₅₀	329 nM Compound: 1	Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by Celltiter-Glo luminescent assay	[PMID: 23214452]
MES-SA/Dx5	IC₅₀	329 nM Compound: 1	Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by CellTitre-Glo assay Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by CellTitre-Glo assay	[PMID: 25025991]
MES-SA/Dx5	IC₅₀	329 nM Compound: 1	Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay	[PMID: 26132075]
MES-SA/Dx5	IC₅₀	757 nM Compound: Colchicine	Antiproliferative activity against multidrug-resistant human MES-SA/Dx5 cells assessed as reduction in cell viability incubated for 72 hrs by prestoblue dye based assay Antiproliferative activity against multidrug-resistant human MES-SA/Dx5 cells assessed as reduction in cell viability incubated for 72 hrs by prestoblue dye based assay	[PMID: 33618157]
MGC-803	IC₅₀	0.177 μM Compound: Colchicine	Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay	[PMID: 30075402]
MGC-803	IC₅₀	0.27 μM Compound: Colchicine	Antiproliferative activity against human MGC803 cells measured after 48 hrs by MTT assay Antiproliferative activity against human MGC803 cells measured after 48 hrs by MTT assay	[PMID: 30690300]
MGC-803	IC₅₀	0.107 μM Compound: Colchicine	Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 32682200]
MGC-803	IC₅₀	1.07 μM Compound: Colchicine	Antiproliferative activity against human MGC-803 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human MGC-803 cells incubated for 48 hrs by CCK8 assay	[PMID: 33965530]
MGC-803	IC₅₀	1.07 μM Compound: Colchicine	Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay	[PMID: 34022412]
MGC-803	IC₅₀	0.09 μM Compound: Colchicine	Antiproliferative activity against human MGC-803 cells assessed as cell growth inhibition measured after 48 hrs by CCK8 assay Antiproliferative activity against human MGC-803 cells assessed as cell growth inhibition measured after 48 hrs by CCK8 assay	[PMID: 34971875]
MGC-803	IC₅₀	0.062 μM Compound: Colchicine	Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 35605363]
MGC-803	IC₅₀	0.062 μM Compound: Colchicine	Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35834904]
MGC-803	IC₅₀	0.056 μM Compound: Colchicine	Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36940611]
MGC-803	IC₅₀	7.99 μM Compound: COL	Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 37099835]
MGC-803	IC₅₀	0.041 μM Compound: Colchicine	Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38150962]
MGC-803	IC₅₀	0.046 μM Compound: Colchicine	Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth measured after 48 hrs by CCK8 method Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth measured after 48 hrs by CCK8 method	[PMID: 38181651]
MGC-803	IC₅₀	0.002 μM Compound: Colchicine	Antiproliferative activity against human MGC-803 assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MGC-803 assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
MHCC97H	IC₅₀	0.11 μM Compound: Colchicine	Cytotoxicity against human MHCC97H cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human MHCC97H cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 25805446]
MIA PaCa-2	IC₅₀	25 nM Compound: colchichine	Cytotoxicity against human MIAPaCa2 cells after 48 hrs by alamar blue assay Cytotoxicity against human MIAPaCa2 cells after 48 hrs by alamar blue assay	[PMID: 19117761]
MIA PaCa-2	IC₅₀	160 nM Compound: 1	Cytotoxicity against 2D culture of human MIAPaCa2 cells measured after 72 hrs by MTT assay Cytotoxicity against 2D culture of human MIAPaCa2 cells measured after 72 hrs by MTT assay	[PMID: 27912174]
MIA PaCa-2	IC₅₀	1.3 nM Compound: 1	Cytotoxic activity in human MIAPaCa2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxic activity in human MIAPaCa2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 29028531]
MIA PaCa-2	IC₅₀	0.042 μM Compound: 1	Cytotoxicity against human Mia PaCa-2 cells incubated for 48 hrs by MTT assay Cytotoxicity against human Mia PaCa-2 cells incubated for 48 hrs by MTT assay	[PMID: 32432867]
MIA PaCa-2	IC₅₀	6.1 nM Compound: Colchicine	Antiproliferative activity against human MIA PaCa-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human MIA PaCa-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33618157]
MKN-45	IC₅₀	15 nM Compound: Colchicine	Cytotoxicity against human MKN45 cell line by methylene blue dye assay Cytotoxicity against human MKN45 cell line by methylene blue dye assay	[PMID: 17154496]
MKN-45	IC₅₀	13 nM Compound: colchichine	Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay	[PMID: 17685504]
MKN-45	IC₅₀	11 nM Compound: 4	Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay	[PMID: 18588280]
MKN-45	IC₅₀	13 nM Compound: 1	Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay	[PMID: 19053773]
MKN-45	IC₅₀	12.4 nM Compound: 3	Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue dye assay Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue dye assay	[PMID: 20148562]
MKN-45	IC₅₀	12 nM Compound: 5	Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue assay Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue assay	[PMID: 21641700]
MKN-45	IC₅₀	19.2 nM Compound: 1	Growth inhibition of human MKN45 cells after 72 hrs by methylene blue assay Growth inhibition of human MKN45 cells after 72 hrs by methylene blue assay	[PMID: 22060033]
MKN-45	IC₅₀	11.5 nM Compound: 1	Cytotoxicity against human MKN45 cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay Cytotoxicity against human MKN45 cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay	[PMID: 24106982]
MKN-45	IC₅₀	14.9 nM Compound: colchicine	Cytotoxicity against human MKN45 cells after 72 hrs by methylene blue assay Cytotoxicity against human MKN45 cells after 72 hrs by methylene blue assay	[PMID: 24657567]
MKN-45	IC₅₀	0.002 μM Compound: Colchicine	Cytotoxicity against human MKN45 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human MKN45 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 25805446]
MKN-45	IC₅₀	14.9 nM Compound: Colchicine	Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue assay Antiproliferative activity against human MKN45 cells after 72 hrs by methylene blue assay	[PMID: 26160020]
MKN-45	IC₅₀	11.5 nM Compound: 6	Antiproliferative activity against human MKN45 cells assessed as inhibition of cell growth after 72 hrs by methylene blue dye assay Antiproliferative activity against human MKN45 cells assessed as inhibition of cell growth after 72 hrs by methylene blue dye assay	10.1039/C0MD00052C
MOLM-13	IC₅₀	4.71 nM Compound: Colchicine	Antiproliferative activity against human MOLM-13 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MOLM-13 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
MRC5	IC₅₀	0.09 μM Compound: Colchicine	Antiproliferative activity against human MRC5 cells by SRB assay Antiproliferative activity against human MRC5 cells by SRB assay	[PMID: 28988750]
MRC5	IC₅₀	6.2 μM Compound: Colchicine	Antiproliferative activity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30878833]
MV4-11	IC₅₀	1.58 nM Compound: Colchicine	Antiproliferative activity against human MV4-11 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MV4-11 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
NCI/ADR-RES	IC₅₀	1113 nM Compound: Colchicine	Anticancer activity against P-gp overexpressing human NCI/ADR-RES cells after 96 hrs by SRB assay Anticancer activity against P-gp overexpressing human NCI/ADR-RES cells after 96 hrs by SRB assay	[PMID: 21557538]
NCI/ADR-RES	IC₅₀	3.12 μM Compound: Colchicine	Cytotoxicity against human MCF7/ADR cells by MTT assay Cytotoxicity against human MCF7/ADR cells by MTT assay	[PMID: 23425970]
NCI/ADR-RES	IC₅₀	420 nM Compound: 1	Cytotoxicity against human NCI/ADR-RES cells assessed as growth inhibition after 96 hrs by Giemsa staining-based light microscopy Cytotoxicity against human NCI/ADR-RES cells assessed as growth inhibition after 96 hrs by Giemsa staining-based light microscopy	[PMID: 25025991]
NCI/ADR-RES	IC₅₀	96 nM Compound: 2	Cytotoxicity against human NCI-ADR-RES cells expressing ABCB1 Cytotoxicity against human NCI-ADR-RES cells expressing ABCB1	[PMID: 25811651]
NCI/ADR-RES	IC₅₀	420 nM Compound: 1	Cytotoxicity against Pgp overexpressing human NCI-ADR-RES cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against Pgp overexpressing human NCI-ADR-RES cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 26132075]
NCI/ADR-RES	IC₅₀	6005 nM Compound: 1	Cytotoxicity against P-gp overexpressing human MCF7/ADR cells assessed as reduction in cell growth after 24 hrs by MTT assay Cytotoxicity against P-gp overexpressing human MCF7/ADR cells assessed as reduction in cell growth after 24 hrs by MTT assay	[PMID: 27213819]
NCI-H1299	EC₅₀	0.034 μM Compound: colchicine	Induction of apoptosis in human H1299 cells assessed as caspase activation after 24 hrs Induction of apoptosis in human H1299 cells assessed as caspase activation after 24 hrs	[PMID: 15566300]
NCI-H1299	EC₅₀	0.05 μM Compound: colchicine	Induction of apoptosis in human H1299 cells assessed as caspase activation after 48 hrs by HTS assay Induction of apoptosis in human H1299 cells assessed as caspase activation after 48 hrs by HTS assay	[PMID: 19464890]
