1. Neuronal Signaling
  2. Amyloid-β
  3. Amyloid β-Peptide (1-42) human

Amyloid β-Peptide (1-42) human (Synonyms: β-Amyloid (1-42), human)

Cat. No.: HY-P1363 Purity: 95.64%
Handling Instructions

Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.

For research use only. We do not sell to patients.

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Amyloid β-Peptide (1-42) human Chemical Structure

Amyloid β-Peptide (1-42) human Chemical Structure

CAS No. : 107761-42-2

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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.

In Vitro

Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Application of Amyloid β-Peptide (1-42) human (1 to 10 μM) in the bathing solution does not change delayed rectifier K+-current and leakage current, but enhances inactivation of Са2+-current and blocks Са2+-dependent К+-current[1]. At 2.5 μM concentration, Amyloid β-Peptide (1-42) human reduces viability of SH-SY5Y cells to 65%. Results show that Amyloid β-Peptide (1-42) human localizes in both the cytoplasm and nucleus of SH-SY5Y cells after 30 min of incubation and after 8 h. In the latter, large accumulations of Amyloid β-Peptide (1-42) human are seen in the cytoplasm and in the nucleus. Increased APP mRNA levels are also detected upon Amyloid β-Peptide (1-42) human treatment[2].

Molecular Weight

4514.04

Formula

C₂₀₃H₃₁₁N₅₅O₆₀S

CAS No.

107761-42-2

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
References
Cell Assay
[2]

SH-SY5Y cells are treated with biotinylated Amyloid β-Peptide (1-42) human peptide 1 μM. Cells are fixed and permeabilized with 3.3% formaldehyde containing 0.5% Triton X-100 followed by 125 mM glycine in PBS containing magnesium and calcium. Cells are blocked with 5% fetal bovine calf serum followed by the primary antibody. Biotin-Amyloid β-Peptide (1-42) human peptide is detected with the monoclonal antibody AB or alternatively with Avidin Fluor488. Nuclei are stained with DAPI. Images are obtained using an LSM 510 meta confocal microscope[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Amyloid β-Peptide (1-42) human
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HY-P1363
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