1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. SGK


Serum- and glucocorticoid-inducible kinase (SGK) is a member of the Ser/Thr protein kinase family that regulates a variety of cell functions. SGK may regulate the cell cycle through the modulation of microtubule (MT) dynamics in tumor cells. SGK depolymerizes MTs through two distinct mechanisms both in vitro and in vivo. First, SGK directly depolymerizes MT independently of its kinase activity. Second, SGK depolymerizes MT through the phosphorylation of tau specifically at Ser214.

SGK is under regulation of several hormones, mediators and cell stressors. SGK is cloned as a gene up-regulated by serum and glucocorticoids in rat mammary tumor cells.

SGK is transcriptionally upregulated by mineralocorticoids and activated by insulin. The kinase enhances renal tubular Na+-reabsorption and accounts for blood pressure increase following high salt diet in mice made hyperinsulinemic by dietary fructose or fat.

SGK Related Products (8):

Cat. No. Product Name Effect Purity
  • HY-15193
    EMD638683 Inhibitor 99.74%
    EMD638683 is a highly selective SGK1 inhibitor, with an IC50 value of 3 μM.
  • HY-15192
    GSK 650394 Inhibitor 99.76%
    GSK 650394 is a novel SGK inhibitor with IC50 of 62 nM and 103 nM for SGK1 and SGK2 in the SPA assay respectively. GSK 650394 also inhibits influenza virus replication.
  • HY-18607
    SGK1-IN-1 Inhibitor 98.76%
    SGK1-IN-1 is a highly active and selective inhibitor of SGK-1, with an IC50 of 1 nM.
  • HY-125878
    PROTAC SGK3 degrader-1 Inhibitor 98.83%
    PROTAC SGK3 degrader-1 (SGK3-PROTAC1), is a potent SKG3 degrader based on PROTAC. PROTAC SGK3 degrader-1 (0.3 μM) induces 50% degradation of endogenous SGK3 within 2 hours, with maximal 80% degradation observed within 8 hours, accompanied by a loss of phosphorylation of NDRG1 (an SGK3 substrate).
  • HY-15193A
    EMD638683 R-Form Inhibitor 99.68%
    EMD638683 R-Form is the R-form of EMD638683. EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM.
  • HY-135893
    SGK1-IN-2 Inhibitor
    SGK1-IN-2 (14h) is a selective SGK1 (serum and glucocorticoid regulated kinase 1) inhibitor, with an IC50 of 5 nM at 10 μM ATP concentration.
  • HY-15193B
    EMD638683 S-Form Inhibitor 98.30%
    EMD638683 S-Form is the S-form of EMD638683. EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM.
  • HY-133028
    CKI-7 free base Inhibitor 99.31%
    CKI-7 free base is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. CKI-7 free base is a selective Cdc7 kinase inhibitor. CKI-7 free base also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 free base has a much weaker effect on casein kinase II and other protein kinases.
Isoform Specific Products

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