BDCA-4/CD304
BDCA-4 (CD304) is the BDCA designation for neuropilin-1, a receptor best known in neurobiology and vascular biology. Neuropilin-1 binds class 3 semaphorins through its extracellular a1/a2 domains and VEGF-A through the b1/b2 domains, functioning as a co-receptor that modulates NRP-associated plexins and VEGF receptor tyrosine kinases rather than signaling on its own. In immunology, CD304 together with BDCA-2 identifies human plasmacytoid dendritic cells, the principal interferon-producing cells. Tumor endothelium and various carcinomas also express the molecule, where it supports angiogenesis and VEGF-driven migration, and soluble neuropilin-1 in plasma has been proposed as an angiogenesis biomarker.
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BDCA-4/CD304 Recombinant Proteins (9)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
