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β-Amyloid (1-42), human

(Synonyms: Amyloid β-peptide (1-42) (human))
27 Cited Publications
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Based on 27 publication(s) in Google Scholar

β-Amyloid (1-42) (Amyloid β-peptide (1-42)), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death.

For research use only. We do not sell to patients.

  • Purity: 99.69%
  • CAS No.: 107761-42-2
  • Formula: C203H311N55O60S
  • Molecular Weight:4514.04
  • Storage:

    Sealed storage, away from moisture.

    Powder   -80°C, 2 years , -20°C, 1 year

    * The compound is unstable in solutions, freshly prepared is recommended.

  • β-Amyloid (1-42), human Chemical Structure
    β-Amyloid (1-42), human Chemical Structure
  • Experimental Validation Results for β-Amyloid (1-42), human
  • Experimental Validation Results for β-Amyloid (1-42), human
  • Experimental Validation Results for β-Amyloid (1-42), human
  • Experimental Validation Results for β-Amyloid (1-42), human
  • Experimental Validation Results for β-Amyloid (1-42), human
  • Experimental Validation Results for β-Amyloid (1-42), human
CAS No.: 107761-42-2
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  • β-Amyloid (1-42), human Chemical Structure
    β-Amyloid (1-42), human Chemical Structure
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    β-Amyloid (1-42), human purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2024 Dec 23;21(1):327. [Abstract]

    Customer Validation
     Protein levels in BV2 cell treated with or without BCAAs/ BCKAs for 4 h in the presence of Aβ (1 μM) and the corresponding quantification results (n = 3).

  • 1/16

    β-Amyloid (1-42), human purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2024 Sep:178:117199. [Abstract]

    Customer Validation
     The effect of NMN on the survival rate of β-Amyloid (1-42) (Aβ, 1 μM; 24 h)-induced PC12 cells was determined by MTT assay.

  • 1/16

    β-Amyloid (1-42), human purchased from MedChemExpress. Usage Cited in: Front Aging Neurosci. 2022 Apr 25;14:890134. [Abstract]

    Customer Validation
     Immunofluorescence showed lost ARC expression after 10 μM Aβ treatment. For Aβ treatment, human β-Amyloid (1-42) (HY-P1363) was dissolved, and the solution was incubated for 3 days at 37°C to form oligomeric Aβ, and then cells were treated with 10 μM Aβ for 48 h.

  • 1/16

    β-Amyloid (1-42), human purchased from MedChemExpress. Usage Cited in: Front Aging Neurosci. 2022 Apr 25;14:890134. [Abstract]

    Customer Validation
     qRT-PCR showed decreased mRNA levels of ARC after 10 μM Aβ treatment (n = 3). For Aβ treatment, human β-Amyloid (1-42) (HY-P1363) was dissolved, and the solution was incubated for 3 days at 37°C to form oligomeric Aβ, and then cells were treated with 10 μM Aβ for 48 h.

  • 1/16

    β-Amyloid (1-42), human purchased from MedChemExpress. Usage Cited in: Front Aging Neurosci. 2022 Apr 25;14:890134. [Abstract]

    Customer Validation
     Western blotting analysis showed declined protein levels of ARC after 10 μM Aβ treatment (n = 3). For Aβ treatment, human β-Amyloid (1-42) (HY-P1363) was dissolved, and the solution was incubated for 3 days at 37°C to form oligomeric Aβ, and then cells were treated with 10 μM Aβ for 48 h.

  • 1/16

    β-Amyloid (1-42), human purchased from MedChemExpress. Usage Cited in: Aging. 2021 Jun 9;13(11):15569-15579. [Abstract]

    Customer Validation
     10 μM Aβ increased the mRNA expression of GRIA1 and GRIN2A, and decreased GRIN1 mRNA expression. n = 3. For the Aβ treatment, cells were incubated with 10 μM human β-Amyloid (1-42) for 48 h.

  • β-Amyloid (1-42), human