NCI-H1299	EC₅₀	0.05 μM Compound: Colchicine	Induction of apoptosis in human H1299 cells assessed as caspase activation after 48 hrs Induction of apoptosis in human H1299 cells assessed as caspase activation after 48 hrs	[PMID: 19500976]
NCI-H1299	GI₅₀	0.063 μM Compound: Colchicine	Growth inhibition of human H1299 cells after 48 hrs Growth inhibition of human H1299 cells after 48 hrs	[PMID: 19500976]
NCI-H1299	IC₅₀	30 nM Compound: colchicine	Cytotoxicity against human H1299 cells after 72 hrs Cytotoxicity against human H1299 cells after 72 hrs	[PMID: 19530698]
NCI-H1299	IC₅₀	0.004 μM Compound: Colchicine	Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 36511661]
NCI-H1437	IC₅₀	0.002 μM Compound: Colchicine	Antiproliferative activity against human NCI-H1437 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H1437 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 36511661]
NCI-H157	IC₅₀	0.01 μM Compound: 1	Cytotoxicity in human NCI-H157 cells assessed as reduction in cell viability after 4 days under dark condition by MTT assay Cytotoxicity in human NCI-H157 cells assessed as reduction in cell viability after 4 days under dark condition by MTT assay	[PMID: 29172077]
NCI-H23	IC₅₀	0.013 μM Compound: 1	Cell cycle arrest in human NCI-H23 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis Cell cycle arrest in human NCI-H23 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis	[PMID: 21126027]
NCI-H23	IC₅₀	3.1 nM Compound: Colchicine	Antiproliferative activity against human NCI-H23 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human NCI-H23 cells incubated for 48 hrs by MTT assay	[PMID: 39197251]
NCI-H358	IC₅₀	0.02 μM Compound: Colchicine	Cytotoxicity against human NCI-H358 cells by MTT assay Cytotoxicity against human NCI-H358 cells by MTT assay	[PMID: 23425970]
NCI-H358	IC₅₀	4 nM Compound: colchicine	Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 25208345]
NCI-H460	IC₅₀	46 nM Compound: Colchicine	Antiproliferative activity against the human non small cell lung carcinoma cell line NCI-H460 Antiproliferative activity against the human non small cell lung carcinoma cell line NCI-H460	[PMID: 11814821]
NCI-H460	IC₅₀	0.07 μM Compound: 2 (Colchicine)	Cytotoxic activity against cellular metabolic activity of Lung NCI-H460 tumor cell line using XTT proliferation assay after incubation with the compound for 48 h Cytotoxic activity against cellular metabolic activity of Lung NCI-H460 tumor cell line using XTT proliferation assay after incubation with the compound for 48 h	[PMID: 12852768]
NCI-H460	EC₅₀	0.03 μM Compound: 1	Cytotoxicity against human H460 after 3 days by SRB assay Cytotoxicity against human H460 after 3 days by SRB assay	[PMID: 15730238]
NCI-H460	IC₅₀	0.07 μM Compound: 2	Antiproliferative activity against NCI-H460 cells by XTT assay after 48 hrs Antiproliferative activity against NCI-H460 cells by XTT assay after 48 hrs	[PMID: 17181164]
NCI-H460	IC₅₀	19 nM Compound: colchichine	Growth inhibition of human H460 cells after 72 hrs by methylene blue dye assay Growth inhibition of human H460 cells after 72 hrs by methylene blue dye assay	[PMID: 17685504]
NCI-H460	IC₅₀	0.07 μM Compound: colchicine	Cytotoxicity against human NCI-H460 cells after 48 hrs by XTT assay Cytotoxicity against human NCI-H460 cells after 48 hrs by XTT assay	[PMID: 17973361]
NCI-H460	IC₅₀	20.2 nM Compound: 4	Growth inhibition of human H460 cells after 72 hrs by methylene blue dye assay Growth inhibition of human H460 cells after 72 hrs by methylene blue dye assay	[PMID: 18588280]
NCI-H460	IC₅₀	18 nM Compound: 1	Growth inhibition of human H460 cells after 72 hrs by methylene blue dye assay Growth inhibition of human H460 cells after 72 hrs by methylene blue dye assay	[PMID: 19053773]
NCI-H460	IC₅₀	0.01 μM Compound: colchicine	Antiproliferative activity against human NCI-H460 cells by XTT assay Antiproliferative activity against human NCI-H460 cells by XTT assay	[PMID: 19220018]
NCI-H460	IC₅₀	18 nM Compound: Colchicine	Cytotoxicity against human H460 cells after 72 hrs by methylene blue dye assay Cytotoxicity against human H460 cells after 72 hrs by methylene blue dye assay	[PMID: 19586033]
NCI-H460	IC₅₀	20.1 nM Compound: 3	Antiproliferative activity against human H460 cells after 72 hrs by methylene blue dye assay Antiproliferative activity against human H460 cells after 72 hrs by methylene blue dye assay	[PMID: 20148562]
NCI-H460	IC₅₀	0.07 μM Compound: 2	Antiproliferative activity against human NCI-H460 cells after 48 hrs by XTT assay Antiproliferative activity against human NCI-H460 cells after 48 hrs by XTT assay	[PMID: 20537765]
NCI-H460	IC₅₀	50.6 nM Compound: Colchicine	Antiproliferative activity against human NCI-H460 cells after 72 hrs by sulforhodamine B assay Antiproliferative activity against human NCI-H460 cells after 72 hrs by sulforhodamine B assay	[PMID: 21480626]
NCI-H460	IC₅₀	0.027 μM Compound: colchicine	Antiproliferative activity against human NCI-H460 cells after 48 hrs by alamar blue assay Antiproliferative activity against human NCI-H460 cells after 48 hrs by alamar blue assay	[PMID: 21563750]
NCI-H460	IC₅₀	20 nM Compound: 5	Antiproliferative activity against human H460 cells after 72 hrs by methylene blue assay Antiproliferative activity against human H460 cells after 72 hrs by methylene blue assay	[PMID: 21641700]
NCI-H460	IC₅₀	0.07 μM Compound: 2	Cytotoxicity against human NCI-H460 cells after 48 hrs by XTT assay Cytotoxicity against human NCI-H460 cells after 48 hrs by XTT assay	[PMID: 21705223]
NCI-H460	IC₅₀	27 μM Compound: Colchicine	Cytotoxicity against human H460 cells by MTT assay Cytotoxicity against human H460 cells by MTT assay	[PMID: 23425970]
NCI-H460	IC₅₀	0.71 μM Compound: Colchicine	Growth inhibition of human NCI-H460 cells after 72 hrs by MTT assay Growth inhibition of human NCI-H460 cells after 72 hrs by MTT assay	[PMID: 23747810]
NCI-H460	IC₅₀	0.022 μM Compound: Colchicine	Cytotoxicity against human H460 cells after 72 hrs by MTT assay Cytotoxicity against human H460 cells after 72 hrs by MTT assay	[PMID: 23932339]
NCI-H460	IC₅₀	19.8 nM Compound: 1	Cytotoxicity against human H460 cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay Cytotoxicity against human H460 cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay	[PMID: 24106982]
NCI-H460	IC₅₀	0.021 μM Compound: Colchicine	Cytotoxicity against human NCI-H460 cells assessed as growth inhibition by MTT assay Cytotoxicity against human NCI-H460 cells assessed as growth inhibition by MTT assay	[PMID: 25091926]
NCI-H460	IC₅₀	49.29 μM Compound: 1	Growth inhibition of human NCI-H460 cells incubated for 48 hrs by MTT assay Growth inhibition of human NCI-H460 cells incubated for 48 hrs by MTT assay	[PMID: 27172319]
NCI-H460	IC₅₀	0.06 μM Compound: 2	Cytotoxicity against human NCI-H460 cells after 68 hrs by MTT assay Cytotoxicity against human NCI-H460 cells after 68 hrs by MTT assay	[PMID: 32243160]
NCI-H460	IC₅₀	0.022 μM Compound: Col	Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay	[PMID: 34311158]
NCI-H460	IC₅₀	35.8 nM Compound: Colchicine	Antiproliferative activity against human NCI-H460 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
NCI-H460	IC₅₀	12 nM Compound: Colchicine	Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35084853]
NCI-H460	IC₅₀	0.054 μM Compound: Colchicine	Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 36511661]
NCI-H460	IC₅₀	19.8 nM Compound: 6	Antiproliferative activity against human H460 cells assessed as inhibition of cell growth after 72 hrs by methylene blue dye assay Antiproliferative activity against human H460 cells assessed as inhibition of cell growth after 72 hrs by methylene blue dye assay	10.1039/C0MD00052C
NCI-H520	GI₅₀	<0.05 μM Compound: Colchicine	In vivo growth inhibitory activity against human neoplastic NCI-H520 cell line In vivo growth inhibitory activity against human neoplastic NCI-H520 cell line	[PMID: 10091693]
NCI-H520	GI₅₀	<0.05 μM Compound: colchicine	Compound was evaluated for growth inhibition against NCI-H520 cells using cellular assay Compound was evaluated for growth inhibition against NCI-H520 cells using cellular assay	[PMID: 9871709]
NCI-H522	IC₅₀	0.014 μM Compound: 1	Cell cycle arrest in human NCI-H522 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis Cell cycle arrest in human NCI-H522 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis	[PMID: 21126027]
NCI-N87	IC₅₀	5.4 nM Compound: 1	Cytotoxicity against human NCI-N87 cells assessed as cell viability after 4 days by MTS assay Cytotoxicity against human NCI-N87 cells assessed as cell viability after 4 days by MTS assay	[PMID: 24210503]
NIH3T3	IC₅₀	0.0026 μM Compound: 1a	Cytotoxicity against mouse NIH/3T3 cells after 24 hrs by MTT assay Cytotoxicity against mouse NIH/3T3 cells after 24 hrs by MTT assay	[PMID: 23524161]
NIH3T3	IC₅₀	1117 nM Compound: 4; COL	Cytotoxicity against mouse NIH/3T3 cells harboring MDR G185 after 48 hrs by MTT assay Cytotoxicity against mouse NIH/3T3 cells harboring MDR G185 after 48 hrs by MTT assay	[PMID: 30448418]
NIH3T3	IC₅₀	25 nM Compound: 4; COL	Cytotoxicity against mouse NIH/3T3 cells after 48 hrs by MTT assay Cytotoxicity against mouse NIH/3T3 cells after 48 hrs by MTT assay	[PMID: 30448418]
NUGC-3	IC₅₀	0.01 μM Compound: Colchicine	Anticancer activity against human NUGC3 cells after 72 hrs by MTS/PMS assay Anticancer activity against human NUGC3 cells after 72 hrs by MTS/PMS assay	[PMID: 20170097]
