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  5. Neuropilin-1 Protein, Cynomolgus (HEK293, His)

Neuropilin-1 Protein, Cynomolgus (HEK293, His)

Cat. No.: HY-P70185
COA Handling Instructions

Neuropilin-1 Protein, a transmembrane glycoprotein, regulates axon guidance, angiogenesis, neuronal development, and immune responses. Neuropilin-1 can interacts with VEGF and semaphorins, and promote the growth, survival, and self-renewal of tumors. Neuropilin-1 also acts as an entry factor and potentiate SARS-CoV-2 and Epstein-Barr virus (EBV) infectivity. Furthermore, Neuropilin-1 acts as a co-receptor for TGF-β, and enhances TGF-β activity via the SMAD2/3 signaling pathway. Neuropilin-1 Protein, Cynomolgus (592a.a, HEK293, His) is the recombinant cynomolgus-derived Neuropilin-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Neuropilin-1 Protein, Cynomolgus (592a.a, HEK293, His) is 592 a.a., with molecular weight of 80-100 kDa.

For research use only. We do not sell to patients.

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Description

Neuropilin-1 Protein, a transmembrane glycoprotein, regulates axon guidance, angiogenesis, neuronal development, and immune responses. Neuropilin-1 can interacts with VEGF and semaphorins, and promote the growth, survival, and self-renewal of tumors. Neuropilin-1 also acts as an entry factor and potentiate SARS-CoV-2 and Epstein-Barr virus (EBV) infectivity. Furthermore, Neuropilin-1 acts as a co-receptor for TGF-β, and enhances TGF-β activity via the SMAD2/3 signaling pathway[1][2][3]. Neuropilin-1 Protein, Cynomolgus (592a.a, HEK293, His) is the recombinant cynomolgus-derived Neuropilin-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Neuropilin-1 Protein, Cynomolgus (592a.a, HEK293, His) is 592 a.a., with molecular weight of 80-100 kDa.

Background

Neuropilin-1 (NRP1) protein is a transmembrane glycoprotein. In mice, NRP1 is selectively expressed on thymic-derived Tregs, and enhances immunosuppressive function. In humans, NRP1 is mainly expressed on plasmacytoid dendritic cells (pDCs) where it aids in priming immune responses, as well as on a subset of T regulatory cells (Tregs) isolated from secondary lymph nodes[1].
Neuropilin-1 transduce signals for VEGFs, together with VEGFR family members. Neuropilin-1 interacts with VEGF and semaphorins, and can promote the growth, survival, and self-renewal of tumors. For example, Neuropilin-1 can complex with VEGFR2 in vascular endothelial cells to induce vessel permeability and angiogenesis[3].
Neuropilin-1 also acts as an entry factor and potentiate SARS-CoV-2 infectivity. Besides, Neuropilin-1 is an entry receptor for Epstein-Barr virus (EBV) infection of nasopharyngeal epithelial cells, and enhances EBV infection[2][3]. NRP-1 plays a central role in axonal guidance and pruning by interaction with Semaphorin-3A (a protein seen widely in both the nervous system and the vasculature)[3].
Furthermore, Neuropilin-1 acts as a co-receptor for TGF-β, and enhances TGF-β activity via the SMAD2/3 signaling pathway. Neuropilin-1 can activate the inactive latent form (LAP-TGF-β), and also promote immune suppression[1].
Neuropilin-1 plays an important role in angiogenesis, neuronal development, and the regulation of immune responses.

Species

Cynomolgus

Source

HEK293

Tag

C-6*His

Accession

G7PEQ1 (F22-G613)

Gene ID
Molecular Construction
N-term
Neuropilin-1 (F22-G613)
Accession # G7PEQ1
6*His
C-term
Synonyms
rCynNeuropilin-1, His; CD304; NRP1; NRPNP1; VEGF165R; BDCA4; Neuropilin-1
AA Sequence

FRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGRLWGKFCGKIAPPPVVSSGQFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEAVGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDISSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISLRFEVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYVNEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNPVDECDDDQANCHSG

Molecular Weight

80-100 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

Neuropilin-1 Protein, Cynomolgus (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Neuropilin-1 Protein, Cynomolgus (HEK293, His)
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HY-P70185
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