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Colchicine Chemical Structure
|Product name: Colchicine|
|Cat. No.: HY-16569|
Colchicine is a tubulin inhibitor, it blocks polymerization of microtubules by binding to tubulin (IC50 = 3.2 μM).
IC50 Value: 3.2 μM
Colchicine causes apoptosis of cells by acting on tissue plasminogen activators (tPA) and disrupting the cytoskeleton of cells. Exposure of cells to Colchicine has also been reported to result in alterations of Ca2+ concentrations in cells which may also result in apoptosis. Since increased rate of mitosis is associated with cancer cell proliferation, blocking microtubule function with Colchicine has been used as an approach to anti-cancer therapy. For instance, Colchicine blocks the growth of MCF-7 human breast carcinoma cells with an IC50 value of 13 nM. Colchicine produces anti-inflammatory effects by inhibiting neutrophil motility and activity (5 μmol/kg in a mouse model of gouty arthritis) and inhibits the deposition of uric acid, a key aspect in the treatment of gout.
|M.Wt||399.44||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
DMSO: ≥ 48 mg/mL
|1 mg||5 mg||10 mg|
|1 mM||2.5035 mL||12.5175 mL||25.0350 mL|
|5 mM||0.5007 mL||2.5035 mL||5.0070 mL|
|10 mM||0.2504 mL||1.2518 mL||2.5035 mL|
|Product Name||Sponsor Only||Condition||Start Date||End Date||Phase||Last Change Date|
|Colchicine||Shaheed Beheshti Medical University||30-SEP-06||Phase 3||18-JAN-13|
|McMaster University||Atrial fibrillation||31-JAN-14||31-DEC-14||Phase 3||21-NOV-13|
|Maria Vittoria Hospital||Atrial fibrillation||31-MAR-12||28-FEB-13||Phase 3||11-SEP-13|
|Azienda Sanitaria Locale 3, Torino||Pericardial disease||30-JUN-05||30-JUN-10||Phase 3||05-SEP-13|
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