OVCAR-3	IC₅₀	0.8 μM Compound: 48, Colchicine	Antitumor activity against human OVCAR-3 cells xenografted in mouse assessed as increase in mouse life span Antitumor activity against human OVCAR-3 cells xenografted in mouse assessed as increase in mouse life span	[PMID: 20187635]
OVCAR-8	IC₅₀	17 nM Compound: Colchicine	Anticancer activity against human OVCAR8 cells after 96 hrs by SRB assay Anticancer activity against human OVCAR8 cells after 96 hrs by SRB assay	[PMID: 21557538]
OVCAR-8	IC₅₀	30 nM Compound: 1	Cytotoxicity against human OVCAR8 cells assessed as growth inhibition after 96 hrs by Giemsa staining-based light microscopy Cytotoxicity against human OVCAR8 cells assessed as growth inhibition after 96 hrs by Giemsa staining-based light microscopy	[PMID: 25025991]
OVCAR-8	IC₅₀	30 nM Compound: 1	Cytotoxicity against human OVCAR8 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human OVCAR8 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 26132075]
P388	ED₅₀	0.012 μM Compound: 1a	Cytotoxic activity against P388 mouse lymphocytic leukemia cell line Cytotoxic activity against P388 mouse lymphocytic leukemia cell line	[PMID: 1956052]
P388	ED₅₀	0.47 μM Compound: 1a	Cytotoxic activity against P388 mouse lymphocytic leukemia cell line (doxorubicin resistant). Cytotoxic activity against P388 mouse lymphocytic leukemia cell line (doxorubicin resistant).	[PMID: 1956052]
P388	IC₅₀	24 nM Compound: Colchicine	Antiproliferative activity against mouse P388 cells after 48 hrs by MTT assay Antiproliferative activity against mouse P388 cells after 48 hrs by MTT assay	[PMID: 2778449]
P388	IC₅₀	0.029 μM Compound: 1	Antiproliferative activity against mouse P388 cells incubated for 72 hrs by Coulter counter method Antiproliferative activity against mouse P388 cells incubated for 72 hrs by Coulter counter method	[PMID: 32432867]
P388	IC₅₀	9.5 nM Compound: colchicine	Inhibition of P388 cell proliferation Inhibition of P388 cell proliferation	[PMID: 7990108]
P388	ED₅₀	100 nM Compound: 1	Cytotoxicity against murine P388 leukemia cell line Cytotoxicity against murine P388 leukemia cell line	[PMID: 8496935]
P388	IC₅₀	0.00062 x 10^-6 M Compound: Colchicine	The compound was evaluated in vitro for the inhibition of murine leukemia P388D1 cell proliferation. The compound was evaluated in vitro for the inhibition of murine leukemia P388D1 cell proliferation.	10.1016/S0960-894X(00)80225-5
P388	IC₅₀	1.0 x 10^-5 M Compound: Colchicine	The compound was evaluated in vitro for the inhibition of P388D1 cell colony formation. The compound was evaluated in vitro for the inhibition of P388D1 cell colony formation.	10.1016/S0960-894X(00)80225-5
P388D1	IC₅₀	28 nM Compound: Col	Antiproliferative activity against mouse P388D1 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against mouse P388D1 cells after 48 hrs by sulforhodamine B assay	[PMID: 21604746]
P388D1	IC₅₀	28 nM Compound: Col	Antiproliferative activity against human P388D1 after 48 hrs by SRB assay Antiproliferative activity against human P388D1 after 48 hrs by SRB assay	[PMID: 21920638]
PANC-1	IC₅₀	0.021 μM Compound: Colchicine	Cytotoxicity against human PANC1 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human PANC1 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 25805446]
PANC-1	GI₅₀	0.01 μM Compound: Colchicine	Antiproliferative activity against human PANC1 cells after 48 hrs by SRB assay Antiproliferative activity against human PANC1 cells after 48 hrs by SRB assay	[PMID: 25827522]
PANC-1	IC₅₀	80 nM Compound: 1	Cytotoxicity against 2D culture of human PANC1 cells measured after 72 hrs by MTT assay Cytotoxicity against 2D culture of human PANC1 cells measured after 72 hrs by MTT assay	[PMID: 27912174]
PANC-1	IC₅₀	0.1 nM Compound: 1	Antiproliferative activity against human PANC-1 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human PANC-1 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 32827941]
PANC-1	IC₅₀	0.025 μM Compound: Colchicine	Antiproliferative activity against human PANC-1 assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human PANC-1 assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
Panel NCI-60 (60 carcinoma cell lines)	GI₅₀	1.7 nM Compound: Olchicine	Growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program Growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program	[PMID: 15743190]
PBMC	IC₅₀	>100 μM Compound: 1a	Cytotoxicity against human PBMC cells after 24 hrs by MTT assay Cytotoxicity against human PBMC cells after 24 hrs by MTT assay	[PMID: 23524161]
PBMC	IC₅₀	>10000 nM Compound: Colchicine	Antiproliferative activity against human PBMC after 72 hrs by MTS assay Antiproliferative activity against human PBMC after 72 hrs by MTS assay	[PMID: 30099258]
PC-12	GI₅₀	31.5 ng/mL Compound: Colchicine	In vitro cytotoxic activity (growth inhibition) of compound against PC-12 human cancer cell line was determined In vitro cytotoxic activity (growth inhibition) of compound against PC-12 human cancer cell line was determined	[PMID: 12372531]
PC-3	GI₅₀	<0.05 μM Compound: Colchicine	In vivo growth inhibitory activity against human neoplastic PC3 cell line In vivo growth inhibitory activity against human neoplastic PC3 cell line	[PMID: 10091693]
PC-3	IC₅₀	11 nM Compound: 1	Cytotoxicity against human PC3 cell line Cytotoxicity against human PC3 cell line	[PMID: 16504507]
PC-3	IC₅₀	0.018 μM Compound: colchicine	Cytotoxicity against human PC3 cells after 3 days by MTT assay Cytotoxicity against human PC3 cells after 3 days by MTT assay	[PMID: 17275318]
PC-3	IC₅₀	0.011 μM Compound: colchicine	Cytotoxicity against human PC3 cells after 48 hrs by SRB assay Cytotoxicity against human PC3 cells after 48 hrs by SRB assay	[PMID: 19243174]
PC-3	IC₅₀	20 nM Compound: 1	Cytotoxicity against human PC3 cells after 72 hrs by crystal violet staining Cytotoxicity against human PC3 cells after 72 hrs by crystal violet staining	[PMID: 20529690]
PC-3	IC₅₀	11 nM Compound: Colchicine	Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay	[PMID: 20919720]
PC-3	IC₅₀	0.033 μM Compound: 1	Cell cycle arrest in human PC3 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis Cell cycle arrest in human PC3 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis	[PMID: 21126027]
PC-3	IC₅₀	0.01 μM Compound: Colchicine	Antiproliferative activity against human PC3 cells after 96 hrs by sulforhodamine B assay Antiproliferative activity against human PC3 cells after 96 hrs by sulforhodamine B assay	[PMID: 21775150]
PC-3	IC₅₀	0.01 μM Compound: Colchicine	Antiproliferative activity against human PC3 cells after 96 hrs by SRB assay Antiproliferative activity against human PC3 cells after 96 hrs by SRB assay	[PMID: 22608389]
PC-3	IC₅₀	11.5 nM Compound: Colchicine	Antiproliferative activity against human PC3 cells after 48 hrs by SRB assay Antiproliferative activity against human PC3 cells after 48 hrs by SRB assay	[PMID: 22783954]
PC-3	IC₅₀	0.06 μM Compound: Colchicine	Cytotoxicity against human PC3 cells assessed as growth inhibition Cytotoxicity against human PC3 cells assessed as growth inhibition	[PMID: 23419737]
PC-3	IC₅₀	0.04 μM Compound: Colchicine	Cytotoxicity against human PC3 cells by MTT assay Cytotoxicity against human PC3 cells by MTT assay	[PMID: 23425970]
PC-3	IC₅₀	0.074 μM Compound: Colchicine	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay Cytotoxicity against human PC3 cells after 72 hrs by MTT assay	[PMID: 23602523]
PC-3	IC₅₀	0.015 μM Compound: 1	Growth inhibition of human PC3 cells incubated for 72 hrs by MTT assay Growth inhibition of human PC3 cells incubated for 72 hrs by MTT assay	[PMID: 27172319]
PC-3	IC₅₀	8 nM Compound: Colchicine	Cytotoxicity against human PC3 cells after 72 hrs by MTS assay Cytotoxicity against human PC3 cells after 72 hrs by MTS assay	[PMID: 29406710]
PC-3	IC₅₀	0.13 μM Compound: Colchicine	Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay	[PMID: 30075402]
PC-3	IC₅₀	0.59 μM Compound: Colchicine	Antiproliferative activity against human PC3 cells measured after 48 hrs by MTT assay Antiproliferative activity against human PC3 cells measured after 48 hrs by MTT assay	[PMID: 30690300]
PC-3	IC₅₀	10.4 nM Compound: Colchicine	Antiproliferative activity against human PC3 cells Antiproliferative activity against human PC3 cells	[PMID: 31251599]
PC-3	IC₅₀	0.04 μM Compound: Colchicine	Antiproliferative activity against human PC3 cells assessed as reduction in cell viability Antiproliferative activity against human PC3 cells assessed as reduction in cell viability	[PMID: 31753698]
PC-3	IC₅₀	19 nM Compound: Colchicine	Antiproliferative activity against human PC3 cells measured after 72 hrs by MTS assay Antiproliferative activity against human PC3 cells measured after 72 hrs by MTS assay	[PMID: 31860298]
PC-3	IC₅₀	0.042 μM Compound: 1	Cytotoxicity against human PC-3 cells incubated for 48 hrs by MTT assay Cytotoxicity against human PC-3 cells incubated for 48 hrs by MTT assay	[PMID: 32432867]
PC-3	IC₅₀	0.338 μM Compound: Colchicine	Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 32682200]
PC-3	IC₅₀	0.03 μM Compound: Colchicine	Cytotoxicity against human PC-3 cells treated for 72 hrs by MTT assay Cytotoxicity against human PC-3 cells treated for 72 hrs by MTT assay	[PMID: 35344904]
