5652-28-8
5652-28-8
Chemical Structure
DL-AP3
- CAS No.: 5652-28-8
- Formula:C3H8NO5P
- Molecular Weight:169.07
IUPAC Name: 2-amino-3-phosphonopropanoic acid
InChIKey: LBTABPSJONFLPO-UHFFFAOYSA-N
SMILES: NC(CP(O)(O)=O)C(O)=O
Biological Activity: DL-AP3 is a competitive mGluR1 and mGluR5 antagonist. DL-AP3 is also an inhibitor of phosphoserine phosphatase. DL-AP3 has neuroprotective effect[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DL-AP3 | 98.0% | DL-AP3 is a competitive mGluR1 and mGluR5 antagonist. DL-AP3 is also an inhibitor of phosphoserine phosphatase. DL-AP3 has neuroprotective effect. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 1.00
HY-108546L-AP3 -
Similarity Score 0.90
HY-100743RDL-AP4 (Standard) -
Similarity Score 0.90
HY-100781D-AP4 -
Similarity Score 0.90
HY-100781AL-AP4 -
Similarity Score 0.88
HY-100781BL-AP4 monohydrate -
Similarity Score 0.87
HY-100714DL-AP5 -
Similarity Score 0.87
HY-100714ARD-AP5 (Standard) -
Similarity Score 0.87
HY-100714BL-AP5 -
Similarity Score 0.85
HY-15129AO-Phospho-D-serine -
Explore the MedChemAI to find more analogs
References
- [1]. Cui D, et al. DL-2-amino-3-phosphonopropionic acid protects primary neurons from oxygen-glucose deprivation induced injury. Bosn J Basic Med Sci. 2017 Feb 21;17(1):12-16. [Content Brief]
- [2]. Hawkinson JE, et al. The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase. Eur J Pharmacol. 1996 Jun 27;307(2):219-25. [Content Brief]
- [3]. Xu ZH, et al. Group I mGluR antagonist rescues the deficit of D1-induced LTP in a mouse model of fragile X syndrome. Mol Neurodegener. 2012 May 28;7:24. [Content Brief]
