1. GPCR/G Protein Neuronal Signaling
  2. mGluR
  3. L-AP4 monohydrate

L-AP4 monohydrate  (Synonyms: L-APB monohydrate)

Cat. No.: HY-100781B Purity: ≥99.0%
COA Handling Instructions

L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively.

For research use only. We do not sell to patients.

L-AP4 monohydrate Chemical Structure

L-AP4 monohydrate Chemical Structure

CAS No. : 2247534-79-6

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Other Forms of L-AP4 monohydrate:

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  • Purity & Documentation

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L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively[1][2].

IC50 & Target[1]


0.13 μM (EC50)


0.29 μM (EC50)


1.0 μM (EC50)


249 μM (EC50)

In Vivo

L-AP4 (5-30 μg, intrathecal inhection 4-5 days) significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. Intrathecal administration of different doses of L-AP4 is not associated with any evident motor dysfunction[2].
Intrathecal injection of 30 μg of L-AP4 does not significantly alter the paw withdrawal latency in these normal rats[2].
Topical application of 5 to 50 μM L-AP4 to the spinal cord significantly inhibited the evoked response of neurons to touch, pressure, pinch, and von Frey filaments in a concentration-dependent fashion[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats.[2]
Dosage: 5-30 μg.
Administration: Intrathecal inhection 4-5 days.
Result: Dose-dependently increased paw withdrawal threshold.
Molecular Weight







White to off-white




Room temperature in continental US; may vary elsewhere.


4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
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L-AP4 monohydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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