PC-3	IC₅₀	0.079 μM Compound: 1	Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 37856840]
PC-3	IC₅₀	0.05 μM Compound: Colchicine	Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth after 72 hrs by MTT assay Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth after 72 hrs by MTT assay	[PMID: 38336655]
PC-3	GI₅₀	<0.05 μM Compound: colchicine	Compound was evaluated for growth inhibition against PC-3 cells using cellular assay Compound was evaluated for growth inhibition against PC-3 cells using cellular assay	[PMID: 9871709]
PPC-1	IC₅₀	0.02 μM Compound: colchicine	Cytotoxicity against human PPC1 cells after 48 hrs by SRB assay Cytotoxicity against human PPC1 cells after 48 hrs by SRB assay	[PMID: 19243174]
PPC-1	IC₅₀	20 nM Compound: Colchicine	Cytotoxicity against human PPC1 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human PPC1 cells after 48 hrs by sulforhodamine B assay	[PMID: 20919720]
PPC-1	IC₅₀	0.02 μM Compound: Colchicine	Antiproliferative activity against human PPC1 cells after 96 hrs by sulforhodamine B assay Antiproliferative activity against human PPC1 cells after 96 hrs by sulforhodamine B assay	[PMID: 21775150]
Raji	EC₅₀	0.014 μM Compound: Colchicine	Cytotoxicity against human Raji cells after 48 hrs by luminescence cell viability assay Cytotoxicity against human Raji cells after 48 hrs by luminescence cell viability assay	[PMID: 18684625]
Raji	IC₅₀	16 nM Compound: 1	Antiproliferative activity against human Raji cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human Raji cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 32827941]
Raji	IC₅₀	18 nM Compound: Colchicine	Antiproliferative activity against human Raji cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Antiproliferative activity against human Raji cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35084853]
Ramos	IC₅₀	2.13 nM Compound: Colchicine	Antiproliferative activity against human Ramos cells incubated for 72 hrs by MTT assay Antiproliferative activity against human Ramos cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
REH	IC₅₀	0.0095 μM Compound: 1a	Cytotoxicity against human REH cells after 48 hrs by MTT assay Cytotoxicity against human REH cells after 48 hrs by MTT assay	[PMID: 23524161]
RKO	IC₅₀	>10 μM Compound: 2 (Colchicine)	Cytotoxic activity against human colon adenocarcinoma RKO cells with ectopic inducible expression of cyclin-dependent kinase inhibitor p27kip1 Cytotoxic activity against human colon adenocarcinoma RKO cells with ectopic inducible expression of cyclin-dependent kinase inhibitor p27kip1	[PMID: 12852768]
RKO	IC₅₀	0.02 μM Compound: 2 (Colchicine)	Cytotoxic activity against human colon adenocarcinoma RKO cells without ectopic inducible expression of cyclin-dependent kinase inhibitor p27kip1 Cytotoxic activity against human colon adenocarcinoma RKO cells without ectopic inducible expression of cyclin-dependent kinase inhibitor p27kip1	[PMID: 12852768]
RKO	IC₅₀	>5 μM Compound: Colchicine	Cytotoxicity against cell cycle arrested RKOp27 cells after 72 hrs by alamar blue assay Cytotoxicity against cell cycle arrested RKOp27 cells after 72 hrs by alamar blue assay	[PMID: 16970401]
RKO	IC₅₀	0.016 μM Compound: Colchicine	Cytotoxicity against proliferating RKOp27 cells after 72 hrs by Alamar Blue assay Cytotoxicity against proliferating RKOp27 cells after 72 hrs by Alamar Blue assay	[PMID: 16970401]
RKO	IC₅₀	>10 μM Compound: 2	Antiproliferative activity against RKO cells with ectopic-induced p27kip1-expression by XTT assay after 48 hrs Antiproliferative activity against RKO cells with ectopic-induced p27kip1-expression by XTT assay after 48 hrs	[PMID: 17181164]
RKO	IC₅₀	0.02 μM Compound: 2	Antiproliferative activity against RKO cells by XTT assay after 48 hrs Antiproliferative activity against RKO cells by XTT assay after 48 hrs	[PMID: 17181164]
RKO	IC₅₀	>14 μM Compound: colchicine	Cytotoxicity against human RKO cells with ectopic-inducible expression of p27kip1 after 48 hrs by XTT assay Cytotoxicity against human RKO cells with ectopic-inducible expression of p27kip1 after 48 hrs by XTT assay	[PMID: 17973361]
RKO	IC₅₀	0.02 μM Compound: colchicine	Cytotoxicity against human RKO cells after 48 hrs by XTT assay Cytotoxicity against human RKO cells after 48 hrs by XTT assay	[PMID: 17973361]
RKO	IC₅₀	>3 μM Compound: colchicine	Antiproliferative activity against human RKO cells containing ecdysone-inducible expression vector of p27kipl by XTT assay Antiproliferative activity against human RKO cells containing ecdysone-inducible expression vector of p27kipl by XTT assay	[PMID: 19220018]
RKO	IC₅₀	0.01 μM Compound: colchicine	Antiproliferative activity against human RKO cells by XTT assay Antiproliferative activity against human RKO cells by XTT assay	[PMID: 19220018]
RKO	IC₅₀	>10 μM Compound: 2	Antiproliferative activity against human RKO cells expressing p27Kip1 after 48 hrs by XTT assay Antiproliferative activity against human RKO cells expressing p27Kip1 after 48 hrs by XTT assay	[PMID: 20537765]
RKO	IC₅₀	0.02 μM Compound: 2	Antiproliferative activity against human RKO cells after 48 hrs by XTT assay Antiproliferative activity against human RKO cells after 48 hrs by XTT assay	[PMID: 20537765]
RKO	IC₅₀	0.043 μM Compound: Colchicine	Antiproliferative activity against human RKO cells after 48 hrs by MTT assay Antiproliferative activity against human RKO cells after 48 hrs by MTT assay	[PMID: 30093295]
RKO	IC₅₀	4.4 μM Compound: COL	Antiproliferative activity against human RKO cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human RKO cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 37099835]
RL	IC₅₀	4.4 nM Compound: Colchicine	Antiproliferative activity against human RL cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human RL cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33618157]
RPMI-7951	IC₅₀	6.6 nM Compound: Colchicine	Cytotoxicity against human RPMI7951 cells after 72 hrs by MTS assay Cytotoxicity against human RPMI7951 cells after 72 hrs by MTS assay	[PMID: 29406710]
RPMI-7951	IC₅₀	13.8 nM Compound: Colchicine	Antiproliferative activity against human RPMI-7951 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay Antiproliferative activity against human RPMI-7951 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay	[PMID: 34406768]
RPMI-7951	ED₅₀	1 nM Compound: 1	Cytotoxicity against human melanoma RPMI-7951 cell line Cytotoxicity against human melanoma RPMI-7951 cell line	[PMID: 8496935]
SAS	IC₅₀	3.5 μM Compound: Colchicine	Cytotoxicity against human SAS cells assessed as growth inhibition Cytotoxicity against human SAS cells assessed as growth inhibition	[PMID: 23419737]
SF-268	IC₅₀	0.05 μM Compound: 2 (Colchicine)	Cytotoxic activity against cellular metabolic activity of Glioma SF-268 tumor cell line using XTT proliferation assay after incubation with the compound for 48 h Cytotoxic activity against cellular metabolic activity of Glioma SF-268 tumor cell line using XTT proliferation assay after incubation with the compound for 48 h	[PMID: 12852768]
SF-268	EC₅₀	0.025 μM Compound: 1	Cytotoxicity against human SF-268 after 3 days by SRB assay Cytotoxicity against human SF-268 after 3 days by SRB assay	[PMID: 15730238]
SF-268	IC₅₀	0.05 μM Compound: 2	Antiproliferative activity against SF268 cells by XTT assay after 48 hrs Antiproliferative activity against SF268 cells by XTT assay after 48 hrs	[PMID: 17181164]
SF-268	IC₅₀	0.05 μM Compound: colchicine	Cytotoxicity against human SF268 cells after 48 hrs by XTT assay Cytotoxicity against human SF268 cells after 48 hrs by XTT assay	[PMID: 17973361]
SF-268	IC₅₀	0.01 μM Compound: colchicine	Antiproliferative activity against human SF268 cells by XTT assay Antiproliferative activity against human SF268 cells by XTT assay	[PMID: 19220018]
SF-268	IC₅₀	0.05 μM Compound: 2	Antiproliferative activity against human SF268 cells after 48 hrs by XTT assay Antiproliferative activity against human SF268 cells after 48 hrs by XTT assay	[PMID: 20537765]
SF-268	IC₅₀	0.05 μM Compound: 2	Cytotoxicity against human SF268 cells after 48 hrs by XTT assay Cytotoxicity against human SF268 cells after 48 hrs by XTT assay	[PMID: 21705223]
SGC-7901	IC₅₀	0.05 μM Compound: Colchicine	Cytotoxicity against human SGC7901 cells after 48 hrs Cytotoxicity against human SGC7901 cells after 48 hrs	[PMID: 23022053]
SGC-7901	IC₅₀	0.134 μM Compound: 1	Antiproliferative activity against human SGC7901 cells after 72 hrs by MTT assay Antiproliferative activity against human SGC7901 cells after 72 hrs by MTT assay	[PMID: 30245397]
SGC-7901	IC₅₀	0.007 μM Compound: Colchicine	Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 34571171]
SGC-7901	IC₅₀	43 nM Compound: Colchicine	Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell growth by MTT assay	[PMID: 36893627]
SGC-7901	IC₅₀	17.3 μM Compound: COL	Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 37099835]
SGC-7901	IC₅₀	0.11 μM Compound: 1	Antiproliferative activity against human SGC-7901 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human SGC-7901 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37182330]
SGC-7901	IC₅₀	0.012 μM Compound: Colchicine	Antiproliferative activity against human SGC-7901 cells measured after 72 hrs by MTT assay Antiproliferative activity against human SGC-7901 cells measured after 72 hrs by MTT assay	[PMID: 38471357]
