1. Neuronal Signaling
  2. Amyloid-β
  3. β-Amyloid (1-42), human TFA

β-Amyloid (1-42), human TFA (Synonyms: Amyloid β-Peptide (1-42) (human) TFA)

Cat. No.: HY-P1363 Purity: 95.64%
Handling Instructions

β-Amyloid (1-42), human TFA (Amyloid β-Peptide (1-42) (human) TFA) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

β-Amyloid (1-42), human TFA Chemical Structure

β-Amyloid (1-42), human TFA Chemical Structure

CAS No. : 107761-42-2

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1 mg USD 295 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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β-Amyloid (1-42), human TFA (Amyloid β-Peptide (1-42) (human) TFA) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease[1].

In Vitro

Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Application of Amyloid β-Peptide (1-42) human (1 to 10 μM) in the bathing solution does not change delayed rectifier K+-current and leakage current, but enhances inactivation of Са2+-current and blocks Са2+-dependent К+-current[1]. At 2.5 μM concentration, Amyloid β-Peptide (1-42) human reduces viability of SH-SY5Y cells to 65%. Results show that Amyloid β-Peptide (1-42) human localizes in both the cytoplasm and nucleus of SH-SY5Y cells after 30 min of incubation and after 8 h. In the latter, large accumulations of Amyloid β-Peptide (1-42) human are seen in the cytoplasm and in the nucleus. Increased APP mRNA levels are also detected upon Amyloid β-Peptide (1-42) human treatment[2].

Molecular Weight








Sequence Shortening



Room temperature in continental US; may vary elsewhere.

Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (10.80 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2161 mL 1.0804 mL 2.1607 mL
5 mM 0.0432 mL 0.2161 mL 0.4321 mL
10 mM 0.0216 mL 0.1080 mL 0.2161 mL
*Please refer to the solubility information to select the appropriate solvent.
Cell Assay

SH-SY5Y cells are treated with biotinylated Amyloid β-Peptide (1-42) human peptide 1 μM. Cells are fixed and permeabilized with 3.3% formaldehyde containing 0.5% Triton X-100 followed by 125 mM glycine in PBS containing magnesium and calcium. Cells are blocked with 5% fetal bovine calf serum followed by the primary antibody. Biotin-Amyloid β-Peptide (1-42) human peptide is detected with the monoclonal antibody AB or alternatively with Avidin Fluor488. Nuclei are stained with DAPI. Images are obtained using an LSM 510 meta confocal microscope[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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β-Amyloid (1-42), humanAmyloid β-Peptide (1-42) (human)Amyloid-ββ-amyloid peptideAbetaInhibitorinhibitorinhibit

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