1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. D-AP4

D-AP4 (Synonyms: D-APB; D-2-Amino-4-phosphonobutyric acid)

Cat. No.: HY-100781
Handling Instructions

D-AP4 (D-APB; D-2-Amino-4-phosphonobutyric acid), a phosphono analogue of glutamate, is an NMDA broad spectrum excitatory amino acid receptor antagonist. D-AP4 also is an agonist for a quisqualate-sensitized AP6 site in hippocampus. D-AP4 inhibits AMPA receptor-stimulated 57Co2+ influx in cultured cerebellar granule cells (IC50 ≥ 100 μM).

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D-AP4 Chemical Structure

D-AP4 Chemical Structure

CAS No. : 78739-01-2

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Description

D-AP4 (D-APB; D-2-Amino-4-phosphonobutyric acid), a phosphono analogue of glutamate, is an NMDA broad spectrum excitatory amino acid receptor antagonist. D-AP4 also is an agonist for a quisqualate-sensitized AP6 site in hippocampus. D-AP4 inhibits AMPA receptor-stimulated 57Co2+ influx in cultured cerebellar granule cells (IC50 ≥ 100 μM)[1][2][3].

Molecular Weight

183.10

Formula

C₄H₁₀NO₅P

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D-AP4
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