SH-SY5Y	GI₅₀	0.04 μM Compound: Colchicine	Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTT assay Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTT assay	[PMID: 28763647]
SH-SY5Y	IC₅₀	7.89 μM Compound: COL	Antiproliferative activity against human SH-SY5Y cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human SH-SY5Y cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 35694693]
SiHa	IC₅₀	0.045 μM Compound: Col	Antiproliferation activity against human SiHa cells assessed as reduction in cell growth measured after 48 to 72 hrs by CCK-8 assay Antiproliferation activity against human SiHa cells assessed as reduction in cell growth measured after 48 to 72 hrs by CCK-8 assay	[PMID: 35339837]
SJSA-1	IC₅₀	0.008 μM Compound: Colchicine	Cytotoxicity against human SJSA1 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human SJSA1 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 25805446]
SK-BR-3	ED₅₀	0.0027 μg/mL Compound: 1	Cytotoxicity against human SKBR3 cells after 2 days Cytotoxicity against human SKBR3 cells after 2 days	[PMID: 20542428]
SK-BR-3	IC₅₀	0.0064 μM Compound: Colchicine	Growth inhibition of human SKBR3 cells after 48 hrs by MTT assay Growth inhibition of human SKBR3 cells after 48 hrs by MTT assay	[PMID: 22850214]
SK-BR-3	IC₅₀	0.04 μM Compound: Colchicine	Cytotoxicity against human SK-BR-3 cells treated for 72 hrs by MTT assay Cytotoxicity against human SK-BR-3 cells treated for 72 hrs by MTT assay	[PMID: 35344904]
SK-BR-3	IC₅₀	5 nM Compound: colchicine	Inhibition of SK-BR-3 cell proliferation Inhibition of SK-BR-3 cell proliferation	[PMID: 7990108]
SK-HEP1	IC₅₀	0.78 μM Compound: Colchicine	Cytotoxicity against human SKHEP1 cells assessed as growth inhibition Cytotoxicity against human SKHEP1 cells assessed as growth inhibition	[PMID: 23419737]
SK-HEP1	IC₅₀	0.17 μM Compound: Colchicine	Cytotoxicity against human SKHEP1 cells by MTT assay Cytotoxicity against human SKHEP1 cells by MTT assay	[PMID: 23425970]
SK-MEL-2	IC₅₀	6 nM Compound: 1; (-)-Colchicine	Antiproliferative activity against human SK-MEL-2 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay Antiproliferative activity against human SK-MEL-2 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay	[PMID: 31655432]
SK-MEL-2	ED₅₀	0.007 μg/mL Compound: colchicine	Cytotoxicity against human SK-MEL-2 cells Cytotoxicity against human SK-MEL-2 cells	[PMID: 8133298]
SK-MEL-2	ED₅₀	0.008 μg/mL Compound: colchicine	The compound was tested for the cytotoxicity for the cell lines of human melanoma cancer (SKMEL-2) using SRB assay. The compound was tested for the cytotoxicity for the cell lines of human melanoma cancer (SKMEL-2) using SRB assay.	[PMID: 9544215]
SK-MEL-2	EC₅₀	0.008 μg/mL Compound: 1	In vitro growth inhibition of SK-MEL-2, malignant melanoma. In vitro growth inhibition of SK-MEL-2, malignant melanoma.	[PMID: 9599244]
SK-MES-1	IC₅₀	18.6 nM Compound: 1	Cytotoxicity against human SKMES1 cells after 48 hrs by Celltiter-Glo luminescent cell viability assay Cytotoxicity against human SKMES1 cells after 48 hrs by Celltiter-Glo luminescent cell viability assay	[PMID: 26985296]
SK-OV-3	IC₅₀	0.02 μM Compound: Colchicine	In vitro inhibitory activity against SK-OV-3 cells using XTT proliferation assay. In vitro inhibitory activity against SK-OV-3 cells using XTT proliferation assay.	[PMID: 11741473]
SK-OV-3	IC₅₀	0.05 μM Compound: 2 (Colchicine)	Cytotoxic activity against cellular metabolic activity of Ovary SKOV3 tumor cell line using XTT proliferation assay after incubation with the compound for 48 h Cytotoxic activity against cellular metabolic activity of Ovary SKOV3 tumor cell line using XTT proliferation assay after incubation with the compound for 48 h	[PMID: 12852768]
SK-OV-3	IC₅₀	0.05 μM Compound: 2	Antiproliferative activity against SKOV3 cells by XTT assay after 48 hrs Antiproliferative activity against SKOV3 cells by XTT assay after 48 hrs	[PMID: 17181164]
SK-OV-3	IC₅₀	0.05 μM Compound: colchicine	Cytotoxicity against human SKOV3 cells after 48 hrs by XTT assay Cytotoxicity against human SKOV3 cells after 48 hrs by XTT assay	[PMID: 17973361]
SK-OV-3	IC₅₀	0.01 μM Compound: colchicine	Antiproliferative activity against human SKOV3 cells by XTT assay Antiproliferative activity against human SKOV3 cells by XTT assay	[PMID: 19220018]
SK-OV-3	IC₅₀	0.05 μM Compound: 2	Antiproliferative activity against human SKOV3 cells after 48 hrs by XTT assay Antiproliferative activity against human SKOV3 cells after 48 hrs by XTT assay	[PMID: 20537765]
SK-OV-3	IC₅₀	71.2 nM Compound: Colchicine	Antiproliferative activity against human SKOV3 cells after 72 hrs by sulforhodamine B assay Antiproliferative activity against human SKOV3 cells after 72 hrs by sulforhodamine B assay	[PMID: 21480626]
SK-OV-3	IC₅₀	0.029 μM Compound: colchicine	Antiproliferative activity against human SKOV3 cells after 48 hrs by alamar blue assay Antiproliferative activity against human SKOV3 cells after 48 hrs by alamar blue assay	[PMID: 21563750]
SK-OV-3	IC₅₀	2.1 nM Compound: Col	Antiproliferative activity against human SKOV3 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human SKOV3 cells after 48 hrs by sulforhodamine B assay	[PMID: 21604746]
SK-OV-3	IC₅₀	0.05 μM Compound: 2	Cytotoxicity against human SKOV3 cells after 48 hrs by XTT assay Cytotoxicity against human SKOV3 cells after 48 hrs by XTT assay	[PMID: 21705223]
SK-OV-3	IC₅₀	2.1 nM Compound: Col	Antiproliferative activity against human SKOV3 after 48 hrs by SRB assay Antiproliferative activity against human SKOV3 after 48 hrs by SRB assay	[PMID: 21920638]
SK-OV-3	IC₅₀	0.12 μM Compound: Colchicine	Cytotoxicity against human SKOV3 cells by MTT assay Cytotoxicity against human SKOV3 cells by MTT assay	[PMID: 23425970]
SK-OV-3	IC₅₀	51.9 nM Compound: 1	Antiproliferative activity against human SKOV3 cells after 24 hrs by MTT assay Antiproliferative activity against human SKOV3 cells after 24 hrs by MTT assay	[PMID: 27213819]
SK-OV-3	IC₅₀	0.05 μM Compound: Colchicine	Antiproliferative activity against human SKOV3 cells by SRB assay Antiproliferative activity against human SKOV3 cells by SRB assay	[PMID: 28988750]
SK-OV-3	IC₅₀	198 nM Compound: 1	Cytotoxicity against human SKOV3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Cytotoxicity against human SKOV3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay	[PMID: 30429975]
SK-OV-3	IC₅₀	210 nM Compound: 1	Cytotoxicity against arrested non-proliferative human SKOV3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Cytotoxicity against arrested non-proliferative human SKOV3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay	[PMID: 30429975]
SK-OV-3	IC₅₀	18 nM Compound: 1; (-)-Colchicine	Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay	[PMID: 31655432]
SK-OV-3	IC₅₀	7.2 nM Compound: Colchicine	Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 36621138]
SK-OV-3	IC₅₀	10.23 nM Compound: Colchicine	Antiproliferative activity against human SK-OV-3 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human SK-OV-3 cells incubated for 48 hrs by CCK8 assay	[PMID: 38972078]
SK-OV-3	IC₅₀	0.011 μM Compound: Colchicine	Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
SNU-16	IC₅₀	0.005 μM Compound: Colchicine	Cytotoxicity against human SNU16 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human SNU16 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 25805446]
SNU-398	EC₅₀	0.004 μM Compound: colchicine	Induction of apoptosis in human SNU398 cells assessed as caspase activation after 24 hrs by HTS assay Induction of apoptosis in human SNU398 cells assessed as caspase activation after 24 hrs by HTS assay	[PMID: 18197614]
SNU-423	IC₅₀	25 nM Compound: colchichine	Cytotoxicity against human SNU423 cells after 48 hrs by alamar blue assay Cytotoxicity against human SNU423 cells after 48 hrs by alamar blue assay	[PMID: 19117761]
SNU-5	IC₅₀	0.034 μM Compound: Colchicine	Cytotoxicity against human SNU5 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human SNU5 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 25805446]
Splenocyte	IC₅₀	2.3 μM Compound: 1	Immunosuppressive activity in mouse splenocytes assessed as inhibition of allogenic mixed lymphocyte reaction Immunosuppressive activity in mouse splenocytes assessed as inhibition of allogenic mixed lymphocyte reaction	[PMID: 19502058]
Splenocyte	IC₅₀	2300 nM Compound: 3	Immunosuppressant activity in mouse splenocytes by mixed-leukocyte reaction assay Immunosuppressant activity in mouse splenocytes by mixed-leukocyte reaction assay	[PMID: 23017885]
SW1990	IC₅₀	0.01 μM Compound: Colchicine	Antiproliferative activity against human SW1990 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human SW1990 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 36511661]
SW480	IC₅₀	0.03 μM Compound: colchicine	Antiproliferative activity against human SW480 cells after 48 hrs by alamar blue assay Antiproliferative activity against human SW480 cells after 48 hrs by alamar blue assay	[PMID: 21563750]
SW480	IC₅₀	0.033 μM Compound: COL	Antiproliferative activity against human SW480 cells after 48 hrs by SRB method Antiproliferative activity against human SW480 cells after 48 hrs by SRB method	[PMID: 25061803]
