1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. L-AP4 monohydrate

L-AP4 monohydrate (Synonyms: L-APB monohydrate)

Cat. No.: HY-100781B Purity: ≥99.0%
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L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively.

For research use only. We do not sell to patients.

L-AP4 monohydrate Chemical Structure

L-AP4 monohydrate Chemical Structure

CAS No. : 2247534-79-6

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5 mg USD 260 In-stock
Estimated Time of Arrival: December 31
10 mg USD 450 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively[1][2].

IC50 & Target[1]

mGlu4

0.13 μM (EC50)

mGlu8

0.29 μM (EC50)

mGlu6

1.0 μM (EC50)

mGlu7

249 μM (EC50)

In Vivo

L-AP4 (5-30 μg, intrathecal inhection 4-5 days) significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. Intrathecal administration of different doses of L-AP4 is not associated with any evident motor dysfunction[2].
Intrathecal injection of 30 μg of L-AP4 does not significantly alter the paw withdrawal latency in these normal rats[2].
Topical application of 5 to 50 μM L-AP4 to the spinal cord significantly inhibited the evoked response of neurons to touch, pressure, pinch, and von Frey filaments in a concentration-dependent fashion[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats.[2]
Dosage: 5-30 μg.
Administration: Intrathecal inhection 4-5 days.
Result: Dose-dependently increased paw withdrawal threshold.
Molecular Weight

201.11

Formula

C₄H₁₂NO₆P

CAS No.
SMILES

O=C(O)[[email protected]@H](N)CCP(O)(O)=O.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

References

Purity: ≥99.0%

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Keywords:

L-AP4L-APBmGluRMetabotropic glutamate receptorswithdrawalthresholdMetabotropicGlutamateneuronInhibitorinhibitorinhibit

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L-AP4 monohydrate
Cat. No.:
HY-100781B
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