1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. mGluR
  4. mGluR Inhibitors

mGluR Inhibitors

mGluR1

mGluR2

mGluR3

mGluR4

mGluR5

mGluR6

mGluR7

mGluR8

mGluR

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

mGluR Inhibitors, Agonists, Antagonists, Activators & Modulators
Product Name mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR Purity
L-Glutamine                
mGluR
≥98.0%
LY341495
mGluR1a, IC50: 7.8 μM
mGluR2, IC50: 21 nM
mGluR3, IC50: 14 nM
mGluR4, IC50: 22 μM
mGluR5a, IC50: 8.2 μM
 
mGluR7, IC50: 990 nM
mGluR8, IC50: 170 nM
  99.37%
Ro 67-7476
mGluR1a, EC50: 60.1 nM
                99.57%
DHPG
mGluR 1
     
mGluR 5
        99.31%
Eglumegad  
mGluR2R, IC50: 5 nM
mGluR3R, IC50: 24 nM
            ≥98.0%
AZ 12216052              
mGlu8
  ≥98.0%
mGluR2 modulator 1  
mGluR2, EC50: 0.03 ± 0.0 μM
             
MPEP Hydrochloride        
mGluR5, IC50: 36 nM
        99.93%
MTEP hydrochloride        
mGluR5, IC50: 5 nM
mGluR5, Ki: 16 nM
        99.71%
Xanthurenic acid  
mGluR2
mGluR3
            98.17%
VU0650786    
mGluR3, IC50: 392 nM
            99.97%
LY404039  
mGlu2 Receptor, Ki: 149 nM (Recombinant human mGluR2)
hmGluR3, Ki: 92 nM
            ≥98.0%
LY367385 hydrochloride
mGluR1a, IC50: 8.8 μM
                98.05%
Mavoglurant        
mGluR5, IC50: 30 nM
        99.72%
CTEP        
mGlu5 Receptor, IC50: 2.2 nM
        99.19%
JNJ-40411813  
mGlu2 Receptor, EC50: 147 nM
              98.97%
Foliglurax monohydrochloride      
mGlu4, EC50: 79 nM
          98.93%
LY2794193  
mGluR2, EC50: 47.5
mGluR2, Ki: 412
mGluR3, EC50: 0.47 nM
mGluR3, Ki: 0.927 nM
           
VU6005649            
mGlu7 Receptor, EC50: 0.65 μM
mGlu8 Receptor, EC50: 2.6 μM
  98.67%
Basimglurant        
mGlu5 Receptor, Kd: 1.1 nM
        99.56%
JNJ16259685
mGluR1, IC50: 19 nM
                98.10%
AZD-8529  
mGluR2, EC50: 285 nM
              98.43%
JNJ-42153605  
mGluR2, EC50: 17 nM
              99.24%
O-Phospho-L-serine
mGluR1
mGluR2
 
mGluR4
 
mGluR6
mGluR7
mGluR8
  ≥98.0%
Dipraglurant        
mGluR5, IC50: 21 nM
        99.99%
CHPG sodium salt        
mGlu5
        99.17%
(S)-3,5-DHPG
mGluR1a, Ki: 0.9 μM
     
mGluR5a, Ki: 3.9 μM
        ≥99.0%
RO0711401
mGluR1, EC50: 56 nM
                99.64%
CDPPB        
mGluR5, EC50: 27 nM
        98.05%
CHPG        
mGlu5
        ≥99.0%
AZD-8529 mesylate  
mGluR2, EC50: 285 nM
              99.05%
mGluR2 antagonist 1  
mGluR2, IC50: 9 nM
              99.06%
ADX88178      
mGluR4, EC50: 4 nM
          99.60%
VU6012962            
mGlu7, IC50: 347 nM
    99.92%
(S)-MCPG                
mGluR
99.61%
FPTQ
Human mGluR1, IC50: 6 nM
Mouse mGluR1, IC50: 1.4 nM
                99.88%
L-Cysteinesulfinic acid monohydrate
mGluR1, pEC50: 3.92
mGluR2, pEC50: 3.9
 
mGluR4, pEC50: 2.7
mGluR5, pEC50: 4.6
mGluR6, pEC50: 4.0
 
mGluR8, pEC50: 3.94
  99.30%
ADX-47273        
mGluR5, EC50: 0.17 μM
        99.34%
HTL14242        
mGlu5
        98.42%
(1R,2S)-VU0155041      
mGluR4
          ≥98.0%
Lu AF21934      
mGlu4 Receptor, EC50: 500 nM
          99.75%
LY3020371 hydrochloride  
mGluR2, Ki: 5.3 nM
mGluR3, Ki: 2.5 nM
            99.13%
CFMTI
Human mGluR1a, IC50: 2.6 nM
Rat mGluR1a, IC50: 2.3 nM
                ≥98.0%
Quisqualic acid
mGluR1R, EC50: 45 nM
mGluR1R, Ki: 10 nM
mGluR2R, IC50: 108 μM
mGluR2R, Ki: 113 μM
 