SW480	IC₅₀	14.9 nM Compound: Colchicine	Antiproliferative activity against human SW480 cells after 72 hrs by MTS assay Antiproliferative activity against human SW480 cells after 72 hrs by MTS assay	[PMID: 30099258]
SW-620	IC₅₀	0.014 μM Compound: 1	Cell cycle arrest in human SW620 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis Cell cycle arrest in human SW620 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis	[PMID: 21126027]
SW-620	IC₅₀	0.005 μM Compound: Colchicine	Cytotoxicity against human SW620 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human SW620 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 25805446]
SW-620	IC₅₀	2.4 nM Compound: 1	Antiproliferative activity against human SW-620 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human SW-620 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay	[PMID: 32827941]
SW780	IC₅₀	6.7 nM Compound: colchicine	Cytotoxicity against human SW780 cells after 96 hrs by MTT assay Cytotoxicity against human SW780 cells after 96 hrs by MTT assay	[PMID: 23176628]
T-24	IC₅₀	0.046 μM Compound: Colchicine	Antiproliferative activity against human T-24 cells assessed as cell growth inhibition incubated for72 hrs by MTT assay Antiproliferative activity against human T-24 cells assessed as cell growth inhibition incubated for72 hrs by MTT assay	[PMID: 37890199]
T47D	EC₅₀	0.014 μM Compound: 12	Tested for caspase activation activity in human breast cancer T47D cells Tested for caspase activation activity in human breast cancer T47D cells	[PMID: 12773051]
T47D	EC₅₀	0.014 μM Compound: colchicine	Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs	[PMID: 15566300]
T47D	EC₅₀	0.009 μM Compound: colchicine	Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs by HTS assay Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs by HTS assay	[PMID: 18197614]
T47D	GI₅₀	0.007 μM Compound: colchicine	Growth inhibition of human T47D cells after 48 hrs Growth inhibition of human T47D cells after 48 hrs	[PMID: 18197614]
T47D	EC₅₀	0.009 μM Compound: colchicine	Induction of apoptosis in human T47D cells assessed as caspase 3 activation after 24 hrs Induction of apoptosis in human T47D cells assessed as caspase 3 activation after 24 hrs	[PMID: 18651728]
T47D	GI₅₀	0.007 μM Compound: Colchicine	Growth inhibition of human T47D cells after 48 hrs Growth inhibition of human T47D cells after 48 hrs	[PMID: 19282188]
T47D	EC₅₀	0.009 μM Compound: colchicine	Induction of apoptosis in human T47D cells assessed as caspase activation after 48 hrs by HTS assay Induction of apoptosis in human T47D cells assessed as caspase activation after 48 hrs by HTS assay	[PMID: 19464890]
T47D	EC₅₀	0.014 μM Compound: Colchicine	Induction of apoptosis in human T47D cells assessed as caspase activation after 48 hrs Induction of apoptosis in human T47D cells assessed as caspase activation after 48 hrs	[PMID: 19500976]
T47D	GI₅₀	0.14 μM Compound: Colchicine	Growth inhibition of human T47D cells after 48 hrs Growth inhibition of human T47D cells after 48 hrs	[PMID: 19500976]
T47D	IC₅₀	0.28 nM Compound: COL	Antiproliferative activity against ERalpha positive human T47D cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay Antiproliferative activity against ERalpha positive human T47D cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay	[PMID: 37584263]
T-cell	IC₅₀	548 nM Compound: 1	Immunosuppressive activity in concanavalin A-activated T cell assessed as inhibition of lymphoproliferation after 3 days by beta-scintillation counting Immunosuppressive activity in concanavalin A-activated T cell assessed as inhibition of lymphoproliferation after 3 days by beta-scintillation counting	[PMID: 19502058]
TE-671	ED₅₀	1 nM Compound: 1	Cytotoxicity against human central nervous system carcinoma TE671 cell line Cytotoxicity against human central nervous system carcinoma TE671 cell line	[PMID: 8496935]
TERT-RPE1	CC₅₀	0.1 μM Compound: Colchicine	Cytotoxicity against hTERT-RPE1 cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay Cytotoxicity against hTERT-RPE1 cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay	[PMID: 30288225]
THP-1	IC₅₀	20.4 nM Compound: 1	Cytotoxicity against human THP1 cells after 24 hrs by Celltiter-Glo luminescent cell viability assay Cytotoxicity against human THP1 cells after 24 hrs by Celltiter-Glo luminescent cell viability assay	[PMID: 26985296]
THP-1	IC₅₀	2.49 nM Compound: Colchicine	Antiproliferative activity against human THP-1 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human THP-1 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
U-251	IC₅₀	20 nM Compound: colchicine	Antiproliferative activity against human U251 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Antiproliferative activity against human U251 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 25208345]
U-251	IC₅₀	0.017 μM Compound: Col	Antiproliferative activity against human U-251 cells after 48 hrs by MTT assay Antiproliferative activity against human U-251 cells after 48 hrs by MTT assay	[PMID: 34311158]
U-266	IC₅₀	0.01 μM Compound: 1	Cell cycle arrest in human U266 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis Cell cycle arrest in human U266 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis	[PMID: 21126027]
U-373MG ATCC	ED₅₀	0.005 μg/mL Compound: colchicine	Cytotoxicity against human U373 cells Cytotoxicity against human U373 cells	[PMID: 8133298]
U-87MG ATCC	IC₅₀	0.036 μM Compound: Colchicine	Antiproliferative activity against human U-87 MG assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human U-87 MG assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
U-937	IC₅₀	0.1 μg/mL Compound: Colchicine	Cytotoxicity against human U937 cells after 48 hrs by MTT assay Cytotoxicity against human U937 cells after 48 hrs by MTT assay	[PMID: 15165134]
U-937	IC₅₀	0.008 μM Compound: Colchicine	Antiproliferative activity against human U937 cells by sulforhodamine B assay Antiproliferative activity against human U937 cells by sulforhodamine B assay	[PMID: 20334421]
U-937	IC₅₀	5.2 nM Compound: colchicine	Inhibition of U937 cell proliferation Inhibition of U937 cell proliferation	[PMID: 7990108]
Vero	EC₅₀	0.27 μM Compound: Colchicine	Cell cycle arrest in african green monkey Vero cells assessed as accumulation at G2/M phase after 18 hrs by flow cytometry using propidium iodide staining Cell cycle arrest in african green monkey Vero cells assessed as accumulation at G2/M phase after 18 hrs by flow cytometry using propidium iodide staining	[PMID: 18684625]
Vero	EC₅₀	0.39 μM Compound: Colchicine	Induction of apoptosis in african green monkey Vero cells assessed as caspase 3/7 activity after 18 hrs by flow cytometry using propidium iodide staining Induction of apoptosis in african green monkey Vero cells assessed as caspase 3/7 activity after 18 hrs by flow cytometry using propidium iodide staining	[PMID: 18684625]
Vero	EC₅₀	0.53 μM Compound: Colchicine	Cytotoxicity against african green monkey Vero cells after 48 hrs by luminescence cell viability assay Cytotoxicity against african green monkey Vero cells after 48 hrs by luminescence cell viability assay	[PMID: 18684625]
WI-38	CC₅₀	0.0476 μM Compound: Colchicine	Cytotoxicity against human WI38 cells assessed as reduction in cellular DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay Cytotoxicity against human WI38 cells assessed as reduction in cellular DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay	[PMID: 17893158]
WI-38	EC₅₀	0.022 μM Compound: Colchicine	Antiviral activity against BKV Gardner ATCC VR837 infected in human WI38 cells assessed as reduction in viral DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay Antiviral activity against BKV Gardner ATCC VR837 infected in human WI38 cells assessed as reduction in viral DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay	[PMID: 17893158]
WM164	IC₅₀	0.03 μM Compound: Colchicine	Antiproliferative activity against human WM164 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human WM164 cells after 48 hrs by sulforhodamine B assay	[PMID: 21775150]
WM164	IC₅₀	0.03 μM Compound: Colchicine	Antiproliferative activity against human WM164 cells after 48 hrs by SRB assay Antiproliferative activity against human WM164 cells after 48 hrs by SRB assay	[PMID: 22608389]
WM164	IC₅₀	29 nM Compound: Colchicine	Antiproliferative activity against human WM164 cells after 48 hrs by SRB assay Antiproliferative activity against human WM164 cells after 48 hrs by SRB assay	[PMID: 22783954]
WM164	IC₅₀	10.8 nM Compound: Colchicine	Antiproliferative activity against human WM164 cells after 72 hrs by MTT assay Antiproliferative activity against human WM164 cells after 72 hrs by MTT assay	[PMID: 31251599]
ZR-75-1	EC₅₀	0.006 μM Compound: 12	Tested for caspase activation activity in human breast cancer ZR-75-1 cells Tested for caspase activation activity in human breast cancer ZR-75-1 cells	[PMID: 12773051]
ZR-75-1	IC₅₀	522 nM Compound: Colchicine	Cytotoxicity against ZR-75-1 cell line Cytotoxicity against ZR-75-1 cell line	[PMID: 17249649]
ZR-75-1	ED₅₀	0.1 μg/mL Compound: Colchicine	Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay	[PMID: 7528785]
ZR-75-1	ED₅₀	0.1 μg/mL Compound: colchicine	Cytotoxicity against human ZR-75-1 cells Cytotoxicity against human ZR-75-1 cells	[PMID: 8133298]

