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Colchicine

HY-16569

Colchicine

Colchicine Chemical Structure

Colchicine is a tubulin inhibitor, it blocks polymerization of microtubules by binding to tubulin (IC50 = 3.2 μM).

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $55 In-stock
200 mg $50 In-stock
500 mg $65 In-stock
1 g Get quote
5 g Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €54 In-stock
200 mg €49 In-stock
500 mg €64 In-stock
1 g Get quote
5 g Get quote

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Inquiry Information
Product name: Colchicine
Cat. No.: HY-16569

Colchicine Data Sheet

  • View current batch:

    Purity: 99.86%

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    DataSheet

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    MSDS

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    COA

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    NMR

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    LCMS

Related Compound Libraries

Biological Activity of Colchicine

Colchicine is a tubulin inhibitor, it blocks polymerization of microtubules by binding to tubulin (IC50 = 3.2 μM).
IC50 Value:  3.2 μM
Target: Microtubule/Tubulin
Colchicine causes apoptosis of cells by acting on tissue plasminogen activators (tPA) and disrupting the cytoskeleton of cells. Exposure of cells to Colchicine has also been reported to result in alterations of Ca2+ concentrations in cells which may also result in apoptosis. Since increased rate of mitosis is associated with cancer cell proliferation, blocking microtubule function with Colchicine has been used as an approach to anti-cancer therapy. For instance, Colchicine blocks the growth of MCF-7 human breast carcinoma cells with an IC50 value of 13 nM. Colchicine produces anti-inflammatory effects by inhibiting neutrophil motility and activity (5 μmol/kg in a mouse model of gouty arthritis) and inhibits the deposition of uric acid, a key aspect in the treatment of gout.

Chemical Information

M.Wt 399.44 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₂₂H₂₅NO₆
CAS No 64-86-8
Solvent & Solubility

DMSO: ≥ 48 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.5035 mL 12.5175 mL 25.0350 mL
5 mM 0.5007 mL 2.5035 mL 5.0070 mL
10 mM 0.2504 mL 1.2518 mL 2.5035 mL

Clinical Information of Colchicine

Product Name Sponsor Only Condition Start Date End Date Phase Last Change Date
Colchicine Shaheed Beheshti Medical University 30-SEP-06 Phase 3 18-JAN-13
Sanofi Tonsillitis 31-OCT-06 Phase 3 12-NOV-12
McMaster University Atrial fibrillation 31-JAN-14 31-DEC-14 Phase 3 21-NOV-13
Maria Vittoria Hospital Atrial fibrillation 31-MAR-12 28-FEB-13 Phase 3 11-SEP-13
Azienda Sanitaria Locale 3, Torino Pericardial disease 30-JUN-05 30-JUN-10 Phase 3 05-SEP-13

References on Colchicine

Inhibitor Kit

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