mGluR4R, IC50: 593 μM
mGluR4R, Ki: 112 μM
          ≥98.0%
trans-ACPD                
mGluR
≥98.0%
FITM
mGlu1, Ki: 2.5 nM
                98.19%
PHCCC                
Group I mGluR receptors, IC50: 3 μM
99.96%
Decoglurant  
mGluR2
mGluR3
            99.71%
FTIDC
mGluR1a, IC50: 5.8 nM
     
mGlu5, IC50: 6200 nM
       
LY2979165  
mGlu2 Receptor
              ≥98.0%
CPPHA        
mGlu5 Receptor
       
JNJ-46778212        
mGlu5 Receptor, EC50: 260 nM
        99.46%
MMPIP hydrochloride            
mGlu7
    99.03%
(S)-3,4-DCPG              
hmGluR8a, EC50: 31 nM
  ≥98.0%
L-AP4 monohydrate      
mGlu4, EC50: 0.13 μM
 
mGlu6, EC50: 1.0 μM
mGlu7, EC50: 249 μM
mGlu8, EC50: 0.29 μM
  ≥99.0%
JNJ-46281222  
mGluR2, Kd: 1.7 nM
              98.79%
Fenobam        
rat mGluR5, Kd: 54 nM
human mGluR5, Kd: 31 nM
        98.53%
LY2812223  
mGluR2, Ki: 144 nM
mGluR3, Ki: 156 nM
            ≥98.0%
L-AP4      
mGlu4, EC50: 0.13 μM
 
mGlu6, EC50: 1.0 μM
mGlu7, EC50: 249 μM
mGlu8, EC50: 0.29 μM
  99.40%
VU0361737      
Human mGlu4, EC50: 240 nM
Rat mGlu4, EC50: 110 nM
          99.83%
E4CPG                
mGluR
≥98.0%
NPS 2390
mGluR1
     
mGluR5
        ≥98.0%
TCN238      
mGlu4 Receptor, EC50: 1 μM
          98.31%
LY379268  
hmGluR2, EC50: 2.69 nM
hmGluR2, Ki: 14.1 nM
hmGluR3, EC50: 4.48 nM
hmGluR3, Ki: 5.8 nM
            99.84%
Methoxy-PEPy        
mGlu5 Receptor, IC50: 1 nM
        98.19%
VU 0364439      
mGlu4 Receptor, EC50: 19.8 nM
          98.65%
Pomaglumetad methionil hydrochloride  
mGluR2
mGluR3
            98.20%
BMT-145027        
mGluR5, EC50: 47 nM
        98.19%
Auglurant        
rat mGluR5, IC50: 11 nM
human mGluR5, IC50: 14 nM
        99.40%
VU0364770      
Rat mGlu4, EC50: 290 nM
Human mGlu4, EC50: 1.1 μM
mGlu5, EC50: 17.9 μM
mGlu6, EC50: 6.8 μM
      99.93%
Oxomemazine
mGluR 1, Ki: 84 nM
mGluR2, Ki: 1.65 μM
              99.18%
LY367385
mGluR1a, IC50: 8.8 μM
                ≥99.0%
(R)-ADX-47273        
mGlu5, EC50: 168 nM
        99.25%
VU0155041      
Human mGlu4, EC50: 798 nM
Rat mGlu4, EC50: 693 nM
          99.32%
L-Cysteinesulfinic acid
mGluR1, pEC50: 3.92
mGluR2, pEC50: 3.9
 
mGluR4, pEC50: 2.7
mGluR5, pEC50: 4.6
mGluR6, pEC50: 4.0
 
mGluR8, pEC50: 3.94
  99.31%
LY3020371  
hmGluR2, Ki: 5.26 nM
hmGluR3, Ki: 2.50 nM
           
(RS)-APICA  
mGluR2
             
Biphenylindanone A  
mGluR2
              99.12%
VU0364770 hydrochloride      
Rat mGlu4, EC50: 290 nM
Human mGlu4, EC50: 1.1 μM
mGlu5, EC50: 17.9 μM
mGlu6, EC50: 6.8 μM
      99.82%
AZD 2066        
mGluR5
        ≥99.0%
YM-298198 hydrochloride
mGluR 1
                ≥99.0%
AZD 2066 hydrate        
mGluR5
        ≥99.0%
Mavoglurant racemate        
mGluR5
        98.44%
VU 0357121        
mGlu5 Receptor, EC50: 33 nM
        99.97%
Pomaglumetad methionil  
mGluR2
mGluR3
           
