SI-113
Based on 1 Customer Validation
SI-113 is a SGK1 inhibitor, with an IC50 of 600 nM. SI113 induces autophagy.
For research use only. We do not sell to patients.
- Purity: 98.09%
- CAS No.: 1392816-46-4
- Formula: C23H24N6O
- Molecular Weight:400.48
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
25.64 μM
Compound: 2; Si113
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Cytotoxicity against human A2780 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human A2780 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
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[PMID: 34161866] |
| A2780 | IC50 |
3.47 μM
Compound: 2; Si113
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Cytotoxicity against human A2780 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human A2780 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
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[PMID: 34161866] |
| A2780 | IC50 |
4.56 μM
Compound: 2; Si113
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Cytotoxicity against human A2780 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human A2780 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
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[PMID: 34161866] |
| HepG2 | IC50 |
15.87 μM
Compound: 2; Si113
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
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[PMID: 34161866] |
| HepG2 | IC50 |
3.15 μM
Compound: 2; Si113
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
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[PMID: 34161866] |
| HepG2 | IC50 |
8.29 μM
Compound: 2; Si113
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
|
[PMID: 34161866] |
| Huh-7 | IC50 |
0.58 μM
Compound: 2; Si113
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Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
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[PMID: 34161866] |
| Huh-7 | IC50 |
1.88 μM
Compound: 2; Si113
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Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
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[PMID: 34161866] |
| Huh-7 | IC50 |
2.05 μM
Compound: 2; Si113
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Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
|
[PMID: 34161866] |
SI-113 exhibits IC50 values of 10.5, 14.4 and 10.7 μM in GIN8, GIN28 and GCE28 GBM cells[1].
SI-113 induces significant increases in caspase-3/7 activation in all GBM cell lines[1].
SI-113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1392816-46-4
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Appearance Solid
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Molecular Weight 400.48
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Formula C23H24N6O
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Color White to off-white
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SMILES
OCCNC1=NC(NCCC2=CC=CC=C2)=C3C(N(/C=C/C4=CC=CC=C4)N=C3)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 250 mg/mL (624.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Marco Radi , et al. A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: from in silico screening to cyclodextrin formulation. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5579-83. [Content Brief]
[2]. Silvia Matteoni, et al. The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells. J Exp Clin Cancer Res. 2019 May 17;38(1):202. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4970 mL | 12.4850 mL | 24.9700 mL | 62.4251 mL |
| 5 mM | 0.4994 mL | 2.4970 mL | 4.9940 mL | 12.4850 mL | |
| 10 mM | 0.2497 mL | 1.2485 mL | 2.4970 mL | 6.2425 mL | |
| 15 mM | 0.1665 mL | 0.8323 mL | 1.6647 mL | 4.1617 mL | |
| 20 mM | 0.1249 mL | 0.6243 mL | 1.2485 mL | 3.1213 mL | |
| 25 mM | 0.0999 mL | 0.4994 mL | 0.9988 mL | 2.4970 mL | |
| 30 mM | 0.0832 mL | 0.4162 mL | 0.8323 mL | 2.0808 mL | |
| 40 mM | 0.0624 mL | 0.3121 mL | 0.6243 mL | 1.5606 mL | |
| 50 mM | 0.0499 mL | 0.2497 mL | 0.4994 mL | 1.2485 mL | |
| 60 mM | 0.0416 mL | 0.2081 mL | 0.4162 mL | 1.0404 mL | |
| 80 mM | 0.0312 mL | 0.1561 mL | 0.3121 mL | 0.7803 mL | |
| 100 mM | 0.0250 mL | 0.1249 mL | 0.2497 mL | 0.6243 mL |
SI-113 Related Classifications
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