1. Literature



  • Science | Cuproptosis,copper-induced programmed cell death
    Tsvetkov et al. published in Science and demonstrated a copper-induced programmed cell death — Cuproptosis. As a novel programmed cell death, excess copper triggers abnormal aggregation of lipoylated proteins in TCA cycle and clearance of Fe-S cluster proteins, ultimately leading to cell death.
  • The infinite possibilities of RNA therapeutics
    RNA therapeutics have changed the landscape of drug development, which possess broader spectrum of drug targets, simplicity and efficiency in development and manufacturing.In this article, we will discuss the underlying mechanisms of RNA-based drugs on the market or in clinical stages.
  • BAC PROTAC independent of ubiquitin protease degradation pathway
    BacPROTACs is composed of a POI ligand, a chemical linker and a ClpCNTD anchor. BacPROTACs can induce in vitro and in vivo degradation of non-eukaryotic proteins in bacteria without the ubiquitin proteasome system.
  • Development of Intestinal Organoid
    3D organoid is one of the revolutionary developments in biomedical field during the past 10 years. The establishment of intestinal organoids is an important milestone in the development of organoid technology.
  • Organoids: from traditional 2D cell Culture to 3D culture models
    Organoids represent an important bridge between 2D cultures and in vivo mouse/human models. The organoid technology exerts enormous potential in evaluation of efficacy and toxicity of drugs, regenerative medicine, and precision medicine.In this article, we will briefly introduce organoid technology.
  • PROTAC—Target Selection and Design
    A PROTAC molecule consists of three components: a target protein binding ligand, an E3 ligase ligand, and a linker connecting these two moieties. Here, we will discuss the conventional approaches for the rational design of PROTAC molecules.
  • PROTAC — Future of Drug Molecules from Modular Construction
    PROTAC, which exploit the ubiquitin-proteasome pathway to specifically degrade target proteins. PROTACs not only solve the problem of undruggability but they also have other advantages compared to traditional drug targeting strategies.
  • Antibody-Drug Conjugates (ADCs), a Growing Class of Targeted Cancer Therapeutics
    The concept of ADC can be traced back to the early 1900s, It is a visionary magic bullet that could deliver a toxic drug to certain malignant cells without affecting other normal tissues. Now, it seems that a golden age of ADC drug development is coming.
  • Tools for SARS-CoV-2 Research — The Battle against COVID-19 has just Begun
    SARS-CoV-2 contains four main structural proteins: spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins. All the proteins and subcellular structures of CoVs are promising targets for SARS-CoV-2 research.

Product Guides

  • Exosomes: isolation, labeling and identification
    Exosomes are nano-sized biovesicles released into surrounding body fluids after the fusion of multivesicular bodies with the plasma membrane. In this article, we will briefly introduce isolation, labeling and identification of exosomes. And the specific application of exosomes will also be mentioned.
  • Cell Apoptosis/Methods for the detection of apoptosis
    Apoptosis is a form of programmed cell death. There are many methods to detect apoptosis which can roughly be divided into three categories: based on cell morphology, biological function and biochemical markers. Some of the most commonly employed assays are described in this article.
  • ROS Probes-All Eyes Are Focused Here!
    In this article, we will introduce different ROS probes: ROS probe H2DCFDA, •O2 probes HKSOX-1 and HKSOX-1r, and H2O2 probe HKPerox-2. Here we will explains the protocol to use these probes, additionally, some case study for probe usage are listed.