1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. mGluR
  4. mGluR5 Inhibitors

mGluR5 Inhibitors

mGluR8

mGluR6

mGluR7

mGluR5

mGluR4

mGluR3

mGluR2

mGluR1

mGluR

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Sorry. There is currently no product that acts on isoform mGluR5 together.

Please try each isoform separately.

mGluR5 Specific Inhibitors, Agonists, Antagonists & Modulators
Product Name mGluR5 mGluR8 mGluR6 mGluR7 mGluR4 mGluR3 mGluR2 mGluR1 mGluR5 Selectivity Purity
MPEP Hydrochloride
mGluR5, IC50: 36 nM
              Selective Antagonist 99.69%
AZD 2066 hydrate
mGluR5
              Selective Antagonist >99.0%
MTEP hydrochloride
mGluR5, IC50: 5 nM
mGluR5, Ki: 16 nM
              Selective Antagonist 99.71%
Mavoglurant
mGluR5, IC50: 30 nM
              Selective Antagonist 99.99%
CTEP
mGlu5 Receptor, IC50: 2.2 nM
              Selective Antagonist 99.43%
JNJ-46778212
mGlu5 Receptor, EC50: 260 nM
              Selective Agonist 99.24%
CPPHA
mGlu5 Receptor
              Selective Modulator 95.01%
Dipraglurant
mGluR5, IC50: 21 nM
              Selective Antagonist 99.99%
Basimglurant
mGlu5 Receptor, Kd: 1.1 nM
              Selective Inhibitor 99.56%
VU 0357121
mGlu5 Receptor, EC50: 33 nM
              Selective Agonist 99.85%
Fenobam
rat mGluR5, Kd: 54 nM
human mGluR5, Kd: 31 nM
              Selective Antagonist >99.0%
CHPG
mGlu5
              Selective Agonist >99.0%
AZD 2066
mGluR5
              Selective Antagonist >99.0%
Mavoglurant racemate
mGluR5
              Selective Antagonist 98.88%
ADX-47273
mGluR5, EC50: 0.17 μM
              Selective Agonist 99.34%
Methoxy-PEPy
mGlu5 Receptor, IC50: 1 nM
              Selective Antagonist 98.19%
CHPG sodium salt
mGlu5
              Selective Agonist
Auglurant
rat mGluR5, IC50: 11 nM
human mGluR5, IC50: 14 nM
              Selective Inhibitor 99.40%
VU-29
rat mGluR5, EC50: 9 nM
rat mGluR5, Ki: 224 nM
     
hmGluR4, EC50: 154 nM
 
rat mGluR2, EC50: 1.5 μM
rat mGluR1, EC50: 557 nM
Selective Agonist
CDPPB
mGluR5, EC50: 27 nM
              Selective Modulator
MPEP
mGluR5, IC50: 36 nM
              Selective Antagonist
BMT-145027
mGluR5, EC50: 47 nM
              Selective Inhibitor 98.19%
LY341495
mGluR5a, IC50: 8.2 μM
mGluR8, IC50: 170 nM
 
mGluR7, IC50: 990 nM
mGluR4, IC50: 22 μM
mGluR3, IC50: 14 nM
mGluR2, IC50: 21 nM
mGluR1a, IC50: 7.8 μM
Pan Antagonist 99.11%
DHPG
mGluR 5
           
mGluR 1
Pan Agonist >97.0%
L-Cysteinesulfinic acid monohydrate
mGluR5, pEC50: 4.6
mGluR8, pEC50: 3.94
mGluR6, pEC50: 4.0
 
mGluR4, pEC50: 2.7
 
mGluR2, pEC50: 3.9
mGluR1, pEC50: 3.92
Pan Agonist
VU0364770
mGlu5, EC50: 17.9 μM
 
mGlu6, EC50: 6.8 μM
 
Rat mGlu4, EC50: 290 nM
Human mGlu4, EC50: 1.1 μM
      Pan Agonist 99.57%
(R)-ADX-47273
mGlu5, EC50: 168 nM
              Pan Modulator 99.25%
L-Cysteinesulfinic acid
mGluR5, pEC50: 4.6
mGluR8, pEC50: 3.94
mGluR6, pEC50: 4.0
 
mGluR4, pEC50: 2.7
 
mGluR2, pEC50: 3.9
mGluR1, pEC50: 3.92
Pan Agonist
(S)-3,5-DHPG
mGluR5a, Ki: 3.9 μM
           
mGluR1a, Ki: 0.9 μM
Pan Agonist
DCG-IV
mGluR5, IC50: 630 μM
mGluR8, IC50: 32 μM
mGluR6, IC50: 39.6 μM
mGluR7, IC50: 40.1 μM
mGluR4R, IC50: 22.5 μM
mGluR3R, EC50: 0.09 μM
mGluR2R, EC50: 0.35 μM
mGluR1R, IC50: 389 μM
Pan Agonist
VU0364770 hydrochloride
mGlu5, EC50: 17.9 μM
 
mGlu6, EC50: 6.8 μM
 
Rat mGlu4, EC50: 290 nM
Human mGlu4, EC50: 1.1 μM
      Pan Agonist 99.82%