In Vitro

Colchicine (5 μM; pretreated 24 h) inhibits MIRI-induced apoptosis of H9C2 by regulating the PI3K/AKT/eNOS pathway^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[3]

Cell Line:

H9C2 cells
Concentration:

5 μM
Incubation Time:

Pretreated 24 h
Result:

Caused a significant reduction (4.490%) of early apoptotic cells as compared with the H/R only groups (6.182%).

Western Blot Analysis^[3]

Cell Line:

H9C2 cells
Concentration:

5 μM
Incubation Time:

Pretreated 24 h
Result:

Observably increased the decreased phosphorylation levels of PI3K, AKT, and eNOS after H/R injury in H9C2 cell.

In Vivo

Animal Model:

Specific-pathogen-free 8-week-old male mice (Wild-type C57BL/6 mice)^[4]
Dosage:

1 or 3 mg/kg
Administration:

Orally; 30 min prior to Indomethacin administration
Result:

Caused less mucosal inflammation and ulceration and a decrease in the size and numbers of lesions compared with vehicle-treated mice with Indomethacin (10 mg/kg; gavage).

Induced Disease Models

Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

Colchicine can be used to induce Alzheimer's disease models^[6].

Induction of Alzheimer’s disease (AD)^[6]

Background

Colchicine is a tubulin inhibitor that binds irreversibly to tubulin dimers and inhibits microtubule assembly with disruption of their polymerization, leading to neurofibrillary degeneration and synaptic loss. This causes neurotrophic factor intracellular trafficking to be disrupted, as well as axonal excitotoxicity and oxidative damage.

Specific Modeling Methods

Rat: Wistar • male • adult, weighing 180-220 g (acclimate: 1 weeks)
Administration: 7.5 μg in 5 μL/site • intracerebroventricular (icv) injection • single dose

Note

(1) For induction of AD, rats are anesthetized using intraperitoneal (i.p.) Thiopental sodium (45 mg/kg) and then positioned in stereotaxic apparatus.
(2) The stereotaxic coordinates are 0.8 mm posterior to bregma, 1.8 mm lateral to sagittal suture and 3.6 mm beneath the cortical surface.
(3) Using a 28-gauge micro-syringe (10 μL) 15 μg Colchicine dissolved in 10 μL ACSF is injected bilaterally into the lateral ventricle (7.5 μg in 5 μL/site). The injection rate is 2 μL/min, then the micro-syringe is remained in place for 2 min to avoid withdrawal of the injected fluid.
(4) Artificial cerebrospinal fluid (ACSF constituents in milli mole: NaCl 147, MgCl₂ 1.6, KCl 2.9, CaCl₂ 1.7, and Dextrose 2.2) is freshly prepared.

Modeling Indicators

Molecular changes: Induced indicators: Aβ 1-40 and Aβ 1-42 peptides level, MDA concentration, TNF-α level in both hippocampus and prefrontal cortex
Decrease indicators: SOD activity in both hippocampus and prefrontal cortex

Correlated Product(s): β-Amyloid (1-42), human TFA (HY-P1363)

Opposite Product(s): Sacubitril/Valsartan (HY-18204A)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 64-86-8
Appearance Solid
Molecular Weight 399.44
Formula C₂₂H₂₅NO₆
Color White to light yellow
SMILES

CC(N[C@H](C1=C2)CCC3=CC(OC)=C(OC)C(OC)=C3C1=CC=C(OC)C2=O)=O
Structure Classification
- Others
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (62)

All Cell Proliferation/Viability AssayWBIF

Sort by:

Journal Impact Factor

Cell Mol Immunol

Arsenic trioxide elicits prophylactic and therapeutic immune responses against solid tumors by inducing necroptosis and ferroptosis. [Abstract]

2023 Jan;20(1):51-64. PMID: 36447031

Colchicine purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2023 Jan;20(1):51-64. [Abstract]

Comparison of drug (Epirubicin hydrochloride, EPI; Daunorubicin hydrochloride, DNR; Vinorelbine ditartrate, VNR; Oxaliplatin, OXA; Vincristine, VCR; Artemisinin, ART; Colchicine, COL) cytotoxicity to TC1 cells at the indicated doses and time points measured with CCK-8 assays. R.U. (Relative unit) was calculated from the average O.D. values in each condition as the indicator of cell viability (n = 3).
Nat Commun

Transferrin-phosphatidylserine liposomes target TDP-43 and neuroinflammation in male mice with neuropathic pain. [Abstract]

2025 Dec 12;16(1):11314. PMID: 41387431
Nat Commun

Berberine-inspired ionizable lipid for self-structure stabilization and brain targeting delivery of nucleic acid therapeutics. [Abstract]

2025 Mar 10;16(1):2368. PMID: 40064874
Nat Commun

Stress fiber anisotropy contributes to force-mode dependent chromatin stretching and gene upregulation in living cells. [Abstract]

2020 Sep 29;11(1):4902. PMID: 32994402
Acta Pharm Sin B

Inhibition of ASCT2 induces hepatic stellate cell senescence with modified proinflammatory secretome through an IL-1 α/NF- κ B feedback pathway to inhibit liver fibrosis. [Abstract]

2022 Sep;12(9):3618-3638. PMID: 36176909
Biomaterials

Single-dose of integrated bilayer microneedles for enhanced hypertrophic scar therapy with rapid anti-inflammatory and sustained inhibition of myofibroblasts. [Abstract]

2025 Jan:312:122742. PMID: 39106821
Cell Discov

Cancer cells sense solid stress to enhance metastasis by CKAP4 phase separation-mediated microtubule branching. [Abstract]

2024 Nov 12;10(1):114. PMID: 39528501
Nano Today

2025 Apr.
Mater Today Bio

Hyaluronic acid-anchored nanoparticles co-delivering emodin and siRNA confers protection against rheumatoid arthritis via macrophage polarization. [Abstract]

2025 Jul 10:33:102074. PMID: 40688667
Cell Death Dis

LAP2α drives breast tumorigenesis by mitigating replication stress. [Abstract]

2026 Feb 3;17(1):201. PMID: 41633992
Adv Healthc Mater

Lipoprotein-Based Nanocatalyst Enables Targeted Treatment of APAP-Induced Liver Injury via Enhanced Macropinocytosis. [Abstract]

2025 May 24:e2500507. PMID: 40411876
Genes Dis

2025 Aug 14.
J Cachexia Sarcopenia Muscle

Klf9 Loss of Function Protects Against Glucocorticoids Induced Skeletal Muscle Wasting. [Abstract]

2025 Aug;16(4):e70020. PMID: 40717541
Phytomedicine

The total xanthones from Gentianella acuta alleviate acute myocardial infarction by targeting BRD4-mediated cardiomyocyte pyroptosis and inflammation. [Abstract]

2025 Aug 13:147:157156. PMID: 40845590
Phytomedicine

Crystal structure of tubulin-barbigerone complex enables rational design of potent anticancer agents with isoflavone skeleton. [Abstract]

2023 Jan:109:154550. PMID: 36610121
Phytomedicine

Baeckein E suppressed NLRP3 inflammasome activation through inhibiting both the priming and assembly procedure: Implications for gout therapy. [Abstract]

2021 Apr:84:153521. PMID: 33667838
EMBO J

A protein palmitoylation cascade regulates microtubule cytoskeleton integrity in Plasmodium. [Abstract]

2020 Jul 1;39(13):e104168. PMID: 32395856
Cancer Immunol Res

Discovery of podofilox as a potent cGAMP-STING signaling enhancer with antitumor activity. [Abstract]

2023 May 3;11(5):583-599. PMID: 36921097
Environ Pollut

Polystyrene nanoplastics promote fish iridovirus replication via inducing inflammatory response, antioxidant damage and enhancing viral entry. [Abstract]

2026 Feb 1:390:127492. PMID: 41349949
Stem Cell Res Ther

Stable expression of a truncated TLX variant drives differentiation of induced pluripotent stem cells into self-renewing neural stem cells for production of extracellular vesicles. [Abstract]

2022 Sep 2;13(1):436. PMID: 36056423
Aging Cell

Telomere Shortening Drives Atrial Fibrillation Through VCAM-1 Mediated Atrial Electrical and Structural Remodeling. [Abstract]

2026 Feb;25(2):e70417. PMID: 41685883
Int J Nanomedicine

The Optimization Design Of Lactoferrin Loaded HupA Nanoemulsion For Targeted Drug Transport Via Intranasal Route. [Abstract]

2019 Nov 27;14:9217-9234. PMID: 31819426
Chin Med

Chikusetsusaponin IVa targeted YAP as an inhibitor to attenuate liver fibrosis and hepatic stellate cell activation. [Abstract]

2025 Mar 17;20(1):36. PMID: 40098188
Biochem Pharmacol

A novel aromatic amide derivative SY-65 co-targeted tubulin and histone deacetylase 1 with potent anticancer activity in vitro and in vivo. [Abstract]

2022 Jul:201:115070. PMID: 35526597
Arab J Chem

2024 Feb, 17(2), 105550.
Inflammation

Kaempferol Remodels Liver Monocyte Populations and Treats Hepatic Fibrosis in Mice by Modulating Intestinal Flora and Metabolic Reprogramming. [Abstract]

2024 Nov 12. PMID: 39531210
Front Pharmacol

CaM/CaMKII mediates activation and proliferation of hepatic stellate cells regulated by ASIC1a. [Abstract]

2022 Dec 15:13:996667. PMID: 36588718
Eur J Pharmacol

Hesperetin alleviates liver fibrosis by improving intestinal microbiota composition and regulating hepatic stellate cell autophagy. [Abstract]

2025 Aug 28:1005:178106. PMID: 40885231
Int Immunopharmacol

Colchicine inhibits myocardial pyroptosis and reduces myocardial cell injury after myocardial infarction through the ESR1-PI3K-Akt-NF-κB signaling pathway. [Abstract]

2025 Apr 27:156:114732. PMID: 40294468
Bioorg Chem

The cytotoxic natural compound erianin binds to colchicine site of β-tubulin and overcomes taxane resistance. [Abstract]

2024 Jun 17:150:107569. PMID: 38905886
Reprod Biol Endocrinol

Establishment of an immortalized stromal cell line derived from human Endometriotic lesion. [Abstract]

2020 Nov 23;18(1):119. PMID: 33225937
Molecules

Colchicine Binding Site Tubulin Inhibitors Impair Vincristine-Resistant Neuroblastoma Cell Function. [Abstract]