VU6001376      
mGlu4, EC50: 50.1 nM
         
Foliglurax      
mGlu4, EC50: 79 nM
         
MGS0274  
mGluR2
mGluR3
           
VU0652835        
mGlu5, IC50: 81 nM
       
UPF-523
mGluR1a, IC50: 214 μM
               
JF-NP-26        
mGlu5 Receptor
       
ML337    
mGluR3, IC50: 593 nM
           
LSN2814617        
rat mGluR5, IC50: 42 ± 9 nM
human mGluR5, IC50: 52 ± 21 nM
       
TASP0433864  
hmGluR2, EC50: 199 nM
rat mGluR2, EC50: 206 nM
             
MMPIP            
mGlu7
   
CPPG                
group II mGlu receptors, IC50: 46.2 nM
group III mGlu receptors, IC50: 2.2 nM
LY3027788  
mGluR2
mGluR3
           
LSP4-2022      
mGluR4, EC50: 0.11 ± 0.0 μM
   
mGluR7, EC50: 11.6 ± 1.9 μM
mGluR8, EC50: 29.2 ± 4.2 μM
 
VU0080241      
mGlu4, EC50: 4.6 μM
          99.47%
mGluR2 modulator 2  
mGluR2, EC50: 0.13 μM
             
VU-1545        
mGluR5, Ki: 156 nM
mGluR5, EC50: 9.6 nM
       
LY3027788 hydrochloride  
mGluR2
mGluR3
           
ML254        
rat mGluR5, EC50: 9.3 nM
rat mGluR5, pEC50: 8.03 nM
       
Ro 01-6128
mGluR 1
               
VU0409106        
mGlu5, IC50: 24 nM
       
DCG-IV
mGluR1R, IC50: 389 μM
mGluR2R, EC50: 0.35 μM
mGluR3R, EC50: 0.09 μM
mGluR4R, IC50: 22.5 μM
mGluR5, IC50: 630 μM
mGluR6, IC50: 39.6 μM
mGluR7, IC50: 40.1 μM
mGluR8, IC50: 32 μM
 
VU0483605
Human mGluR1, EC50: 390 nM
rat mGluR1, EC50: 356 nM
   
Human mGlu4, EC50: >10 μM
         
mGlu4 receptor agonist 1      
mGluR4, EC50: 308 ± 35 nM
         
ADX71743            
mGlu7
   
SIB-1757        
human mGluR5, IC50: 0.4 μM
       
(RS)-PPG      
hmGluR4a, EC50: 5.2 μM
 
hmGluR6, EC50: 4.7 μM
hmGluR7b, EC50: 185 μM
hmGluR8a, EC50: 0.2 μM
 
EGLU  
mGluR2, Kd: 66 μM
             
MFZ 10-7 hydrochloride        
rat mGluR5, Ki: 0.67 nM
       
VU-29
rat mGluR1, EC50: 557 nM
rat mGluR2, EC50: 1.5 μM
 
hmGluR4, EC50: 154 nM
rat mGluR5, EC50: 9 nM
rat mGluR5, Ki: 224 nM
        98.04%
VU0422288      
mGluR4, EC50: 108 nM
   
mGluR7, EC50: 146 nM
mGluR8, EC50: 128 nM
 
VU0364289        
mGlu5, EC50: 1.6 μM
       
Ro 67-4853
Rat mGluR1a, pEC50: 7.16
               
LY 541850  
mGluR2, IC50: 0.161 μM
mGluR3, IC50: 1.05 μM
           
Pomaglumetad methionil anhydrous  
mGluR2
mGluR3
           
DCB        
mGluR 5
       
A-841720
Human mGluR1, IC50: 10 nM
     
human mGluR5, IC50: 342 nM
       
VU 0360223                
mGluR, IC50: 61 nM
cis-ACPD  
mGluR2, EC50: 13 μM
 
mGluR4, EC50: 50 μM
         
ML289    
mGluR3, IC50: 0.66 μM
           
VU0424465        
mGlu5
       
VU0469650
mGluR 1, IC50: 99 nM
               
mGluR2 modulator 3  
mGluR2, EC50: 0.87 μM
             
mGluR2 modulator 4  
mGluR2, EC50: 0.8 μM
             
(2R,4R)-APDC                
group II mGlu receptors
CPCCOEt
mGluR1b
               
NPEC-caged-LY379268                
group II mGlu receptors
VU0155041 sodium      
mGluR4, EC50: 693 nM
         
VU6001966  
mGluR2, IC50: 78 nM
mGluR3, IC50: >30 μM
           
ABP688        
human mGluR5, Ki: 1.7 nM
       
Cinnabarinic acid      
mGluR4
         
DFMTI
mGluR1
                99.32%
VU6010572    
mGluR3, IC50: 245 nM
           
MPEP        
mGluR5, IC50: 36 nM
       
AZD 9272        
mGluR5