2025 May 16;30(10):2186. PMID: 40430358
Mol Oncol

Lung cancer cells expressing a shortened CDK16 3'UTR escape senescence through impaired miR-485-5p targeting. [Abstract]

2022 Mar;16(6):1347-1364. PMID: 34687270
Front Microbiol

Rice Yellow Stunt Nucleorhabdovirus Matrix Protein Mediates Viral Axonal Transport in the Central Nervous System of Its Insect Vector. [Abstract]

2019 May 9:10:939. PMID: 31143161
Mol Neurobiol

DLK-MAPK Signaling Coupled with DNA Damage Promotes Intrinsic Neurotoxicity Associated with Non-Mutated Tau. [Abstract]

2024 May;61(5):2978-2995. PMID: 37955806
FASEB J

FGF13 enhances the function of TRPV1 by stabilizing microtubules and regulates acute and chronic itch. [Abstract]

2024 May 31;38(10):e23661. PMID: 38733310
iScience

Phenotype specific nuclear lamina remodeling in hiPSC derived cardiomyocytes bearing TNNT2 sarcomeric variants. [Abstract]

2025 Oct 30;28(12):113901. PMID: 41321620
APL Bioeng

Mechanomemory after short episodes of intermittent stresses induces YAP translocation via increasing F-actin. [Abstract]

2025 Apr 18;9(2):026107. PMID: 40256417
Sci Rep

The hydroxamate based HDAC inhibitor WMJ-J-09 induces colorectal cancer cell death by targeting tubulin and downregulating survivin. [Abstract]

2025 Jun 4;15(1):19590. PMID: 40467895
J Virol

Bovine coronavirus enters HRT-18 cells via membrane fusion and clathrin-mediated endocytosis in a low pH-, dynamin-, cholesterol-, microtubule-, Rab7-, and Rab11-dependent manner. [Abstract]

2025 Nov 18:e0127425. PMID: 41251346
Biochim Biophys Acta

The small molecule CS1 inhibits mitosis and sister chromatid resolution in HeLa cells. [Abstract]

2018 May;1862(5):1134-1147. PMID: 29410075

Colchicine purchased from MedChemExpress. Usage Cited in: Biochim Biophys Acta. 2018 May;1862(5):1134-1147. [Abstract]

CS1 and Colchicine (Col) induce the phosphorylation of H1 (T18) and H3 (S29) as detected by western blotting.
Toxicol Appl Pharmacol

Glycosylation on breast cancer cell surface promotes the internalization and enhances therapeutic efficacy of cationic antimicrobial peptide L-K6. [Abstract]

2025 Oct:503:117481. PMID: 40684813
Vet Microbiol

Dynein- and kinesin- mediated intracellular transport on microtubules facilitates RABV infection. [Abstract]

2021 Nov:262:109241. PMID: 34555731
Rejuvenation Res

Wedelolactone Attenuates Liver Fibrosis and Hepatic Stellate Cell Activation by Suppressing the Hippo Pathway. [Abstract]

2024 Dec;27(6):207-219. PMID: 39276092
Fitoterapia

Protective effect of water extracts of Veronicastrum latifolium (Hemsl.) Yamazaki on carbon tetrachloride-induced liver fibrosis in mice and its effect on intestinal flora. [Abstract]

2023 Oct:170:105653. PMID: 37595643
Am J Reprod Immunol

Establishment and characterization of immortalized human eutopic endometrial stromal cells. [Abstract]

2020 Mar;83(3):e13213. PMID: 31802565
Biochem Biophys Res Commun

Structure of quercetin 3,4'-dimethyl ether in complex with tubulin provides a rationale for drug design. [Abstract]

2025 Jun 23:777:152245. PMID: 40578283
Biochem Biophys Res Commun

Alleviation of fibrosis and oxidative stress in pressure overload-induced cardiac remodeling and heart failure via SIRT3 activation by colchicine. [Abstract]

2025 May 8:770:151957. PMID: 40373382
G3 (Bethesda)

Regulation of intestinal stem cell activity by a mitotic cell cycle regulator Polo in Drosophila. [Abstract]

2023 Jun 1;13(6):jkad084. PMID: 37154439
Biochem Biophys Res Commun

Veliparib overcomes multidrug resistance in liver cancer cells. [Abstract]

2020 Jan 15;521(3):596-602. PMID: 31679697
Indian J Ophthalmol

Ranitidine protects Müller cells against ferroptosis in diabetic retinopathy by regulating the AKT1/GSK3β pathway. [Abstract]

2026 Feb 1;74(2):250-258. PMID: 41581041
Stem Cell Res

Generation of an induced pluripotent stem cell line (CSBZZUi003-A) from a healthy male volunteer. [Abstract]

2025 Dec:89:103867. PMID: 41218450
bioRxiv

Circulating biomarkers in serum from aortic valve stenosis patients predict sex-specific drug responses in valve myofibroblasts. [Abstract]

2026 Jan 20:2026.01.16.700010. PMID: 41648356
Middle Tennessee State University

2025.
Patent

US20250129012A1.
bioRxiv

2023 May 18.
Research Square Preprint

2022 May.
Oxid Med Cell Longev

Combination of Colchicine and Ticagrelor Inhibits Carrageenan-Induced Thrombi in Mice. [Abstract]

2022 Jan 17:2022:3087198. PMID: 35082966
Health Science Journal

August 31, 2021.
Health Sci J

(2021): 1-7.
Oxid Med Cell Longev

Colchicine Alleviates Cholesterol Crystal-Induced Endothelial Cell Pyroptosis through Activating AMPK/SIRT1 Pathway. [Abstract]

2020 Jul 15;2020:9173530. PMID: 32733639

Colchicine purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2020 Jul 15;2020:9173530. [Abstract]

Colchicine alleviates NLRP3 inflammasome activation relevant in pyroptosis. HUVECs are treated for 24 h with different doses of Colchicine (0-10 nM) in the presence of cholesterol crystal (0.5 mg/mL. Western blotting Is dedicated to examine the protein expression levels of NLRP3, ASC-1, procaspase-1, caspase-1, IL-18, and IL-1β. Colchicine treatment significantly blocks NLRP3 signal activity. Colchicine significantly inhibits CC-induced mRNA and protein expression of IL-18 and IL-1β, particularl

Colchicine purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2020 Jul 15;2020:9173530. [Abstract]

Colchicine plays an antipyroptosis role by inhibiting intracellular oxidative stress. HUVECs are treated for 10 or 24 h with different doses of Colchicine (0-10 nM) in the presence of cholesterol crystal (0.5 mg/mL). Intracellular ROS level is detected using a DCFH-DA probe. JC-1 Staining Kit is used for the detection of mitochondrial membrane potential.
bioRxiv

2020 Feb.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (250.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 33.33 mg/mL (83.44 mM)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5035 mL

12.5175 mL

25.0350 mL

5 mM

0.5007 mL

2.5035 mL

5.0070 mL

10 mM

0.2504 mL

1.2518 mL

2.5035 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG400 50% Saline

Solubility: 25 mg/mL (62.59 mM); Clear solution; Need ultrasonic

Protocol 2

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 5 mg/mL (12.52 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 3

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 5 mg/mL (12.52 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 4

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 5 mg/mL (12.52 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 2.78 mg/mL (6.96 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (294 KB)
SDS (644 KB)
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- Norwegian - NO (644 KB)
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COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
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OR (2659 KB)
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References

[1]. Bonfoco E, et al. Colchicine induces apoptosis in cerebellar granule cells. Exp Cell Res. 1995 May;218(1):189-200. [Content Brief]

[2]. Hastie SB. Interactions of colchicine with tubulin. Pharmacol Ther. 1991;51(3):377-401 [Content Brief]

[3]. Yuanjun Tang, et al. Network Pharmacology-Based Investigation and Experimental Exploration of the Antiapoptotic Mechanism of Colchicine on Myocardial Ischemia Reperfusion Injury. Front Pharmacol. 2021 Dec 16:12:804030. [Content Brief]

[4]. Otani K, et al. Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Sci Rep. 2016 Sep 2;6:32587. [Content Brief]

[5]. Carola Muñoz-Montesino, et al. Inhibition of the Glycine Receptor alpha 3 Function by Colchicine. Front Pharmacol. 2020 Jul 30;11:1143. [Content Brief]

[6]. Sami H Hammadi, et al. Effect of sacubitril/valsartan on cognitive impairment in colchicine-induced Alzheimer's model in rats. Fundam Clin Pharmacol. 2023 Apr;37(2):275-286. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	2.5035 mL	12.5175 mL	25.0350 mL	62.5876 mL
	5 mM	0.5007 mL	2.5035 mL	5.0070 mL	12.5175 mL
	10 mM	0.2504 mL	1.2518 mL	2.5035 mL	6.2588 mL
	15 mM	0.1669 mL	0.8345 mL	1.6690 mL	4.1725 mL
	20 mM	0.1252 mL	0.6259 mL	1.2518 mL	3.1294 mL
	25 mM	0.1001 mL	0.5007 mL	1.0014 mL	2.5035 mL
	30 mM	0.0835 mL	0.4173 mL	0.8345 mL	2.0863 mL
	40 mM	0.0626 mL	0.3129 mL	0.6259 mL	1.5647 mL
	50 mM	0.0501 mL	0.2504 mL	0.5007 mL	1.2518 mL
	60 mM	0.0417 mL	0.2086 mL	0.4173 mL	1.0431 mL
	80 mM	0.0313 mL	0.1565 mL	0.3129 mL	0.7823 mL
DMSO	100 mM	0.0250 mL	0.1252 mL	0.2504 mL	0.6259 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Colchicine

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Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Mass Spectrometry Human Metabolite Library

Antitussive and Antiasthmatic Traditional Chinese Medicine Active Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Pattern Recognition Receptors Library

Mongolian Medicine Compound Library

High-Efficiency Gene Editing Compound Library

Tonifying Traditional Chinese Medicine Monomer Compound Library

Environmental Pollutant Compound Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Colchicine

All NOD-like Receptor (NLR) Isoforms

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Publications (62)

Solvent & Solubility

Purity & Documentation